Clinical trials: Differentiation
Hypertrophic Cardiomyopathy, Hypertensive Heart Disease
Differentiation HHD From HCM (EARLY-MYO-HHD)
Differentiating hypertrophic cardiomyopathy (HCM) from hypertensive heart disease (HHD) unavoidably encounters diagnostic challenges especially in patient of suspected HCM with history of hypertension.
- Trial name
- NCT03271385
- Testing
- evaluated by the predetermined differentiating formula
- Where
- China
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Erythroid Leukemia (M6)
Tipifarnib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Tipifarnib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. This phase I trial is studying the side effects and best dose of tipifarnib in treating patients with relapsed or refractory…
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Erythroid Leukemia (M6), Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00101296
- Testing
- tipifarnib, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Locally Advanced or Metastatic Radioiodine-refractory Differentiated Thyroid Carcinoma
Study of Anlotinib in Patients With Radioiodine Refractory Differentiated Thyroid Cancer
This study aims to observe and explore the efficacy and safety of Anlotinib combined with penpulimab in the treatment of radioiodine refractory differentiated thyroid cancer with first-line resistance to angiogenesis inhibitors…
- Trial name
- NCT06062563
- Testing
- Anlotinib Hydrochloride Capsule and Penpulimab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
Differentiated Thyroid Cancer
rhTSH for Radioactive Iodine Remnant Ablation in Participants With Differentiated Thyroid Cancer (DTC)
This study was conducted in patients with differentiated thyroid cancer who had undergone total/near-total thyroidectomy. After surgery patients were randomized to one of two methods of performing thyroid remnant ablation.
- Trial name
- NCT04964284
- Testing
- rhTSH, Radioiodine (131I)
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
Idarubicin and Cytarabine With or Without Bevacizumab in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Drugs used in chemotherapy, such as idarubicin and cytarabine, work in different ways to stop cancer cells from dividing so they stop growing or die.
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00096148
- Testing
- idarubicin, cytarabine, bevacizumab
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
Carcinoid Syndrome, Metastatic Nonfunctional Well Differentiated Neuroendocrine Neoplasm
AMT-PET in Monitoring Telotristat Etiprate Treatment in Participants With MetastaticNeuroendocrine Neoplasm
This pilot trial studies how well telotristat etiprate works in treating participants with well differentiated neuroendocrine neoplasm that has spread to other places in the body and monitored by carbon C 11…
- Trial name
- NCT03453489
- Testing
- Carbon C 11 Alpha-methyltryptophan, Laboratory Biomarker Analysis, Positron Emission Tomography
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Breast Cancer, Colorectal Cancer
Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer
RATIONALE: Measuring levels of transforming growth factor-beta (TGF-beta) in the blood of patients with epithelial cancers (head and neck, lung, breast, colorectal, and prostate) may help doctors predict how patients will respond…
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00897793
- Testing
- venipuncture, radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Advanced Solid Tumor, Metastatic Solid Tumor
Lurbinectedin Monotherapy in Participants With Advanced or Metastatic Solid Tumors
This is an open-label, multicenter, phase 2 study of lurbinectedin monotherapy in participants with advanced (metastatic and/or unresectable) solid tumors.
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Urothelial Cancer, Poorly Differentiated Neuroendocrine Carcinomas
- Trial name
- JAZZ EMERGE201 (NCT05126433)
- Testing
- Lurbinectedin
- Where
- 17 sites in United States
- Volunteers
- 47 people
- Sponsor
- Jazz Pharmaceuticals
Differentiated Thyroid Cancer
Effect of Thyrotropin Level on Iodine Uptake in Metastatic Differentiated Thyroid Cancer
Distant metastases is the leading cause of differentiated thyroid cancer-related death. Radioactive iodine (RAI) treatment is the most effective therapy for RAI-avid metastatic differentiated thyroid cancer (DTC).
- Trial name
- NCT04880798
- Testing
- 124I PET/CT
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
Assess the Efficacy of Differentiated and Undifferentiated Stem Cell Therapy in Improving Endometrial Receptivity.
Role of Stem Cells in Improving Implantation Rates in ICSI Patients
Background: Improving implantation rates in ICSI cycles has been the focus of research in recent decades. Because success rates is not satisfactory enough especially when transferring good embryos to the uterine cavity and…
- Trial name
- NCT01649752
- Testing
- Differentiated stem cells to endometrium is deposited in the uterine cavity through an IUI catheter, Undifferentiated MSC is deposited in the uterine cavity through an IUI catheter.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Cancer
Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer
RATIONALE: Cyproheptadine hydrochloride may prevent weight loss caused by cancer or cancer treatment. It is not yet known whether cyproheptadine is more effective than a placebo in preventing weight loss in young patients…
- Trial name
- NCT01132547
- Testing
- cyproheptadine hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of South Florida
Differentiated Thyroid Cancer
PET-guided External Beam Radiotherapy in Differentiated Thyroid Cancer
Description of the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.
- Trial name
- NCT03191643
- Volunteers
- 16 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
HIV/AIDS
Village-based vs Clinic-based ART Care - a Cluster Randomized Controlled Trial in Lesotho
This cluster-randomized trial tests a differentiated care model for HIV-positive individuals not on ART during a home-based HIV testing campaign in rural Lesotho, Southern Africa.
- Trial name
- VIBRA (NCT03630549)
- Testing
- Standard of Care, Village-based ART refill
- Where
- 2 sites in Lesotho
- Volunteers
- 257 people
- Sponsor
- Niklaus Labhardt
Metastatic Differentiated Thyroid Cancer, Metastatic Poorly Differentiated Thyroid Cancer
Phase II Trial of Sorafenib (Nexavar) in Patients With Advanced Thyroid Cancer
The goal of this study is to determine the activity of sorafenib in patients with advanced (metastatic or recurrent) thyroid cancer.
- Conditions
- Metastatic Differentiated Thyroid Cancer, Metastatic Poorly Differentiated Thyroid Cancer, Metastatic Anaplastic Thyroid Cancer, Metastatic Medullary Thyroid Cancer
- Trial name
- NCT00654238
- Testing
- sorafenib
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Pennsylvania
Well-differentiated Neuroendocrine Tumors
A Pilot Study of Metformin Treatment in Patients With Well-differentiated Neuroendocrine Tumors
Neuroendocrine tumors are rare but recent data showed a relevant increase in its incidence. The Mammalian Target of Rapamycin (mTOR), one of most important area of research, has demonstrated be a therapeutic target in these…
- Trial name
- MetNet (NCT02279758)
- Testing
- Metformin
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Carcinoma, Neuroendocrine Tumors
A Study of Cixutumumab (IMC-A12) in Islet Cell Cancer
Determine the 6-month progression free survival (PFS) rate associated with cixutumumab in combination with depot octreotide acetate (octreotide) in participants with metastatic neuroendocrine tumors.
- Trial name
- NCT00781911
- Testing
- Cixutumumab, depot octreotide
- Where
- 10 sites in United States
- Volunteers
- 43 people
- Sponsor
- Eli Lilly and Company
Relapsed or Refractory Plasma Cell Neoplasms, Lymphomas/Leukemias With Plasmacytic Differentiation
CAR19BCMA CAR-T Cells for the Treatment of R/R Plasma Cell Neoplasms and Lymphomas/Leukemias With Plasmacytic Differentiation
This is a single arm study to evaluate the safety and efficacy of CAR19BCMA CAR-T cells in the treatment of relapsed/refractory CD19/BCMA positive plasma cell neoplasms and lymphomas/leukemias with plasmacytic differentiation.
- Trial name
- NCT06986434
- Testing
- CAR19BCMA-T cells, fludarabine and cyclophosphamide
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Neuroendocrine Tumors
A Study of LEE011 With Everolimus in Patients With Advanced Neuroendocrine Tumors
The purpose of this study is to test any good and bad effects of the combination of LEE011 with everolimus on the participant and the cancer.
- Trial name
- NCT03070301
- Testing
- LEE011, everolimus
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Diabetes Mellitus, Type 2, Metabolic Syndrome
TCM Syndrome Differentiation of T2DM & MetS
This study aims to include type 2 diabetes (T2DM) patients comorbid with metabolic syndrome (MetS). The primary aim of the study is to investigate the TCM (Traditional Chinese Medicine) syndrome differentiation of T2DM comorbid…
- Trial name
- NCT06703684
- Testing
- Cross-sectional observational study
- Where
- Hong Kong
- Volunteers
- 470 people
- Sponsor
- Hong Kong Baptist University
CD19+ Malignancies: Relapse Post-allogeneic Transplant
CAR19 Donor Lymphocytes for Relapsed CD19+ Malignancies Following Allogeneic Transplantation
Eligible patients will receive escalating doses of 4G7-CARD T-cells paralleling clinical standard of care with unmanipulated donor lymphocytes. There are 3 intra-patient dose levels planned.
- Trial name
- CARD (NCT02893189)
- Testing
- Infusion of modified CAR19 T-cells (4G7-CARD T-cells)
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University College, London