Clinical trials: Diffuse Parenchymal Lung Diseases
Interstitial Lung Disease
Interpretation of the Role of Eosinophils in Diffuse Interstitial Pneumopathies
Diffuse interstitial lung diseases (ILDs) represent a group of rare, heterogeneous disorders of various etiologies, all sharing a common histopathological feature: fibrotic remodeling of the pulmonary parenchyma induced by a…
- Trial name
- INTREPID (NCT06980844)
- Testing
- No intervention: no treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hopital Foch
Lung Diseases, Interstitial
Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis
To characterize stem cell compartments in their niches in different clinical situations (non-diseased compared to emphysematous and fibrotic pulmonary tissue) and to assess their proliferative and developmental properties in…
- Trial name
- NCT02705144
- Testing
- analysis of the number of stem cell niches
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Systemic Sclerosis-associated Interstitial Lung Disease (Ssc-ild)
Efficacy and Safety of Pirfenidone in Patient With Systemic Sclerosis-associated Interstitial Lung Disease
The purpose of this study is to evaluate the eEfficacy and safety of pirfenidone in subjects with systemic sclerosis-associated interstitial lung disease (SSc-ILD)
- Trial name
- NCT03856853
- Testing
- Pirfenidone
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Respiratory Failure, Interstitial Lung Disease
Bio-Banking of Specimens for Advanced Lung Disease and Lung Transplant Research
A major goal of this protocol is to support biomarker studies in advanced lung diseases, lung transplantation care, and to improve our understanding of the effects of viral and other infectious exposures to outcomes in our lung…
- Conditions
- Respiratory Failure, Interstitial Lung Disease, Lung Diseases
- Trial name
- ALD Biobank (NCT04664192)
- Testing
- Patient Biospecimen Registry (observational and blood sampling)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Pulmonary Sarcoidosis
Mycophenolate for Pulmonary Sarcoidosis
Corticosteroids are presently the drug of choice for the treatment of pulmonary sarcoidosis. However, corticosteroids are associated with many significant side effects.
- Trial name
- NCT00262132
- Testing
- Mycophenolate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Idiopathic Pulmonary Fibrosis
A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of SV001 in Chinese Healthy Adult Volunteers.
The purpose of this study is to evaluate safety, tolerability, PK and immunogenicity of SV001 compare to placebo in Chinese healthy adult volunteers.
- Trial name
- NCT06267183
- Testing
- SV001
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Shanghai Synvida Biotechnology Co.,Ltd.
Interstitial Lung Disease, Desquamative
Sequential Changes of Serum KL-6 Predict Progression in Interstitial Lung Disease
Interstitial lung disease is a chronic progressive fibrosis lung disease that with a highly variable clinical process.thence it is significant for the patient to search a convenient and accurate prediction method.
- Trial name
- NCT02960672
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Obstructive Pulmonary Disease Severe, Interstitial Lung Disease
Effect of HIgh-flow Therapy in Long-term Oxygen Therapy
This is a registry-based, randomized, controlled clinical trial of the effect of added high-flow oxygen therapy (using the device Lumis HFT) during one year in people with long-term oxygen therapy (LTOT) for chronic obstructive…
- Conditions
- Chronic Obstructive Pulmonary Disease Severe, Interstitial Lung Disease, Chronic Respiratory Failure With Hypoxia
- Trial name
- HILOT (NCT06247397)
- Testing
- Added high-flow oxygen therapy, Standard care
- Where
- 2 sites in Sweden
- Volunteers
- 310 people
- Sponsor
- Skane University Hospital
Primary Sjogren's Syndrome, Interstitial Lung Disease
Clinical Study of Jianfei Kangfu Cao in the Treatment of pSS-ILD
This study will evaluate the safety and efficacy of Jianfei Kangfu Cao in the treatment of primary Sjogren's syndrome associated interstitial lung disease.
- Trial name
- NCT04544722
- Testing
- Jianfei Kangfu Cao, lung rehabilitation training
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Idiopathic Pulmonary Fibrosis
A Study to Evaluate the Safety and Efficacy of GS-6624 (Formerly AB0024) in Patients With Idiopathic Pulmonary Fibrosis
The study consists of 2 parts: Part A is a randomized, multiple-dose, double-blind, placebo-controlled sequential dose escalation study to evaluate GS-6624 in subjects with Idiopathic Pulmonary Fibrosis (IPF) and was completed in…
- Trial name
- NCT01362231
- Testing
- GS-6624
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Gilead Sciences
Idiopathic Pulmonary Fibrosis, Usual Interstitial Pneumonia
Turkish Thoracic Society Usual Interstitial Pneumonia Registry Study
The Turkish Thoracic Society Usual Interstitial Pneumonia Registry (TURK-UIP) is a collaborative project to coordinate a team of investigators from various regions of Turkey.
- Trial name
- TURK-UIP (NCT02821039)
- Where
- 46 sites in Turkey (Türkiye)
- Volunteers
- 1,678 people
- Sponsor
- Turkish Thoracic Society
Idiopathic Pulmonary Fibrosis
To Evaluate Drug-drug Interactions Between HEC585 and Pirfenidone or Nintedanib in Healthy Volunteers
An open label study to evaluate drug-drug interactions between HEC585 and Pirfenidone or Nintedanib in healthy volunteers
- Trial name
- NCT05383131
- Testing
- HEC585, Pirfenidone, Nintedanib
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Asthma, Chronic Obstructive Pulmonary Disease
Use Of Capnography As Surrogate Measure Of PC02 In Medical Intensive Care Unit (ICU) Patients
The purpose of this study is to evaluate the use of Capnography (Continuous recording of the carbon dioxide content of expired air)as an alternative test to measure PC02 levels in patients with asthma, chronic obstructive…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
- Trial name
- NCT00744614
- Testing
- Capnography
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Lahey Clinic
Heart Failure, Pulmonary Disease, Chronic Obstructive
Virtual Nurse and Social Worker Palliative Care Team to Improve Quality of Life in Veterans With Heart Failure or COPD
Many Veterans living with heart failure or chronic obstructive pulmonary disease (COPD) experience significant symptoms - such as breathlessness, fatigue, depression, and anxiety -that reduce their quality of life.
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Interstitial Lung Disease
- Trial name
- VITALVET:ADAPT (NCT07714252)
- Testing
- Virtual Nurse and Social Worker Palliative Care Team, Enhanced Implementation Support, Standard Implementation Support
- Where
- 7 sites in United States
- Volunteers
- 420 people
- Sponsor
- VA Office of Research and Development
Covid-19, Pulmonary Fibrosis
Development of Interstitial Lung Disease (ILD) in Patients With Severe SARS-CoV-2 Infection (COVID-19)
COVID-19, the infectious disease caused by the novel coronavirus SARS-CoV-2, currently poses a global economic, social, political and medical challenge.
- Trial name
- CovILD (NCT04416100)
- Testing
- Pulmonary function tests, Imaging, Blood sampling
- Where
- Austria
- Volunteers
- 130 people
- Sponsor
- Medical University Innsbruck
Idiopathic Pulmonary Fibrosis
Clinical Trial of Chinese Herbal Medicine for Idiopathic Pulmonary Fibrosis (IPF)
This open label clinical study will be conducted in School of Chinese Medicine Clinics at The University of Hong Kong (HKU) to preliminarily determine whether treatment with the herbal formula PROLUNG could improve Idiopathic…
- Trial name
- NCT03274544
- Testing
- PROLUNG
- Where
- Hong Kong
- Volunteers
- 6 people
- Sponsor
- The University of Hong Kong
COPD, Asthma (Diagnosis)
A Study to Evaluate the Diagnostic Performance of Portable Oscillometry Across Chronic Respiratory Diseases
This is a prospective, multicenter, observational cohort study enrolling approximately 4,000 subjects across about 50 centers, including patients with COPD (confirmed and suspected), asthma (confirmed and suspected)…
- Conditions
- COPD, Asthma (Diagnosis), Chronic Respiratory Diseases, Bronchiectasis
- Trial name
- NCT07631507
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Pulmonary Fibrosis, Hypertension, Pulmonary
Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects an individual's ability to breathe. This study will evaluate the effectiveness of sildenafil, a medication that increases blood flow to the lungs, at…
- Trial name
- STEP-IPF (NCT00517933)
- Testing
- Sildenafil Citrate
- Where
- 13 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duke University
ANCA-associated Vasculitis, Granulomatosis With Polyangiitis
Observation Study of Clinical Manifestation and Outcome in Chinese Patients With Pulmonary Vasculitis
The purpose of this study is to observe the clinical manifestation, Lab findings including chest CT scans, pathological findings and outcomes in chinese patients with pulminary vasculitis.
- Conditions
- ANCA-associated Vasculitis, Granulomatosis With Polyangiitis, Microscopic Polyangiitis, EosinphilicGranulomatosis With Polyangiitis
- Trial name
- NCT02126098
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases
TRANSREG will assess the safety and biological efficacy of low-dose IL2 as a Treg inducer in a set of 14 autoimmune and auto-inflammatory diseases, with the aim to select diseases in which further therapeutic development will be…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus, Psoriasis
- Trial name
- TRANSREG (NCT01988506)
- Testing
- Interleukin 2
- Where
- 11 sites in France
- Volunteers
- 81 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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