Clinical trials: Digestive System Fistula
Crohn's Disease
A Survey of Darvadstrocel in People With Crohn's Disease
This study is a survey in Japan of Darvadstrocel injection used to treat Crohn's disease people with complicated anal fistula. The study sponsor will not be involved in how the participants are treated but will provide…
- Trial name
- J-INSPIRE (NCT05113095)
- Testing
- Darvadstrocel
- Where
- Japan
- Volunteers
- 275 people
- Sponsor
- Takeda
Pancreatic Fistula, Pancreatic Neoplasms
Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy
The study evaluates the safety and efficacy of Neoprene-based glue in the management of pancreatic stump after pancreatoduodenectomy (PD) in patients at high risk for pancreatic fistula and early neoplastic recurrence, compared…
- Conditions
- Pancreatic Fistula, Pancreatic Neoplasms, Postoperative Complications
- Trial name
- NCT03738787
- Testing
- Pancreatic duct occlusion with Neoprene, Pancreato-Jejunal anastomosis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Pancreatic Fistula
A Prospective Randomized Trial of Efficacy of Stump Closure for Distal Pancreatectomy
Overall morbidity rate remained high after distal pancreatectomy (DP), ranging from 30% to 60%. Whilst postoperative pancreatic fistula (POPF) remains serious and also is one of the most common complications after DP (12% to…
- Trial name
- NCT03201653
- Testing
- Stump closure using NU-KNIT SURGICEL
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- National Taiwan University Hospital
Anal Fistula
LIFT Technique Versus Seton in Management of Anal Fistula
Abscesses and anal fistulas represent about 70% of perianal suppuration, with an estimated incidence of 1/10,000 inhabitants per year and representing 5% of queries in coloproctology.
- Trial name
- NCT03311035
- Testing
- Seton, LIFT technique
- Volunteers
- 60 people
- Sponsor
- Assiut University
Tracheoesophageal Fistula, Esophageal Atresia
Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients
The investigators propose a preliminary study performing exome sequencing on samples from patients and their biologically related family members with tracheal and esophageal birth defects (TED).
- Conditions
- Tracheoesophageal Fistula, Esophageal Atresia, Laryngeal Cleft, Tracheal Stenosis
- Trial name
- TED (NCT03455881)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Perianal Fistula, Hemorrhoids
Adding Ketamine to Low Dose Bupivacaine in Saddle Block for Perianal Surgery
Evaluation of the anesthetic quality and analgesic efficacy of adding ketamine to intrathecal bupivavaine in selective saddle block for perianal surgery.
- Trial name
- NCT03264430
- Testing
- Ketamine, bupivacaine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Esam Eldin Mohamed Abdalla
Fistula Vagina, Fistula;Rectal
Rectovaginal Fistula Repair
This study is a prospective evaluation of quality-of-life after rectovaginal fistula repair at our institution
- Trial name
- NCT05006586
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Uppsala University
Crohn Disease
Treatment and Fate in Fistulizing Crohn's Disease in a Pediatric Population
Crohn's disease is a inflammatory bowel disease evolving towards the destruction of the intestinal wall resulting in stenosing or perforating complications (fistulas, abscesses).
- Trial name
- NCT05759104
- Testing
- Infliximab, Stomy
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Pancreatic Fistula
Comparison of Effectiveness of TissuePatchTM in Preventing Postoperative Pancreatic Fistula
Postoperative pancreatic fistula is one of the most serious complications after gastric cancer surgery and can lead to surgery-related death.
- Trial name
- NCT05404256
- Testing
- Radical gastrectomy +D2 lymphadenectomy+TissuePatchTM to seal pancreatic tissue surface, Radical gastrectomy +D2 lymphadenectomy
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Anal Fistula
Study of GORE® BIO-A® Fistula Plug for Use in Anal Fistula Repair
Primary outcome variable is healing at the final follow up visit.
- Trial name
- NCT01290666
- Testing
- Fistula Plug
- Volunteers
- 93 people
- Sponsor
- W.L.Gore & Associates
Hemorrhoids, Anal Fissure
Topical vs Oral Metronidazole After Benign Anorectal Surgery
While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole.
- Conditions
- Hemorrhoids, Anal Fissure, Anal Fistula
- Trial name
- NCT05038605
- Testing
- Topical metronidazole, oral metronidazole
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Crohn Disease, Fistula
Anal Crohn Fistula Surgery
The purpose of this study is to demonstrate, in patients treated with adalimumab, the efficacy of proctological surgery in anoperineal fistula healing after the removal of seton drain.
- Conditions
- Crohn Disease, Fistula, Anoperineal Fistula, Anal Fistula
- Trial name
- FACC (NCT01388257)
- Testing
- All types of surgery procedures, Simple seton drain removal
- Where
- 15 sites in France
- Volunteers
- 180 people
- Sponsor
- French Society of Coloproctology
Hernia, Ventral, Intestinal Fistula
RCT of Two Noncrosslinked Porcine Acellular Dermal Matrices in Ab Wall Reconstruction
The purpose of the study is to compare the clinical outcomes of two commonly used, FDA-approved biologic meshes in hernia repair and abdominal wall reconstruction (Strattice and XenMatrix).
- Conditions
- Hernia, Ventral, Intestinal Fistula, Fibromatosis, Abdominal
- Trial name
- NCT02228889
- Testing
- Abdominal wall reconstruction with Strattice, Assess pain intensity at last office visit preoperatively, Assess pain interference at last office visit preoperatively
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Jeffrey Janis
Pancreatic Fistula
Buttressed Pancreatico-Gastrostomy for Soft Pancreas With Small Diameter Pancreatic Duct in Whipple Procedure
Post-operative pancreatic fistula after Pancreaticoduodenectomy procedure, is still a major complication that might be affected by pancreatic stump reconstruction technique. More than 60 techniques were published in literature.
- Trial name
- NCT05682768
- Testing
- Duct to Mucosa Pancreatico-Gastrostomy with trans-pancreatic transverse mattress U- Shaped sutures
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- South Valley University
Perianal Abscess, Anal Fistulas
Multicenter Study for Diagnosis and Treatment of Perianal Abscesses
Drainage of perianal abscesses is a well established treatment. Traditionally its been done in general anesthesia after the swelling has been localised its been drained with a knife.
- Conditions
- Perianal Abscess, Anal Fistulas, Incontinence
- Trial name
- NCT02306382
- Testing
- Perianal abscess drainage, 3D ultrasonography
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Umeå
Quality of Recovery
Comparison of Propofol and Sevoflurane Anesthesia on the Quality of Recovery After Ambulatory Surgery in Obese Patients
This study was designed to compare propofol intravenous anesthesia to sevoflurane inhalation anesthesia on the quality of recovery after surgery for anal fistula in obese patients.
- Trial name
- NCT05529875
- Testing
- Propofol, sevoflurane
- Where
- China
- Sponsor
- Jiangang Song
Anal Fistula, LIFT-plug
LIFT-plug vs LIFT, a RCT Trial
To validate the effect of Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug procedure for Anal Fistula Repair in 7 medical centers
- Conditions
- Anal Fistula, LIFT-plug, Healing Rate, Anal Function
- Trial name
- LIFT 02 (NCT04310800)
- Testing
- LIFT-plug technique
- Where
- 7 sites in China
- Volunteers
- 384 people
- Sponsor
- Zhen Jun Wang
Postprocedural Gastric Stasis
Gastric Emptying After Infracolic or Supracolic Gastrojejunostomy Following Pancreaticoduodenectomy
Patients undergoing whipples pancreaticoduodenectomy tend to develop delayed gastric emptying. The study compares two types of anastamosis of stomach to jejunum (supracolic and infracolic) and compares whether it influences the…
- Trial name
- NCT01191138
- Testing
- Infracolic gastrojejunal anastamosis, Supracolic gastrojejunal anastamosis
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Asian Institute of Gastroenterology, India
Crohn Disease
Dose Escalation of Allogeneic Adipose Derived Stroma/Stem Cells for the Treatment of Crohn's Fistula
Perianal fistulas are in the forefront (42 to 72, 4%) of morbid complication of Crohn's disease, affecting nearly one- third of patients and complicating abscesses in 35-48% of cases.
- Trial name
- ALLOFIST (NCT06636032)
- Testing
- AdMSC (CellReady®)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Toulouse
Anal Fistula
LIFT With or Without Injection of BM-MNCs
To improve the outcome of LIFT, some authors used a combined approach of LIFT. Pooled analysis of seven studies including 192 patients revealed a success rate of 83.5 % after combined LIFT approach.
- Trial name
- NCT05134168
- Testing
- bone marrow mononuclear cell injection, LIFT
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University