Clinical trials: Disabilities, Intellectual
Autistic Spectrum Disorder, Patient Empowerment
Development and Evaluation of "Period Kits" for Adolescents With Intellectual and Developmental Disabilities
This study will involve the development, distribution, and evaluation of "period kits" for pre-menarchal adolescents with intellectual and cognitive disabilities (IDD) (e.g., autism spectrum disorder and Down syndrome) in…
- Conditions
- Autistic Spectrum Disorder, Patient Empowerment, Menstrual Discomfort
- Trial name
- NCT05497167
- Testing
- Period Kit
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Fragile X Syndrome (FXS), Creatine Transporter Deficiency
Optical Imaging in X-linked Disorders.
Fragile X syndrome (FXS, OMIM #300624) and Creatine Transporter Deficiency (CTD, #300352) are the two most common causes of X-linked intellectual disability.
- Trial name
- IMAGINER (NCT06868979)
- Testing
- Clinical assessment, Parental questionnaires, Cognitive assessment
- Where
- France
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Stress
Parent Supports Intervention Project
The purpose of this study is to evaluate the impact of two community based interventions for parents of adults with intellectual or developmental disabilities (IDD) who are requesting services.
- Trial name
- NCT01981070
- Testing
- Mindfulness Intervention for Parents, Support and Information for Parents
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Being 18 Years of Age or Older, Having a Child Registered in a Special Education School
Awareness Of Home Accident Preventıon Among Parents Of Disabled Children And Evaluation Of The Basic First Aid Training Provided
This study was conducted to assess the awareness of parents of children with disabilities regarding the prevention of home accidents and the effectiveness of the basic first aid training provided.
- Conditions
- Being 18 Years of Age or Older, Having a Child Registered in a Special Education School, Providing Care for a Child With an Intellectual Disability, Providing Care for a Visually Impaired Child
- Trial name
- NCT07698860
- Testing
- Prevention of Household Accidents and Basic First Aid Training for Accidents
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Kayseri University
Down Syndrome, Intellectual Disability
Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin
Analyze genetic and biological markers in patients with Intellectual Deficiencies (ID) of genetic origin in order to better understand the mechanisms of modified genes, cellular mechanisms, pathways involved in different…
- Trial name
- BioJeL (NCT05767203)
- Testing
- Biological samplings
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institut Jerome Lejeune
Down Syndrome
Motor Learning Through Virtual Reality Task in Individuals With Down Syndrome
Background: Down syndrome (DS) has unique physical, motor and cognitive characteristics. Despite cognitive and motor difficulties, there is a possibility of intervention based on the knowledge of motor learning.
- Trial name
- NCT02719600
- Testing
- Virtual reality
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Emotional Adjustment, Intellectual Disability
The Effects of Therapeutic Recreation Activities on Emotional Adjustment of Individuals With Intellectual Disabilities
The aim of this study was to determine the effect of Therapeutic Recreation Activities on Emotional Adjustment of Adolescents With Intellactual Disabilities.
- Trial name
- NCT04102683
- Testing
- Therapeutic recreation activity program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Selcuk University
PTSD, Trauma, Psychological
Narrative Exposure Therapy for Adults With Intellectual Disability
The purpose of the study is to identify how Narrative Exposure Therapy (NET) can be adapted for delivery with adults with mild Intellectual Disability (ID) and to explore whether NET can reduce symptoms of traumatic stress in…
- Trial name
- NCT04418752
- Testing
- Psychological therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nottingham
Down Syndrome
Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy
Background: Down syndrome is a genetic disorder that can cause heart defects and other problems in the body. People with Down syndrome are more likely to have infections, autoimmunity, and blood diseases.
- Trial name
- NCT07416201
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autism Spectrum Disorder, Intellectual Disability, Mild
Computer-Mediated Intervention to Enhance Emotional Competence in Children With Autism in Schools
Autism spectrum condition (ASC) is a neurodevelopmental disorder characterized fundamentally by social deficits. Emotional competence - the ability to express, recognize, understand, and regulate emotions - is a key aspect of…
- Trial name
- NCT05902832
- Testing
- EmotiPlay
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bar-Ilan University, Israel
Adrenoleukodystrophy, Adrenomyeloneuropathy
Modeling Macrophages Activation Pattern in X-linked Adrenoleukodystrophy, Metachromatic Leukodystrophy and Adult Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia
This study is a national, non-randomized, open-label, multi-site with minimal risk study in adult with adrenomyeloneuropathy (AMN), childhood and adult subjects with cerebral ALD (cALD), juvenile/adult metachromatic…
- Conditions
- Adrenoleukodystrophy, Adrenomyeloneuropathy, Metachromatic Leukodystrophy, Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia
- Trial name
- MATRIX (NCT04925349)
- Testing
- Blood sample collection
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome X, Down Syndrome
Frequency of Metabolic Syndrome in Down Syndrome Patients
The aim of this study is to assess the frequency of metabolic syndrome in Down syndrome patients because the prevalence of diabetes mellitus and obesity is higher in individuals with Down syndrome than in the general population.
- Trial name
- NCT00864461
- Where
- Mexico
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Intellectual Disability
The Quality of Life, Perceived Stress and Coping Ways of Caregivers of Mentally Handicapped Individuals
Disability is a dynamic, multidimensional and diverse public health problem. Although the primary care burden of the disabled is mostly on mothers, caregivers cannot find little or no support socially and they have a high risk of…
- Trial name
- NCT04790461
- Testing
- Pre-post test, face-to-face training + PMR exercise, mobile health education + PMR exercise
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Intellectual Disability
Development and Application-Smart Football for Movement Evaluation and Training in the Special Education Population
Children with disabilities are frequently ignored by the general population, hence the development of movement evaluation and training devices for use in special education settings are relatively overlooked.
- Trial name
- NCT02486081
- Testing
- smart soccer ball
- Where
- 2 sites in Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy Volunteers, Down Syndrome
Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease
Leucettinib-21 First-in-Human Phase 1 Study in 6 Parts: Single (Part 1 and 5) and Multiple (Part 3 and 6) Ascending Doses, and Food-Effect (Part 2) in Healthy Subjects, and Single Dose (Part 4) in People with Down Syndrome (DS)…
- Conditions
- Healthy Volunteers, Down Syndrome, Alzheimer's Disease
- Trial name
- LEUCETTA (NCT06206824)
- Testing
- Leucettinib-21
- Where
- France
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Perha Pharmaceuticals
Angelman Syndrome, Prader-Willi Syndrome
Development of a Newborn Screening Assay for Angelman Syndrome and Prader-Willi Syndrome
The overall purpose of this project is to establish the capability of screening for Angelman syndrome (AS) and Prader-Willi syndrome (PWS) in public health newborn screening (NBS) programs, with an aim of developing and…
- Trial name
- NCT05783791
- Testing
- Newborn Screening Assay
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aneuploidy, Trisomy 21
Prenatal Test for Fetal Aneuploidy Detection
The purpose of this study is to develop and evaluate a blood test for pregnant women for detection of fetal aneuploidy.
- Trial name
- NCT01256606
- Where
- 6 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Roche Sequencing Solutions
Stereotyped Behavior, Mental Retardation
Phase II Study of Stereotypes and Mental Retardation: Neurobiological Basis
OBJECTIVES: I. Determine differences between persons with repetitive behavior disorders and matched controls on measures of motor control relevant to basal ganglia pathophysiology. II.
- Trial name
- NCT00004300
- Testing
- bromocriptine, sertraline hydrochloride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Down Syndrome
Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises
This randomized clinical trial investigates the comparative effects of Cuevas Medak Exercises Vs Rebound Exercises on physical fitness in DS.
- Trial name
- DownSyndrome (NCT07248449)
- Testing
- Cuevas Medak Exercises
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Intellectual Disability, Exercise
Effects of Guided Exercise on Functional Performance and Independence in Adults With Intellectual Disability
Adults with intellectual disabilities (ID) have significantly lower levels of fitness compared to the general population. The health benefits of enhanced muscular strength in the general population are well established.
- Conditions
- Intellectual Disability, Exercise, Obesity
- Trial name
- NCT04616638
- Testing
- Resistance Training for Empowerment (RT-POWER), A traditional RT intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Delaware