Clinical trials: Diminished Ovarian Reserve
Diminished Ovarian Reserve
In Vitro Oocyte Maturation With Autologous Exosomes in Women
This study is a preliminary, prospective, randomized, controlled clinical trial designed to evaluate the safety and feasibility of supplementing in vitro maturation (IVM) media with autologous exosomes in women with diminished…
- Trial name
- Exosom2025-1 (NCT07249411)
- Testing
- MI oocytes were cultured in conventional IVM medium supplemented with 10 µg of autologous exosomes obtained using the ExoSMarT® exosome filtration system
- Where
- Venezuela
- Volunteers
- 32 people
- Sponsor
- Biotech Fertility C.A.
Diminished Ovarian Reserve (DOR), Thin Endometrium
A Randomized Controlled Study on the Effect of MRJPs on Improving Ovarian Function and Endometrial Receptivity
This study will assess the effects of the rose tablet candies produced by MRJPs on the subjects, evaluate the role of MRJPs in the ovarian function and endometrial receptivity of women, reveal the potential application value of…
- Trial name
- NCT07246733
- Testing
- Oral MRJPs Candy
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Diminished Ovarian Reserve
Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve
The goal of this observational study is to investigate the distinct tongue manifestation characteristics in patients with diminished ovarian reserve (DOR) compared to healthy individuals, and to clarify the features of tongue…
- Trial name
- CGTCMPDOR (NCT07124260)
- Testing
- gut microbiota, tongue coating microbiota, tongue picture
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University
Diminished Ovarian Reserve (DOR)
The Clinical Trial of Electro-thumbtack Needle on Live Birth Rate in Patients With Ovarian Reserve Dysfunction (DOR)
This study will include 246 patients with ovarian reserve dysfunction (DOR), who will be randomly divided into a treatment group and a control group, with 123 patients in each group.
- Trial name
- NCT07142187
- Testing
- electro-thumbtack needle
- Volunteers
- 368 people
- Sponsor
- Huazhong University of Science and Technology
Diminished Ovarian Reserve (DOR), Primary Ovarian Insufficiency (Poi)
Safety and Efficacy of Autologous Adipose-Derived Regenerative Cells (ADRCs) Injection for Improving Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) poses significant challenges to fertility and hormonal health, with limited effective treatments.
- Conditions
- Diminished Ovarian Reserve (DOR), Primary Ovarian Insufficiency (Poi), Ovarian Failure, Premature
- Trial name
- ARISE-01 (NCT07117682)
- Testing
- Autologous Adipose-Derived Regenerative Cells (ADRCs) Intraovarian Injection
- Volunteers
- 25 people
- Sponsor
- Cytori Therapeutics
Diminished Ovarian Reserve, IVF Outcomes
The Effect of VitC on IVF Outcome of DOR Patients
In the context of the accelerating aging population and the continuous decline in birth rates nationwide, delaying reproductive aging in women and protecting the fertility of women of childbearing age have become urgent issues…
- Trial name
- DORIVF-VC (NCT06794047)
- Testing
- Vitamin C
- Where
- 6 sites in China
- Volunteers
- 1,100 people
- Sponsor
- Peking University Third Hospital
Diminished Ovarian Reserve, Ovarian Failure
Study of PRP in Women With Evidence of Diminished Ovarian Reserve
The hypothesis of the study is that ovaries of women with a history of poor response to ovulation induction may benefit from exposure to growth factors known to be present in Platelet Rich Plasma (PRP).
- Trial name
- PRP4AGE (NCT04275700)
- Testing
- A-PRP
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Diminished Ovarian Reserve
Ovarian PRP for Diminished Ovarian Reserve
This prospective double-blinded randomized placebo control study aims to determine if In Vitro Fertilization (IVF) outcomes are improved by ovarian platelet-rich plasma injections (oPRP) for women diagnosed with diminished…
- Trial name
- oPRP (NCT05790655)
- Testing
- oPRP
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
Polycystic Ovary Syndrome, Diminished Ovarian Reserve
Clinical Trial of Anovulatory Infertility
This project aims to study the expression of clock genes and related proteins in follicular fluid and granulosa cells, depicting the periodic, amplitude, and phase changes of biological clock genes and related proteins in women…
- Conditions
- Polycystic Ovary Syndrome, Diminished Ovarian Reserve, Ovulation Disorder
- Trial name
- NCT06601452
- Testing
- a compound prescription of Chinese medicine
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nanjing University of Chinese Medicine
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
The Correlation Between Ovarian Function and Serum Biomarkers
The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.
- Conditions
- Premature Ovarian Insufficiency, Diminished Ovarian Reserve, Biomarker, Copper
- Trial name
- NCT06096766
- Testing
- blood test
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI)
The VL-POI-01 study is designed to evaluate the safety and efficacy of human placental mesenchymal stem cell derived exosome treatment in patients with premature ovarian insufficiency (POI) and diminished ovarian reserve.
- Trial name
- VL-POI-01 (NCT06072794)
- Testing
- VL-PX10
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vitti Labs, LLC
Diminished Ovarian Reserve
The Effeciency of NMN in Improving IVF/ICSI-ET Pregnancy Outcomes in Patients With DOR
The purpose of the study is to understand the effect of nicotinamide mononucleotide (NMN) on patients with diminished ovarian reserve and the outcomes of IVF/ICSI-ET.
- Trial name
- NCT06426355
- Testing
- NMN
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Diminished Ovarian Reserve
Study of Acupoints in Diminished Ovarian Reserve Based on Biological Characteristics
Diminished Ovarian Reserve (DOR) is characterized by decreased female fertility, menstrual disorders and perimenopausal symptoms due to sex hormone deficiency or fluctuations.
- Trial name
- NCT06395623
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xiaomei Shao
Diminished Ovarian Reserve
Efficacy of Thumb-tack Needle Treatment for Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) is characterized as an important cause of infertility. Acupuncture has been extensively used to treat female infertility.
- Trial name
- NCT06223178
- Testing
- thumb-tack needle, Basic gynecological treatment
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Xiaomei Shao
Diminished Ovarian Reserve
The Effect of "KB-120" Small Molecular Nutrient in Women With Decreased Ovarian Reserve
"KB-120" small molecular nutrient is a structural multi-molecular natural nutrient with different components. It is produced from strains and natural plant culture-medium that can be used in food and is designed according to…
- Trial name
- NCT06081257
- Testing
- "KB-120" small molecular nutrient and vitamin E, Vitamin E
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Infertility, Diminished Ovarian Reserve
The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol
Ovarian reserve defines the quantity and quality of the ovarian primordial follicular pool. Diminished ovarian reserve (DOR) indicates a reduction in the quantity of ovarian follicular pool to less than expected for age.
- Conditions
- Infertility, Diminished Ovarian Reserve, IVF
- Trial name
- NCT04447872
- Testing
- Timing of injectable gonadotropins
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Northwell Health
Diminished Ovarian Reserve
SMART Protocol vs Antagonist Protocol in IVF
This retrospective study aims to assess the effect of adding letrozole in patients who have previously undergone an IVF cycle with either an antagonist or short protocol, with patients who have undergone a second cycle of IVF…
- Trial name
- NCT05677828
- Where
- Canada
- Volunteers
- 426 people
- Sponsor
- Clinique Ovo
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
Precise Stratification of Genetic Risk of Ovarian Function Impairment
Aging is a common problem in human society at present. The fertility decline, perimenopausal symptoms and senile diseases caused by ovarian aging seriously affect women's own health, offspring's health, family and social…
- Conditions
- Premature Ovarian Insufficiency, Diminished Ovarian Reserve, Early Menopause
- Trial name
- NCT05665010
- Testing
- Genetic susceptibility
- Where
- 18 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Diminished Ovarian Reserve, Infertility, Female
Efficacy of Traditional Chinese Medicine on Ameliorating IVF-ET Outcomes of Diminished Ovarian Reserve Patients
Patients with diminished ovarian reserve (DOR) who undergo in vitro fertilization and embryo transfer (IVF-ET) are included as the research subjects.
- Trial name
- NCT05577455
- Testing
- Medical prescription before ovulation, Medical prescription after ovulation
- Volunteers
- 266 people
- Sponsor
- Peking University Third Hospital
Diminished Ovarian Reserve
A Clinical Study of Chinese Herbal Compound TJAOA101 in Therapy of Diminished Ovarian Reserve
Currently, no drugs have been developed for DOR. We developed the Chinese herbal compound TJAOA101 and has validated its effects in animals.
- Trial name
- NCT05459493
- Testing
- TJAOA101
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital