Clinical trials: Diastolic Function
Fetal Growth Retardation
Fetal Cardiac Function
The aim of our study is to evaluate the effect of PE and FGR on fetal cardiac function. Pregnancies with preeclampsia and FGR, and preeclampsia with normal fetal growth are evaluated by echocardiography and compared with…
- Trial name
- NCT06381258
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypertension
Study to Determine the Effects of Nebivolol and Hydrochlorothiazide in African Americans With Hypertension
The main purpose of this study is to evaluate the effects of Nebivolol and Hydrochlorothiazide on blood pressure in African Americans with high blood pressure.
- Trial name
- NASAA (NCT00999752)
- Testing
- Nebivolol, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- InVasc Therapeutics, Inc.
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pulmonary Disease, Chronic Obstructive
Effects of Dynamic Hyperinflation on the Left-ventricular Diastolic Function in Healthy Male Subjects
The aim of this study is to identify whether actively induced dynamic hyperinflation can cause left-ventricular diastolic dysfunction in healthy male subjects in order to explore the mechanisms of developing cardiac dysfunctions…
- Trial name
- NCT03500822
- Testing
- Metronome-paced tachypnea, Expiratory-stenosis breathing
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Otto Wagner Hospital
Type 2 Diabetes, Coronary Heart Disease
Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to examine the existence of heart abnormalities in patients with diabetes and the effect of pioglitazone in correcting these abnormalities.
- Trial name
- NCT01588470
- Testing
- pioglitazone
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Congestive Heart Failure
Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes
This study will evaluate the safety and effectiveness of the drug rosiglitazone for improving heart function in patients with heart failure and glucose intolerance or type II (adult-onset) diabetes, or both.
- Trial name
- NCT00064727
- Testing
- Avandia (Rosiglitazone), Avanclia (Rosiqlitazone)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolic Syndrome
Effect of Physical Activity and Diet on the Treatment of Metabolic Syndrome
Metabolic syndrome has been defined as a group of associated risk factors for cardio-vascular diseases and diabetes. It is usually treated with an association of restrictive diet, physical exercise and drugs.
- Trial name
- NCT00917917
- Testing
- Type of physical activity (resistance, endurance), Restrictive diet
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Diastolic Dysfunction, Neonatal Encephalopathy
Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography
The goal of this single-centre longitudinal observational study is to create reference values for diastolic function parameters in neonates born at 35 weeks' gestation or above, and to assess the influence of pre-defined…
- Conditions
- Diastolic Dysfunction, Neonatal Encephalopathy, Small for Gestational Age at Delivery, Transient Tachypnea of the Newborn
- Trial name
- DiFuSE (NCT06200519)
- Where
- Ireland
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University College Cork
Diastolic Dysfunction, Systolic Dysfunction
Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES
Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions.
- Conditions
- Diastolic Dysfunction, Systolic Dysfunction, Diastolic Heart Failure
- Trial name
- CardiacAging (NCT05408559)
- Testing
- Sulforaphane
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Heart Failure
Effect of Exercise-based Rehabilitation on Circulatory Functions in Patients With Diastolic Heart Failure
The purpose of this study is to investigate how exercise-base rehabilitation influences circulatory functions in patients with diastolic heart failure (DHF).
- Trial name
- NCT01053091
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Obesity, Heart Failure, Diastolic
Improving Metabolic Health in Patients With Diastolic Dysfunction
The purpose of this study is to determine whether 1 year of supervised exercise training in obese individuals at high risk for developing HF, incorporating high intensity interval training (HIIT) two to three times per week in…
- Conditions
- Obesity, Heart Failure, Diastolic, Metabolic Syndrome
- Trial name
- MTG (NCT03448185)
- Testing
- High intensity exercise, Omega-3 fish oil, Yoga
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Sleep Apnea Syndromes
Left Atrial Volume and Function Evaluation in Patients With Obstructive Sleep Apnea
The purpose of this study is to determine whether patients with obstructive sleep apnea have any changes in left atrial morphology and function evaluated by echocardiography three dimensional
- Trial name
- NCT00570115
- Where
- Brazil
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Diastolic Dysfunction
MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women
In this pilot study, the investigators will determine whether supplementation with a mitochondrial-targeted antioxidant (Mitoquinone (MitoQ)) improves mitochondrial function, left ventricular diastolic and vascular function.
- Trial name
- NCT03586414
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes Mellitus
Effect of Pioglitazone on Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus
This study is being done to determine if pioglitazone (Actos) is helpful to patients with type 2 diabetes and could possibly prevent harmful consequences of cardiovascular disease in diabetic patients.
- Trial name
- NCT00232362
- Testing
- Pioglitazone (Actos), Anti-diabetic agent other than pioglitazone or rosiglitazone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Autonomic Nervous System Diseases, Baroreflex Failure
Effects of Water and Glucose Drinks on Cardiovascular Function in Subjects With and Without Postprandial Hypotension
To determine whether the changes in blood pressure (BP) which occur following meals in normal people and patients who have substantial falls in BP after a meal postprandial hypotension (PPH)) are associated with changes in…
- Conditions
- Autonomic Nervous System Diseases, Baroreflex Failure, Blood Pressure, Hypotension
- Trial name
- NCT02713412
- Testing
- Glucose, Water
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
Ventricular Function
The Effect of Exercise and Alagebrium on the Diastolic Function of the Heart
The purpose of this study is to determine whether an investigational drug (Alagebrium (generic: ALT-711), a type of medication referred to as an advanced glycaton end-product clever) can be combined with exercise training to…
- Trial name
- AGE (NCT01014572)
- Testing
- Aerobic Exercise Training, Alagebrium (generic: ALT-711), Tai Chi and/or Yoga Training
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Type 1, Systolic Dysfunction
Tumor Necrosis Factor-alpha Levels and Cardiac Functions in Type 1 Diabetes Mellitus
The goal of this clinical trial is to learn about the effect of type 1 diabetes mellitus on cardiac functions and evaluate the correlation of the dysfunction with the tumor necrosis factor-α (TNF-α) an inflammation-related…
- Conditions
- Diabetes Mellitus, Type 1, Systolic Dysfunction, Diastolic Dysfunction
- Trial name
- NCT06129448
- Testing
- transthoracic echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sirnak State Hospital
Atrial Fibrillation, Heart Failure, Diastolic
The Effect of Different Low-Level Tragus Stimulation Parameters On Autonomic Nervous System Function
Low level transcutaneous vagus nerve stimulation (LLTS) involves delivery of electrical impulses transcutaneously at the auricular branch of vagus nerve and it has been shown to have anti-inflammatory and anti-arrhythmic effects.
- Trial name
- LLT-SPANS (NCT04682704)
- Testing
- Parasym
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Menopause
Estrogen Diastolic Heart Failure
Peri-menopausal women will be randomized to hormone replacement therapy or placebo for 12 weeks to determine if markers of systolic and diastolic function change by echocardiography as well as laboratory markers of heart failure…
- Trial name
- NCT02693002
- Testing
- Estradiol/Norethindrone acetate
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Gretchen Wells