Clinical trials: Diet, High-Fat
Cardiovascular Disease, Hypercholesterolemia
Low Fat Vegan or American Heart Association Diets & Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol
The purpose of this study is to investigate the short-term effects of a reduced fat plant-based diet on biomarkers of inflammation, oxidative stress and cardiovascular risk.
- Conditions
- Cardiovascular Disease, Hypercholesterolemia, Obesity, Fatty Liver
- Trial name
- NCT01817491
- Testing
- American Heart Association Diet, Reduced Fat Vegan Diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Hypercholesterolemia
Effects of Various Higher Fat and Lower Fat Snacks on Cardiovascular Risk Factors in Men and Women.
The purpose of this study is to determine whether snacks differing in fat amount and type result in changes in cardiovascular disease risk factors in men and women who have mildly elevated cholesterol levels.
- Trial name
- NCT00349765
- Testing
- higher fat, high polyunsaturated fat diet, higher fat, high saturated and trans fat diet, lower fat diet
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy
"ADAPT" The Adaptation to High Fat Diets Extention
This study is designed to predict weight gain overtime after a high fat diet.
- Trial name
- NCT00493701
- Testing
- High Fat Diet, Low Fat Diet
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Metabolic Response to Dietary Modification
NUtriGenomic Analysis in Twins
This is an intervention study in healthy adult twins with the aim to investigate the genetic determination of metabolic responses towards an isocaloric high carbohydrate, low fat diet versus an isocaloric low carbohydrate, high…
- Trial name
- NUGAT (NCT01631123)
- Testing
- Isocaloric high carbohydrate diet intervention, Isocaloric high fat diet intervention
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Body Weight, Appetitive Behavior
High Fat vs High Protein and Appetite Hormones
This study will investigate the effects of high-protein, high-fat snacks, specifically Greek yogurt, and peanuts, on satiety, gut hormones, and insulin secretion in overweight and obese women.
- Conditions
- Body Weight, Appetitive Behavior, Dietary Exposure, Hormone Deficiency
- Trial name
- NCT04518930
- Testing
- Peanuts or plain Greek yogurt
- Where
- Jordan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Al-Balqa Applied University
Obesity, Visceral, Diet, Healthy
Long-term Benefits of Abdominal Fat Loss in Abdominally Obese Dyslipidemic Patients (SYNERGIE Study)
The objective of this clinical trial is to verify whether the beneficial effects of weight loss on visceral fat measured by computed tomography and metabolic risk factors for coronary heart disease are maintained once high-risk…
- Conditions
- Obesity, Visceral, Diet, Healthy, Cardiometabolic Syndrome, Lifestyle-related Condition
- Trial name
- SYNERGIE (NCT06158191)
- Testing
- Lifestyle modification program
- Volunteers
- 186 people
- Sponsor
- Laval University
Insulin Sensitivity/Resistance
Protective Effect of Exercise on Acute High-fat Overfeeding
Metabolic flexibility is the ability to switch rapidly from one substrate (i.e. fuel source) to another (e.g. fats to carbohydrates) in response to ingested foods.
- Trial name
- HFDEXC (NCT07633704)
- Testing
- High Fat Overfeeding, High Fat Overfeeding + Exercise
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- George Washington University
Diet Habit, Pollution; Exposure
Children's Health Study Diet and Air Pollution
This study is built upon the existing data in the Children's Health Study to examine the longitudinal association between childhood exposure to air pollutants and changes in diet among adolescents.
- Conditions
- Diet Habit, Pollution; Exposure, Child Obesity
- Trial name
- CHS DIET (NCT03379298)
- Volunteers
- 3,142 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Type 2 Diabetes Mellitus
Effect of Gemigliptin on Metabolic Endotoxemia and Lipemia
This is an exploratory study on the metabolic endotoxemia associated with type 2 diabetes. The investigators will measure systemic endotoxin level and lipid level after ingestion of high fat diet to evaluate the effect of…
- Trial name
- NCT02186080
- Testing
- Gemigliptin
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Insulin Resistance, Type 2 Diabetes
The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity
This study will investigate the effect of high-carbohydrate vs. high-fat overfeeding (130% of energy requirements) on whole body insulin sensitivity.
- Conditions
- Insulin Resistance, Type 2 Diabetes, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT03863431
- Testing
- High-fat diet, High-carbohydrate diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Diabetes
Effect of High Fat Diet on Muscle Metabolism
Skeletal muscle burns a significant amount of the fat and sugar that circulates in the blood stream. Ideally, when sugar is elevated in the blood stream, the muscle will either use it to make new energy or store it for later use.
- Trial name
- NCT02328235
- Testing
- High Saturated Fat Diet
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Kevin Davy
Overweight, Obesity
Effects of Red Beetroot Juice on High-Fat Meal-Induced Endothelial Dysfunction and Cardiometabolic Disturbances
Aside from aging, numerous factors increase the risk for developing cardiovascular disease (CVD) including diet and nutrition. High-fat meal consumption induces postprandial vascular endothelial dysfunction and other…
- Conditions
- Overweight, Obesity, Aging, Menopause
- Trial name
- NCT02949115
- Testing
- 70 mL red beetroot juice, 70 mL red beetroot juice without nitrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Hypertriglyceridemia
Metabolic Effects of Egg Protein and Unsaturated Fat Intakes in Subjects With Hypertriglyceridemia
The goal of this study is to evaluate the effects of replacing some refined starches and added sugars with a combination of egg protein and unsaturated fatty acids on markers of cardiometabolic health in men and women with…
- Trial name
- NCT02924558
- Testing
- Egg protein/unsaturated fatty acid, Control
- Volunteers
- 28 people
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Type 2 Diabetes
A Food-drug Interaction Study of SY-004 in Healthy Subjects
A randomized, open, two cycle, double crossover, single center study was conducted to evaluate the effect of high-fat diet on the pharmacokinetics of SY-004 in healthy subjects
- Trial name
- NCT04907006
- Testing
- SY-004 capsule
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
Overweight, Obesity
"Improving Diet, Exercise And Lifestyle (IDEAL) for Women" Study
Diets all share the same principle: eat less energy than you need. This results in weight loss. However, the weight loss is usually a combination of a loss of body fat and muscle mass.
- Trial name
- NCT00710398
- Testing
- Exercise - Aerobic and Resistance, Dietary - Caloric Restriction
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy
Molecular and Hormonal Responses to Diet-Induced Insulin Resistance
This study determined the effect of 7 days of high-fat overfeeding on whole-body glycaemic control, glucose kinetics, skeletal muscle insulin signalling, and markers of skeletal muscle microvascular function in 15 healthy young…
- Trial name
- NCT03879187
- Testing
- High-fat, high-energy diet
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Insulin Resistance
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity
High rates of de novo lipogenesis (DNL) and high saturated fatty acid (SFA) fraction in the liver both have been associated with poor metabolic health and hepatic insulin resistance.
- Trial name
- NCT05017675
- Testing
- High fructose diet, High saturated fat diet
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Breast Cancer
To Discuss the Best Mode for Taking Lapatinib Under the Influence of the Diet
Food can make a big difference on the bioavailability of lapatinib in breast cancer patients,and fatty food can increase the lapatinib bioavailability.By examine the steady blood drug concentration in the same individual at…
- Trial name
- NCT03075995
- Testing
- hight-fat breakfast
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Sun Yat-sen University
Metabolic Syndrome
The ACT-OUT Trial: ACTivity OUTcomes Based on High Carbohydrate or High Fat Diet in Metabolic Syndrome
Current obesity prevention emphasizes caloric restriction and avoidance of high fat foods. The result is an approach that replaces dietary fat with carbohydrates.
- Trial name
- NCT01357382
- Testing
- Low carbohydrate diet
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- St. Paul's Hospital, Canada
Cardiovascular Risk Factor
Short Term Ketone Supplementation and Cardiometabolic Health
The purpose of this research study is to determine if short-term consumption of a dietary ketone drink, which increases the blood circulation concentrations of beta-hydroxybutyrate, a ketone, affects blood vessel health and…
- Trial name
- NCT04236388
- Testing
- Ketone drink
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University