Clinical trials: Digestive System Fistula
Pancreatic Fistula After Pancreaticoduodenectomy, C-Reactive Protein
Postoperative Pancreatic Fistula in Patients Undergoing Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality.
- Conditions
- Pancreatic Fistula After Pancreaticoduodenectomy, C-Reactive Protein, Albumin
- Trial name
- popf (NCT06300801)
- Testing
- Is the preoperative c-reactive protein/albumin ratio successful in predicting postoperative pancreatic fistula in patients undergoing pancreatoduodenectomy?
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Postoperative Complications, Postoperative Pancreatitis
Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy and Distal Pancreatic Resection
The purpose of this randomized, placebo-controlled trial is to investigate whether postoperative pancreatitis and other immediate complications after pancreaticoduodenectomy or distal pancreatic resection may be reduced with…
- Trial name
- NCT01460615
- Testing
- Hydrocortisone
- Where
- Finland
- Sponsor
- Tampere University Hospital
Anal Fistula, Crohn Disease
Stem Cells Treatment of Complex Crohn's Anal Fistula
A pilot study to investigate the safety and feasibility of stem cells treatment of complex anal fistula in patients with Crohn's disease.
- Trial name
- fistula (NCT03466515)
- Testing
- stem cells injection
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Southern Denmark
Pancreas Neoplasm, Stump
Routine Staple Line Reinforcement for Minimally Invasive Distal Pancreatectomy
Postoperative fistula is the major complications of distal pancreatectomies which prohibit patients' recovery. Previous studies have reported controversial results regarding the efficacy of pancreatic stump reinforcement methods.
- Conditions
- Pancreas Neoplasm, Stump, Surgery--Complications
- Trial name
- Double-Lock (NCT04663789)
- Testing
- reinforcement of the staple line, staple only
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Peking Union Medical College Hospital
Perianal Crohn Disease, Perianal Fistula
The Impact of Perianal Disease on Patient's Sex Life
Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage.
- Conditions
- Perianal Crohn Disease, Perianal Fistula, Fistula in Ano, Perianal Abscess
- Trial name
- SEXTON (NCT07519850)
- Testing
- Patient Reported Outcome Assessment (Questionnaires)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Anal Fistula
Imaging Template for Reporting Anal Fistula
Magnetic resonance imaging (MRI) is the most used diagnostic tool for pre-operative assessment of anal fistula. However, there is lack of standardization in reporting this investigation.
- Trial name
- ITRAF (NCT04541238)
- Testing
- MRI
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Treviso Regional Hospital
Crohn Disease, Perianal Fistula
Permacol Paste in Perianal Crohn's Disease
The purpose of this study is to collect data about the efficacy of Permacol Paste treatment in perianal Crohn's Disease.
- Trial name
- UPpCro (NCT03776825)
- Testing
- Permacol Paste
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Clinico Humanitas
Anal Fistula, Minimal Invasive Surgery
Treatment of Anal Fistulas With Obsidian RFT®
The study conducted a retrospective analysis from January 2018 to December 2022 on patients who received anal fistula closure with Obsidian RTF® at the Department of General Surgery, Medical University of Vienna.
- Conditions
- Anal Fistula, Minimal Invasive Surgery, Platelet-rich Fibrin Foam
- Trial name
- NCT06136325
- Testing
- Obsidian RFP anal fistula surgery
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- Medical University of Vienna
Hemorrhoids, Anal Fissure
Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases
New produced and patented sodium pantaborat based gel will be use for treatment of benign perianal diseases (hemooroidal disease, anal fissura anda perianal fistula)
- Conditions
- Hemorrhoids, Anal Fissure, Perianal Fistula
- Trial name
- NCT03780998
- Testing
- Life7
- Volunteers
- 250 people
- Sponsor
- SB Istanbul Education and Research Hospital
Pancreatic Fistula
Enteral Nutrition in the Treatment of Pancreatic Fistulas - A Prospective Study
The primary objective of this study is to evaluate the effectives of enteral nutrition in the treatment of pancreatic fistulas. The ratio of pancreatic fistula closure after 30 days is selected as the primary outcome measure with…
- Trial name
- FIS-1 (NCT01025414)
- Testing
- enteral nutrition, Parenteral nutrition
- Where
- Poland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Pancreatic Fistula
Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula
For periampullary and pancreatic head disorders, pancreaticoduodenectomy (PD) is the standard treatment. However, PD is technically demanding and has high morbidity and mortality rates.
- Trial name
- NCT05687825
- Testing
- pancreaticoduodenectomy procedure
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- South Valley University
Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus
Azygos Vein Preservation; Its Impact on Early Outcomes After Neonatal EA/TOF Repair
Azygos vein preservation revisited: impact on early outcomes after repair of Esophageal atresia/ Tracheo-Esophageal Fistula in newborns. A randomized controlled study.
- Conditions
- Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus, Leak, Anastomotic, Stricture Esophagus
- Trial name
- EArAzygousvp (NCT05957562)
- Testing
- EA/TOF primary repair with Azygos vein preservation, EA/TOF primary repair with Azygos vein sacrifice (disconnection)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Crohn Disease (CD), Cryptoglandular Perianal Fistula
A Study Comparing Transperineal Ultrasound, Magnetic Resonance Imaging, Endoscopic Ultrasound, and Examination Under Anesthesia to Detect and Classify Perianal Fistulas in Patients With Crohn's Disease or Fistulas of Unknown Cause
The goal of this study is to learn how well different imaging tests detect and describe perianal fistulas in adults with Crohn's disease or fistulas with no known cause (cryptogenic).
- Trial name
- TRANSIT CD (NCT07794410)
- Testing
- Transperineal Ultrasound (TPUS), Magnetic Resonance Imaging (MRI), Endoscopic Ultrasound (EUS)
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Hemorrhoid, Peri Anal Fistula
Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl
In this prospective randomized study the investigators aimed to investigate difference of the duration of spinal anesthesia, discharge times and efficacy between low dose heavy Prilocaine-Fentanyl and heavy Bupivacaine-Fentanyl…
- Trial name
- NCT01880775
- Testing
- Prilocaine, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Pancreatic Neoplasms, Pancreatic Fistula
Different Stapler Cartridge For Pancreatic Stump Texture To Prevent Pancreatic Fistula
The purpose of this trial is to establish an objective criterion for assessing pancreatic stump texture, and unify stapler cartridge according to pancreatic stump texture and thickness.
- Trial name
- NCT02790333
- Testing
- traditional reloads, Tri-Staple reloads
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Yi-Ping Mou
PDAC of the Body and the Tail of the Pancreas, CR- POPF
Oncologic Impact of Pancreatic Fistula
Clinically-relevant post-operative fistula is a major complication after DP, but it did not affect post-operative therapeutic path nor oncologic long-term outcomes.
- Trial name
- POPF-DSS (NCT04348084)
- Where
- France
- Volunteers
- 382 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Fistula
Closed Suction Drainage and Natural Drainage of the Pancreatic Duct in Pancreaticojejunostomy
Pancreaticojejunal anastomosis leakage is a major complication after pancreatoduodenectomy and various technical methods have been examined to improve the situation.However, none of methods have been successful at improving…
- Trial name
- NCT00679952
- Testing
- closed suction drainage of pancreatic duct, natural drainage of pancreatic duct
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Seoul National University Hospital
Anorectal Fistula
Effect of Short Term Versus Long Term Treatment With Seton Prior to LIFT Surgery for Complex Anal Fistula
The aim of this study is to compare short term (3 week) with long term (6 months) treatment with seton prior to LIFT surgery. The main end-points are recurrence rates and complication rates after surgery.
- Trial name
- NCT01913249
- Testing
- LIFT
- Where
- Norway
- Sponsor
- Sykehuset Innlandet HF
Crohn Disease, Fistula
Treatment of Perianal Fistulas in Crohn's Disease With Autologous Microfragmented Adipose Tissue With the Lipogems System
The aim of the study is to verify the efficacy of microfragmented autologous adipose tissue with the Lipogems® system, in the treatment of perianal fistulas of m. Crohn's.
- Conditions
- Crohn Disease, Fistula, Adipose Tissue
- Trial name
- NCT05766566
- Testing
- Perianal fistula surgery
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Pancreatic Fistula, Pancreatic Neoplasms
HYPAR Trial - Hydrocortisone vs. Pasireotide in Reducing Pancreatic Surgery Complications
Pancreatic resections carry a high risk for complications, especially pancreatic fistula. Both hydrocortisone and pasireotide have been shown to be effective in reducing complications in earlier RCTs.
- Trial name
- HYPAR (NCT02775227)
- Testing
- Hydrocortisone, Pasireotide
- Where
- Finland
- Volunteers
- 126 people
- Sponsor
- Helsinki University Central Hospital