Clinical trials: Diarrheal Diseases
Chemotherapeutic Agent Toxicity, Colorectal Cancer
Calcium Aluminosilicate Anti-Diarrheal in Treating and Preventing Diarrhea in Patients With Metastatic Colorectal Cancer Receiving Irinotecan
RATIONALE: Calcium aluminosilicate anti-diarrheal (CASAD) may help treat and prevent diarrhea caused by irinotecan. It is not yet known whether CASAD is more effective than a placebo in treating and preventing diarrhea in…
- Conditions
- Chemotherapeutic Agent Toxicity, Colorectal Cancer, Diarrhea
- Trial name
- NCT00748215
- Testing
- calcium aluminosilicate anti-diarrheal
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Seroimmunity, Diarrhea
Diarrhea and Bivalent Oral Polio Vaccine Immunity
Global eradication of poliomyelitis has proven to be elusive. Although 99% of cases have been eliminated since 1988, outbreaks continue to occur, and new tools are needed to accelerate eradication.
- Conditions
- Seroimmunity, Diarrhea, Polio
- Trial name
- NCT01559636
- Testing
- bivalent oral polio vaccine
- Where
- Nepal
- Volunteers
- 699 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Gastroenteritis
Impact of Emergency Department Probiotic Treatment of Diarrheal Illness on Daycare Attendance
The objective of this study is to determine for previously healthy children, who present to an ED with acute gastroenteritis, if the probability of daycare absenteeism is significantly different in those who receive a probiotic…
- Trial name
- NCT00760773
- Testing
- Lacidophil (experimental high dose), Lacidophil (experimental standard dose)
- Where
- 3 sites in Canada
- Volunteers
- 132 people
- Sponsor
- The Hospital for Sick Children
Diarrhoeal Disease
Development of a Live Attenuated Rotavirus Vaccine as a Human Infection Challenge Model
The impact of licensed rotavirus vaccines in LMICs is limited by their lower immunogenicity and efficacy in these settings. Improved vaccines and vaccination schedules would result in substantially greater reductions in infant…
- Trial name
- NCT04123119
- Testing
- Rotavirus vaccine
- Where
- Zambia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Diarrhoeal Disease
Health Impact of Treating and Safely Storing Shallow Tubewell Drinking Water
When shallow tubewells replaced highly contaminated surface water as the primary source of drinking water in Bangladesh in the late 20th century, contemporary studies demonstrated no reduction in diarrheal disease with this…
- Trial name
- NCT01350063
- Testing
- Sodium dichloroisocyanurate (NaDCC) tablet (Aquatab), Water storage container (Jerry can), No intervention
- Where
- Bangladesh
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Irritable Bowel Syndrome
Low FODMAPs Diet vs. Specific Dietary Advice in Patients With IBS Diarrheal Variant
A reduced content of FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) in the diet may be beneficial for patients with IBS diarrheal variant, but so far few randomized trials have reported data…
- Trial name
- DIETSINIBS (NCT03423069)
- Testing
- Diet low in FODMAPs, Specific dietary advice for IBS
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Compliant Behavior, Diarrheal Disease
Rural China Electric Kettle Promotion Program
This study will evaluate the impact of a pilot Rural Electric Kettle Promotion Program offered to low-income households in rural Anhui Province, China.
- Conditions
- Compliant Behavior, Diarrheal Disease, Pollution; Exposure
- Trial name
- NCT03376152
- Testing
- Electric Kettle Promotion
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Telemedicine, Pediatrics
Improving Nighttime Access to Care and Treatment; Part 4-Haiti
Children in resource-limited settings who develop illness at night are often isolated from care, resulting in progression to an emergency.
- Trial name
- INACT4-H (NCT05480930)
- Testing
- paper-based clinical decision support (dCDS) tool, digital clinical decision support (dCDS) tool
- Where
- Haiti
- Volunteers
- 7,124 people
- Sponsor
- University of Florida
Diarrhea
Prevention of Diarrheal Disease Due to Infection With Enterotoxigenic E. Coli (ETEC)
This is a Phase II b, double-blind, randomized, placebo-controlled study in healthy adults (age 18-65 years) to evaluate the safety, immunogenicity, different diagnostic tools and efficacy of ETVAX.
- Trial name
- NCT03729219
- Testing
- E. coli ETVAX
- Where
- Finland
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Scandinavian Biopharma AB
Acute Diarrhea, Acute Respiratory Infection
Improving Nighttime Access to Care and Treatment (Part 2)
Children in resource-limited settings who develop illness at night are often isolated from pre-emergency care, resulting in progression to an emergency because families are forced to wait until morning to seek care.
- Conditions
- Acute Diarrhea, Acute Respiratory Infection, Acute Febrile Illness
- Trial name
- INACT2 (NCT03943654)
- Testing
- MotoMeds Healthline- illness assessment and treatment recommendation for non-emergent cases by telephone
- Where
- Haiti
- Volunteers
- 391 people
- Sponsor
- University of Florida
Enteric Infections, Diarrhea
The Safe Start Trial - Kisumu, Kenya
This a cluster randomised controlled trial (cRCT) to evaluate the effect of a novel food hygiene intervention on infant health.
- Trial name
- NCT03468114
- Testing
- Safe Start, Active Control
- Where
- Kenya
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cryptosporidium; Diarrhea, Cryptosporidiosis
Trial of Ceramic Water Filters to Reduce Cryptosporidium Infection in Kenya
The aim of the study is to examine the efficacy of ceramic water filters to reduce the burden of waterborne diarrheal illness among infants in selected villages in Kenya.
- Conditions
- Cryptosporidium; Diarrhea, Cryptosporidiosis, Communicable Diseases, Diarrheal Disease
- Trial name
- NCT01695304
- Testing
- Ceramic water filter
- Where
- Kenya
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Anemia
Effect of Soaking Complementary Foods Flour on Hemoglobin Concentration, Anthropometric Deficits and Episode of Diarrheal, Cough and Fever Morbidities
Removing anti nutrient factors using simple cost-effective and sustainable household methods to improve nutritional status of children in communities were plant based complementary foods are the main source of Nutrients is highly…
- Trial name
- NCT05254717
- Testing
- counselling
- Where
- Ethiopia
- Volunteers
- 700 people
- Sponsor
- Madda walabu university
Healthy, Diarrhea
Calcium, Probiotics and Acute Diarrheal Disease Among Indonesian Children
This is a long term study on the efficacy of dietary calcium with or without probiotic strains in reducing the mean number of episodes and duration of diarrheal disease.
- Trial name
- NCT00512824
- Testing
- low calcium milk of 180 ml, regular milk of 180 ml, regular milk of 180 ml + probiotics
- Where
- Indonesia
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Diarrhea
Evaluation of a mHealth Platform for Diarrheal Disease Decision-support
The study hypothesis is that clinical decision-support on a smartphone for the management of diarrheal disease will improve the assessment of dehydration, reduce IV fluid usage, and increase guideline adherence for the use of…
- Trial name
- NCT03154229
- Testing
- Smartphone-based decision-support, Paper-based decision-support, Pre-Assessment of practices
- Where
- Bangladesh
- Volunteers
- 4,975 people
- Sponsor
- University of Florida
Acute Respiratory Infection, Diarrheal Disease
Efficacy and Tolerance of a Follow-On Formula Fed to Children From 36-48 Months of Age
The purpose is to determine if the consumption of study product has an effect on acute respiratory infections and/or diarrheal disease.
- Trial name
- NCT01488435
- Testing
- Cow's milk, Follow-On Formula
- Where
- China
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Diarrhea Infectious, Algorithms
The Acceptability and Impact of Diarrheal Etiology Prediction (DEP) Algorithm
This is a randomized crossover study, where clinicians will be randomized to periods where they will use a rehydration calculator application with or without the Diarrheal Etiology Prediction (DEP) algorithm.
- Conditions
- Diarrhea Infectious, Algorithms, Decision Support Systems, Clinical, Clinical Decision-Making
- Trial name
- NCT04602676
- Testing
- Rehydration calculator application with DEP algorithm, Rehydration calculator application
- Where
- 2 sites in Bangladesh, Mali
- Volunteers
- 30 people
- Sponsor
- University of Utah
Diarrhoeal Disease, Prolonged Diarrhea
Green Banana Added Diet on Prolong Diarrhea in 6-59 Months Old Children (GB in ProD)
The study likely to yield improved therapeutic modalities for children with prolonged diarrhea, a sequalae often leads to persistent diarrhea, which is linked to as much as 35% of diarrhea-associated deaths in children <5 years…
- Trial name
- GB in ProD (NCT07848789)
- Testing
- MS, MS +GB
- Where
- Bangladesh
- Volunteers
- 104 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Dietary Rice Bran Supplementation
Pilot Feasibility of Rice Bran Supplementation in Children
The purpose of this study is to assess feasibility of rice bran consumption in weaning children and to identify dietary rice bran mediated changes to the stool microbiome and stool metabolome.
- Trial name
- NCT02557373
- Testing
- Vitamin A, Rice Bran + Vitamin A
- Where
- 2 sites in United States, Mali
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Diarrheal Disease, Infectious, Gastrointestinal Disease
Phase 1 Trial for Safety, Tolerability, and Immunogenicity of a Live, Attenuated, Oral Shigella/ETEC Combination Vaccine to Healthy Adults
This is a Phase 1 dose escalating study to assess the safety, tolerability, and immunogenicity of ShigETEC, a live, attenuated Shigella/ETEC combination vaccine given orally to healthy European adults 18 to 45 years of age.
- Conditions
- Diarrheal Disease, Infectious, Gastrointestinal Disease, Reactive Arthritis
- Trial name
- NCT05409196
- Testing
- ShigETEC live, attenuated, oral vaccine
- Where
- Hungary
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Eveliqure Biotechnologies GmbH