Clinical trials: Digestive System Fistula
Tracheo Esophageal Fistula, Congenital Diaphragmatic Hernia
Cerebral Blood Flow in Neonates During Thoracoscopic Surgeries
the aim of this study is to compare the effect of different modes of mechanical ventilation by using volume-controlled ventilation and pressure-controlled ventilation on cerebral blood flow monitored by cerebral oximetry during…
- Trial name
- NCT04507295
- Testing
- cerebral oximetry ( INVOS 5100 )
- Volunteers
- 30 people
- Sponsor
- Cairo University
Anal Fistula
Study on the Mechanism of Zuoqing San Promoting Postoperative Wound Healing of Anal Fistula by Inhibiting ROS-dependent NETosis
This study adopted a randomized, double-blind, placebo-controlled clinical trial design to evaluate the efficacy and safety of Zuoqing San fumigation and washing on the wound healing after anal fistula surgery.
- Trial name
- ZQS (NCT07128953)
- Testing
- Solution of Zuoqing San for fumigation and washing of the postoperative wound of anal fistula
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Pancreatic Fistula
Risk Factors for Post Whipple Pancreatic Fistula
Postoperative pancreatic fistula (POPF) following pancreaticoduodenectomy is considered a life-threatening complication. This study was designed to analyze the risk factors for development of such fistula in a tertiary care…
- Trial name
- NCT05014425
- Testing
- pancreaticoduodenectomy
- Volunteers
- 96 people
- Sponsor
- Assiut University
Disease of Pancreatic or Periampullary Lesions
PoLyglycolic Acid Felt reiNforcEmenT of the PancreaticoJejunostomy (PLANET-PJ Trial)
The polyglycolic acid (PGA) felt is a felt-like absorbable suture reinforcing material. The pancreatojejunostomy aimed at reducing POPF is not established at present. We devised a new method using doubly PGA felt.
- Trial name
- NCT03331718
- Testing
- PGA felt reinforcement
- Where
- Japan
- Volunteers
- 514 people
- Sponsor
- University of Toyama
Anal Fistula, Complex Perianal Fistula
Evaluating an rhPDGF-BB-enhanced Collagen Plug for Perianal Fistula Healing
The average success rate for healing and remission of complex perianal fistulas, idiopathic or Crohn's-related, is approximately 50%.
- Trial name
- NCT06632418
- Testing
- RhPDGF-BB
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Alexander Hawkins
Pancreatic Fistula
A Multicenter Randomized Controlled Study of External Pancreatic Duct Stents in Pancreaticoduodenectomy
The prognostic value of external vs internal pancreatic duct stents after pancreaticoduodenectomy remains controversial. This study aimed to evaluate the benefits of external and internal stents using the Updated Alternative…
- Trial name
- NCT05725590
- Testing
- External pancreatic duct stent, Internal pancreatic duct stent
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hemorrhoids, Anal Fissure
Topical vs Oral Metronidazole After Benign Anorectal Surgery
While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole.
- Conditions
- Hemorrhoids, Anal Fissure, Anal Fistula
- Trial name
- NCT05038605
- Testing
- Topical metronidazole, oral metronidazole
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Pancreatic Diseases
The Effect of Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide on the Complications After Pancreatectomy. A Prospective, Multicenter Clinical Trial
The Effect of Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide on the Complications After Pancreatectomy. A Prospective, Multicenter Clinical Trial
- Trial name
- NCT03398941
- Testing
- Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chengfeng Wang
Anal Fistula, Crohn's Disease
Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences
Main purposes of this study are : Analysis of relapse risk of anal fistulae with prospective follow-up of patients undergoing pelvic MRI every 6 months for one year.
- Trial name
- FISTULE (NCT02883296)
- Testing
- Pelvis Magnetic resonance imaging
- Volunteers
- 15 people
- Sponsor
- Central Hospital, Nancy, France
Crohn Disease, Perianal Fistulas
Adipose Tissue Injection in Perianal Fistulas in Crohn´s Disease
This randomized and placebo controlled study investigates the efficacy of injections with freshly harvested autologous adipose tissue in CD patients with complex perianal fistulas refractory to standard surgical and/or medical…
- Conditions
- Crohn Disease, Perianal Fistulas, Cell- and Tissue-Based Therapy, Treatment
- Trial name
- NCT03904212
- Testing
- Adipose tissue injection, saline
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- University of Aarhus
Hemorrhoids, Anal Fistula
Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery?
The aim of this single-center prospective observational trial is to study the influence of physical and psychological factors on the intensity of pain syndrome after anorectal interventions and to determine the association…
- Conditions
- Hemorrhoids, Anal Fistula, Anal Fissure, Incontinence
- Trial name
- NCT06049524
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Center of Endourology "Endocenter"
Endothelial Degeneration, Pancreatic Cancer
Glycocalyx Levels in Patients Undergoing Pancreatectomy
Background: On the surface of every healthy cellular membrane resides a layer known as the glycocalyx. This structure consists of extracellular domains of receptor, adhesion and transmembrane molecules such as syndecan-1…
- Conditions
- Endothelial Degeneration, Pancreatic Cancer, Pancreatectomy, Postoperative Pancreatic Fistula
- Trial name
- NCT04058236
- Testing
- human albumin 5%, gelofusine.
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- University of Malaya
Anal Fistula, LIFT-plug
LIFT-plug vs LIFT, a RCT Trial
To validate the effect of Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug procedure for Anal Fistula Repair in 7 medical centers
- Conditions
- Anal Fistula, LIFT-plug, Healing Rate, Anal Function
- Trial name
- LIFT 02 (NCT04310800)
- Testing
- LIFT-plug technique
- Where
- 7 sites in China
- Volunteers
- 384 people
- Sponsor
- Zhen Jun Wang
Esophageal Atresia With Tracheo-esophageal Fistula, Congenital Diaphragmatic Hernia
Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases
This is a pilot randomised controlled trial comparing open versus thoracoscopic surgery for repair of oesophageal atresia with tracheo-oesophageal fistula or congenital diaphragmatic hernia in neonates.
- Trial name
- CO2 (NCT01467245)
- Testing
- Hypercapnia during thoracoscopy, Open surgery
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Achalasia, Gastric Fistula
Outcome Analysis of POEM and Endoluminal Therapies
Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.
- Conditions
- Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer
- Trial name
- NCT03123835
- Testing
- Endoscopic Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Crohn's Disease, Complex Perianal Fistula
Long-term Follow-up Study With Darvadstrocel in the Treatment of Complex Perianal Fistula
The main aim is to follow-up on long term side effect and symptom improvement of Darvadstrocel in the treatment of complex perianal fistula in adults. Participants will not receive any drug in this study.
- Trial name
- NCT04075825
- Testing
- Darvadstrocel
- Where
- 58 sites in United States, Belgium and 7 more
- Volunteers
- 150 people
- Sponsor
- Takeda
Anastomosis; Complications, Pancreatic Fistula
Pancreaticogastrostomy for High-Risk Pancreas
In 2013, a double purse-string telescoped pancreaticogastrostomy (PG) technique appeared to significantly reduce the risk of postoperative pancreatic fistula (POPF).
- Trial name
- GASTROPAN (NCT04724174)
- Testing
- pancreaticogastrostomy, pancreaticojejunostomy
- Volunteers
- 198 people
- Sponsor
- Institut Paoli-Calmettes
Crohns Disease, Fistula
Study to Look at Benefit of Surgical Drainage Before Beginning Medical Therapy for Crohns Perianal Fistulas
This study is looking at the advantage of establishing surgical drainage for Crohn's fistulas and abscesses prior to starting medical therapy.
- Conditions
- Crohns Disease, Fistula, Abscess
- Trial name
- NCT01145365
- Testing
- Exam under anesthesia (EUA)
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Recto Vaginal Fistula
Transperineal Repair of Primary Obstetric Rectovaginal Fistulas
Introduction: A rectovaginal fistula (RVF) is an epithelium-lined abnormal tract between the rectum and the vagina and is often a challenging problem for both the patients and to the surgeons.
- Trial name
- NCT04267757
- Testing
- rectovaginal fistula repair with Martius flap
- Where
- Egypt
- Volunteers
- 4 people
- Sponsor
- Zagazig University
Periampullary Carcinoma, Pancreatic Fistula
Trial of Omental Roll-up Technique on Pancreato-jejunostomy Anastomosis for Reducing Perioperative Complication in Patients Undergoing Pancreatoduodenectomy
Despite the fact that pancreatoduodenectomy is the standard treatment of malignant tumor at periampullary area, the morbidity and mortality rate with intra-abdominal collection, post pancreatectomy hemorrhage, and delayed gastric…
- Trial name
- NCT03083938
- Testing
- Omental Roll-up
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University