Clinical trials: Digestive System
Hepatocellular Carcinoma
to Evaluate the Efficacy and Safety of MG4101(Ex Vivo Expanded Allogeneic NK Cell)
To see the safety and efficacy of injecting MG4101 as a secondary treatment after curative liver resection on the patient with advanced HCC who has high risk of recurrence.
- Trial name
- MG4101 (NCT02008929)
- Testing
- MG4101
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Samsung Medical Center
Obesity, Morbid Obesity
Effectiveness and Tolerability of Phentermine in Patients Under Bariatric Surgery
Surgical management of Morbid Obesity is increasingly frequent. A low-calorie diet is recommended with the main goal of reducing intrahepatic fat infiltration, fat tissue and making easier the surgery.
- Conditions
- Obesity, Morbid Obesity, Bariatric Surgery, Non-alcoholic Fatty Liver
- Trial name
- NCT03849729
- Testing
- Phentermine
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- Hospital Juarez de Mexico
Tracheoesopharyngeal Fistula, Bronchoesophageal Fistula
Adipose Derived SVF for Aero-digestive & Enterocutaneous Fistulae
Determine safety and feasibility of using institutionally prepared autologous, uncultured SVF on patients with aerodigestive and enterocutaneous fistulae secondary to malignancy, trauma or surgery.
- Conditions
- Tracheoesopharyngeal Fistula, Bronchoesophageal Fistula, Tracheoesophageal Fistula
- Trial name
- NCT03792360
- Testing
- SVF (Stromal Vascular Fraction)
- Sponsor
- Mayo Clinic
Pancreatic Cancer
Early Increase in Blood Flow (EIBS) in the Duodenum in Patients With Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death in the United States and is associated with a poor prognosis. The average life expectancy after diagnosis is approximately 5 to 8 months.
- Trial name
- NCT01015820
- Testing
- EGD with EUS, 4D-ELF
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Mayo Clinic
Pancreatic Alpha Cell Carcinoma, Pancreatic Beta Islet Cell Carcinoma
Temozolomide and Pazopanib Hydrochloride in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors That Cannot Be Removed By Surgery
This phase I/II trial studies the side effects and best dose of temozolomide and pazopanib hydrochloride when given together and to see how well they work in treating patients with advanced pancreatic neuroendocrine tumors (PNET)…
- Conditions
- Pancreatic Alpha Cell Carcinoma, Pancreatic Beta Islet Cell Carcinoma, Pancreatic Delta Cell Carcinoma, Pancreatic G-cell Carcinoma
- Trial name
- NCT01465659
- Testing
- temozolomide, pazopanib hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Northwestern University
Hepatitis B, Hepatitis B, Chronic
Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity
In this project proposal, the investigators will investigate the genetic alterations of Hepatitis B Virus (HBV) strains circulating in Belgian patients who developed end stage liver disease.
- Conditions
- Hepatitis B, Hepatitis B, Chronic, End Stage Liver Disease, Carcinoma, Hepatocellular
- Trial name
- NCT02148562
- Where
- Belgium
- Volunteers
- 274 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Non-Alcoholic Steatohepatitis (NASH)
Evaluating the Efficacy and Safety of Roflumilast in Patients with NASH
Study type :clinical trial Main purpose :esnsure safety and efficacy of Roflumilast to treat patients with Non-Alcoholic Steatohepatitis Background and aim: Non-alcoholic fatty liver disease is the most prevalent chronic liver…
- Trial name
- NCT06677788
- Testing
- Roflumilast 500 Mcg Oral Tablet, Vitamin E capsule
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Tanta University
Metastatic Colorectal Cancer
Detection of the Emergence of RAS (Rat Sarcoma Viral Oncogene Homolog) Mutations in Circulating DNA (Deoxyribonucleic Acid) in Patients With mCRC (Metastatic Colorectal Cancer) During Treatment With Anti-EGFR (Epidermal Growth Factor Receptor) Therapy
The analysis of circulating DNA (Deoxyribonucleic acid) to identify potential resistance mechanisms during anti-EGFR (epidermal growth factor receptor) treatment is of great interest, as evidenced by the recent journal published…
- Trial name
- EmutRAS (NCT03908788)
- Testing
- Intplex test
- Where
- 2 sites in France
- Volunteers
- 130 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Mucosal Inflammation, Contraceptive; Complications, Intrauterine
Impact of Contraceptives on Cervico-Vaginal Mucosa
UMPALA is a research study to look at the effect of four different, approved contraceptives on the cervical and vaginal tissues as well as on factors in the blood.
- Trial name
- UMPALA (NCT04814927)
- Testing
- Copper IUD, Etonogestrel implant, Levonorgestrel IUS
- Where
- 2 sites in United States, Kenya
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Cancer, Hepatocellular, Radiotherapy Side Effect
A Pilot Study For Patients Receiving Radiation Therapy for Liver Cancer
The purpose of this study is to evaluate the role of quantitative MR imaging and blood-based biomarkers to measure liver function in patients receiving radiation therapy for liver cancer or cancer that has spread to the liver.
- Trial name
- HepQuant (NCT06144827)
- Testing
- Multiparametric MRI scans, Multiparametric MRI scans + HepQuantShunt Test
- Sponsor
- Montefiore Medical Center
Non-alcoholic Steatohepatitis
Investigate Safety, Tolerability, PK/PK of J2H 1702 in Healthy Males
1. Research Purpose: To evaluate the safety, tolerability, pharmacokinetic/pharmacodynamic properties of J2H-1702 (a candidate for treatment of non-alcoholic steatohepatitis) in healthy men. 2.
- Trial name
- NCT06308861
- Testing
- Single administration Amg dose Group, Single administration Bmg dose Group, Single administration Cmg dose Group
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- J2H Biotech
Hepatocellular Carcinoma
Study of Hepatocellular Carcinoma in Cirrhotic Patients
The project is based on a case-control study including cirrhotic patients with (200 cases) and without (400 controls) Hepatocellular carcinoma.
- Trial name
- CIRCE ProSpec (NCT01904942)
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hepatocellular Carcinoma
TIPS Plus Cadonilimab in Advanced HCC with Tumor Thrombosis-associated Portal Hypertension:a Prospective, Single-arm, Phase II Study
The purpose of this study is to evaluate the efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) plus Cadonilimab (a PD-1/CTLA-4 bispecific antibody) in advanced hepatocellular carcinoma (BCLC-C Stage)…
- Trial name
- NCT05882370
- Testing
- Cadonilimab, transjugular intrahepatic portosystemic shunt (TIPS)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fei Gao
Crohn Disease
Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease
An assessment of the efficacy of topical tacrolimus in the treatment of cutaneous crohns disease
- Trial name
- NCT01233570
- Testing
- Tacrolimus
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen
Hysterectomy, Pneumoperitoneum
Effect of Lower Pneumoperitoneum Pressure During Laparoscopic and Robotic Hysterectomy
With the limited evidence that lower pneumoperitoneum pressures improve postoperative pain in laparoscopic or robotic hysterectomy for benign indications, we would like to determine if we can both further validate this idea but…
- Trial name
- NCT04125173
- Testing
- Pneumoperitoneum pressure = 15mmHg, Pneumoperitoneum pressure = 12mm Hg, Pneumoperitoneum pressure = 10mmHg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Fissure in Ano
Percutaneous Tibial Nerve Stimulation (PTNS) for the Treatment of Chronic Anal Fissure
Chronic anal fissure rarely heals spontaneously. About 50% heal on administration om topical muscle relaxants (e.g. diltiazem) and/or injection of Botulinum toxin, but for the remainder of patients surgery (with lateral internal…
- Trial name
- NCT04604483
- Testing
- PTNS
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
A Phase 2 Study of Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Junction (GEJ) Cancer
The main purpose of this study was to evaluate the safety and pharmacokinetics of administering various dose regimens of ramucirumab in participants with advanced gastric cancer whose disease has progressed during or following…
- Trial name
- NCT02443883
- Testing
- Ramucirumab
- Where
- 45 sites in United States, Argentina and 10 more
- Volunteers
- 164 people
- Sponsor
- Eli Lilly and Company
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted, Hepatitis B, Chronic
Laboratory Profile of Hepatitis B and C in Users of a Reference Service
Chronic hepatitis by the B virus (HBV) and/or by the C virus (HCV) is a major public-health problem since it presents a long phase of clinical latency which makes its early diagnosis difficult and results in the development of a…
- Trial name
- NCT00512941
- Where
- 2 sites in Brazil
- Volunteers
- 531 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Liver Neoplasms, Primary Liver Cancer
Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)
The goal of this observational study is to collect information on the use of the HistoSonics Edison System for the treatment of liver tumors.
- Conditions
- Liver Neoplasms, Primary Liver Cancer, Secondary Liver Cancer, Tumor Liver
- Trial name
- NCT06486454
- Testing
- HistoSonics Edison System
- Where
- 33 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- HistoSonics, Inc.
Clinical Stage IV Gastric Cancer AJCC v8, Gastric Adenocarcinoma
Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis
This phase Ib trial test effects of aldesleukin in combination with nivolumab and standard chemotherapy in treating patients with gastric cancer that has spread to the tissue lining of the abdomen (peritoneal metastasis).
- Conditions
- Clinical Stage IV Gastric Cancer AJCC v8, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Metastatic Gastric Carcinoma
- Trial name
- NCT05802056
- Testing
- Aldesleukin, Biopsy Procedure, Biospecimen Collection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
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