Clinical trials: Diffuse Systemic Sclerosis
Systemic Scleroderma, Diffuse Cutaneous Scleroderma
Diffuse Cutaneous Scleroderma (DSSc) SFDI Study
Scleroderma (SSc) is an autoimmune disease characterized by fibrosis (or collagen deposition) of the skin and internal organs. The extent of skin fibrosis is an important predictor of internal organ complications and increased…
- Trial name
- SFDI (NCT07090226)
- Testing
- Spatial-frequency domain imaging (SFDI)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Boston University
Autoimmune Diseases, Sickle Cell Disease
Microvascular and Fibrosis Imaging Study
In this study, Laser Doppler Flowmetry (LDF), Laser Doppler Imaging (LDI), Orthogonal Polarization Spectral Imaging (OPSI), Nail fold video capillaroscopy (NVC) and Optical Coherence Tomography (OCT) will be used to assess…
- Conditions
- Autoimmune Diseases, Sickle Cell Disease, Chronic Graft Versus Host Disease
- Trial name
- NCT01758250
- Testing
- Acoustic Radiation Force Impulse (ARFI), Laser Doppler Flowmetry (LDF), Laser Doppler Perfusion Imaging (LDI)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
Scars, Scleroderma
Laser Treatment for the Improvement of Scars and Scleroderma
In this study, the investigators seek to evaluate the effects of a laser treatment on the redistribution/regeneration of collagen on the clinical, microscopic, and molecular profiles of hypertrophic scars and scleroderma.
- Trial name
- NCT04567537
- Testing
- Laser Treatment
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Scleroderma, Systemic
Treprostinil Iontophoresis : a Pharmacodynamic and Pharmacokinetic Study
The purpose of the study is to assess skin blood flow after non-invasive local administration of treprostinil by using a low-intensity current (i.e.
- Trial name
- TIPPS (NCT01554540)
- Testing
- Cutaneous iontophoresis of treprostinil
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Systemic Sclerosis, Pulmonary Hypertension
Endothelial Microparticles in Systemic Sclerosis Pulmonary Hypertension
Systemic sclerosis (SSc, also known as scleroderma) is a disease characterized by fibrosis of the skin and organs, inflammation, and an abnormal endothelial cell lining inside of vessels.
- Conditions
- Systemic Sclerosis, Pulmonary Hypertension, Scleroderma
- Trial name
- NCT02331225
- Testing
- No intervention given
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Systemic Sclerosis, Scleroderma
Effects of Probiotics on Gastrointestinal Symptoms and on the Immune System in Patients With Systemic Sclerosis
Systemic sclerosis (SSc) is an autoimmune disease with unknown etiology, which affects especially the gastrointestinal tract, lungs, heart and kidneys.
- Trial name
- SSc (NCT02302352)
- Testing
- Probiotic
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Scleroderma, Gastroparesis
Transcutaneous Electroacupuncture for Gastric Complications of Scleroderma
An innovative method of needleless transcutaneous electroacupuncture (TEA) using a newly developed watch-size stimulator is proposed.
- Trial name
- NCT03294616
- Testing
- transcutaneous electroacupuncture
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Systemic Sclerosis (Scleroderma)
Treatment of Early Systemic Sclerosis by Bosentan
Systemic sclerosis (ssc) is characterised by extensive tissue fibrosis. Using drugs that are capable of inhibiting fibroblast activity may be beneficial if administrered early in the disease course.
- Trial name
- TRANOS (NCT00226889)
- Testing
- bosentan
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rikshospitalet University Hospital