Clinical trials: Digestive System
Colorectal Neoplasms, Confocal Laser Endomicroscopy
Clinical Validation of Multimodal Digestive Endoscopy
According to the latest global cancer epidemiological data published by the International Agency for Research on Cancer, colorectal cancer (CRC) ranks 3rd in total incidence and 2nd in total mortality among all malignancies…
- Conditions
- Colorectal Neoplasms, Confocal Laser Endomicroscopy, Endoscopy, Digestive System, Molecular Imaging
- Trial name
- NCT05575765
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Cystic Fibrosis, Contraception
MyVoice:CF Decision Aid for Women With Cystic Fibrosis
This project is a single-center feasibility study of MyVoice:CF, a patient-facing, web-based decision aid. Aim 1) Assess the acceptability, feasibility, and usability of MyVoice:CF for women with CF and multidisciplinary adult CF…
- Conditions
- Cystic Fibrosis, Contraception, Physician-Patient Relations, Pregnancy Complications
- Trial name
- NCT04825236
- Testing
- MyVoice:CF
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Pittsburgh
Advanced or Metastatic Hepatocellular Carcinoma
Residual Plasma Concentration of Sorafenib and Adverse Events in CHC
To date, Sorafenib is the only drug therapy to have demonstrated a benefit in overall survival in patients with advanced or metastatic hepatocellular carcinoma.
- Trial name
- PharmacoCHC (NCT03340636)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Colitis, Ulcerative, Cholangitis, Sclerosing
Compare Conventional Colonosocpy to Endoscopic AFI, NBI for Dysplasia Detection for Ulcerative Colitis & Cholangitis
This study is being done to: To attempt to increase the detection of precancerous colon tissue in patients with chronic ulcerative colitis and primary sclerosing cholangitis; To determine if an investigational scope that can look…
- Trial name
- NCT00587236
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Mayo Clinic
Hepatitis C, Hepatitis C Relapse
Direct Acting Agents in Hepatitis C Patients
This study is a retrospective study conducted at 36 sites. Planned target patient number is 1000.
- Conditions
- Hepatitis C, Hepatitis C Relapse, Hepatitis C Recurrent
- Trial name
- HEPCTURKEY (NCT03145844)
- Where
- Turkey (Türkiye)
- Volunteers
- 2,700 people
- Sponsor
- Fehmi Tabak
Metastatic Gastric Cancer, Locally Advanced Gastric Adenocarcinoma
Conversion Effects of PD-1 Antibody Camrelizumab Combined With Nab-POF Regimen Chemotherpy in Patients With Initially Unresectable Locally Advanced or Limited Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma：FDZL-GC001 Trial
This study is to evaluate the efficacy and safety of domestic programmed death 1（ PD-1） antibody (Camrelizumab for injection) combined with fluorouracil plus leucovorin, oxaliplatin, and albumin bound paclitaxel (Nab-POF) regimen…
- Conditions
- Metastatic Gastric Cancer, Locally Advanced Gastric Adenocarcinoma, Gastric Cancer Adenocarcinoma Metastatic
- Trial name
- NCT04510064
- Testing
- Camrelizumab plus mFLOT regimen, R0 surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fudan University
Benign Biliary Stricture, Biliary Stricture
Kaffes Stent in the Management of Post-surgical Biliary Strictures
Post-surgical biliary strictures are common especially after cholecystectomy. Standard treatment involves the performance of multiple procedures over a 1 year period at least using several plastic stents to achieve permanent…
- Conditions
- Benign Biliary Stricture, Biliary Stricture, Cholangitis, Bile Duct Stricture
- Trial name
- NCT03716232
- Testing
- Metallic stent, Multiple plastic stents
- Where
- 3 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Liver Mass, Liver Fibroses
Pre-procedure Planning for Liver Biopsy or Radiofrequency Ablation Using CT or MR/US Fusing Imaging
The purpose of this study is to determine whether fusion technique of preradiofrequency ablation (RFA) or percutaneous liver biopsy cross-sectional imaging (CT or MR) and real-time ultrasonography would improve feasibility of RFA…
- Trial name
- NCT02967198
- Testing
- CT/US fusion, ultrasound shear wave elastography
- Where
- South Korea
- Volunteers
- 185 people
- Sponsor
- Seoul National University Hospital
Liver Cancer, Ablation Techniques
The Safety and Efficacy of Irreversible Electroporation for the Treatment of Perivascular Liver Cancers
Malignant liver tumors are among the most common cancers worldwide, with over 10,000 new cases reported annually in Taiwan. Despite the availability of various treatment options, the prognosis for primary hepatocellular carcinoma…
- Conditions
- Liver Cancer, Ablation Techniques, Radiology
- Trial name
- NCT07214363
- Testing
- Irreversible Electroporation Ablation Generator
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer, Colon Cancer
The PAI Trial for Breast and Colon Cancer Survivors
The purpose of the study is to determine if a Physical Activity Index (PAI) tool that collects measures on physical activity, strength training and sedentary behavior can be used in a clinical setting to monitor patient behavior…
- Trial name
- NCT05156463
- Testing
- PAI Tool and Exercise Coaching
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Laparoscopic Gynecological Surgery
Effects of Standard and Modified Z-Trendelenburg Positions on Cerebral Oxygenation and Optic Nerve Sheath Diameter
The purpose of this study is to compare the effects of the standard Trendelenburg position and the modified Z-Trendelenburg position on cerebral oxygenation and optic nerve sheath diameter (ONSD) in patients undergoing…
- Trial name
- MOD-TREND (NCT07632287)
- Testing
- Standard Trendelenburg Position, Modified Z-Trendelenburg Position
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Biliary Stricture, Chronic Pancreatitis
Endoscopic Treatment of Biliary Stricture Caused by Chronic Pancreatitis
Benign biliary strictures can be endoscopically treated with plastic or self-expandable metal stents (SEMS). The purpose of the prospective randomized study is to compare the safety and feasibility of covered SEMS with multiple…
- Trial name
- NCT01085747
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Helsinki University Central Hospital
Colorectal Cancer Metastatic, Colorectal Cancer Recurrent
Safety and Efficacy Study of Famitinib in Patients With Advanced Colorectal Adenocarcinoma（FACT）
Famitinib is a tyrosin-inhibitor agent targeting at c-Kit, VEGFR2, PDGFR, VEGFR3, Flt1 and Flt3, whose anti-tumor and anti-angiogenesis effects have been validated in preclinical tests.
- Trial name
- FACT (NCT02390947)
- Testing
- Famitinib
- Where
- 44 sites in China
- Volunteers
- 543 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Cystic Fibrosis
Aztreonam Lysine for Pseudomonas Infection Eradication Study
This is an open-label, multi-center study in pediatric patients age 3 months to less than 18 years with cystic fibrosis (CF) and newly detected Pseudomonas aeruginosa (PA) pulmonary colonization/infection.
- Trial name
- ALPINE (NCT01375049)
- Testing
- Aztreonam for Inhalation Solution (AZLI)
- Where
- 58 sites in United States, Austria and 7 more
- Volunteers
- 105 people
- Sponsor
- Gilead Sciences
Esophageal Cancer, Gastric Cancer
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00005638
- Testing
- cisplatin, irinotecan hydrochloride, radiation therapy
- Where
- 2 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Locally Advanced Alveolar Soft Part Sarcoma, Metastatic Alveolar Soft Part Sarcoma
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Background: A type of drug called monoclonal antibody immune checkpoint inhibitors are often used in cancer treatment. These drugs help the body s immune system fight cancer by blocking proteins that cause cancer cells to grow.
- Conditions
- Locally Advanced Alveolar Soft Part Sarcoma, Metastatic Alveolar Soft Part Sarcoma, Locally Advanced Non Small Cell Lung Cancer, Metastatic Non Small Cell Lung Cancer
- Trial name
- NCT06066138
- Testing
- Atezolizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
HepatoCellular Carcinoma, Cirrhosis
Mutational Landscape in Hepatocellular Carcinoma
The MUTHEC project aims to describe the mutational and transcriptomic landscape of HCC treated by curative treatments (resection, radio frequency ablation, transplantation) as well as advanced HCC together with the analysis of…
- Trial name
- MUTHEC (NCT03071458)
- Where
- France
- Volunteers
- 808 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Colorectal Cancer
Effects of Reiki Applied to Patients Undergoing Colorectal Cancer Surgery on Postoperative Pain, Anxiety, Physiological Parameters and Recovery
Reiki touch therapy has been used for many years, especially on pain, anxiety and physiological parameters, and studies have been found to show that it is effective.
- Trial name
- NCT07175558
- Testing
- Reiki
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul University - Cerrahpasa
Sarcopenia, Gastrointestinal Neoplasms
Preoperative Sarcopenia and Postoperative Outcomes in Older Patients With Gastrointestinal Cancer
This prospective cohort study aims to evaluate the association between preoperative sarcopenia and postoperative outcomes in patients aged 60 years or older undergoing elective surgery for gastrointestinal cancer.
- Trial name
- NCT07817758
- Testing
- Preoperative Sarcopenia Status
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Van Training and Research Hospital
Inflammatory Bowel Disease, Ulcerative Colitis
The Home Telemanagement (UC HAT) Trial for Patients With Ulcerative Colitis
The purpose of this study is to determine if home automated telemanagement improves bowel symptoms, quality of life, compliance with medications, and health care utilization compared to best available care in patients with…
- Trial name
- UCHAT (NCT00620126)
- Testing
- UC Home Automated Telemanagement, Best Available Care
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of Maryland, Baltimore
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