Clinical trials: Diaphragmatic Injury
Respiratory Failure, Long-term Non-invasive Ventilation
Ventilator-associated Injury (VAI) in Chronic Home Mechanical Ventilation
Rationale: The pathophysiological changes in respiratory muscle morphology and functioning in patients with end-stage pulmonary disease are not very well known.
- Trial name
- NCT04521426
- Testing
- No other than standard care
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Hernia, Ventral, Hernia, Hiatal
GORE® ENFORM Biomaterial Product Study
A prospective, retrospective, non-randomized, multicenter study with two independent hernia study cohorts (Ventral / Incisional Hernia Repair and Diaphragmatic / Hiatal Hernia Repair).
- Conditions
- Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
- Trial name
- ENF 18-06 (NCT04718168)
- Testing
- Gore ENFORM Biomaterial (Preperitoneal), Gore ENFORM Biomaterial (Intraperitoneal)
- Where
- 9 sites in United States
- Volunteers
- 245 people
- Sponsor
- W.L.Gore & Associates
Injury of Diaphragm, Mechanical Ventilation Complication
Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients
Mechanical ventilation can be life saving strategy for patients with respiratory failure due to a variety of reasons. Once the underlying illness has resolved, intensive care doctors have to take a decision on when the patient is…
- Conditions
- Injury of Diaphragm, Mechanical Ventilation Complication, Critical Illness
- Trial name
- NCT03139695
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cervical Spinal Cord Injury
Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
The goal of this clinical trial is to determine whether people with paralysis due to a spinal cord injury can benefit from breathing short intermittent bouts of air with low oxygen (O2) combined with slightly higher levels of…
- Trial name
- AIHH+tSCS (NCT06101199)
- Testing
- Acute Intermittent Hypercapnic Hypoxia, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Emergencies, Trauma Injury
Pre-Hospital Zone 1 Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Injured Patients With Exsanguinating Sub-diaphragmatic Haemorrhage
It is unknown whether this evolved strategy (Pre-Hospital Zone I P-REBOA) is feasible and with an acceptable safety profile. This study will address this question, therefore informing the design of a prospective multicentre…
- Conditions
- Emergencies, Trauma Injury, Trauma, Multiple
- Trial name
- P-PRO (NCT04145271)
- Testing
- Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
- Where
- 4 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- Barts & The London NHS Trust
Diaphragm Injury, Weaning Failure
The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
This study is designed to determine whether maximal diaphragm thickening fraction measured by ultrasound during volitional maximal inspiratory efforts is a valid measure of diaphragm function in mechanically ventilated patients.
- Conditions
- Diaphragm Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- SNIFF III (NCT03129217)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University Health Network, Toronto
Diaphragm Injury
Comparison of Supraclavicular and Costoclavicular Brachial Plexus Blocks in Adult Patients
Hemidiaphragmatic paresis is a common side effect of brachial plexus blocks such as supraclavicular or infraclavicular block techniques.
- Trial name
- NCT06329440
- Testing
- Ultrasonographic measurement of diaphragm thickness
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Diaphragm Injury, Mechanical Ventilation Complication
Evaluation of the Regeneration Capacity of Satellite Cells From the Quadriceps Compared to That of the Diaphragm
Actually no treatment exists to prevent the loss of diaphragmatic function induced by mechanical ventilation during an intensive care unit stay.
- Trial name
- ECARS (NCT05194631)
- Testing
- Quadriceps microbiopsy using a Tru-Cut biopsy needle
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Septic Shock, Acute Respiratory Distress
Diaphragmatic Atrophy Related to Mechanical Ventilation
Ventilatory support during critical phase result in inactivity of respiratory muscles especially diaphragm muscle. These inactivity also result in change of contractile capability and quick muscular atrophy.
- Trial name
- ECHODIAPH (NCT02766946)
- Testing
- Ultrasound, Neuromyopathy score, Respiratory performances
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Phrenic Nerve Injury
Modified Diaphragmatic Plication Rectifies Dyspnea
Traditional diaphragmatic plication (DP) surgery is employed to ameliorate respiratory function in patients with diaphragmatic paralysis, which is rather complicated. This study introduces a modified method of DP.
- Trial name
- NCT06775873
- Testing
- Modified diaphragmatic plication
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tongji University
Ventilator Lung, Ventilator-Induced Lung Injury
Phrenic Identification in the ICU
This will be a prospective observational study where the investigator will scan patients' necks with an ultrasound and look for anatomical landmarks that may help identify the phrenic nerve.
- Conditions
- Ventilator Lung, Ventilator-Induced Lung Injury, Diaphragm Disease, Phrenic Nerve
- Trial name
- NCT05875883
- Testing
- Neck ultrasound
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Unity Health Toronto
Respiratory Failure, Diaphragm Injury
Diaphragm Ultrasound as a Powerful Tool in Managing Acute Hypoxemic Respiratory Failure in Hematological Patients
Acute hypoxemic respiratory failure due to parenchymal disfunction is one of the main complications of immunocompromised hematological patients.
- Conditions
- Respiratory Failure, Diaphragm Injury, Ultrasound, Mechanical Ventilation Complication
- Trial name
- NCT04026217
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Weaning, Spontaneous Breathing Trial
Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial
Currently, measurement of transdiaphragmatic pressure (Pdi) using oesophageal and gastric balloons is the gold standard for the assessment of diaphragmatic effort.
- Conditions
- Weaning, Spontaneous Breathing Trial, Mechanical Ventilation, Speckle Tracking
- Trial name
- DIAST (NCT06009731)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Stroke, Diaphragm Injury
Effect of Body Tilting on Diaphragm Excursion and Thickness in the Stroke Patients With Tracheotomy by Ultrasonography
The purpose of this study was to examine whether if the effect of standing with assistance of the tilt table on diaphragm excursion and thickness in the stroke patients with tracheotomy.
- Conditions
- Stroke, Diaphragm Injury, Tracheostomy
- Trial name
- NCT05041894
- Testing
- tilt table
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Shenzhen Second People's Hospital
Injuries, Spinal Cord
Diaphragm Pacing After Spinal Cord Injury
Respiratory dysfunction is the leading cause of death in individuals with spinal cord injuries (SCIs). Nearly one quarter of all SCI cases involve injury to the upper spinal cord segments which impairs neural activation of the…
- Trial name
- NCT02556125
- Testing
- Diaphragm pacing
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Florida
Diaphragm Injury, Pathology
Effects of Mechanical Ventilation on the Diaphragm in COVID-19 Intensive Care Patients. A Post-mortem Pathology Study
The diaphragm is the fundamental muscle of the respiratory system. The diaphragmatic dysfunction is present in 60% of critical patients at hospital admission and up to 80% after prolonged mechanical ventilation and difficult…
- Conditions
- Diaphragm Injury, Pathology, COVID-19 Acute Respiratory Distress Syndrome, Ventilation Therapy; Complications
- Trial name
- NCT05191433
- Where
- 2 sites in Italy
- Volunteers
- 41 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Diaphragm Injury, Respiratory Failure
Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
- Conditions
- Diaphragm Injury, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- DIASPORA (NCT03667027)
- Testing
- Respiratory support
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Lung Transplantation
Lung and Diaphragm Ultrasound in the Early Postoperative Course Following Lung Transplantation
This feasibility study tries to define the value of daily Lung and Diaphragm Ultrasound in the early postoperative course following Lung transplantation by comparing its diagnostic accuracy with that of standard of care…
- Trial name
- LUS (NCT04891094)
- Testing
- Ultrasound
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Ludwig-Maximilians - University of Munich
COVID-19, Diaphragm Injury
Respiratory Muscles After Inspiratory Muscle Training After COVID-19
It is the aim of the current (follow-up) project for the first time in post-COVID-19 patients who continue to complain of shortness of breath and for whom there is no other explanation than possibly proven diaphragmatic weakness…
- Trial name
- NCT05582642
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- RWTH Aachen University
Noninvasive Ventlation, COVID-19 Respiratory Infection
Effects of Body Position on Diaphragmatic Activity in Patients Requiring Noninvasive Ventilation for Acute Respiratory Failure COVID-19 Related
The present investigation aims to assess the diaphragmatic thickening fraction, reflecting the diaphragmatic activity, during supine (baseline) and at 1 hour following prone position in patients assisted through non invasive…
- Conditions
- Noninvasive Ventlation, COVID-19 Respiratory Infection, Diaphragm Injury
- Trial name
- DiaCOVIDProne (NCT04904731)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Azienda Ospedaliera di Perugia