Clinical trials: Diffuse Parenchymal Lung Diseases
Lung Cancer, Radiation-Induced Disorder
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy.
- Conditions
- Lung Cancer, Radiation-Induced Disorder, Radiation Pneumonitis, Pulmonary Disease
- Trial name
- ASPECT (NCT04676828)
- Testing
- Single-photon-emission CT scan
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Pirfenidone, Connective Tissue Diseases
Efficacy and Safety of Pirfenidone in CTD-ILD
A single-center randomized controlled study will be used to observe the efficacy and safety of pirfenidone on CTD-ILD patients for 24 months. The main research endpoints is the lung function (FVC) at 6 months.
- Conditions
- Pirfenidone, Connective Tissue Diseases, Interstitial Lung Disease
- Trial name
- NCT05505409
- Testing
- Pirfenidone, glucocorticoid and immunosuppressant
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University
Lung Diseases, Interstitial, Pneumonitis, Interstitial
Rituximab in Interstitial Pneumonitis
This project will address rare immune mediated inflammatory diseases (IMIDs) involving the lungs, i.e. interstitial pneumonitis (IP).
- Trial name
- RITUX-IP (NCT02251964)
- Testing
- Rituximab, Zr-89-rituximab immuno PET/CT
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Human Adams
Langerhans Cell Histiocytosis
Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders
This research study is evaluating a drug called clofarabine as a possible treatment for Langerhans Cell Histiocytosis (LCH) and and other histiocytic disorders.
- Trial name
- NCT02425904
- Testing
- Clofarabine
- Where
- 15 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- Dana-Farber Cancer Institute
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Biomarkers in the Evaluation of Chronic Lung Disease
We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a…
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Interstitial Lung Disease
- Trial name
- NCT00926523
- Testing
- Blood Gas, Pulmonary Exercise Test, Spirometry
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Idiopathic Pulmonary Fibrosis
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Monoclonal Antibody (mAb) in Patients With IPF (SAD).
Assess the safety of CHF10067 (study drug) and any side effects that might be associated with it. The study also evaluated how much of the study drug gets into the bloodstream and how long the body takes to remove it.
- Trial name
- NCT05513950
- Testing
- CHF10067 starting dose -- 1000mg (Cohort A), CHF10067 intermediate dose -- 2000mg (Cohort B), CHF10067 high dose -- 3000mg (Cohort C)
- Where
- 9 sites in North Macedonia, Ukraine and 1 more
- Volunteers
- 52 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Idiopathic Pulmonary Fibrosis (IPF)
A Phase I Study of HW241045 in Healthy Subjects
This is a Phase I, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and food effect (FE) of HW241045 in healthy participants.
- Trial name
- NCT07593690
- Testing
- HW241045 Formulation A, HW241045 Formulation B
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.
Interstitial Lung Disease (ILD)
VR-Assisted Exercise for Symptom Management and Rehabilitation in Interstitial Lung Disease
This project aims to create and improve a VR-based breathing exercise program for patients with interstitial lung diseases (ILDs).
- Trial name
- NCT07628725
- Testing
- Flyer, VR-based
- Volunteers
- 32 people
- Sponsor
- University of Manitoba
Idiopathic Pulmonary Fibrosis
Safety, Tolerability and PK of Nintedanib in Combination With Pirfenidone in IPF
This is a phase IV, twelve week, open label, randomized, parallel group study to assess safety and tolerability of combined treatment with nintedanib and pirfenidone.
- Trial name
- NCT02579603
- Testing
- Nintedanib, Pirfenidone
- Where
- 23 sites in United States, Canada and 4 more
- Volunteers
- 105 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Fibrosis
Assessment of Peripheral Endothelial Function in Idiopathic Pulmonary Fibrosis
The aim of the study is to assess the peripheral endothelial function in adult patients with idiopathic pulmonary fibrosis (IPF) and the relationship between the peripheral endothelial function and the severity of the IPF.
- Trial name
- Endoth-FPI (NCT02594059)
- Testing
- endothelial function
- Where
- 2 sites in France
- Volunteers
- 43 people
- Sponsor
- Hopital Foch
Pulmonary Fibrosis, Scleroderma, Systemic
Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma
Clinical and experimental studies suggest that bosentan could delay the progression of interstitial lung disease (ILD) associated with systemic sclerosis (SSc), a condition for which no established efficacious treatment is…
- Trial name
- NCT00070590
- Testing
- Bosentan
- Volunteers
- 132 people
- Sponsor
- Actelion
Idiopathic Pulmonary Fibrosis, Mechanical Ventilation Pressure High
End-expiratory Trans-pulmonary Pressure Guided PEEP Titration in Patients With Pulmonary Fibrosis and UIP Pattern Undergoing Mechanical Ventilation
Patients with pulmonary fibrosis and associated usual interstitial pneumonia that require mechanical ventilation for acute respiratory failure experience poor clinical outcomes.
- Trial name
- ETROPON (NCT05098717)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Modena and Reggio Emilia
Idiopathic Pulmonary Fibrosis, Lung; Disease, Interstitial, With Fibrosis
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of RSN0402 in Healthy Volunteers
This is a phase 1, randomized, First in Human (FIH), double-blinded, placebo-controlled study to assess the safety, tolerability, and PK of RSN0402 in healthy volunteers.
- Trial name
- NCT06482190
- Testing
- RSN0402 Part 1, RSN0402 Part 2
- Where
- 3 sites in Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shenzhen Resproly Biopharmaceutical Co., Ltd
Scleroderma
Morbidity and Mortality Follow Up for the Scleroderma Lung Study
The primary intent of this study is to add to the body of knowledge on scleroderma patients with interstitial lung disease. While lung disease is recognized as the leading cause of death amongst patients with scleroderma, there…
- Trial name
- NCT01762449
- Testing
- Followup survey
- Volunteers
- 158 people
- Sponsor
- Duke University
Idiopathic Pulmonary Fibrosis
Lung MRI in the Management of Idiopathic Pulmonary Fibrosis
High resolution computed tomography (HRCT) plays a major role in the management of idiopathic pulmonary fibrosis (IPF) by identifying characteristic lesions of usual interstitial pneumonia (UIP).
- Trial name
- PIC'IRM (NCT03078426)
- Testing
- MRI, Thoracic HRCT (standard reference)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Interstitial Lung Disease (ILD), Idiopathic Pulmonary Fibrosis (IPF)
Pulmonary Fibrosis Foundation Patient Registry
The Pulmonary Fibrosis Foundation Patient Registry will collect data on at least 2,000 patients with interstitial lung disease (ILD) at approximately 40 clinical sites in the US.
- Trial name
- PFFR (NCT02758808)
- Where
- 42 sites in United States
- Volunteers
- 2,004 people
- Sponsor
- Pulmonary Fibrosis Foundation
Vascular Access Complication, Apheresis Related Complication
Vascular Access Complications for Therapeutic Apheresis in Nephrology
The aim of this study is to describe vascular access complications which are used for therapeutic apheresis in Nephrology.
- Trial name
- VACTANE (NCT05894317)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Transbronchial Lung Cryobiopsy
The Role of Standardized Training in the Diagnosis of Interstitial Lung Disease by Transbronchial Lung Cryobiopsy
The aim of this study was to conduct a prospective randomized controlled trial to design simulator and in vitro lung standardized training, to perform a learning curve evaluation of transbronchial lung cryobiopsy (TBLC) operating…
- Trial name
- NCT06245954
- Testing
- simulated training, traditional bedside teaching
- Where
- China
- Volunteers
- 20 people
- Sponsor
- China-Japan Friendship Hospital
Idiopathic Pulmonary Fibrosis
To Evaluate the Effect of Different Doses of SAR156597 Given to Patients With Idiopathic Pulmonary Fibrosis (IPF)
Primary Objective: To assess in adult patients with Idiopathic Pulmonary Fibrosis (IPF) the safety and tolerability of ascending doses of SAR156597 administered subcutaneously (SC) once weekly over a 6-week period.
- Trial name
- NCT01529853
- Testing
- SAR156597
- Where
- 21 sites in United States, Canada and 3 more
- Volunteers
- 24 people
- Sponsor
- Sanofi
Idiopathic Pulmonary Fibrosis
Outcome of Idiopathic Pulmonary Fibrosis With Pregnancy
case-control study was conducted between December 2018 to April 2020. To document outcome of IPF with pregnancy.
- Trial name
- NCT04775277
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Sohag University
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