Clinical trials: Digestive System
Chronic Hepatitis c
Management of Patients With Hepatitis C in a Public Health Care Setting: The Punjab Model
Background and Aims: The prevalence of hepatitis C virus infection (HCV) infection in Punjab, India is 3.29%, with an estimated burden of around 650,000 viremic chronic HCV (CHC) patients.
- Trial name
- NCT03488485
- Testing
- Direct Acting Antivirals
- Where
- India
- Volunteers
- 50,000 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Diaphragmatic Plication, Diaphragmatic Paralysis
Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis
Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity. Diaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed…
- Conditions
- Diaphragmatic Plication, Diaphragmatic Paralysis, Diaphragmatic Eventration
- Trial name
- RAPIDLY (NCT06919185)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala County Council, Sweden
Rectovaginal Fistula, Anovaginal Fistula
Feasibility and Safety of Additional Injection of Autologous Platelet-rich Stroma to Surgical Treatment of Rectovaginal Fistulas
Is the addition of platelet-rich stroma (PRS) injection, a form of autologous call therapy, to surgical treatment for rectovaginal fistula feasible and safe? The primary endpoints of this study are feasibility and safety until 12…
- Trial name
- PRS-RVF (NCT06798935)
- Testing
- autologous platelet-rich stroma
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Erasmus Medical Center
Deglutition Disorders, Multiple Sclerosis
Neuromuscular Electrostimulation in Multiple Sclerosis People With Dysphagia
Dysphagia is a disabling, life-threatening symptom that can cause death in Multiple Sclerosis people (pwMS) through aspiration pneumonia.
- Trial name
- NCT05063708
- Testing
- Experimental: traditional dysphagia therapy plus Neuromuscular electrostimulation
- Where
- Italy
- Volunteers
- 136 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Ulcerative Colitis, Inflammatory Bowel Diseases
Comparison of Ustekinumab, Infliximab and Combination Therapy in Moderately to Severely Active Ulcerative Colitis
The goal of this clinical trial is to learn if combined therapy with infliximab and ustekinumab works better than using these drugs alone in adult patients with ulcerative colitis.
- Trial name
- COMBO-UC (NCT06453317)
- Testing
- Infliximab, Ustekinumab
- Where
- Poland
- Volunteers
- 172 people
- Sponsor
- Medical University of Lodz
Adenocarcinoma of the Gastroesophageal Junction, HER2-positive Breast Cancer
Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With Locally Advanced or Metastatic HER2-Positive Breast , Gastric, or Gastroesophageal Cancer That Cannot Be Removed By Surgery
This phase I trial studies the side effects and best dose of Akt inhibitor MK2206 and lapatinib ditosylate when given together with trastuzumab in treating patients with locally advanced or metastatic human epidermal growth…
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, HER2-positive Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer
- Trial name
- NCT01705340
- Testing
- Akt inhibitor MK2206, trastuzumab, lapatinib ditosylate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Staphylococcus Aureus
Aurexis® in Cystic Fibrosis Subjects Chronically Colonized With Staphylococcus Aureus in Their Lungs
Patients who are at least 7 years old with stable Cystic Fibrosis who have Staphylococcus aureus in their Lungs will be enrolled into the study and receive one dose of Aurexis® intravenously on Study Day 1, and will be followed…
- Trial name
- NCT00198289
- Testing
- Aurexis® (tefibazumab)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Bristol-Myers Squibb
Sedation and Analgesia
Dexmedetomidine Versus Ketamine Versus Midazolam in Endoscopic Procedures
This study aims to assess the safety and efficacy of dexmedetomidine versus ketamine versus midazolam combined with propofol in cancer patients undergoing gastrointestinal endoscopic procedures.
- Trial name
- NCT04597268
- Testing
- Dexmedetomidine, Ketamine, Midazolam
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute, Egypt
Cystic Fibrosis, Bronchiectasis
Prevention of Bronchiectasis in Infants With Cystic Fibrosis
The general aim of this project is to conduct a randomized, double-blind, placebo-controlled clinical trial of azithromycin to determine whether treatment from infancy is safe and will prevent the onset of bronchiectasis.
- Trial name
- COMBATCF (NCT01270074)
- Testing
- Azithromycin
- Where
- 10 sites in Australia, New Zealand
- Volunteers
- 130 people
- Sponsor
- The University of Queensland
Gastric Cancer
Deep vs Moderate Neuromuscular Blocks on Remifentanil for Laparoscopic Gastrectomy
The primary purpose is to compare the remifentanil requirements in deep vs moderate neuromuscular blocks during the surgical pleth index -guided anesthesia in patients undergoing laparoscopic gastrectomy.
- Trial name
- NCT04205097
- Testing
- Neostigmine + glycopyrate, Sugammadex
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Ajou University School of Medicine
Crohn Disease
Evaluation of a New Oral Contrast Agent for MR Enterography in the Assessment of Crohn Disease in the Small Bowel
The purpose of this study is to assess the exam quality and accuracy of MR using a new oral contrast agent for the evaluation of Crohn Disease in the small bowel.
- Trial name
- NCT00587210
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Hepatic Encephalopathy
Lactulose, L-ornithine L-aspartate, or Rifaximin Versus Placebo for Preventing Hepatic Encephalopathy in Variceal Bleeding
The aim of this study is to determine whether lactulose, L-ornithine L-aspartate, and rifaximin are effective in the prevention of the development of hepatic encephalopathy in cirrhotic patients with acute variceal bleeding
- Trial name
- NCT02158182
- Testing
- Lactulose, L-ornithine L-aspartate, Rifaximin
- Where
- Mexico
- Volunteers
- 88 people
- Sponsor
- Hospital General de Mexico
Pancreatic Adenocarcinoma Non-resectable
PEGPH20 Plus Gemcitabine With Radiotherapy in Patients With Localized, Unresectable Pancreatic Cancer
This is a single arm phase II trial assessing the potential activity of combination PEGPH20 plus Gemcitabine with radiotherapy in ten patients with localized, unresectable pancreatic adenocarcinoma.
- Trial name
- HALO-IST (NCT02910882)
- Testing
- PEGylated Recombinant Human Hyaluronidase (PEGPH20), Gemcitabine, Radiation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Scripps Health
Pancreatitis, Chronic Pancreatitis
Internet-Delivered Pain Self-Management for Persons With Acute Recurrent and Chronic Pancreatitis Pain
Severe and disabling abdominal pain is common in individuals with chronic pancreatitis. Although pain is associated with reduced quality of life and high economic and societal costs, there are limited effective options for pain…
- Conditions
- Pancreatitis, Chronic Pancreatitis, Acute Recurrent Pancreatitis
- Trial name
- IMPACT-2 (NCT06386224)
- Testing
- Internet-delivered pain self-management (CBT Condition), Education Program
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Seattle Children's Hospital
Acute Pancreatitis
The Effect of Dietary Fat Content on the Recurrence of Pancreatitis
This trial aims to test the effects of two different diets on the recurrence of acute pancreatitis, and acute pancreatitis associated mortality.
- Trial name
- EFFORT (NCT04761523)
- Testing
- Dietary intervention: reduced fat diet, Dietary intervention: standard healthy diet
- Where
- Hungary
- Volunteers
- 384 people
- Sponsor
- University of Pecs
Pancreatic Fistula
Ultrasound Elastography for Prediction of Postoperative Pancreatic Fistula
The purpose of this study is to assess the value of preoperative objective modalities such as endoscopic ultrasound elastography and magnet resonance imaging in predicting development of postoperative pancreatic fistula in…
- Trial name
- PMPPOPF (NCT02589379)
- Testing
- Pancreatic Resection
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Growth Hormone, Recombinant, Fatty Liver
The Effect of Growth Hormone Replacement on Liver Fat
We will examine a cohort of growth hormone deficient adults starting growth hormone (GH) replacement. The purpose of this study is to determine whether GH replacement reduces the fat content of the liver.
- Trial name
- NCT00774579
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Non-Alcoholic Fatty Liver Disease
Effect of Dapagliflozin on Metabolic Parameters in Patients With Non-Alcoholic Fatty Liver Disease
This study was designed to assess the effect of dapagliflozin on body weight, blood sugar, liver enzymes, and blood fats in adults with non-alcoholic fatty liver disease (NAFLD), a condition involving excess fat accumulation in…
- Trial name
- NCT07881796
- Testing
- Dapagliflozin (10mg Tab)
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Shalamar Hospital
Pancreatic Neoplasms
Randomized, Controlled Trial of Endoscopic Ultrasound-Guided Bilateral Celiac Plexus Neurolysis vs Celiac Ganglia Neurolysis to Control Pain in Inoperable Pancreatic Cancer Patients With Inadequate Pain Control by Pain Killer
Pancreatic cancer related pain can be difficult to control, even with high doses of narcotics, whose adverse effects may further impair quality of life.
- Trial name
- NCT02220062
- Testing
- EUS-CPN, EUS-CGN
- Volunteers
- 166 people
- Sponsor
- Samsung Medical Center
Hepatocellular Carcinoma
Evaluation of Diagnostic Efficiency of PIVKA-II and Other Tumor Markers in HCC
The incidence of Hepatocellular carcinoma (HCC) is increasing worldwide. However, most of HCC cases were at advanced stage when the diagnosis established.Early diagnosis improves the prognosis.The study is intended to evaluate…
- Trial name
- NCT03047603
- Testing
- PIVKA-II
- Where
- China
- Volunteers
- 4,005 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
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