Clinical trials: Digestive System Cancer
Digestive System Cancer
Association Between Body Composition and Digestive System Cancer Survival
Investigators intend to utilize clinical data from the Department of Oncology at Jiangsu Provincial People's Hospital to analyze changes in body composition in digestive system tumor patients before and after receiving anti-tumor…
- Trial name
- NCT06054685
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
To Predict Early Post-hepatectomy Mortality for HCC
Calculator Predicts Early Mortality Post Hepatocellular Carcinoma Resection
Using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma.
- Trial name
- NCT06621485
- Where
- China
- Volunteers
- 4,966 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Esophageal Carcinoma
Comparable Study of Different Radiation Dose in Esophageal Carcinoma
Radiation therapy plus concurrent chemotherapy is now the standard therapy for patients with localized carcinoma of the esophagus selected for nonsurgical treatment.
- Trial name
- NCT01937208
- Testing
- intensity modulated radiation therapy in both arms, concurrent chemotherapy with radiation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhejiang Cancer Hospital
Gastrointestinal Stromal Tumors, Small-cell Lung Cancer
A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
This open-label clinical trial will evaluate the safety and tolerability of NN3201 in subjects with advanced and/or metastatic solid tumors known to express c-Kit.
- Conditions
- Gastrointestinal Stromal Tumors, Small-cell Lung Cancer, Adenoid Cystic Carcinoma, Uveal Melanoma
- Trial name
- NCT06805825
- Testing
- NN3201
- Where
- 5 sites in United States
- Volunteers
- 67 people
- Sponsor
- Novelty Nobility, Inc.
Cholangiocarcinoma, Biliary Stenosis
Contribution of the EyeMAX™ 11Fr (Micro-Tech) Digital Single-Operator Cholangioscope With a Wide Working Channel
Background and aims Digital single-operator cholangioscopy (DSOC) enhances biliary stricture diagnosis, but the collection of quality samples can be difficult due to the small diameter of the working channel.
- Conditions
- Cholangiocarcinoma, Biliary Stenosis, Bile Duct Stones, Bile Duct Stenosis
- Trial name
- EyeMAX-CREGG (NCT06933576)
- Testing
- DSOC EyeMAX 11Fr
- Where
- 5 sites in France
- Volunteers
- 28 people
- Sponsor
- Clinique Paris-Bercy
Inflammatory Bowel Diseases, Colon Cancer
Pre-Habilitation Exercise Intervention
The purpose of this study is to see whether exercise can improve the health and well-being of patients scheduled to undergo surgery for a bowel related condition.
- Conditions
- Inflammatory Bowel Diseases, Colon Cancer, Rectal Cancer, Diverticular Disease
- Trial name
- NCT02849717
- Testing
- Exercise for Cancer Patients
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Rochester
Lymph Node Metastases, Colorectal Cancer
Ex Vivo Intraarterial Methylene Blue Injection Improve Nodal Staging Accuracy in Colorectal Cancer
Nodal staging holds both important prognostic and predictive value at colorectal cancer. Regional lymph nodes are located close to the primary tumor in the mesocolon / mesorectum.
- Trial name
- MB (NCT04842968)
- Testing
- Methylene blue injection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- St. Borbala Hospital
Gastric/Gastroesophageal Junction Adenocarcinoma, Metastatic Colorectal Cancer (CRC)
A Phase II Clinical Study Evaluating SSGJ-706 in Combination Therapy for Advanced Gastrointestinal Cancers
This study is a multicenter, open-label, phase II clinical trial evaluating the combination of SSGJ-706 with standard therapy for advanced gastrointestinal tumors.
- Conditions
- Gastric/Gastroesophageal Junction Adenocarcinoma, Metastatic Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Oesophageal Cancer
- Trial name
- NCT07233850
- Testing
- SSGJ-706+XELOX, SSGJ-706+Bevacizumab+XELOX, SSGJ-706+AG
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Endoscopic Mucosal Resection With Circumferential Incision
Endoscopic Mucosal Resection With Circumferential Incision for Colorectal Neoplasms
This is a prospective randomized trial to improve the results of treatment of patients with colorectal neoplasms.
- Trial name
- C-EMR (NCT05690490)
- Testing
- Endoscopic mucosal resection with circumferential incision, Endoscopic submucosal dissection
- Where
- Russia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Barrett Esophagus, Dysplasia
A Study Comparing the Effectiveness of EndoRotor Versus Radiofrequency in Treating Barrett's Esophagus
Barrett Esophagus is a common pathology, with an estimated prevalence of 1.6% at risk of progression to precancerous mucosa (low to high grade dysplasia). The incidence of adenocarcinoma on BE is 0.5% per year.
- Trial name
- ENDOBARRETT (NCT04867590)
- Testing
- Endorotor, Radiofrequency
- Where
- 17 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Angers
Colorectal Cancer
Liposomal Irinotecan Plus Bevacizumab in Irinotecan-refractory Metastatic Colorectal Cancer
To evaluate the efficacy and safety of liposomal irinotecan plus bevacizumab in irinotecan-refractory metastatic colorectal cancer
- Trial name
- NCT06434090
- Testing
- Liposomal irinotecan, Bevacizumab
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Sun Yat-sen University
Pancreatic Cancer, Adenocarcinoma
Slide Interpretation or Standard Surgical Pathology in Assessing Margin Status in Patients With Pancreatic Cancer Undergoing Surgery
This study is being done to investigate another way of evaluating margin status after pancreatectomy by using cytopathology (slide interpretation) as compared to the traditional method of surgical pathology
- Trial name
- NCT01646697
- Testing
- cytology specimen collection procedure
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colon Cancer
Neoadjuvant Chemotherapy for Obstructive Colon cancER First Treated by cOlostomy
The aim of this study is to determine whether chemotherapy prior to tumor removal (neoadjuvant chemotherapy), in patients undergoing treatment for colon cancer in occlusion (CCO), would improve the rate of patients able to…
- Trial name
- COnCERTO (NCT06107920)
- Testing
- Neoadjuvant chemotherapy
- Where
- 28 sites in France
- Volunteers
- 232 people
- Sponsor
- University Hospital, Rouen
Colon Cancer
Comparison of Limb Size of Transverse Coloplasty Pouch
The aim of the study is the comparison of pouch function with two different sizes of limb of transverse coloplasty pouch after rectal resection and total mesorectal excision.
- Trial name
- NCT01071824
- Testing
- Transverse coloplasty pouch (Long limb), Transverse coloplasty pouch (Short limb)
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Kantonsspital Liestal
Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
XELOX Combined With Fruquintinib and Sintilimab Regimen Conversion Therapy for Gastric Cancer/Gastroesophageal Junction Adenocarcinoma Only With Liver and/or Retroperitoneal Lymph Node Metastasis, a Prospective Single-arm, Multicenter Study
Gastric cancer is the third leading cause of morbidity and mortality among malignant tumors in China, and less than 30% of patients can be cured by surgery.
- Trial name
- NCT06091423
- Testing
- XELOX combined with Fruquintinib and Sintilimab
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Xiaofeng Chen
Cutaneous Melanoma, Pleural Mesothelioma
A Study of SGN-CD228A in Advanced Solid Tumors
This trial will study SGN-CD228A to find out whether it is an effective treatment for different kinds of cancer. It will also look at what side effects (unwanted effects) may occur. The study will have two parts.
- Conditions
- Cutaneous Melanoma, Pleural Mesothelioma, HER2 Negative Breast Neoplasms, Non-small Cell Lung Cancer
- Trial name
- NCT04042480
- Testing
- SGN-CD228A
- Where
- 14 sites in United States, France and 3 more
- Volunteers
- 88 people
- Sponsor
- Seagen Inc.
Esophagus Cancer
Neoadjuvant Comprehensive Treatment for Unresectable Esophageal Cancer
Patients diagnosed with locally advanced esophageal squamous cell carcinoma (ESCC) that is deemed unresectable face a bleak prognosis.
- Trial name
- NEXUS-2 (NCT06430658)
- Testing
- Tislelizumab (BGB-A317) with chemoradiotherapy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Adenocarcinoma
Neo-adjuvant Chemoradiotherapy Using Infusional Gemcitabine Followed by Surgery for Locally Advanced Rectal Cancer
Phase II Study of Neo-adjuvant Chemoradiotherapy using infusional Gemcitabine followed by Surgery for Locally Advanced (T3 and T4 or Node positive) Rectal Adenocarcinoma.
- Trial name
- NCT02919878
- Testing
- Gemcitabine, XRT, capecitabine
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Colorectal Cancer
An Observational Study of Continued Bevacizumab Plus Chemotherapy Until First Progression in Participants With Metastatic Colorectal Cancer (CRC)
This prospective, multicenter, observational study will investigate the effectiveness and safety of bevacizumab in routine clinical practice in participants with metastatic CRC.
- Trial name
- AVACONT (NCT02305615)
- Testing
- Bevacizumab, Chemotherapy
- Where
- 22 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Hoffmann-La Roche
Pancreas Cyst, Pancreas Mass
RNA Sequencing of Solid and Cystic Lesions of the Pancreas
The nature of cysts and solid masses in the pancreas can be difficult to diagnose. They may be benign, precancerous, or cancer. Current tests such as cytology (looking under a microscope) and tumor markers do not always give us…
- Trial name
- NCT01807325
- Testing
- pancreas biopsy
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Oregon Health and Science University
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