Clinical trials: Digestive Disease
H Pylori Infection, H Pylori Gastritis
Helicobacter Pylori Screening and Treatment in the At-risk South Florida Community- AIM 1
H. pylori is an infection of the stomach that can cause chronic gastritis, gastric cancer and peptic ulcer disease. The goal of this study is to screen people for this infection and offer treatment for those who test positive for…
- Conditions
- H Pylori Infection, H Pylori Gastritis, Gastric Cancer
- Trial name
- NCT07224035
- Testing
- PYTEST® 14C-Urea Breath Test, VOQUEZNA® Triple Pak®
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Miami
Chronic Hepatitis C
Phase I/II Trial of KRN7000 in Patients With Chronic Hepatitis C Infection
Phase I/II trial of KRN7000 in patients with chronic hepatitis C. Study objectives: To evaluate and compare the safety and tolerability of 3 ascending doses of a-GalCer.
- Trial name
- NCT00352235
- Testing
- KRN7000
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Foundation for Liver Research
Dysphagia
PRO-ACTIVE: Prophylactic Swallow Intervention for Patients Receiving Radiotherapy for Head and Neck Cancer
Dysphagia (difficulty swallowing) is a common and potentially life-threatening toxicity of radiotherapy (RT) for patients with head and neck cancer (HNC).
- Trial name
- PRO-ACTIVE (NCT03455608)
- Testing
- RE-ACTIVE, PRO-ACTIVE EAT, PRO-ACTIVE EAT + EXERCISE
- Where
- 13 sites in United States, Canada
- Volunteers
- 952 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer, Quality of Life
Quality of Life in Colorectal (ex-)Cancer Patients, Based on the Belgian Cancer Registry.
This study is collecting data on quality of life, (care)needs and socio-economic factors in colorectal (ex-)cancer patients via a written questionnaire completed by the patient him/herself.
- Trial name
- QOLColorect (NCT02545725)
- Testing
- Questionnaire on Quality of Life
- Where
- Belgium
- Volunteers
- 1,220 people
- Sponsor
- Elizabeth Van Eycken
Esophagus Cancer, Stage III
GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC)
Caffeic acid can target inhibit GASC1 (gene amplified in squamous cell carcinoma 1, also known as KDM4C and JMJD2C) expression and GASC1 is confirmed to be a new oncogene in several cancers including esophageal cancer.
- Trial name
- GiCAEC (NCT04648917)
- Testing
- Caffeic acid
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Ulcerative Colitis
Fecal Transplantation Using a Diet for Donor and Recipient in Refractory Colitis
Changing the microbiota has become the most intriguing target for intervention in inflammatory bowel disease (IBD). Dietary therapy is successful in mild to moderate Crohn's disease and may be effective in mild to moderate…
- Trial name
- NCT02734589
- Testing
- Fecal transplantation, Unique novel Diet for UC and Unique novel Diet for the donor + FMT, Unique novel Diet for UC
- Where
- 5 sites in France, Israel and 1 more
- Volunteers
- 54 people
- Sponsor
- Wolfson Medical Center
Colorectal Cancer
High-Dose Folic Acid in Preventing Colorectal Cancer in Patients Who Have Had Polyps Surgically Removed
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of folic acid may be an effective way to prevent colorectal cancer in patients with polyps that…
- Trial name
- NCT00002650
- Testing
- folic acid
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- Eastern Cooperative Oncology Group
Irritable Bowel Syndrome
Smartphone Training for Attention Regulation for IBS
In the largest and most well-controlled randomized control trial of mindfulness-based interventions (MBIs) training in irritable bowel syndrome (IBS) to-date (N=360), the investigators will evaluate whether a smartphone MBI…
- Trial name
- NCT05083091
- Testing
- Mindfulness and Attention Training, Mindfulness training, Coping Condition
- Where
- United States
- Volunteers
- 359 people
- Sponsor
- Carnegie Mellon University
Pancreatic Neoplasm
A Study On An Immunostimulant Antibody In Combination With Chemotherapy For Advanced Cancer Of The Pancreas
This study aims to seek evidence that activation of certain cells of the immune system will be safe and well tolerated in combination with cytotoxic chemotherapy.
- Trial name
- NCT00711191
- Testing
- monoclonal antibody, chemotherapy
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Hoffmann-La Roche
Pancreatic Cancer
Gemcitabine and Bevacizumab in Treating Patients With Pancreatic Cancer That Has Been Completely Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00410774
- Testing
- bevacizumab, gemcitabine hydrochloride, adjuvant therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Bowel Disease
Study of NPO-13 During Colonoscopy
This study will investigate the safety, efficacy and dose-response of NPO-13 in subjects with moderate to severe colonic spasm during colonoscopy.
- Trial name
- NCT04097574
- Testing
- NPO-13: l-menthol
- Where
- 13 sites in Japan
- Volunteers
- 158 people
- Sponsor
- Nihon Pharmaceutical Co., Ltd
Appendicitis, Yersinia Enterocolitica Infection
Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies
Trial The aim of the study is to investigate which infectious diseases might mimic the symptoms of acute appendicitis to a degree to cause a diagnostic laparoscopy or laparoscopic appendectomy.
- Conditions
- Appendicitis, Yersinia Enterocolitica Infection, Yersinia Pseudotuberculosis Infections, Appendectomy
- Trial name
- NCT03349814
- Testing
- Diagnostic laparoscopy without appendectomy, Diagnostic laparoscopy with appendectomy
- Where
- Denmark
- Volunteers
- 225 people
- Sponsor
- Herlev Hospital
Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer
Patients With Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a chronic autoimmune disease characterized by progressive destruction of the small intrahepatic bile ducts, leading to cholestasis and potential progression to cirrhosis.
- Conditions
- Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer, Cancer Liver
- Trial name
- BILIFLEX (NCT07573514)
- Testing
- Reflex AMA and ANA testing
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatocellular Carcinoma (HCC), Radiotherapy, Adjuvant
Adjuvant Radiotherapy of Sintilimab Versus TACE for HCC
This study is an open-label, randomized controlled, multicenter, phase III clinical trial
- Conditions
- Hepatocellular Carcinoma (HCC), Radiotherapy, Adjuvant, Immune Checkpoint Inhibitor, TACE
- Trial name
- NCT07186621
- Testing
- Sintilimab, radiotherapy, TACE
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colonic Neoplasms, Crohn Disease
Comparison of Intracorporeal and Extracorporeal Anastomoses for Minimally Invasive Right Colectomy
The primary objective of this study is to retrospectively compare the perioperative and short-term (discharge through 30 days) outcomes of intracorporeal and extracorporeal anastomosis in minimally invasive right colectomies for…
- Trial name
- NCT03019016
- Testing
- Right Colectomy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Intuitive Surgical
Appendicitis
The Hospital Volume Relationship in Appendicectomy Outcomes
Background Appendicitis is a common condition which represents a significant resource burden for the Scottish National Health Service (NHS).
- Trial name
- NCT02018016
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Chronic Cough, Extraesophageal Reflux
Individualized Diagnosis and Treatment of Extraesophageal Reflux in Patients With Chronic Cough
Chronic cough is a very unpleasant symptom, significantly reduces the patient's quality of life, and bothers the neighborhood. A very common cause or co-factor of chronic cough is extraesophageal reflux (EER).
- Conditions
- Chronic Cough, Extraesophageal Reflux, Laryngopharyngeal Reflux, Allergy
- Trial name
- NCT04984304
- Testing
- Lifestyle modifications and Antireflux diet, Extraesophageal reflux diagnostic
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Ostrava
Biotherapy, Chronic Inflammatory Disease
Skin Adverse Reactions Occuring in Children Treated by Biotherapy for Chronic Inflammatory Disease
Biological treatments (BT) are commonly prescribed to treat chronic inflammatory diseases in children. Paradoxical reactions during treatment with a biological agent can be defined as the appearance or exacerbation of a…
- Conditions
- Biotherapy, Chronic Inflammatory Disease, Allergic Skin Reaction, Pediatric Disorder
- Trial name
- MDEBMIC (NCT04327752)
- Testing
- dermatological consultation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Colorectal Cancer
Lymphatic Mapping for Sentinel Node Identification and Analysis
The main objective of this study is to determine whether the first (sentinel) lymph nodes in the drainage pathway of colonic tumour can be detected at the time of surgery using a new technique.
- Trial name
- NCT01662752
- Testing
- Indocyanine green
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Intraoperative Bleeding, Hemorrhage, Surgical
GATT-Patch Versus TachoSil in Liver Surgery
This is a pre-market, prospective, randomized (2:1), multicenter, multi-national pivotal clinical investigation. The purpose of this investigation is to determine the clinical safety and performance of GATT-Patch as compared with…
- Conditions
- Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases
- Trial name
- NCT05385952
- Testing
- GATT-Patch (currently named ETHIZIA), TachoSil
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 132 people
- Sponsor
- GATT Technologies BV
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