Clinical trials: Diastolic Heart Failure
Heart Failure, Diastolic
Multimodality Imaging in the Screening, Diagnosis and Risk StratifictiON of HFpEF
The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are…
- Trial name
- NCT04603404
- Where
- China
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Diastolic Heart Failure
Non-invasive Evaluation of Myocardial Stiffness by Elastography
SITUATION ON RESEARCH Diastolic heart failure (HF) or heart failure with preserved systolic function (SF) is the primary cause of heart failure in the elderly (over 2/3 of heart failure in patients over 60 years).
- Trial name
- Elasto-Cardio (NCT02537041)
- Testing
- elastography function ShearWave Imaging, MRI
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Heart Failure, Diastolic
Respiratory Muscle Function in Heart Failure
This study is being done because investigators are trying to determine how respiratory muscle and lung function influence the exercise responses in heart failure and healthy participants.
- Trial name
- NCT03924479
- Testing
- PowerBreathe (Breathing muscle training)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Heart Failure
Effect of Exercise-based Rehabilitation on Circulatory Functions in Patients With Diastolic Heart Failure
The purpose of this study is to investigate how exercise-base rehabilitation influences circulatory functions in patients with diastolic heart failure (DHF).
- Trial name
- NCT01053091
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Heart Failure and Preserved Ejection Fraction, Obesity (Disorder)
OBESE-HFpEF: Towards Preventing Obesity Related HFpEF
Obesity, severe overweight, is a growing problem worldwide and increases the risk of heart failure, especially a type called heart failure with preserved ejection fraction (HFpEF). In HFpEF, the heart becomes stiffer.
- Conditions
- Heart Failure and Preserved Ejection Fraction, Obesity (Disorder), Heart Failure
- Trial name
- OBESE-HFpEF (NCT07539766)
- Where
- Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Diastolic Heart Failure, Hypertensive Heart Disease
Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)
The purpose of this study is to examine how dietary changes affect the heart and blood vessels in patients with hypertension (high blod pressure) who have a condition called 'heart failure with preserved ejection fraction"…
- Trial name
- NCT01942395
- Testing
- DASH/sodium-restricted diet (DASH/SRD), Control Diet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Atrial Fibrillation, Heart Failure, Diastolic
The Effect of Different Low-Level Tragus Stimulation Parameters On Autonomic Nervous System Function
Low level transcutaneous vagus nerve stimulation (LLTS) involves delivery of electrical impulses transcutaneously at the auricular branch of vagus nerve and it has been shown to have anti-inflammatory and anti-arrhythmic effects.
- Trial name
- LLT-SPANS (NCT04682704)
- Testing
- Parasym
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Hypertension
Systolic Blood Pressure Intervention Trial
Elevated blood pressure (BP) is an important public health concern. It is highly prevalent, the prevalence may be increasing, and it is a risk factor for several adverse health outcomes, especially coronary heart disease, stroke…
- Trial name
- SPRINT (NCT01206062)
- Testing
- Intensive control of SBP, Standard control of SBP
- Where
- United States
- Volunteers
- 9,361 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Kidney Diseases, Diastolic Heart Failure
Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease
To explore the distribution of retinal vasculature parameters in patients with different subtypes of cardiovascular and ocular disease.
- Conditions
- Kidney Diseases, Diastolic Heart Failure, Small Vessel Disease, Glaucoma
- Trial name
- NCT06485128
- Testing
- Optical coherence tomography(-angiography) OCT(A), Fundus pictures, DVA 3.0
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Menopause
Estrogen Diastolic Heart Failure
Peri-menopausal women will be randomized to hormone replacement therapy or placebo for 12 weeks to determine if markers of systolic and diastolic function change by echocardiography as well as laboratory markers of heart failure…
- Trial name
- NCT02693002
- Testing
- Estradiol/Norethindrone acetate
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Gretchen Wells
Heart Failure, Diastolic, Edema Brain
Feasibility Study of a New Peripheral Oedema Monitor for Heart Failure
The study aims at assessing the usefulness of the Heartfelt1 device in patients suffering from heart failure, who have peripheral oedema. The device is non-contact and does not requires patient compliance to work.
- Conditions
- Heart Failure, Diastolic, Edema Brain, Decompensated Heartfailure
- Trial name
- NCT02993601
- Testing
- Heartfelt-1, Weighing scales, Medical grading of oedema
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Heartfelt Technologies
Heart Failure With Preserved Ejection Fraction, Cardiovascular Morbidity
Arterial Stiffening as a Predictor for Diastolic Cardiac Dysfunction and HFpEF
Patients at risk for developing heart failure with preserved ejection fraction (HFpEF) will undergo a structured clinical assessment, transthoracic echocardiography and pulse-wave analysis to investigate the association of…
- Trial name
- ARTSPREDICTION (NCT06208007)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Heart Failure, Cardiovascular Diseases
Heart Failure and Related Risk-factors After Preeclampsia
This study is a cross-sectional case-control study where classical as well as more innovative risk factors for CVD will be explored.
- Conditions
- Heart Failure, Cardiovascular Diseases, Pre-Eclampsia
- Trial name
- QoH (NCT02347540)
- Where
- Netherlands
- Volunteers
- 2,580 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Heart Failure, Preserved Ejection Fraction, Cardiac Fibrosis
Characterization of Heart Failure With Preserved Ejection Fraction
The goals of this research will be to define some of the mechanisms underlying the progression and complications of heart failure (HF) with preserved left ventricular ejection fraction (HFPEF) Aim 1: to evaluate the differences…
- Conditions
- Heart Failure, Preserved Ejection Fraction, Cardiac Fibrosis, Biomarkers, Magnetic Resonance Imaging
- Trial name
- NCT03197350
- Testing
- cMR, biomarker
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Heart Failure, Diastolic
External Body Pressure in Heart Failure With Preserved Ejection Fraction
The primary objective of the study is to test the impact of positive and negative body pressure on exercise capacity, symptoms, blood volume distribution and central cardiac hemodynamics in patients with heart failure and…
- Trial name
- NCT05764564
- Testing
- Positive or negative pressure
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Duke University
Hypertension, Heart Failure
The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study
AIMS Despite evidence-based therapeutic approaches, target blood pressure is obtained by less than half of patients with hypertension.
- Conditions
- Hypertension, Heart Failure, Hypertensive Heart Disease, Diastolic Dysfunction
- Trial name
- NCT04190420
- Where
- Sweden
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Preeclampsia, Heart Failure Preserved Ejection Fraction
Exercise Testing After Preeclampsia
Though cardiovascular disease (CVD) is the leading cause of mortality in women, traditional epidemiology in this area has focused on later life, when cardiometabolic risk has already exacted a cumulative toll on the vascular…
- Conditions
- Preeclampsia, Heart Failure Preserved Ejection Fraction, Hypertension
- Trial name
- NCT06741436
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Diastolic Heart Failure, Left Ventricular Diastolic Dysfunction
2 New Measurements Used to Describe the Filling Phase of the Left Ventricle (LV).
As we live longer our population experiencing heart failure (HF) continues to grow consuming an increasing percent of healthcare dollars.
- Conditions
- Diastolic Heart Failure, Left Ventricular Diastolic Dysfunction, Left Ventricular Diastolic Collapse
- Trial name
- INDEX (NCT04154878)
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Diastolic Heart Failure
Parasympathetic Augmentation Via Respiratory Training for Patients With Systolic Heart Failure
This is a prospective, randomized, controlled clinical trial in which participants with NYHA class II or III and symptomatic Heart Failure with reduced Ejection Fraction (HFrEF) (Ejection Fraction (EF) ≤ 45%) will be assigned to…
- Trial name
- PART-HF (NCT05223751)
- Testing
- Meo Health Breathing and humming exercises
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Heart Failure, Diastolic
Energetic Abnormalities in Heart Failure With Preserved Ejection Fraction
Up to half of all patients with heart failure are found to have normal pumping function of the heart muscle, but show abnormalities in the way the heart muscle relaxes and fills with blood.
- Trial name
- NCT00628082
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham