Clinical trials: Digestive Neoplasms
Colonic Neoplasms
Right-sided Retroflexion With Standard Adult Versus Pediatric Colonoscopes
Screening colonoscopy has been shown to be less effective in preventing colorectal cancer in the proximal colon compared to the distal colon.
- Trial name
- NCT01675934
- Testing
- Retroflexion with the adult colonoscope., Retroflexion with the pediatric colonoscope.
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Colorectal Cancer
Radiation Therapy on Pelvic Floor Disorders in Women
Investigators propose a retrospective cohort study to examine the impact of radiation therapy on the global pelvic floor function of women who have completed the immediate surveillance period for colorectal cancer
- Trial name
- RadPFD (NCT04623515)
- Testing
- REDCap Questionnaires
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Digestive Cancer, Gynecological Cancer
Analysis of Chronic Neuropathic Pain Markers in Patients Treated With Oxaliplatin
The role of oxidative stress in the development of oxaliplatin-induced peripheral neuropathy has been previously described in mice and in neuronal cell cultures (Massicot 2013); clinical manifestations and pathophysiological…
- Trial name
- LIPIDOXA (NCT02169908)
- Testing
- Thermotest, von Frey hairs
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fondation Hôpital Saint-Joseph
Biliary Tract Cancer
Trial of Infusional FOLFIRINOX in First Line Treatment of Advanced Biliary Tract Cancers
This study is to evaluate the response rate and toxicity profile of infusional 5 fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFIRINOX) in first-line treatment of advanced biliary tract cancers and also to assess…
- Trial name
- FBI-TRAC (NCT03291899)
- Testing
- FOLFIRINOX
- Where
- Saudi Arabia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Locally Advanced Rectal Adenocarcinoma, Metastatic Rectal Adenocarcinoma
Circulating Tumor Cells in Patients With Locally Advanced Rectal Cancer
This study looks at the level of circulating tumor elements (cancer cells or DNA pieces floating in the blood) and how it may be related to how the tumor responds to standard treatment in patients with rectal cancer that has…
- Conditions
- Locally Advanced Rectal Adenocarcinoma, Metastatic Rectal Adenocarcinoma, Rectosigmoid Adenocarcinoma, Recurrent Rectal Adenocarcinoma
- Trial name
- NCT02874885
- Testing
- Biospecimen Collection
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Biliary Tract Carcinoma
A Phase 2 Trial of Regorafenib as A Single Agent in Advanced and Metastatic Biliary Tract Carcinoma/Cholangiocarcinoma Patients Who Have Failed First-line Chemotherapy
Based on the facts of multiple pathways involvement in cholangiocarcinoma tumor genesis, including EGFR, Ras, Raf, VEGFR, and PDGFR, with evidence of overexpression of these proteins associated with tumor stage, prognosis and…
- Trial name
- NCT02053376
- Testing
- Regorafenib
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Nathan Bahary, MD
Colorectal Cancer
Adaptive Intervention to Maximize Colorectal Screening in Safety Net Populations
The goal of this study is to find the best ways to increase colorectal cancer (CRC) screening.
- Trial name
- AIMSS (NCT03100461)
- Testing
- I2, Health Education
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Breast Cancer, Colorectal Cancer
Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
To identify Black individuals who are eligible for genetic testing through trusted community organizations, and to connect Black individuals and their families to genetic testing and counseling so that they can know their cancer…
- Trial name
- NCT05694559
- Testing
- Genetic Testing and Counseling, Screening Form
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Celiac Disease, Coeliac Disease
MAgnetic Resonance Imaging in COeliac Disease
One in 100 people suffers from coeliac disease. It affects the lining of the bowel and causes many symptoms such as diarrhoea, wind, stomach pain, constipation and nausea.
- Conditions
- Celiac Disease, Coeliac Disease, Celiac Sprue, Gluten Enteropathy
- Trial name
- MARCO (NCT02551289)
- Testing
- Gluten free diet
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Pancreatic Diseases, Pancreatic Neoplasms
POstopeRative Standardization of Care: THe Implementation of Best Practice After Pancreatic Resection
This Nationwide stepped-wedge cluster randomized trial is designed to evaluate if the implementation of a best practice algorithm for postoperative care results in a decrease in incidence of major complications and death after…
- Conditions
- Pancreatic Diseases, Pancreatic Neoplasms, Pancreatic Cancer, Pancreatitis
- Trial name
- PORSCH (NCT03400280)
- Testing
- Best practice algorithm for postoperative care
- Where
- 17 sites in Netherlands
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Rectal Neoplasms
Short-course Radiotherapy or Long-course Chemoradiation Followed by mFOLFOXIRI Consolidation Chemotherapy for Organ Preservation in Low Rectal Cancer
Given the growing focus on preserving organ function and the utilization of neoadjuvant therapy, it is important to investigate and enhance the application of comprehensive neoadjuvant therapy in low rectal cancer.
- Trial name
- NCT06417476
- Testing
- Short-course radiotherapy, Irinotecan, Oxaliplatin
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Pei-Rong Ding
Lung Neoplasms, Neoplasm Metastasis
Mediastinal Lymph Node Dissection in Conjunction With Pulmonary Metastasectomy From Colorectal Cancer
To study whether or not total mediastinal lymph node dissection in conjunction with pulmonary metastasectomy from colorectal cancer is associated with improved survival compared to pulmonary metastasectomy only.
- Conditions
- Lung Neoplasms, Neoplasm Metastasis, Colorectal Cancer
- Trial name
- NCT03113318
- Testing
- Total mediastinal lymph node dissection and pulmonary metastasectomy, Only pulmonary metastasectomy
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
The purpose of this research is to see if adding blood-based tests and symptom review to standard-of-care pancreatic cancer screening procedures can identify cancer early among individuals with increased risk.
- Conditions
- Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06122896
- Testing
- Screening Blood Tests, Endoscopic Ultrasound, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Endometrial Adenocarcinoma, Endometrial Carcinoma
Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care
This clinical trial studies universal screening for deoxyribonucleic acid (DNA) mismatch repair deficiency in patients with endometrial cancer, mutations in the genes responsible for Lynch syndrome (inherited forms of endometrial…
- Conditions
- Endometrial Adenocarcinoma, Endometrial Carcinoma, Lynch Syndrome, Relatives
- Trial name
- OPTEC (NCT03460483)
- Testing
- Genetic Counseling, Genetic Testing, Laboratory Biomarker Analysis
- Where
- 9 sites in United States
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colorectal Cancer
Point of Care Test to Diagnosed Colorectal Cancer and Polyps in Low Middle Income Countries
This is a-two phase study. Phase 1 will adapt a 3-metabolite biosensor that identifies patients with colorectal cancer (CRC) and precancerous polyps to Nigerian patients.
- Trial name
- NCT03173729
- Testing
- Biosensor Point of Care Device
- Where
- 5 sites in Nigeria
- Volunteers
- 926 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Cancer, Gastrointestinal Cancer
Long-term Cancer Risk in the Randomised Oslo Diet and Antismoking Study
This study examines the effect of a five-year multifactorial lifestyle intervention in the Oslo diet and antismoking study on long-term cancer risk.
- Conditions
- Cancer, Gastrointestinal Cancer, Lung Cancer, Urinary Tract Cancer
- Trial name
- NCT03410641
- Testing
- Diet and antismoking advice
- Volunteers
- 1,216 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Gastro Esophageal Reflux Disease, Barrett Esophagus
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer.
- Trial name
- NCT06693622
- Testing
- Patient survey
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Colorectal Cancer
A Prospective Cohort Study on Colorectal Cancer Screening in Community Population
This study will validate the real world results of polygene methylation detection in colorectal cancer in a large prospective community cohort.
- Trial name
- NCT05485077
- Where
- China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Colorectal Cancer
Development and Validation of Metabolic Biomarkers for Early Diagnosis, Prognosis, and Recurrence of Colorectal Cancer：MetBio-CRC
This prospective clinical observational study aims to construct a metabolite database specifically for colorectal cancer patients using metabolomics technology.
- Trial name
- NCT07068529
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Cancer of Rectum, Lymph Node Disease
Fluorescence Targeted Pelvic Lymph Node Mapping
This study aims to assess the lymphatic drainage of rectal tumours by using ICG as a fluorescent non-specific marker. As a feasibility study, it will also assess its technique and timing along with its ability to assist in…
- Trial name
- NCT03204994
- Testing
- Indocyanine Green
- Where
- United Kingdom
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
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