Clinical trials: Diet, Sodium-Restricted
Idiopathic Intracranial Hypertension
Idiopathic Intracranial Hypertension Treatment Trial
Idiopathic intracranial hypertension (IIH), also called pseudotumor cerebri, is a disorder of elevated intracranial pressure of unknown cause [Corbett, et al., 1982; Wall, et al., 1991].
- Trial name
- IIHTT (NCT01003639)
- Testing
- Acetazolamide, Formal weight loss counselling program
- Where
- 41 sites in United States, Canada
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Hypertension
Efficacy of Dietary Sodium Restriction of Improving Vascular Endothelial Function in Middle Aged and Older Adults
The investigators hypothesize that reducing salt in the diet will improve the function of blood vessels in middle aged and older adults with moderately elevated systolic blood pressure, by increasing the amount of BH4 and nitric…
- Trial name
- NCT01566084
- Testing
- Slow sodium tablets
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Safety
First in Human Single Ascending Dose Study of MOR107
This is the first in human study of MOR107. It is a 2 part, single centre, double-blind, randomised, placebo-controlled study in healthy male subjects.
- Trial name
- NCT03067363
- Testing
- MOR107, Low sodium diet
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Alan Richardson
Hypertension
Effect of High- and Low-sodium Intake on the Pharmacokinetics and Pharmacodynamic Effects of Fimasartan
It has been known that the blood pressure lowering effect of angiotensin receptor antagonists (ARBs) and angiotensin converting enzyme (ACE) inhibitors is impaired in patients on high sodium intake.
- Trial name
- NCT02147704
- Testing
- High-sodium diet, low-sodium diet
- Where
- South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- DongGuk University
Polycystic Kidney, Autosomal Dominant
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease
The aim of the study is to test the following hypotheses: 1. that the function and/or regulation of AQP2 and /or ENaC in the principal cells is abnormal in autosomal dominant polycystic kidney disease. 2.
- Trial name
- NCT00410007
- Testing
- High Sodium Diet, Low Sodium Diet, Hypertonic saline infusion
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Carolina Cannillo
Diet, Sodium-Restricted, Heart Failure C14.280.434
Assessing Knowledge of Dietary Sodium Content and Implementation of Color-Coded Cue Cards and Dietary Sodium
Develop an evidence-based intervention aimed at patients with heart failure (HF) using color-coded cue cards to assist in the selection of foods appropriate to their sodium restricted diet.
- Trial name
- NCT02679690
- Testing
- Standard Dietary Sodium Education, Color-Coded Cue Cards
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Idiopathic Hypersomnia
Low Sodium Oxybate in Patients With Idiopathic Hypersomnia
Low sodium oxybate has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of idiopathic hypersomnia.
- Trial name
- NCT05837091
- Testing
- Low Sodium Oxybate, 24-hour polysomnography, Nextsense EEG earbuds
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Kidney Failure, Chronic, Dietary Modification
Dietary Sodium-Restriction (DIS) and Renal Meals (RM) for Hemodialysis (HD)(DISaRM-HD)
Chronic volume overload (VO) is a primary factor responsible for the excessive cardiovascular morbidity and mortality in hemodialysis (HD) patients.
- Trial name
- DISaRM-HD (NCT04991441)
- Testing
- Controlled Dietary Sodium Restriction, Control Diet & Controlled Dietary Sodium Restriction
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois at Urbana-Champaign
Satiety Response, Carbohydrate Metabolism
Low Sodium Neapolitan Pizza Prepared With Seawater: Nutritional Properties, Sensory Characteristics, Metabolic Effects
Seawater is rich in minerals which may help confer good palatability to foods, favouring the use of smaller amounts of salt, a recognized measure of cardiovascular prevention.
- Conditions
- Satiety Response, Carbohydrate Metabolism, Sodium Retention
- Trial name
- NCT04629742
- Testing
- Seawater Pizza, Standard pizza
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federico II University
Hypertension
The Effect of a Low Sodium-High Potassium Salt on Blood Pressure in Vietnamese Adults
The purpose of this study was to investigate the effects of low-sodium, high-potassium condiments and salt on blood pressure in untreated (pre)hypertensive Vietnamese adults.
- Trial name
- NCT02016404
- Testing
- Low-sodium, high-potassium salt, Regular salt
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Essential Hypertension and Healthy Controls
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Essential Hypertension
The aim of the study is to test the following hypotheses: that the function and/or regulation of AQP2 and/or ENaC in the principal cells is abnormal in essential hypertension.
- Trial name
- NCT00345124
- Testing
- high sodium diet, Low Sodium Diet
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Cirrhosis, Liver, Liver Diseases
Give a MANNA a Fish, Teach a MANNA to Fish
This study is a randomized pilot seeking to address low patient adherence to a low sodium diet as a strategy to improve outcomes of patients with cirrhosis of the liver.
- Conditions
- Cirrhosis, Liver, Liver Diseases, Malnutrition
- Trial name
- NCT03969199
- Testing
- Intervention
- Sponsor
- University of Pennsylvania
Hypertension
Dietary Counseling to Reduce Salt Intake in Patients With High Blood Pressure
High salt diet increases risk of development of hypertension. In hypertensive patients, low salt diet decreases blood pressure. Not surprisingly public health authorities endorse low salt diet in hypertensive patients.
- Trial name
- NCT02283697
- Testing
- Dietary Counseling, Control: Standard Care
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Renal Failure, Hypertension
Low Sodium Dialysate and Ambulatory Blood Pressure Measurement Parameters
End stage renal disease (ESRD) is related with increased cardiovascular mortality and morbidity. Hypertension (HT) is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients.
- Trial name
- NCT02621450
- Testing
- standart dialysis, low sodium dialysis
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Hypertension
The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension
The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are: Is the risk of hyperkalemia after the initiation of Low…
- Trial name
- NCT07460882
- Testing
- Low-sodium salt substitute
- Where
- Bangladesh
- Volunteers
- 607 people
- Sponsor
- Johns Hopkins University
Hypertension, Chronic Kidney Disease
Effects of Low Sodium Intake on the Anti-proteinuric Efficacy in Hypertensive Patient With Olmesartan
Purpose of this study 1. Intensive education for low salt diet will be enhance the anti-proteinuric effect of Olmesartan, a popular anti-hypertensive drug of angiotensin II receptor blocker, in Koreans compared to conventional…
- Conditions
- Hypertension, Chronic Kidney Disease, Microalbuminuria
- Trial name
- ESPECIAL (NCT01552954)
- Testing
- Intensive education of low salt diet
- Where
- 7 sites in South Korea
- Volunteers
- 269 people
- Sponsor
- Seoul National University Bundang Hospital
Hypertension
Effects of Low Salt Diet Versus High Salt Diet on Blood Pressure
High blood pressure is a global public health problem in developed and developing countries including Pakistan. Various studies conducted around the world have linked salt intake to variation in the blood pressure.However…
- Trial name
- NCT00330356
- Testing
- Low Salt Diet versus High salt diet
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Kidney Stone, Hypernatriuria
Software Application for Low-Sodium Diet Trial (SALT)
This a single-center prospective randomized controlled trial. Subjects will be assigned to the standard of care dietary recommendations for a low sodium diet (LSD) vs.
- Trial name
- NCT04438551
- Testing
- Standard dietary counseling, Mobile app
- Where
- United States
- Sponsor
- University of Rochester
Hypertension
Sodium Watchers Program - Hypertension
Hypertensive adults are a vulnerable population at high risk of developing cardiovascular disease. Despite the many interventions tested to reduce hypertension, it remains a major risk factor that is not appropriately managed in…
- Trial name
- SWAPHTN (NCT04076280)
- Testing
- Sodium Watcher Program-Hypertension, Usual Care
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Misook L. Chung
Hydration Status
Hydration To be Optimized (H2O) With a Low-sodium Beverage
In this study, the investigators want to assess the effects of a new beverage containing whey protein and glycerol (two different dosages) on hydration status in healthy adults when compared to the control (water).
- Trial name
- H2O (NCT06981468)
- Testing
- Low Sodium Beverage 1, Low Sodium Beverage 2
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)