Clinical trials: Dietary Zinc Deficiency
HIV, HIV Infection
Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Subjects
This research study is being carried out to study a new way to possibly treat human immunodeficiency virus (HIV). The agent is called SB-728-T which are CD4+ T-cells obtained from an individual that are genetically modified at…
- Trial name
- NCT01252641
- Testing
- SB-728-T
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- Sangamo Therapeutics
HIV Infection
Atazanavir/Ritonavir and Zinc Pharmacokinetic Study
The study is being conducted as the most common side effect of the HIV drug atazanavir (taken with ritonavir) is hyperbilirubinaemia.
- Trial name
- SSAT043 (NCT01475227)
- Testing
- 1 Solvazinc tablet, day 2 to day 15, 1 Solvazinc tablet, day 15 to day 28
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- St Stephens Aids Trust
Zinc Deficiency
Assessment of Zinc Intake From Enriched Water and Other Dietary Sources in Kisumu, Kenya
Introduction: The prevalence of low serum zinc in children under 5 in East Seme, Kisumu is 73.5% and this is likely due at least in part to low bioavailable zinc from the local cereal-based diet.
- Trial name
- NCT02162238
- Testing
- LSF-filtering device
- Where
- Kenya
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Iron Deficiency Anemia, Infectious Diseases
Efficacy Trial to Examine Efficacy of Multimicronutrient Home Supplementation in Infants
The objective of the program is to examine the efficacy of 6 month home micronutrient supplementation in Bedouin and Jewish children on improvements in nutritional status including measures of iron, ferritin, zinc and folic acid…
- Conditions
- Iron Deficiency Anemia, Infectious Diseases, Undernutrition
- Trial name
- NCT00276198
- Testing
- Sprinkles, Ferripel-3, Vitamins A&D drops
- Where
- Israel
- Volunteers
- 771 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Iron Deficiency
Iron Bioavailability From Encapsulated Ferrous Sulphate
Salt is one of the very few regularly purchased food item in all socioeconomic classes including poor remote areas with subsistence farming.
- Trial name
- NCT02353325
- Testing
- non-encapsulated FeSO4, encapsulated FeSO4, before cooking, encapsulated FeSO4, after cooking
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Critical Illness, Nutritional Deficiency
Trace Element Repletion Following Severe Burn Injury
Major burn patients are characterized by large exudative losses of Cu, Se and Zn. Trace element (TE) repletion has been shown to improve clinical outcome.
- Conditions
- Critical Illness, Nutritional Deficiency, Trace Element Deficiency, Burn Injury
- Trial name
- NCT03204669
- Testing
- Trace elements replacement
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
HIV Infections
CCR5-modified CD4+ T Cells for HIV Infection
A Comparative Study of Autologous CD4+ T Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 versus ex vivo Expanded Unmodified Autologous CD4+ T Cells in Treated HIV-1 Infected Subjects
- Trial name
- TRAILBLAZER (NCT03666871)
- Testing
- SB-728-T, Expanded unmodified autologous CD4+ T cells
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Iron-deficiency, Anemia
Non-invasive Diagnostics of Iron Deficiency in Surgical Patients by Measuring Zinc Protoporphyrin-IX
In approx. 40% of the incidences anemia is caused by iron deficiency (= ID). In turn, preoperative iron-deficiency anemia (= IDA) is associated with an increase in morbidity and mortality as well as with the need for a blood…
- Conditions
- Iron-deficiency, Anemia, Iron Deficiency Anemia
- Trial name
- NCT03071497
- Testing
- Non-invasive analysis of Zinc protoporphyrin
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Dietary Selenium Deficiency, Dietary Zinc Deficiency
Zinc and Selenium Supplementation in Atherosclerosis
The aim of this randomized double-blind study was to evaluate the effect of oral zinc and selenium supplementation on oxidative stress and inflammation biomarkers as well as the status of zinc and selenium in patients with…
- Trial name
- NCT01547377
- Testing
- zinc and selenium supplementation
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Iron Deficiency and/or Anemia
Comparison of Iron Absorption From Extruded FePP-fortified Rice Containing Zinc, Citric Acid/Trisodium Citrate and EDTA
Rice can only be fortified with ferric pyrophosphate (FePP), which is of low bioavailability in human subjects. Compounds such as citric acid/trisodium citrate (CA/TSC) or sodium ethylene-diamine tetraacetic-acid (EDTA) could…
- Trial name
- MM_Rice (NCT02714075)
- Testing
- Ferric Pyrophosphate and Zinc Oxide, Ferric Pyrophosphate and Zinc Sulphate, Ferric Pyrophosphate, ZnO, Citric Acid and Trisodium Citrate
- Where
- 2 sites in Ghana, Switzerland
- Volunteers
- 30 people
- Sponsor
- Swiss Federal Institute of Technology
HIV, HIV Infections
Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV
This research study is being carried out to study a new way to possibly treat HIV. This agent is called a "Zinc Finger Nuclease" or ZFN for short. ZFNs are proteins that can delete another protein named CCR5.
- Trial name
- Zinc-Finger (NCT00842634)
- Testing
- ZFN modified T cells, Structured Treatment Interruption
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Pennsylvania
Zinc Deficiency
Effects of Liquid Zinc Supplementation and Dispersible Zinc Tablets on Plasma Zinc Concentration
The study aims to compare the effects of two different formulations of zinc supplements on plasma zinc concentrations among young Burkinabe children.
- Trial name
- NCT00944853
- Testing
- Liquid zinc syrup, Zinc tablet
- Where
- Burkina Faso
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Vitamin A Deficiency
Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age
The primary purpose of this study is to determine whether daily consumption of orange-fleshed sweet potatoes increases the vitamin A status of Bangladeshi women of reproductive age.
- Trial name
- NCT00453648
- Testing
- White-fleshed sweet potatoes, Orange-fleshed sweet potatoes (boiled), Orange-fleshed sweet potatoes (fried)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Zinc Deficiency
Evaluation of Human Zinc Absorption From Wheat-based Meals
Study part 1 and 2 Assessment of Zn absorption from regular and biofortified wheat: stable isotope absorption studies in women of childbearing age consuming test meals prepared from either the biofortified Zn wheat, regular wheat…
- Trial name
- NCT01775319
- Testing
- Biofortified wheat, Fortified wheat
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
HIV Infection, Alcohol Use
Alcohol's Impact on Inflammatory Markers in HIV Disease - Russia ARCH Cohort
The purpose of this study is to assess the longitudinal association between alcohol consumption and biomarkers of microbial translocation (sCD14) and inflammation/altered coagulation (IL-6/D-dimer); to establish a cohort of…
- Trial name
- NCT01614626
- Where
- Russia
- Volunteers
- 351 people
- Sponsor
- Boston Medical Center
Iron Deficiency, Vitamin A Deficiency
Nutritional Status and Bouillon Use in Northern Ghana
This pilot aims to generate data that are critical for informing the design of a planned, more detailed study to evaluate the effect of multiple micronutrient (MN)-fortified bouillon cube on biomarkers of nutrient status of women…
- Conditions
- Iron Deficiency, Vitamin A Deficiency, Vitamin B 12 Deficiency, Folate Deficiency
- Trial name
- NCT04632771
- Testing
- N/A (observational study)
- Where
- Ghana
- Volunteers
- 995 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Anemia, Iron-Deficiency
Non-invasive Optical Detection of Iron Deficiency
This study aims to evaluate a prototype device detecting zinc protoporphyrin-IX fluorescence non-invasively from the intact oral mucosa. Zinc protoporphyrin-IX is an established indicator of iron deficiency.
- Trial name
- NCT02310607
- Testing
- Not an interventional study
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Klinikum der Universitaet Muenchen, Grosshadern
Iron Deficiency Anemia of Pregnancy, Iron-deficiency
Non-invasive Detection of Iron Deficiency in Obstetrics
Validation of non-invasive measurement of zinc protoporphyrin for detection of iron deficiency in pregnancy. In addition, the impact of iron deficiency on the incidence of postpartum depression, restless legs syndrome, obstetric…
- Conditions
- Iron Deficiency Anemia of Pregnancy, Iron-deficiency, Restless Leg Syndrome in Pregnancy, Restless Leg Syndrome Due to Iron Deficiency Anaemia
- Trial name
- PICCOLINO (NCT07083492)
- Testing
- non-invasive measurement of zink protoporphyrin
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Immunity, Vaccine Reaction
Efficacy and Tolerability of ABBC1 in Volunteers Receiving the Influenza or Covid-19 Vaccine
The immune system response needs to be forceful but also balanced for a rapid recovery from infection which avoids harmful overreactions.
- Conditions
- Immunity, Vaccine Reaction, Influenza, Covid19
- Trial name
- NCT04798677
- Testing
- ABBC1 Immunoessential
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AB Biotek
HIV-infection/Aids, Malnutrition
Impact of RUTF on Body Composition, Anemia and Zinc Status of PLWHA
A clinical trial was conducted in 65 PLWH randomly allocated to receive standard hospital diet alone (Control group: n=33), or the diet combined with 100 g/day of RUTF (RUTF group: n=32).
- Trial name
- PLWHA (NCT02433743)
- Testing
- Ready-to-use therapeutic food (RUTF)
- Where
- Senegal
- Volunteers
- 65 people
- Sponsor
- Cheikh Anta Diop University, Senegal