Clinical trials: Digestive System Fistula
Periampullary Carcinoma, Pancreatic Fistula
Trial of Omental Roll-up Technique on Pancreato-jejunostomy Anastomosis for Reducing Perioperative Complication in Patients Undergoing Pancreatoduodenectomy
Despite the fact that pancreatoduodenectomy is the standard treatment of malignant tumor at periampullary area, the morbidity and mortality rate with intra-abdominal collection, post pancreatectomy hemorrhage, and delayed gastric…
- Trial name
- NCT03083938
- Testing
- Omental Roll-up
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Fistula-in-ano, Draining Wound
A Study Of Cryptoglandular Fistula-in-ano And Associated Non-healing Draining Wounds With Kerecis SurgiClose
The purpose of this study is to determine feasibility of Kerecis intact fish skin for healing of fistula-in-ano and associated non-healing draining wounds.
- Trial name
- NCT07098715
- Testing
- Kerecis fish skin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
High Perianal Fistula, Fistula-in-Ano
Seton Re-routing for High Perianal Fistula
High perianal fistulae involve a significant portion of the external anal sphincter muscle, making standard surgical fistulotomy risky due to the potential for postoperative fecal incontinence.
- Conditions
- High Perianal Fistula, Fistula-in-Ano, High Anal Fistula
- Trial name
- NCT07850440
- Testing
- Seton Re-routing
- Volunteers
- 35 people
- Sponsor
- Assiut University
Anal Fistula, Crohn's Disease
Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences
Main purposes of this study are : Analysis of relapse risk of anal fistulae with prospective follow-up of patients undergoing pelvic MRI every 6 months for one year.
- Trial name
- FISTULE (NCT02883296)
- Testing
- Pelvis Magnetic resonance imaging
- Volunteers
- 15 people
- Sponsor
- Central Hospital, Nancy, France
Anorectal Fistula
Anal Sphincter Reconstruction After High Recurrent Anorectal Fistula Excision
A retrospective analysis of patients treated for recurrent posterior anorectal fistula, who previously had undergone radical excision of fistula-in-ano, was performed.
- Trial name
- NCT04357210
- Testing
- fistula tract excision and anal sphincter reconstruction
- Volunteers
- 14 people
- Sponsor
- Russian Society of Colorectal Surgeons
Rectovaginal Fistula, Crohn Disease
Mesenchymal Stem Cells for the Treatment of Rectovaginal Fistulas in Participants With Crohn's Disease
Approximately 10% of all female Crohn's patients have a rectovaginal fistula. Rectovaginal fistulas cause air, stool, and/or drainage per vagina and may be associated with pain, recurrent urinary tract infections and diminished…
- Conditions
- Rectovaginal Fistula, Crohn Disease, Crohn Disease of Vulva, Rectolabial; Fistula
- Trial name
- RVF (NCT04519697)
- Testing
- Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Anthony Lembo
Esophageal Squamous Cell Carcinoma (ESCC), Esophageal Fistula
Standardized Management of Esophageal Fistula in Esophageal Squamous Cell Carcinoma
This prospective, multi-center, observational registry study (PKU-ESCC-EF) aims to evaluate the safety and effectiveness of a standardized diagnosis and treatment protocol for esophageal fistula (EF) in patients with advanced…
- Trial name
- PKU-ESCC-EF (NCT07353541)
- Testing
- Standardized Management Protocol for Esophageal Fistula
- Volunteers
- 32 people
- Sponsor
- Peking University Cancer Hospital & Institute
Anal Fistula, Treatment
The Efficacy of Human Acellular Dermal Matrix in the Treatment of Anal Fistula
The purpose of this study is to determine whether human acellular dermal matrix plug is effective in the treatment of anal fistula
- Conditions
- Anal Fistula, Treatment, Postoperative Complications, Acellular Dermal Matrix
- Trial name
- NCT00951002
- Testing
- acellular dermal matrix plug
- Where
- 13 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Zhen Jun Wang
Pancreatic Fistula
Influence of Pancreatic Transection With CUSA on Postoperative Pancreatic Fistula Incidence (PANCUT)
Objective: To compare the outcomes after elective pancreatic resections using cavitron ultrasonic surgical aspirator (CUSA) and selective closure of small blood vessels and branch pancreatic ducts versus surgical scalpel or…
- Trial name
- PANCUT (NCT06135012)
- Testing
- Cavitron ultrasonic surgical aspirator (CUSA), Scalpel
- Where
- Slovenia
- Volunteers
- 160 people
- Sponsor
- University Medical Centre Ljubljana
Pancreaticoduodenectomy, Pancreatic Fistula
Intravenous Human Albumin In Improving Pancreaticoduodenectomy Outcomes
Pancreaticoduodenectomy (PD), more commonly known as Whipple's surgery is the mainstay treatment for pancreatic head and periampullary cancer.
- Conditions
- Pancreaticoduodenectomy, Pancreatic Fistula, Delayed Gastric Emptying, Pancreatic Cancer
- Trial name
- NCT04418739
- Testing
- Human albumin
- Where
- Malaysia
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Trial of Early Versus Standard Drainage Removal After Pancreatic Resections
Despite a substantial decrease in postoperative mortality, morbidity after pancreatic resections is still high, even at high-volume centers.
- Conditions
- Pancreaticoduodenectomy, Distal Pancreatectomy, Pancreatic Fistula, Abdominal Abscess
- Trial name
- NCT00931554
- Testing
- Postoperative drain removal
- Where
- Italy
- Volunteers
- 114 people
- Sponsor
- Universita di Verona
Anal Fistula
Cross-cultural Adaptation of the Chinese Version of QoLAF-Q (Quality of Life in Patients With Anal Fistula Questionnaire) ：A Multi-center Study
The investigators verify the reliability and practicality of the Chinese adaptation results of QoLAF-Q, which helps Chinese doctors better master the methods and techniques of quality of life assessment.
- Trial name
- NCT06962228
- Testing
- Anal fistula surgery
- Volunteers
- 150 people
- Sponsor
- Changhai Hospital
Anal Fistula
Fistulectomy and Primary Sphincter rEconstruction vs. endorectaL Advancement Flap in the Treatment of High Anal Fistulas
The optimal method of surgical treatment of complex anorectal fistulas has not been found yet. The aim of this study is to compare two techniques in treatment of high anorectal fistulas.
- Trial name
- SELF (NCT04119700)
- Testing
- Muco-muscular endorectal advancement flap after fistulectomy, Primary sphincter reconstruction after fistulectomy
- Where
- Russia
- Volunteers
- 142 people
- Sponsor
- Russian Society of Colorectal Surgeons
Crohn Disease, Fistula Perianal
Efficacy of Cx601 (Darvadstrocel) for the Treatment of Perianal Fistulizing Crohn's Disease
The use of mesenchymal stem cells is considered a novel and promising therapeutic option for patients with perianal fistulizing Crohn's disease.
- Trial name
- NCT05322057
- Testing
- Darvadstrocel
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Pancreatic Fistula, Distal Pancreatectomy
Comparison Between Two Methods of Pancreatic Transection in Distal Pancreatectomy
Several systematic reviews have investigated the management of the pancreatic stump in order to reduce the postoperative pancreatic fistula (POPF) rate after distal pancreatectomy (DP).
- Trial name
- TRUDY (NCT03880773)
- Testing
- Stapler, ultrasonic shears
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Esophageal Atresia, Tracheoesophageal Fistula
Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair
This trial will compare the effectiveness of two common surgical practices for Type C esophageal atresia repair: esophageal atresia (EA) with distal tracheoesophageal fistula (TEF).
- Trial name
- TEF (NCT03730454)
- Testing
- Transanastomotic Tube (5FR), No Transanastomotic Tube
- Where
- 10 sites in United States
- Volunteers
- 142 people
- Sponsor
- Phoenix Children's Hospital
Simple Anal Fistula
Effect of Platelet-Rich Plasma Injection on Wound Healing After Fistulotomy for Simple Anal Fistula Randomized Controlled Trial (RCT)
Anal fistula is a common benign anorectal condition characterized by an abnormal tract between the anal canal and perianal skin, often resulting from cryptoglandular infection.
- Trial name
- PRPIWHAFSAFRCT (NCT07248007)
- Testing
- PRP injection
- Volunteers
- 70 people
- Sponsor
- Assiut University
Postoperative Fistula, Complications of Surgical and Medical Care: General Terms
External Drainage Versus Internal Drainage of Pancreatic Duct With a Stent After Pancreaticoduodenectomy (EDIDPD)
Postoperative pancreatic fistula (POPF) and other surgical complications are common after pancreatoduodenectomy (PD) and POPF is a major complication.
- Trial name
- EDIDPD (NCT01634971)
- Testing
- Internal Drainage of Pancreatic Duct after pancreatomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Pancreas Neoplasm
The Neutrophil-to-Lymphocyte Ratio to Exclude Pancreatic Fistula
There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF).
- Trial name
- NLR (NCT04724551)
- Testing
- pancreatoduodenectomy (PD)
- Volunteers
- 648 people
- Sponsor
- Institut Paoli-Calmettes
Crohn's Disease, Fistula
Follow-up Study of Autologous Cultured Adipose-derived Stem Cells for the Crohn's Fistula
This is an open follow-up clinical trials to evaluate a sustained efficacy and safety of Adipoplus inj. for 10 months (12 months after final dose injection)after Phase II clinical trial.
- Trial name
- ANTG-ASC-203 (NCT01314079)
- Where
- 3 sites in South Korea
- Volunteers
- 37 people
- Sponsor
- Anterogen Co., Ltd.