Clinical trials: Digestive System Cancer
Pancreatectomy, Distal Pancreatectomy (DP)
Laparoscopic Versus Robot-assisted Left-sided Pancreatectomy for Benign and Pre-malignant Lesions (DIPLOMA-3)
The DIPLOMA-3 trial is an international, multicenter, patient-blinded randomized controlled trial comparing laparoscopic and robot-assisted left-sided pancreatectomy.
- Conditions
- Pancreatectomy, Distal Pancreatectomy (DP), Pancreatic Neoplasms, Pancreatic Adenoma
- Trial name
- DIPLOMA-3 (NCT06939023)
- Testing
- Laparoscopic minimally invasive left-sided pancreatecomy, Robot-assisted minimally invasive left-sided pancreatecomy
- Where
- Netherlands
- Volunteers
- 256 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatic Neoplasms, Neoplasm Metastasis
Oxaliplatin Combined With Irinotecan Liposome Injection II Through Hepatic Artery Infusion (HAIC) Followed by 5-FU/LV (HAIC) or Tegorgor Oral Combination Therapy for Hepatic Metastasis of Pancreatic Cancer
The study explores the efficacy and safety of oxaliplatin combined with irinotecan liposome injection II via hepatic arterial infusion (HAIC) followed by sequential treatment with 5-FU/LV (HAIC) or oral administration of S-1 in…
- Conditions
- Pancreatic Neoplasms, Neoplasm Metastasis, Hepatic Metastasis of Pancreatic Cancer
- Trial name
- NCT06538623
- Testing
- Liposome Irinotecan Injection II combined with Oxaliplatin, Fluorouracil, Leucovorin, Tegodor
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Anal Cancer
Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some find tumor cells and kill them or carry tumor-killing substances to them.
- Trial name
- NCT00316888
- Testing
- cetuximab, cisplatin, fluorouracil
- Where
- 125 sites in United States
- Volunteers
- 63 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Colorectal Neoplasms, Colorectal Adenoma
A Novel Oral Synbiotic Formula in Reducing Advanced Adenoma Recurrence and Colorectal Neoplasia-related Bacterial Gene Markers
This multicenter, double blinded randomized controlled trial aims to assess the efficacy of a novel oral synbiotic formula (SMT04) in reducing advanced adenoma recurrence and colorectal neoplasia-related bacterial gene markers…
- Conditions
- Colorectal Neoplasms, Colorectal Adenoma, Colorectal Cancer, Advanced Adenoma
- Trial name
- NCT05592886
- Testing
- SMT04 formula
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 649 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer, Inflammatory Bowel Diseases
The Deep South Surgical Equity Research Network: Addressing Socioecological Determinants of Health
Rationale: Older African Americans undergoing surgery are a vulnerable and growing population at high risk for poor surgical outcomes and disparities.
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Diverticular Diseases, Social Behavior
- Trial name
- NCT05345054
- Testing
- no intervention
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Liver Steatoses, Liver Metastasis Colon Cancer
Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis
Non-alcoholic fatty liver disease is becoming increasingly common in Canada and throughout the world. Fatty liver can increase the risks of perioperative complications for those who need liver surgery.
- Conditions
- Liver Steatoses, Liver Metastasis Colon Cancer, NAFLD
- Trial name
- NCT05884723
- Testing
- Ketogenic Diet
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Anton Skaro
Hepatocellular Carcinoma
Axitinib as Second-line Treatment for Advanced Hepatocellular Carcinoma
This is a phase II study of axitinib as the second-line on the treatment of advanced hepatocellular carcinoma (HCC). The purpose of this study is a proof-of-concept study to see if axitinib has any anti-tumor effect in HCC.
- Trial name
- NCT01273662
- Testing
- AG-013736
- Where
- 3 sites in Taiwan
- Volunteers
- 45 people
- Sponsor
- National Taiwan University Hospital
Gastric Cancer, Colon Cancer
Clinical Study of CEA-targeted CAR-T Therapy for CEA-positive Advanced/Metastatic Malignant Solid Tumors
This is a phase I clinical study to evaluate the safety and tolerability of CAR-T in patients with CEA-positive advanced/metastatic solid tumors, and to obtain the maximum tolerated dose of CAR-T and phase II Recommended dose.
- Conditions
- Gastric Cancer, Colon Cancer, Pancreas Cancer, Esophagus Cancer
- Trial name
- NCT06010862
- Testing
- CEA CAR-T cells
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Postoperative Ileus, Colon Cancer
Trial of Acupuncture for Reduction of Post-Colectomy Ileus
The purpose of this study is to see whether acupuncture may help patients recover from colon cancer surgery.
- Conditions
- Postoperative Ileus, Colon Cancer, Pain, Postoperative, Postoperative Nausea and Vomiting
- Trial name
- NCT00402961
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Rectal Neoplasms
Genetic Profile on Predicting Sensibility of Preoperative Chemoradiotherapy on Locally Advanced Rectal Carcinoma
The aim of this study is to find some genetic factors in predicting the sensibility of preoperative chemoradiotherapy for locally advanced rectal carcinoma.
- Trial name
- NCT01930942
- Testing
- preoperative concurrent chemoradiation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese Academy of Medical Sciences
Pancreatic Cancer
ATX Study:A Study of Avastin (Bevacizumab), Tarceva (Erlotinib) and Xeloda (Capecitabine) in Patients With Locally Advanced and/or Metastatic Pancreatic Cancer
This 2 part study will evaluate the safety and efficacy of a combination of Avastin, Tarceva and Xeloda (ATX) as second-line treatment in patients with locally advanced and/or metastatic pancreatic cancer.
- Trial name
- NCT00925769
- Testing
- bevacizumab [Avastin], capecitabine [Xeloda], erlotinib [Tarceva]
- Where
- 2 sites in Austria
- Volunteers
- 32 people
- Sponsor
- Hoffmann-La Roche
Esophageal Cancer, Gastrooesophageal Cancer
Esophageal Stump Washout
Intraluminally shed viable tumor cells might contribute to local recurrence in cancer of the esophagus and the cardia. The aim of the the study was to establish a method of mechanical lavage of the remaining part of the esophagus…
- Trial name
- NCT01980394
- Testing
- Esophageal Stump Washout
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Kantonsspital Liestal
Hepatocellular Carcinoma
SCT-I10A Plus SCT510 Versus Sorafenib as First-Line Therapy for Advanced Hepatocellular Carcinoma
The purpose of the study is to assess the safety and effectiveness of SCT-I10A in combination with SCT510 in patients with HCC who have not received prior systemic therapy.
- Trial name
- HCC (NCT04560894)
- Testing
- SCT-I10A, SCT510, Sorafenib 200mg
- Where
- China
- Volunteers
- 405 people
- Sponsor
- Sinocelltech Ltd.
Colorectal Cancer Metastatic
Sorafenib Plus Capecitabine (SorCape) in Previously Treated Metastatic Colorectal Cancer
Combining Sorafenib with standard cytotoxic fluoropyrimidine therapy for advanced colorectal cancer may provide clinical benefit when no other treatment remains.
- Trial name
- SorCape (NCT01471353)
- Testing
- Sorafenib Plus Capecitabine (SorCape)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
Rectal Cancer, Comorbidities and Coexisting Conditions
Watch and Wait Management on Rectal Cancer Patients Using New Swift Local Therapy
Within our institution, the principal investigator have acquired expertise in endorectal brachytherapy, a localized treatment for colorectal cancer.
- Conditions
- Rectal Cancer, Comorbidities and Coexisting Conditions, Inoperable Disease, Brachytherapy
- Trial name
- Whistle (NCT04336202)
- Testing
- External beam radiotherapy + Endorectal brachytherapy
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Colorectal Cancer
Diet, Genes and Colorectal Cancer - With Focus on Toll-like Receptor Polymorphisms
The aim of this study is to investigate the interaction between diet - primary meat and fiber - and polymorphisms in Toll-like receptors in relation to risk of colorectal cancer in a Danish prospective cohort.
- Trial name
- NCT03250637
- Testing
- Observational
- Volunteers
- 2,895 people
- Sponsor
- University of Southern Denmark
Colorectal Cancer
Evaluation of a New Invitation Procedure to the French Organized Colorectal Cancer Screening Program
This is a randomized controlled trial comparing the effect on participation rates to colorectal cancer screening between an intervention arm (invitation letter to the screening program including a FIT test with or without prior…
- Trial name
- KITCOLO22 (NCT05589675)
- Testing
- Dispatch of the screening test along the invitation letter to the national colorectal cancer screening program, Sending of a prior notification to the new entrants of the national program
- Where
- 3 sites in France
- Volunteers
- 71,117 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Microsatellite Instability High, Mismatch Repair Deficiency
Anti-PD-1 +/- RT for MSI-H Solid Tumors
To determine if the out-of-field ORR is improved with the addition of radiation therapy to anti-PD-1 for patients with MSI-H/dMMR metastatic solid tumors.
- Conditions
- Microsatellite Instability High, Mismatch Repair Deficiency, Colorectal Cancer
- Trial name
- NCT04001101
- Testing
- RT and Anti-PD-1, Anti-PD-1
- Where
- United States
- Sponsor
- University of Colorado, Denver
Liver Cancer
Real-time Diagnosis of Serum LECT 2 in Patient With Liver Cancer Using Electronic Antibody Sensor (e- Ab Sensor)
To develop a real-time diagnostic technique with e- Ab sensor for specific LECT2 detection in clinical specimens of Hepatocellular carcinoma (HCC) patients, the investigators conduct a prospective clinical study.
- Trial name
- NCT01388101
- Testing
- Electrosensing antibody probing system (e- Ab sensor)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer
A Small-sample, Real-world Study of Sintilimab Plus Bevacizumab/Cetuximab Plus XELOX Regimen for Conversion Therapy in Patients With Advanced Colorectal Cancer
The purpose of this study is to acssess the efficacy and the safety of Sintilimab plus bevacizumab/cetuximab plus XELOX regimen for conversion therapy in patients with advanced colorectal cancer
- Trial name
- NCT05544812
- Testing
- Sintilimab ，bevcizumab/cetuximab，XELOX
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
The first 5,000 results can be paged through. Add a filter or change the sort order to reach the rest.