Clinical trials: Diaphragmatic Weakness
Intensive Care Unit Acquired Weakness
Application of the Concept of Proprioceptive Neuromuscular Facilitation in Trunk Control in Patients Admitted to the ICU.
Muscle weakness acquired in the ICU (FAUTI) is related to the functional decline of patients admitted to an Intensive Care Unit (ICU).
- Trial name
- PNF (NCT07584564)
- Testing
- Proprioceptive Neuromuscular Facilitation (PNF), Standard physiotherapy
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Mechanical Ventilation Complication, Diaphragm Injury
Effect of Diaphragm Stimulation During Surgery
During major surgical procedures general anesthesia is used to make the patient unconscious. General anesthesia insures that the patient is unaware of any pain caused by surgery.
- Trial name
- NCT03303040
- Testing
- Electrical stimulation of hemidiaphragm
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Diaphragmatic Dysfunction, Muscle Weakness
Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
The effect of neuromuscular blocking agents (NMBA, e.g. rocuronium) on respiratory muscle activity is well known. However, since the availability of sugammadex, to our knowledge, no study has been conducted to evaluate the effect…
- Conditions
- Diaphragmatic Dysfunction, Muscle Weakness, Muscle Fatigue
- Trial name
- SUDIA (NCT01962298)
- Testing
- sugammadex 2mg/kg, neostigmine, sugammadex 4mg/kg
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- University Hospital, Antwerp
Pelvic Floor Muscle Weakness
Verbal Instruction for Contraction Pelvic Floor Muscles Among Males
The aim of this study is to compare the effectiveness of different verbal instruction on pelvic floor muscle contraction among males. Pelvic floor contraction will be measured via ultrasound.
- Trial name
- NCT03507660
- Testing
- verbal instruction
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Critical Illness Myopathy, Respiratory Paralysis
ICU Acquired Neuromyopathy and Diaphragm Function
Critical illness neuromyopathy is a common disease acquired during ICU stay leading to a deep weakness involving the respiratory muscle work which result in a delayed weaning of mechanical ventilation.
- Trial name
- NCT01968889
- Testing
- Non invasive phrenic nerve stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Covid19, Diaphragm Injury
Respiratory Muscle Assesment in COVID-patients Without Hospitalization
Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles. The aim of the project is to measure respiratory muscle function and strength in our respiratory…
- Trial name
- RMA-COVID-19 (NCT06105450)
- Testing
- Comprehensive assessment of respiratory muscle function.
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- RWTH Aachen University
Muscle Weakness
Effect of EPA and HMB on Strength in ICU Patients
The investigators will determine if administration of HMB (hydroxymethylbutyrate) or EPA (eicosapentaenoic acid) will increase diaphragm and limb muscle strength for patients on breathing machines in an intensive care unit.
- Trial name
- NCT01270516
- Testing
- HMB, hydroxymethylbutyrate, EPA, eicosapentaenoic acid, Saline
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Gerald Supinski
COVID-19, ICU Acquired Weakness
One-Year Quality of Life and Functional Prognosis of COVID-19 Patients in Post-ICU Setting
The COVID-19 disease has been subject to numerous publications since its emergence. Almost 20% of people suffering from COVID-19 develop severe to critical symptoms and require hospitalization, often in Intensive Care Unit (ICU).
- Conditions
- COVID-19, ICU Acquired Weakness, Weaning Failure
- Trial name
- COVENTRY (NCT04373811)
- Testing
- Lung ultrasound, Muscle ultrasound
- Where
- 3 sites in France
- Volunteers
- 65 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Dyspnea After Interscalene Nerve Block
Preoperative Maximum Inspiratory Pressure and Outcomes After Interscalene Block in Obese Patients
The study aims to explore if Maximum Inspiratory Pressure can predict postoperative breathlessness in obese patients receiving interscalene blocks for shoulder surgery.
- Trial name
- NCT06549244
- Testing
- Maximum Inspiratory Pressure monitoring
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of North Carolina, Chapel Hill
Pelvic Floor Muscle Weakness
What is the Best Verbal Instruction for Contraction the Pelvic Floor Muscles?
The aim of this study is to T to compare the effectiveness of producing a pelvic floor muscle contraction by different verbal instruction.
- Trial name
- NCT03400540
- Testing
- verbal instruction
- Where
- Israel
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Phrenic Nerve Palsy
Does Saline Injection Around Phrenic Nerve Reduce Incidence of Diaphragmatic Paresis Following Interscalene Block?
Hemi-diaphragmatic palsy is a common undesirable effect of interscalene block, with an incidence of up to 100%. Mechanism of palsy is thought to be related to spread of local anaesthetic anterior to the anterior scalene muscle.
- Trial name
- NCT02893228
- Testing
- Saline, Levobupivacaine
- Where
- Ireland
- Volunteers
- 36 people
- Sponsor
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
Frailty Syndrome, Respiratory Muscle Weakness
Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Muscle Training in Frail Older Adults
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on diaphragmatic and respiratory muscle function in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Respiratory Muscle Weakness, Age-Related Frailty, Geriatric Health
- Trial name
- IMT-1 (NCT07258615)
- Testing
- Inspiratory Muscle Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Francisco de Vitoria
Muscle Atrophy or Weakness, Ventilator-associated Lung Injury
Serial Daily Diaphragm Ultrasounds in Ventilated Patients
When a person is put on a breathing machine the investigators think that the breathing muscles can get weaker. The investigators are not sure how quickly this happens but in some people this leads to problems when they try to…
- Trial name
- NCT02174029
- Testing
- Ventilation- mandatory, Ventilation- voluntary mode only, Voluntary with preceding mandatory
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Steve Reynolds
Septic Shock
Muscle Ultrasound Study in Shock Patients
Intensive Care Unit (ICU) patients are known to lose muscle mass and function for many reasons, ranging from prolonged immobilization, to the effects of ICU treatments such as mechanical ventilation (MV), to the critical illness…
- Trial name
- MUSiShock (NCT04550143)
- Testing
- Diaphragm ultrasound (DUS), Peripheral Muscle Ultrasound (PMUS), Airway occlusion pressure (P0.1)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Systemic Sclerosis, Diaphragm Defect
Muscular Respiratory Involvement and Systemic Sclerosis
Dyspnea in systemic sclerosis (ScS) constitute a major factor of functional disability. Intensity of dyspnea is sometimes discordant with objectives data from cardiopulmonary involvements, suggesting unknown additional factors.
- Conditions
- Systemic Sclerosis, Diaphragm Defect, Respiratory Insufficiency, Pulmonary Function Test
- Trial name
- SIROCO (NCT04118725)
- Testing
- Pulmonary function test
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Poitiers University Hospital
Surgery, Cardiac
Contract-Relax (CR) Technique in the Management of Diaphragmatic Paresis After Cardiac Surgery
Postoperative respiratory complications are common complications of patients after cardiac surgery and increase morbidity and mortality and hospital length of stay.
- Trial name
- COREDIA (NCT05068219)
- Testing
- Usual physical therapy, Contract-Relax technique
- Where
- France
- Volunteers
- 27 people
- Sponsor
- CMC Ambroise Paré
Diaphragm Dysfunction
Incidence and Impact of ICU-acquired Diaphragm Weakness
ICU survivors are at an increased risk of hospital and ICU readmission. Among the complications of ICU stay, diaphragmatic dysfunction is common, with a prevalence of 60 to 80%, and is associated with increased mortality and…
- Trial name
- PRODIGY (NCT06420999)
- Testing
- Diaphragmatic ultrasound and data collection
- Where
- France
- Volunteers
- 194 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, Regional, Shoulder
Hemi-diaphragmatic Paresis and Erector Spinae Plane Block
To assess the incidence of hemi-diaphragmatic paresis following ultrasound-guided erector spinae plane (ESP) block
- Trial name
- NCT05096377
- Testing
- ESP block
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Antalya Training and Research Hospital
Intensive Care Unit Acquired Weakness
The Effect of Inspiratory Muscle Training on Diaphragmatic Function in Mechanically Ventilated Patients
In this study, the effect of inspiratory muscle training on diaphragmatic functions will be investigated radiologically in mechanically ventilated patients.
- Trial name
- NCT05303623
- Testing
- Conventional Physiotherapy, Conventional Physiotherapy+ inspiratory muscle training, inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University