Clinical trials: Diaphragmatic Hernia
Congenital Diaphragmatic Hernia
High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia
The purpose of this study is to conduct a prospective study of all congenital diaphragmatic hernia (CDH) neonates managed at the University of Utah newborn intensive care unit (NICU) and Primary Children's Hospital NICU that…
- Trial name
- NCT04774848
- Testing
- High Frequency Jet Ventilator, High Frequency Oscillatory Ventilator
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Feeding and Eating Disorders
Improving Gastrointestinal Function In High-Risk Newborns By Stimulation Of The Enteric Nervous System
The goal of this therapeutical intervention trial is to investigate whether tactile-kinesthaetic and oral sensorimotor stimulation can improve gastrointestional function in preterm infants born before gestational age of 30 weeks…
- Trial name
- NeoHemoHapt (NCT06057415)
- Testing
- HAPTOS (Handling Adapted to Postnatal age with Tactile-kinaesthetic and Oral sensorimotor Stimulation
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Hiatal Hernia, Paraesophageal Hernia
The Biologic Basis of Hernia Formation
The study will examine potential biological and genetic mechanisms leading to hiatal and paraesophageal hernia formation in predisposed individuals.
- Trial name
- NCT01099033
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Washington University School of Medicine
Congenital Diaphragmatic Hernia
Preliminary Study of Pediatric Diaphragmatic Elastography
This diaphragmatic elastography study is a preliminary pilot study to have first values of diaphragmatic stiffness in patients with a history of diaphragmatic hernia and to estimate the difference in stiffness compared to a group…
- Trial name
- ECHODIA (NCT06666140)
- Testing
- Ultrasonic elastography
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
GERD, Hiatal Hernia
Long-term Follow-up After Hiatal Hernia Repair by Tension-free Mesh Closure or Simple Suturing
10 years of follow-up after surgery for hiatal hernia by tension-free mesh closure or simple suturing.
- Conditions
- GERD, Hiatal Hernia, Dysphagia, Esophageal, Quality of Life
- Trial name
- NCT05069493
- Testing
- simple suturing, mesh
- Where
- Sweden
- Volunteers
- 103 people
- Sponsor
- Karolinska University Hospital
Congenital Diaphragmatic Hernia
Initiation of Resuscitation While Attached to the Cord With Congenital Diaphragmatic Hernia
This study aims to measure the cardio-respiratory physiological consequences of initiating resuscitation during placental transfusion (PT) with an intact umbilical cord in infants with congenital diaphragmatic hernia (CDH).
- Trial name
- INSPIRE-CDH (NCT03094039)
- Testing
- Ventilatory support while attached to the cord, Immediate cord clamping
- Where
- Canada
- Sponsor
- University of Alberta
Congenital Diaphragmatic Hernia
Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)
This is a single site pilot trial to assess the feasibility and safety of treating severe CDH with Fetal Endoscopic Tracheal Occlusion with the Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter…
- Trial name
- FETO (NCT04052828)
- Testing
- FETO with Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Dr Erin Perrone
Paraesophageal Hernia
Effect of Hernia Sac Excision on Crural Tension in Paraesophageal Hernia Repair
Paraesophageal hernia can cause significant clinical symptoms, including reflux, chest pain, nausea, regurgitation, and even life threatening conditions such as bowel obstruction, and gastric volvulus.
- Trial name
- NCT07197619
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Corewell Health West
Congenital Diaphragmatic Hernia
Children With Congenital Diaphragmatic Hernia and the Quality of Their Daily Lives
Background: Congenital diaphragmatic hernia is a rare disease, resulting from a developmental malformation of the diaphragm. Over the last years, management of the affected children has improved significantly.
- Trial name
- NCT07432672
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Safety and Efficacy of FETO in CDH: A Phase III Trial
Congenital diaphragmatic hernia (CDH) is a birth defect characterized by the development of a hole in the diaphragm, the breathing muscle that separates the chest from the abdomen.
- Trial name
- CHOP FETO (NCT06884423)
- Testing
- FETO with GoldBAL2 Balloon and BALTACCIBDPE100 Catheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Holly L Hedrick, MD
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in Fetuses With Severe Congenital Diaphragmatic Hernia
The goal of this pilot trial is to learn more about the role of Fetal Endotracheal Occlusion (FETO) as an intervention in fetuses with severe congenital diaphragmatic hernia (CDH).
- Trial name
- NCT06281717
- Testing
- Fetal Endotracheal Occlusion (FETO)
- Where
- United States
- Sponsor
- Eyal Krispin
Congenital Diaphragmatic Hernia
Fetoscopic Endoluminal Tracheal Occlusion (FETO) With Smart-TO
The purpose of this study is to make the proof of concept and to evaluate the safety of fetoscopic endoluminal tracheal occlusion (FETO) using Smart-TO device in fetuses with congenital diaphragmatic hernia and moderate to severe…
- Trial name
- Smart-FETO (NCT04931212)
- Testing
- FETO with Smart-TO balloon
- Where
- 2 sites in France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Achalasia, Paraesophageal Hernia
Minimally Invasive Surgery of the Gastro-esophageal Junction
This study will assess short and long term outcomes of individuals undergoing minimally invasive surgery of the gastro-esophageal junction (MISGEJ).
- Conditions
- Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula
- Trial name
- MISGEJ (NCT01799967)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Congenital Diaphragmatic Hernia
Airway Inflammation in Congenital Diaphragmatic Hernia Patients
We propose to examine Congenital Diaphragmatic Hernia (CDH) patients for evidence of airway inflammation as a first step to characterize the reported bronchodilator responsiveness.
- Trial name
- NCT02453750
- Testing
- Hypersaline, Bronchodilator Response
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children
Esophageal Hernia, Hernia, Esophageal
Use of Strattice Mesh in Paraesophageal Hernia Surgery
The objective of this study is to examine the safety and efficacy of porcine acellular dermal matrix mesh (Strattice; LifeCell Corp., Branchburg, NJ) in crural reinforcement of laparoscopic large paraesophageal hernia repair.
- Conditions
- Esophageal Hernia, Hernia, Esophageal, Hernia, Paraesophageal, Hiatal Hernia
- Trial name
- Strattice (NCT01678157)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Nebraska
Sepsis, Congenital Diaphragmatic Hernia
Inflammatory Cytokine Quantification in Infants
This study proposes to quantify inflammatory cytokine profiles in three neonatal disease states, namely, neonatal sepsis, infants with a congenital diaphragmatic hernia defect, and infants suffering cardiopulmonary failure…
- Conditions
- Sepsis, Congenital Diaphragmatic Hernia, Neonatal Cardiopulmonary Failure
- Trial name
- NCT01155830
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Utah
Congenital Diaphragmatic Hernia
Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH)
The purpose of this study is to investigate the use of autologous umbilical cord blood (UCB) mononuclear cells to mitigate hypoxic neurologic injury among infants with high-risk congenital diaphragmatic hernia (CDH).
- Trial name
- NCT03526588
- Testing
- Autologous umbilical cord blood
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hernia, Paraesophageal
Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo
We aim to study the impact of perioperative IV lidocaine on postoperative pain control in patients undergoing paraesophageal hernia repair. This is in the context of an established ERAS protocol.
- Trial name
- PEH (NCT04096170)
- Testing
- IV lidocaine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Congenital Diaphragmatic Hernia
Infant Survival and Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia, A Phase III Trial
The purpose of the study is to determine the infant survival and long-term effects of performing Fetoscopic Endoluminal Tracheal Occlusion (FETO) surgery and removal of the BALT Goldbal2 balloon at Children's Mercy Hospital.
- Trial name
- NCT06179472
- Testing
- BALT GOLDBAL2 Balloon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Inna Lobeck
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Safety and Efficacy of FETO in CDH Phase III
Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses and standard of care control group
- Conditions
- Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary Hypertension
- Trial name
- CDH FETO (NCT07187206)
- Testing
- FETO, Fetal Endoluminal Tracheal Occlusion
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati