Clinical trials: Diarrhea
Prevention of Travelers' Diarrhea
Traveler's Diarrhea (TD) Automated Process
To evaluate and compare the immune responses and safety following a two vaccination regimen by transcutaneous immunization with heat-labile enterotoxin of E. coli (LT) patches or placebo patches.
- Trial name
- NCT00751777
- Testing
- heat-labile enterotoxin of E. coli (LT)
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Intercell USA, Inc.
Malnutrition, Diarrhea
Evaluation of Zinc and / or Micronutrient Supplementation on Intestinal Flora, Diarrheal Disease Burden, Intestinal Mucosal Integrity and Growth Among Children of Pakistan
Information on the mechanisms of zinc is still in developing phase. Ecological and biological implications of long term zinc supplementation at population level requires assessment.
- Conditions
- Malnutrition, Diarrhea, Pneumonia, Growth
- Trial name
- NCT00705445
- Testing
- Micronutrient Supplementation without Zinc, Micronutrient Supplementation with Zinc, Nutritional Counselling and Education
- Where
- 2 sites in Pakistan
- Volunteers
- 2,745 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Antibiotic-associated Diarrhea
Mechanisms of Probiotics and Antibiotic-Associated Diarrhea
The focus of the study is to better understand the mechanisms causing antibiotic-associated diarrhea (AAD) and how probiotics may prevent some of the iatrogenic effects of antibiotic medications.
- Trial name
- OURBIOTIC (NCT04414722)
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control Yogurt
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Respiratory Tract Infections, Diarrhea
Effect of L. Rhamnosus Yoba on RTI and Other Health Outcomes Among Children (3-6 Years) in Uganda
This is a nutritional trial with two arms: 1) Intervention arm of Probiotic Yoghurt containing Lactobacillus rhamnosus yoba 2012 and 2) Control arm of custard-like dairy product.
- Conditions
- Respiratory Tract Infections, Diarrhea, Skin Diseases, Tinea Capitis
- Trial name
- NCT04144491
- Testing
- Probiotic
- Where
- Uganda
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
Clostridium Difficile Associated Diarrhea (CDAD)
A Study of Ascending Multiple Doses of Oral Surotomycin in Healthy Participants (MK-4261-009)
This study aims to assess the safety, tolerability, and pharmacokinetics (PK) of oral doses of surotomycin (CB-183,315) administered for 14 consecutive days in healthy males and females.
- Trial name
- NCT02835118
- Testing
- Surotomycin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diarrhea Predominant Irritable Bowel Syndrome
The Effects of Multi-strain Probiotics in Adults With Diarrhea Predominant Irritable Bowel Syndrome
The investigators will evaluate the efficacy of multi-strain probiotics in adults with diarrhea predominant irritable bowel syndrome.
- Trial name
- NCT01637714
- Testing
- Multi-strain probiotics
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cholera, Diarrhea
Immunogenicity of One Versus Two Doses of Killed Oral Cholera Vaccine
The purpose of this study is to compare the safety and immunogenicity of one and two doses of the killed oral cholera vaccine.
- Conditions
- Cholera, Diarrhea, Vibrio Infections
- Trial name
- NCT00419133
- Testing
- Killed bivalent whole cell oral cholera vaccine
- Where
- India
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Absenteeism, Diarrhea
Evaluation of the Dubai Cares WASH in School Initiative
This study will use longitudinal data collection to quantify the impact of a school-based water, sanitation and hygiene (WASH) program in Mali, West Africa, on pupil absenteeism, diarrheal illness, and respiratory illness.
- Conditions
- Absenteeism, Diarrhea, Respiratory Tract Infections
- Trial name
- NCT01787058
- Testing
- Dubai Cares beneficiary
- Where
- Mali
- Volunteers
- 10,308 people, healthy volunteers welcome
- Sponsor
- Emory University
Rotavirus Infections
Surveillance of Hospitalizations Due to Rotavirus Infections Among Children From Israel
Objectives 1. To determine the burden and characteristics of rotavirus-associated hospitalizations among children under five years of age of northern Israel 2.
- Trial name
- NCT00484952
- Where
- 2 sites in Israel
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Diarrhea, Diarrhea Rotavirus
Human Challenge With Live-attenuated Rotavirus to Assess Next-generation Rotavirus Vaccines in Africa
Despite the widespread introduction of vaccines against Rotavirus, Rotavirus continues to be a cause of significant morbidity and mortality in the developing world.
- Trial name
- NCT04658914
- Testing
- Rotarix, Trivalent P2-VP8
- Where
- Zambia
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Child Diarrhea
What Drives Poor Care for Child Diarrhea: A Standardized Patient Experiment
Diarrhea is the second leading cause of death for children around the world, although nearly all of these deaths could be prevented with an inexpensive and simple treatment: oral rehydration salts (ORS).
- Trial name
- NCT04833790
- Testing
- Free distribution of ORS, Standardized patient with ORS preference, Standardized patient with Antibiotic preference
- Where
- India
- Volunteers
- 2,451 people, healthy volunteers welcome
- Sponsor
- RAND
Gastrointestinal Disorders
Change in Permeability of the Small Intestine After Treatment With Gluten
The overall hypothesis of this research study is that gluten intake alters intestinal barrier function in patients with Irritable Bowel Syndrome (IBS) diarrhea who also exhibit non-celiac gluten sensitivity (NCGS).
- Trial name
- NCT02098057
- Testing
- Gluten Healthy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diarrhea
Health Impact Study of Aquatabs in Tamale, Ghana
The purpose of this study to determine whether Aquatabs, a water treatment tablet, reduces diarrheal diseases in a peri-urban population of Tamale, Ghana.
- Trial name
- NCT00252928
- Testing
- Sodium dichloroisocyanurate (NaDCC) tablets
- Where
- 3 sites in United States, Ghana
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Diarrhea, Pneumonia
Folic Acid and Vitamin B12 in Young Indian Children
Hypothesis: Supplementation of two recommended daily allowances (RDA) of folic acid with or without simultaneous administration of vitamin B12 reduces the rates of acute lower respiratory tract infections (ALRI), clinical…
- Trial name
- NCT00717730
- Testing
- Folic Acid, Vitamin B12, Folic acid and vitamin B12
- Where
- India
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tor A. Strand
Diarrhea Rotavirus
Immune Response to Rotavirus Vaccine After a Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali
This study is an evaluation of the immune response to pentavalent rotavirus vaccine (PRV) after an additional fourth dose is given at 9 months of age with local World Health Organization (WHO) Expanded Programme on Immunization…
- Trial name
- NCT02286895
- Testing
- pentavalent rotavirus vaccine (PRV), measles vaccine (MV), yellow fever vaccine (YFV)
- Where
- Mali
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- PATH
Clostridium Difficile Infection, Clostridium Difficile Diarrhea
Phase I Randomized, Placebo-Controlled, Double-Blind, Dose Ranging Study, Safety, Tolerability and Immunogenicity
This Phase I, randomized, placebo-controlled, double-blinded, dose ranging study to assess the safety, tolerability, and immunogenicity of 2 dose levels of C. difficile vaccine.
- Trial name
- NCT00772954
- Testing
- Vaccine diluent buffer, Clostridium difficile toxoid vaccine (50 μg), Clostridium difficile toxoid vaccine (100 μg)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sanofi
Diarrhoea Predominant Irritable Bowel Syndrome, IBS
Analyzing IBS to Identify Biomarkers and Microbiome Signatures
Microbiota from fecal samples from IBS-D patients, in combination with vitamin D supplementation added to our 3-D immunocompetent intestinal models will establish a high fidelity disease model to achieve our long-term goal to…
- Trial name
- NCT02419963
- Testing
- endoscopy for tissue biopsy, Blood Sample, Stool Sample
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastrointestinal, Tolerance
Gastrointestinal Tolerance of Erythritol-containing Beverages in Young Children
Purpose of this study: assess the maximum tolerated bolus dose of erythritol, delivered in a clear beverage, compared with placebo (saccharose) in 4-6 year old children.
- Trial name
- NCT02016703
- Testing
- Erythritol drink
- Where
- 3 sites in France
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Cargill
Zinc Deficiency, Diarrhea
Impact of Preventive and Therapeutic Zinc Supplementation Programs Among Young Children
Zinc supplementation can either be provided in a lower daily dose to prevent zinc deficiency or in a higher dose for 10-14 days as part of the treatment of diarrhea.
- Conditions
- Zinc Deficiency, Diarrhea, Malaria
- Trial name
- NCT00944359
- Testing
- Surveillance control group
- Where
- Burkina Faso
- Volunteers
- 7,680 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Antibiotic-associated Diarrhea, Diarrhea
The Impact of Zinc and Probiotics in Preventing Pediatric Antibiotic-Associated Diarrhea in Southern Iran
The Impact of Zinc and Probiotics in Preventing Pediatric Antibiotic-Associated Diarrhea in Southern Iran
- Trial name
- AAD (NCT06665503)
- Testing
- Zinc Supplement, probiotic
- Where
- Iran
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hormozgan University of Medical Sciences