Clinical trials: Digestive System Fistula
Pancreatic Diseases
The Effect of Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide on the Complications After Pancreatectomy. A Prospective, Multicenter Clinical Trial
The Effect of Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide on the Complications After Pancreatectomy. A Prospective, Multicenter Clinical Trial
- Trial name
- NCT03398941
- Testing
- Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chengfeng Wang
Crohn's Disease
A Study to Assess Efficacy, Safety and Tolerability of the Anti-IL-13 Monoclonal Antibody QAX576 in the Treatment of Perinanal Fistulas in Patients Suffering From Crohn's Disease
Test safety and efficacy and of a novel IL-13 AB in the treatment of perianal fistulas Trial with medicinal product
- Trial name
- NCT01316601
- Testing
- QAX567
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Gerhard Rogler
Anal Fistula Surgery, Anal Fistula
The Modified Clipped-LIFT Procedure for High Transsphincteric or Suprasphincteric Fistula
A retrospective analysis was performed on 96 patients who underwent modified LIFT procedures to treat transsphincteric or suprasphincteric fistulas.
- Trial name
- NCT07102134
- Testing
- Suturing-LIFT procedure, Clipped-LIFT procedure
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Anal Fistula
E-CEL UVEC as an Adjunct Cell Therapy for Treatment of Anal Fistulas
The purpose of this study is to determine if endothelial cells derived from human umbilical vein are safe for use in conjunction with fistulotomy for the treatment of simple anal fistulas.
- Trial name
- NCT04190862
- Testing
- E-CEL UVEC
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Weill Medical College of Cornell University
Crohn's Disease
MRI-Based Screening in a Retrospective Cohort Reveals Adverse Prognosis of Asymptomatic Perianal Fistulas in Crohn's Disease: A Long-term Follow-Up Study
The goal of this observational study is to learn about the necessity of imaging screening for perianal fistula in Crohn's disease (CD) patients without perianal symptoms by comparing the natural history and long-term outcomes…
- Trial name
- NCT07555808
- Volunteers
- 669 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Postoperative Acute Pancreatitis, Pancreaticoduodenectomy
Clinical and Economic Validation of the ISGPS Definition of PPAP
This prospective validation study aims to investigate the incidence of PPAP after pancreaticoduodenectomy (PD) by applying the ISGPS definition and grading system, to demonstrate its clinical impact by examining associated…
- Conditions
- Postoperative Acute Pancreatitis, Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Postoperative Complications
- Trial name
- ISGPS-PPAP (NCT05680623)
- Testing
- PPAP diagnosis
- Where
- Italy
- Volunteers
- 2,900 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Anorectal Malformations
Outcomes in ARMs: Comparison Between Surgical Techniques in Patients With Perineal or Vestibular Fistula - a Multicenter Italian Study
This is a national, multicenter, retro-prospective longitudinal cohort study evaluating mid- and long-term outcomes of different surgical techniques used for the correction of anorectal malformations (ARM) with perineal or…
- Trial name
- MAR-ITA (NCT07438691)
- Where
- 21 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Meyer Children's Hospital IRCCS
Pancreatic Fistula
Study of Pancreatic Enzymes in the Drains as Early Biomarkers of Post-operative Pancreatic Fistula and Its Clinical Repercussions
Surgery is the principal treatment for benign and malignant pancreatic tumours. This surgery can be accompanied by complications among which the main one is pancreatic fistula, which leads to the flow of pancreatic juices into…
- Trial name
- LIPA-DRAIN (NCT02784990)
- Testing
- Lipase, amylase and CRP (C-reactive protein) dosages
- Where
- 10 sites in France
- Volunteers
- 770 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Gallbladder Diseases
Cholecystoduodenal Fistula With and Without Gallstone Ileus
Observative and descriptive study of 10 patients, which were diagnosed with a Cholecystoduodenal fistula, All electronic medical records were retrospectively reviewed.
- Trial name
- NCT03888976
- Testing
- Cholecystectomy
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Tecnologico de Monterrey
Microbial Colonization, Pancreas Cancer
The Microbiome of Pancreatic Cancer: "PANDEMIC" Study
Microbiome in patients affected by pancreatic ductal adenocarcinoma may present specific and identifiable patterns. These variations could affect the surgical outcome and increase the risk of life-threatening infections supported…
- Conditions
- Microbial Colonization, Pancreas Cancer, Pancreas Infection, Pancreas; Fistula
- Trial name
- PANDEMIC (NCT04274972)
- Testing
- Microbiome evaluation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Perianal Fistula, Crohn's Disease
Study of ExoFlo for the Treatment of Perianal Fistulas
To evaluate the safety and feasibility of ExoFlo as a treatment for Perianal Fistulizing Crohn's Disease.
- Trial name
- NCT05836883
- Testing
- ExoFlo, Local injection of normal saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Direct Biologics, LLC
Anal Fistula
Study on the Mechanism of Zuoqing San Promoting Postoperative Wound Healing of Anal Fistula by Inhibiting ROS-dependent NETosis
This study adopted a randomized, double-blind, placebo-controlled clinical trial design to evaluate the efficacy and safety of Zuoqing San fumigation and washing on the wound healing after anal fistula surgery.
- Trial name
- ZQS (NCT07128953)
- Testing
- Solution of Zuoqing San for fumigation and washing of the postoperative wound of anal fistula
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Hemorrhoid, Anal Fistulas
Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery
The study, "Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery," aims to evaluate the impact of preoperative listening to standardized music sequences on postoperative pain…
- Conditions
- Hemorrhoid, Anal Fistulas, MUSICAL THERAPY, Anal Fissure and Fistula
- Trial name
- MUSICOPROCTO (NCT06798155)
- Testing
- Standardized Music Listening Therapy
- Where
- 2 sites in Reunion
- Volunteers
- 550 people
- Sponsor
- Clinique Saint-Vincent
Crohn's Disease, Fistula
Mesenchymal Stem Cells for the Treatment of Pouch Fistulas in Crohn's
The purpose of this study is to determine the safety and feasibility of using allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat people with an ileal pouch anal anastomosis (IPAA) who develop a fistula in the…
- Conditions
- Crohn's Disease, Fistula, Anal Fistula, Pouch, Ileal
- Trial name
- IPAAF (NCT04073472)
- Testing
- mesenchymal stem cells (MSCs)
- Sponsor
- The Cleveland Clinic
Fistula
3D BIO-STRUCTURES FOR G.I. POST-SURGICAL DEFECTS
The study is focused on evaluating the safety and efficacy of using vascular stromal tissue, derived from autologous adipose tissue, and subjected to microfragmentation and emulsification (Stromal Vascular Fraction Micro-Emulsion…
- Trial name
- 3DReG (NCT06587633)
- Testing
- Endoscopic procedure
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pancreas Cancer, Surgery-Complications
Relieving the Bile Ducts Prior to Pancreatoduodenectomy
The aim of this study was to assess the risk and complications after preoperative drainage of biliary obstruction in patients who underwent pancreatoduodenectomy.
- Conditions
- Pancreas Cancer, Surgery-Complications, Biliary Fistula
- Trial name
- NCT05434520
- Testing
- Preoperative biliary drainage (ERC og PTC-aided)
- Where
- Denmark
- Volunteers
- 722 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Perianal Fistula, Perianal Crohn Disease
Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases
Consecutive patients with complex anal fistula were prospectively followed for 12 months. Routine MRI was performed before and at 4 and 12 months after surgery. Continence was assessed likewise using a validated questionnaire.
- Conditions
- Perianal Fistula, Perianal Crohn Disease, Anal Fissure, Rectovaginal Fistula
- Trial name
- NCT05709717
- Testing
- Regenerative therapy with SVF-PRP to supplement perianal surgery
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Kantonsspital Winterthur KSW
Pancreatic Fistula
Total pancrEaTectomy vs High-Risk Pancreatic anastomosiS
Postoperative pancreatic fistula (POPF) is the main driver of surgical morbidity after pancreatoduodenectomy (PD). The aim of the present study is to compare total pancretectomy (TP) and primary pancreatic anastomosis (PA) in a…
- Trial name
- TETRIS (NCT05212350)
- Testing
- Total pancreatectomy, Pancreatic anastomosis
- Where
- 5 sites in Germany, Italy
- Volunteers
- 98 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Fistula, Surgery Site Fistula
ERAS in Gastrointerstinal Fistulas.
An enterocutaneous fistula (ECF) poses a major surgical problem. The definitive surgical repair of persistent fistulas remains a surgical challenge with a high rate of re-fistulation and mortality, and the reasons for that is not…
- Trial name
- NCT04771832
- Testing
- ERAS
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Stanley Dudrick's Memorial Hospital
Quality of Life, Anal Fistula
Changes in Patients' Quality of Life With Differences in Seton Application
Investigators aim to investigate the changes in patients' quality of life with different type of seton application.
- Trial name
- NCT05348473
- Testing
- Alpha type, Beta type, Comfort type
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Ankara University