Clinical trials: Diminished Pleasure
Anxiety Disorders
FASTMAS (Fast-Fail Trials in Mood and Anxiety Spectrum Disorders) Kappa Opioid Receptor Phase 1 Study
The available treatments for patients with mood and anxiety spectrum disorders have significant limitations. This study will contribute significantly to public health by taking steps to address these limitations by aiding in the…
- Trial name
- KOR1 (NCT02218775)
- Testing
- LY2456302
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Andrew Krystal
Healthy
Chatbot Intervention Effects on Emotional Arousal in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on affective arousal in college students with elevated levels of depression and anhedonia by…
- Trial name
- NCT07671131
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Emotions, Anhedonia
Geolocation Positional System (GPS) Experience
The purpose of this study is to use smartphone technology to capture individual location emotional and cognitive data, to examine how real-world behaviors thoughts, emotions, and brain activity are related to one another.
- Conditions
- Emotions, Anhedonia, Depression
- Trial name
- NCT05991713
- Testing
- Modifying Exploration
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depression, Depressive Disorder
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information.
- Conditions
- Depression, Depressive Disorder, Major Depressive Disorder, Major Depressive Episode
- Trial name
- NCT06080646
- Testing
- cross-sectional MRI and EEG assessments (NO INTERVENTION)
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center
Anhedonia, Stress Response
Stress Trajectories and Anhedonia in Adolescence Research Study
This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence.
- Conditions
- Anhedonia, Stress Response, Adolescent Development
- Trial name
- STAARS (NCT07040449)
- Testing
- Montreal Imaging Stress Task, Trier Social Stress Test for Children
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression
Understanding Brain Reward Responses in Individuals With Major Depressive Disorder
This study will examine brain responses associated with reinforcement and reward tasks in individuals with major depressive disorder (MDD).
- Trial name
- NCT00183755
- Where
- 3 sites in United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Conduct Disorder, Depression
Anhedonia Beyond Depressive Symptoms in Children and Adolescents With Conduct Disorder
Conduct Disorder (CD) is a common psychiatric disorder among children and adolescents and is characterized by a persistent pattern of behaviors that violate the rights of others or major age-appropriate social norms and rules.
- Trial name
- NCT07849985
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Major Depressive Disorder
Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine
The main purpose of this study is to investigate the effects of ketamine on decision-making and emotion processing in a sample of individuals diagnosed with Major Depressive Disorder (MDD).
- Trial name
- NCT05327699
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Emory University
Anhedonia, Depression
Sleep and Healthy Aging Research on Depression for Younger Women
Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood.
- Trial name
- NCT03848715
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Mood, Anhedonia
Behavioral Activation Plus Savoring for University Students
The current investigation aims to examine whether a brief, two-session, virtual behavioral activation plus savoring intervention will increase daily positive emotion in university students.
- Conditions
- Mood, Anhedonia, Depression
- Trial name
- NCT05234476
- Testing
- Behavioral Activation plus Savoring, Empathic Listening
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Anhedonia in Healthy Volunteers
The Effect of an Edible Algal Extract (Ulva Lactuca) on the Component of Depression in Healthy Volunteers With Anhedonia
The effects of the seaweed extract were evaluated on the animal model equivalent of depression compared with a control group treated with the carrier (spring water) and a reference group treated with Imipramine and showed…
- Trial name
- NCT03545399
- Testing
- Ulva Lactuca
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- CEN Biotech
Major Depressive Disorder, Bipolar Disorder
Brain Insulin Resistance in Mood Disorders
The overarching aim of the study is to determine the role of insulin signaling on the neurobiological substrates subserving anhedonia within individuals with mood disorders (i.e., Bipolar Disorder (BD) and Major Depressive…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Anhedonia, Intranasal Insulin
- Trial name
- NCT03915613
- Testing
- Humulin R, Diluent
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
Brain Regulation of Emotions in People With Depression and Anhedonia
This study will use magnetic resonance imaging (MRI) to examine how the brain regulates emotions in healthy people and in patients who have major depression and anhedonia (loss of feeling of pleasure in things that normally give…
- Trial name
- NCT00059579
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Emotional Processing, Mood
Combined Blood Pressure Medication and Activity Scheduling for Low Mood
This study explores the effects of 7-day losartan (50mg) versus placebo with brief behavioural activation on emotional processing in young volunteers low in positive mood
- Trial name
- NCT07017023
- Testing
- Losartan with BA
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Oxford
ASD
Proof of Mechanism Study for the Treatment of Social Anhedonia in ASD
This project will use the experimental medicine approach of a Phase IIa Proof of Mechanism 16-week, randomized, double-blind, controlled trial of L-DOPA versus placebo administration in combination with a 16 week social skills…
- Trial name
- ACEP4 (NCT03243552)
- Testing
- Social Skills Training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity
The Experience of Affective Touch in Obesity
The aim of the present research is to verify if the pleasantness of affective touch is comparable between women with obesity and healthy women, while measuring the level of social anhedonia and the lifespan experience of…
- Trial name
- AffTouch_OB (NCT05768685)
- Testing
- Affective touch paradigm
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Depression, Depression, Postpartum
TrueBlue Clinical Study - Investigating the Use of a Mobile Phone App TrueBlue for Monitoring Depression and Anxiety
This trial will assess the safety, feasibility, acceptability, usability and agreement with validated scales of an automated mood monitoring App (TrueBlue), in adult, perinatal participants (recruited between 12 weeks of…
- Conditions
- Depression, Depression, Postpartum, Anxiety in Pregnancy, Anxiety
- Trial name
- NCT06364488
- Testing
- TrueBlue App
- Where
- 2 sites in United Kingdom
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- BlueSkeye AI
Major Depressive Disorder
tVNS Effects on Motivation in Depression
Attaining goals or rewards commonly entails response costs. In light of cost and benefits, how do participants decide what effort should be put in to give it a shot? Figuratively, you may "go with your gut", but the literal…
- Trial name
- NCT05120336
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Schizophrenia, Depression
Validating Reward-related Biomarkers (RTOC)
Deficits or abnormalities in reward processing are present in a number of psychiatric disorders. The overarching objective of the study is to conduct initial validation work towards optimising three experimental tasks - which…
- Conditions
- Schizophrenia, Depression, Motivation, Anhedonia, Physical
- Trial name
- RTOC (NCT04024371)
- Testing
- Self-rating Questionnaires, Measures of Reward processing/reinforcement learning, Additional Schizophrenia-specific Questionnaires and Interviews
- Where
- 4 sites in Germany, Greece and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Anhedonia, Cognitive Function
Pitolisant Effects on Affect and Cognition Exploratory Study (PEACE Study)
The goal of this study is to investigate the effects of selective histamine 3 antagonist pitolisant on brain function and cognition in healthy individuals. The main questions it aims to answer are: 1.
- Trial name
- PEACE (NCT05849675)
- Testing
- Pitolisant 17.8 MG [Wakix]
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oxford