Clinical trials: Digital Ulcers
Systemic Sclerosis
ADMSCs for the Treatment of Systemic Sclerosis
Systemic sclerosis (SSc) is a rare autoimmune disease, mainly characterized by cutaneous and visceral fibrosis. Digital ulcer and sclerosing skin are commonly affected on hands, but the treatment for these manifestations are…
- Trial name
- NCT02975960
- Testing
- injection of autologous stromal vascular fraction
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- The Catholic University of Korea
Systemic Sclerosis, Digital Ulcer
Autologous Adipose Tissue in the Treatment of Systemic Sclerosis Digital Ulcers
A randomized controlled trial will be performed to confirm preliminary uncontrolled data indicating that regional adipose tissue grafting is effective in inducing digital ulcer healing in patients with systemic sclerosis.
- Trial name
- ADUL-SSc (NCT03406988)
- Testing
- Autologous fat grafting
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- ASST Gaetano Pini-CTO
Digital Ulcer of Scleroderma
Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers
Digital ulcers are one of the most prevalent complications of scleroderma (systemic sclerosis). There can be found few surveys on effect of topical agents on healing process of the ulcers.
- Trial name
- NCT02801305
- Testing
- Diltiazem Gel 2%, Nitroglycerin Ointment 2%, Vaseline
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Mohammad Ali Nazarinia
Systemic Sclerosis
CSL Behring Sclero XIII
Many patients with Scleroderma (Systemic sclerosis) experience damage to blood vessels, mainly to the small arteries. A common manifestation of this is Raynaud's phenomenon (fingers or toes turning white then blue in the cold)…
- Trial name
- NCT02551042
- Testing
- Fibrogammin®P, coagulation factor XIII concentrate (Human), 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University College, London
Systemic Sclerosis, Ulcers
Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients
The DUAL-1 study is designed as a multicenter, double-blind two-period study with an initial fixed 16-week Period 1, followed by a Period 2 of variable duration.
- Trial name
- DUAL-1 (NCT01474109)
- Testing
- macitentan 3mg, macitentan 10mg
- Where
- 77 sites in United States, Australia and 16 more
- Volunteers
- 289 people
- Sponsor
- Actelion
Systemic Sclerosis, Digital Ulcers
Digital Ulceration
The CAP study is a multicenter, observational, clinical study in patients with systemic sclerosis. The study aims at determining the usefulness of nailfold videocapillaroscopy and patient-specific disease-related factors in…
- Trial name
- CAP (NCT01377090)
- Where
- 50 sites in Austria, Belgium and 13 more
- Volunteers
- 630 people
- Sponsor
- Actelion
Pressure Ulcers, Multi-disciplinary Wound Care Teams
Pressure Ulcer Multi-disciplinary Teams Via Telemedicine (PUMTT): A Trial in Long Term Care
The purpose of this study is to evaluate the effectiveness of 'enhanced' multi-disciplinary wound care teams (MDTs) vs. 'usual' care teams in Long Term Care (LTC) facilities in Ontario for the treatment of pressure ulcers.
- Conditions
- Pressure Ulcers, Multi-disciplinary Wound Care Teams, Remote Support, Digital Wound Photography
- Trial name
- PUMTT (NCT01232764)
- Testing
- Exposure to multi-disciplinary wound care team
- Where
- Canada
- Volunteers
- 137 people
- Sponsor
- University of Toronto
Foot Ulcer, Diabetic, Diabetes Complications
Safety and Efficacy Study of MRE0094 to Treat Chronic, Neuropathic, Diabetic Foot Ulcers
This is a clinical research study of an experimental topical drug for the treatment of chronic, neuropathic, diabetic foot ulcers.
- Trial name
- NCT00312364
- Testing
- MRE0094
- Where
- 63 sites in United States
- Volunteers
- 322 people
- Sponsor
- Pfizer
Foot Ulcer, Diabetic, Diabetes Complications
Safety and Efficacy Study of MRE0094 to Treat Large, Single or Multiple, Chronic, Neuropathic, Diabetic Foot Ulcers
This is a clinical research study of an experimental topical drug for the treatment of chronic, neuropathic, diabetic foot ulcers.
- Trial name
- NCT00318214
- Testing
- MRE0094, Vehicle gel
- Where
- 19 sites in United States
- Volunteers
- 16 people
- Sponsor
- Pfizer
Raynaud's Phenomenon, Digital Ulcers
A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma
Raynaud's phenomenon (RP) associated with scleroderma is a difficult problem to treat. Many patients develop ischemic digital ulcers due to severe RP that causes considerable morbidity and adversely affects the quality of life.
- Conditions
- Raynaud's Phenomenon, Digital Ulcers, Scleroderma
- Trial name
- NCT01117298
- Testing
- Tadalafil
- Where
- 4 sites in India
- Volunteers
- 66 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Active Digital Ulcers
Sildenafil for Treatment of Digital Ulcers in Patients With Systemic Sclerosis
This is a pilot study analyzing the effect of sildenafil therapy on digital ulcers in systemic sclerosis. We want to analyze ulcer healing by measuring the size of digital ulcers and their count and analyze the effect of…
- Trial name
- Sildenafil (NCT00624273)
- Testing
- Sildenafil therapy
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Charite University, Berlin, Germany
Systemic Sclerosis
Effect of Different Iloprost Doses on Symptoms in Systemic Sclerosis
This study compared the efficacy of different dosages of long-term iloprost treatment on Raynaud's phenomenon, ulcer healing, skin thickening, and progression of internal organ sclerosis in systemic sclerosis (SSc). Methods.
- Trial name
- ILODOSE (NCT00622687)
- Testing
- iloprost, iloprost low dose, iloprost therapy up to 2 ng/kg x min
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany