Clinical trials: Diaphragmatic Hernia
Isolated Non Syndromic Left CDH With Postero Lateral Diaphragmatic Defect With Good Perinatal Outcome
Genetic Basis of Non Syndromic Congenital Diaphragmatic Hernia
In isolated congenital diaphragmatic hernia (CDH), recurrent risk is low suggesting the occurrence of novo mutations (dominant or recessive).
- Trial name
- HCD GENE (NCT02175264)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Diaphragmatic Hernia
North American Fetal Therapy Network for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia
The purpose of this study is to evaluate successful placement and removal of Fetoscopic Endoluminal Tracheal Occlusion (FETO) device in cases of intrathoracic liver herniation with isolated left congenital diaphragmatic hernia…
- Trial name
- NCT06739356
- Testing
- Fetal Treatment arm (FETO Group)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diaphragmatic Hernia
Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)
This is a single site, single arm, non-randomized, pilot trial to assess the feasibility and safety of treating severe congenital diaphragmatic hernia (CDH) with Fetal Endoscopic Tracheal Occlusion (FETO) at Columbia University…
- Trial name
- NCT05354505
- Testing
- Placement of the GOLDBAL2 balloon
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vincent Duron
Congenital Diaphragmatic Hernia
De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia
The purpose of this study is to determine if de-implementation of inhaled nitric oxide (iNO) in the post-natal resuscitation/stabilization phase affects the composite outcome of extracorporeal life support (ECLS) use and/or…
- Trial name
- NCT05213676
- Testing
- Inhaled Nitric Oxide (iNO) use, De-implementation of Inhaled Nitric Oxide (iNO) use
- Where
- 19 sites in United States
- Volunteers
- 900 people
- Sponsor
- The University of Texas Health Science Center, Houston
Congenital Diaphragmatic Hernia
Measurement of Lung Area at Chest Radiography to Define the Prognosis in Newborns With CDH
CDH represents a malformative disorder characterized by an incomplete diaphragm formation. This results in poor lung development (pulmonary hypoplasia), associated with altered vascularization of the lung (pulmonary…
- Trial name
- NeoAPACHE (NCT04396028)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Congenital Diaphragmatic Hernia
Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia
CDH is associated with lung hypoplasia, pulmonary hypertension, and left ventricular hypoplasia. Use of new STE techniques (heart ultrasound) showed that CDH newborns have decreased LV size and function, potentially explaining…
- Trial name
- NCT04114578
- Testing
- Echocardiography
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hiatus Hernia, Gastreoesophageal Reflux Disease
Phrenoesophageal Ligament Reconstruction With Mesh
Introduction: The phrenoesophageal ligament (PEL) is a crucial structure that attaches the esophagus to the diaphragm, allowing for independent movement during respiration and swallowing.
- Trial name
- NCT07251010
- Testing
- Phrenoesophageal Ligament Reconstruction with Mesh: A New Approach to Hiatal Hernia Repair (Alinasser's Technique), Classic approach
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Clinical Trial Aseer
Paraesophageal Hernia, Hiatal Hernia
Sutures Versus Polyglactin Mesh in Hiatal Hernia Repair
Paraesophageal hernia causes pain, heartburn, regurgitation, anemia and in extreme, life-threatening strangulation. For symptomatic patients, laparoscopic surgery is offered which includes hiatal defect closure and antireflux…
- Conditions
- Paraesophageal Hernia, Hiatal Hernia, Hiatal Hernia, Paraesophageal, Recurrence
- Trial name
- NCT05201508
- Testing
- Polyglactin mesh, Sutures only
- Where
- Finland
- Volunteers
- 110 people
- Sponsor
- Oulu University Hospital
Hiatal Hernia
A Prospective Randomised Multi - Center Trial on the Repair of Large Hiatal Hernias: Absorbable Mesh vs. Pledgeted Sutures vs. Sutures Only
A prospective randomised multi - center trial on the repair of large hiatal hernias with sutures versus pledgeted sutures versus absorbable mesh The primary objective of the present trial is to compare the hiatal hernia…
- Trial name
- NCT04591860
- Testing
- Laparoscopic or robot-assisted hiatal closure (sutures only vs. absorbable mesh vs. pledgeted sutures) and fundoplication according to Toupet
- Volunteers
- 165 people
- Sponsor
- Paracelsus Medical University
Rectointercostal, Laparoscopic
Recto-intercostal Facial Plane Block in Laparoscopic Hiatus Hernia Repair
The aim of this study is to evaluate the perioperative analgesic and intraoperative hemodynamic effects of ultrasound-guided bilateral recto-intercostal fascial plane block in patients undergoing laparoscopic Hiatus hernia repair.
- Conditions
- Rectointercostal, Laparoscopic, Hiatus Hernia
- Trial name
- NCT06820216
- Testing
- Rectointercostal facial plane block using bupivacaine 0.25%, No Intervention as a control
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Gastroesophageal Reflux, Esophageal Atresia
Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.
The purpose of this study is to compare the efficacy of oral and rectal omeprazole treatment in infants with gastroesophageal reflux due to esophageal atresia or congenital diaphragmatic hernia.
- Conditions
- Gastroesophageal Reflux, Esophageal Atresia, Hernia, Diaphragmatic
- Trial name
- NCT00226044
- Testing
- Omeprazole rectally 1mg/kg
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Rijnstate Hospital
Congenital Diaphragmatic Hernia
Machine and Deep Learning for Congenital Diaphragmatic Hernia (CLANNISH)
Congenital Diaphragmatic Hernia (CDH) is characterized by an incomplete diaphragm formation, resulting in poor lung development (pulmonary hypoplasia), associated with altered vascularization of the lung (pulmonary hypertension)…
- Trial name
- CLANNISH (NCT04609163)
- Testing
- data collection
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Fetal Surgery, Myelomeningocele
Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery
Open maternal-fetal surgery is currently used on fetuses with myelomeningocele (MMC). Fetoscopic or minimal access fetal surgery is also being used to treat fetuses with congenital diaphragmatic hernia (CDH).
- Conditions
- Fetal Surgery, Myelomeningocele, Congenital Diaphragmatic Hernia
- Trial name
- NCT03788122
- Testing
- In-depth interview
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophagogastric Junction Distensibility, Hiatal Hernia
Esophagogastric Junction Distensibility During Hiatal Hernia Repair
The investigators aim to ascertain the effects of hiatal hernia repair and fundoplication on the distensibility of the esophagogastric junction (EGJ) as measured by FLIP topography/impedance planimetry.
- Trial name
- NCT04450628
- Testing
- EndoFLIP
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Hernia, Hiatal, Laparoscopic
Laparoscopic Primary Diaphragm Versus Mesh Repair for Hiatus Hernia: a Long-Term Follow-Up
Assessment of the recurrence of hiatal hernia five to ten years after repair using sutures versus sutures reinforced with non-absorbable mesh.
- Conditions
- Hernia, Hiatal, Laparoscopic, Surgery, Recurrence
- Trial name
- PRIME LTFU (NCT05662735)
- Testing
- Mesh repair, Suture repair
- Volunteers
- 60 people
- Sponsor
- Rijnstate Hospital
Diaphragmatic Hernia
Fetoscopic Tracheal Balloon Occlusion in Left Diaphragmatic Hernia
Left diaphragmatic hernia detected during fetal life carries a high risk for postnatal lung failure due to lung underdevelopment and pulmonary hypertension.
- Trial name
- NCT00373438
- Testing
- Fetoscopic tracheal balloon occlusion
- Where
- Germany
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Congenital Diaphragmatic Hernia
Retrospective Comparative Study on Imaging Between the Bochdalek Hernia and Congenital Diaphragmatic Eventration
The imaging manifestations of diaphragmatic hernia and diaphragmatic distension were retrospectively analyzed and summarized, combined with the surgical findings, to summarize the differences in indirect signs of diaphragmatic…
- Trial name
- NCT05985564
- Testing
- imaging diagnosis
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Congenital Diaphragmatic Hernia, Pulmonary Hypertension
A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)
Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 3000 US live births, similar to the incidence seen within the Utah Birth Defects cohort.
- Trial name
- NCT05201144
- Testing
- Sildenafil Oral Suspension
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Diaphragm Injury
Laparoscopy Versus Clinical Follow up to Detect Diaphragm Injury
Title: A randomized prospective study comparing non operative management with laparoscopic treatment in patients with a diaphragm injury following left thoracoabdominal stab wounds.
- Trial name
- NCT01044550
- Testing
- Laparoscopy, Clinical follow up
- Where
- South Africa
- Volunteers
- 66 people
- Sponsor
- University of Cape Town
Hiatal Hernia, Paraesophageal, Hiatal Hernia Large
Laparoscopic Nissen Versus Toupet Fundoplication for Hiatal Hernia.
This randomized controlled trial compares laparoscopic Nissen fundoplication and laparoscopic Toupet fundoplication in patients undergoing surgical treatment for hiatal hernia associated with gastroesophageal reflux disease.
- Conditions
- Hiatal Hernia, Paraesophageal, Hiatal Hernia Large, Hiatal Hernia With Gastroesophageal Reflux Disease
- Trial name
- NCT07718828
- Testing
- Laparoscopic Nissen Fundoplication, Laparoscopic Toupet Fundoplication
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Sofia Med Hospital