Clinical trials: Digestive Neoplasms
Helicobacter Pylori Infection, Gastric Ulcer
A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA
Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer.
- Conditions
- Helicobacter Pylori Infection, Gastric Ulcer, Duodenal Ulcer, Stomach Cancer
- Trial name
- NCT03057171
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Colorectal Cancer
Study of In-home Tests for Colorectal Cancer
The objective of this study is to compare the performance characteristics or accuracy of different in-home screening tests for colorectal cancer (fecal occult blood tests), among patients without symptoms of colorectal cancer.
- Trial name
- SIT (NCT01998009)
- Testing
- fecal occult blood tests
- Where
- 2 sites in United States
- Volunteers
- 1,382 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Colorectal Cancer, Colorectal Adenomas
Double-balloon Colonoscopy to Increase Colonoscopy Completion Rate
The aim of colonoscopy is to visualize the inside of the entire large bowel. Several factors can make the procedure difficult, and sometimes a complete examination is not possible.
- Conditions
- Colorectal Cancer, Colorectal Adenomas, Inflammatory Bowel Disease
- Trial name
- NCT01587872
- Testing
- Fujinon EC-450BI5 double-balloon colonoscope
- Where
- Norway
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Preference, Patient, Pharmacist-Patient Relations
Preferences of Patients Treated With Oral Cancer Drugs and Informal Caregivers for Pharmaceutical Consultation in Hospital
To ensure the safe use of oral anticancer drugs, oncology pharmacy consultations (OPCs) have been established in France. Their goal is to provide the patient with the means to identify, prevent and limit adverse effects and to…
- Conditions
- Preference, Patient, Pharmacist-Patient Relations, Caregiver, Cancer
- Trial name
- IMPLICATION (NCT05970471)
- Where
- France
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Colorectal Adenoma, Colorectal Polyp
Endocuff Vision Colonoscopy vs. AmplifEYE Colonoscopy
The study aims to compare the results between colonoscopies with two different attachments on the distal end of the colonoscope.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colorectal Cancer
- Trial name
- NCT03560128
- Testing
- Endocuff Vision device, AmplifEYE device
- Where
- United States
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pancreas Cancer
A Decision Support Tool for Pancreatic Cancer Screening -Aim 2
Pancreatic cancer has a rising incidence and poor survival. Early detection in high-risk individuals may substantially improve outcomes.
- Trial name
- NCT07808671
- Testing
- Electronic Decision Support Tool
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer, Adenomatous Polyps
Liquid Biopsy Based Multiomics Study for Colorectal Cancer Early Screening
The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed liquid biopsy based multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo) for detecting advanced neoplasia…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- COLO-LIMULOID (NCT06258434)
- Testing
- multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo)
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Stomach Neoplasms, Stomach Cancer
Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer
Background: Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers.
- Conditions
- Stomach Neoplasms, Stomach Cancer, Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), Hereditary Diffuse Gastric Cancer (HDGC)
- Trial name
- NCT03030404
- Where
- United States
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Colorectal Cancer Screening French Organizations for the Follow-up After Colonoscopy
France is one of the European countries where the incidence of colorectal cancer is the highest among cancers for both sexes. Fecal occult blood screening has been implemented since 2008.
- Trial name
- Tempo-colo (NCT03383367)
- Testing
- Tempo Colo
- Where
- France
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Association pour le Dépistage Organisé des Cancers dans le Rhône
Colonic Neoplasms
Yoga and Bolus Lukewarm Saline as Rapid Colonoscopy Preparation
A quality colonoscopy examination remains as the gold standard for colorectal cancer screening, but effective large bowel cleansing prior to colonoscopy is still not achieved in all cases that undergo the procedure.
- Trial name
- NCT01547130
- Testing
- Normal (0.9%) saline, HalfLytely
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Arya, Vijaypal, M.D., P.C.
Quality of Life
Impact of Different Carbohydrate Feedings on a Hydrogen Breath Curve and Self-reported Gastrointestinal Complaints
GI distress is widely prevalent among athletes, ranging from 30 to 90% in recreationally and professionally active athletes. As the recipient of nutrients, the gastrointestinal (GI) tract plays an important role in athleticism.
- Trial name
- NCT06648967
- Testing
- Supplementation with a multi-ingredient whey supplement
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Liver Neoplasms, Hepatitis B
Lay Health Worker Model to Reduce Liver Cancer Disparities in Asian Americans
The study was conducted between April 2013 and October 2014. In the parent study, 600 foreign-born Asian American adults 18 years of age and older were drawn from the community in the Baltimore Washington Metropolitan Area.
- Trial name
- LHWAA (NCT02760537)
- Testing
- Lay Health Worker Intervention
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Colon Cancer
TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.
Primary Objective To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable cancers Secondary Objectives To…
- Trial name
- NCT02980029
- Testing
- TVB-2640
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Mark Evers
Colorectal Cancer, Advanced Adenocarcinoma
A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation
To evaluate the performance characteristics of Signal-C™ a plasma circulating free-DNA test, to detect colorectal cancer and advanced precancerous lesions (APL) in an average risk screening population for 45 and over.
- Trial name
- NCT06059963
- Testing
- Signal-C™
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Universal Diagnostics
Esophageal Neoplasms
Pronase Improves Efficacy of Chromoendoscopy Screening on Esophageal Cancer
Lugol's solution staining was regarded as a gold standard to detect early superficial lesion during esophageal cancer screening using endoscopy.
- Trial name
- NCT02030769
- Testing
- Pronase, Control
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Lung Cancer, Breast Cancer
Large Language Models Assist in Tumor MDT
Multidisciplinary teams (MDTs) represent the gold standard for personalized tumor treatment, but they are limited by medical resources and accessibility Limitation.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Stomach Cancer
- Trial name
- NCT07504367
- Testing
- LLM assists in MDT report writing
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Gastrointestinal Neoplasms
Intervention to Motivate Standing &Walking in Gastrointestinal Cancer Surgical Patients
Observational research has linked physical activity with faster recovery, improved quality of life, and greater survival; however, little is known about the effects of physical activity in pre-operative, peri-operative, or…
- Trial name
- NCT01982994
- Testing
- Education/Daily Planning
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Colon Cancer
A Prospective Study of a New Immunochemical Fecal Occult Blood Test in U.S. Veteran Patients Undergoing Colonoscopy
The purpose of our study is to evaluate the diagnostic validity of a new immunofecal occult blood test (IFOBT) (Teco Diagnostics) in U.S. veterans and to compare it with the guaiac based FOBT.
- Trial name
- NCT00533975
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Metastatic Cancer, Foregut Carcinoid Tumor
Study Comparing Standard of Care Chemotherapy With/ Without Sequential Cytoreductive Surgery for Patients With Metastatic Foregut Cancer and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid Levels
This study is designed for participants who have cancer of the upper gastrointestinal (GI) tract such as cancer of the esophagus, stomach, duodenum (the initial portion of your small intestine), pancreas, bile duct…
- Conditions
- Metastatic Cancer, Foregut Carcinoid Tumor, Gastric Adenocarcinoma, Gallbladder Adenocarcinoma
- Trial name
- NCT04931420
- Testing
- Standard of Care Chemotherapy, Video-Assisted Thoracic Surgery (VATS), Lobectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Metastatic Pancreatic Cancer
Nab-paclitaxel and Gemcitabine in Metastatic Pancreatic Cancer
This is a single arm, open-label Phase II clinical trial to Evaluate the Efficacy and Safety of the Combination of Nab-paclitaxel and Gemcitabine in Treating Patients with metastatic pancreatic cancer.
- Trial name
- NCT03929094
- Testing
- Paclitaxel for Injection（Albumin Bound）, Gemcitabine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fudan University
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