Clinical trials: Disabilities, Intellectual
Down Syndrome
Remote Exercise Study for Individuals With Down Syndrome
This pilot study aims to test whether remote delivery of the exercise intervention provides a sufficient training stimulus. This pilot study will be remote and online-only, and will have no in-person interaction, data collection…
- Trial name
- NCT04647851
- Testing
- Remote exercise intervention Down syndrome
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Rare Intellectual Disabilities
Multi-Omics and IPSCs to Improve Diagnosis of Rare Intellectual Disabilities
Background Genetic factors play a major role in intellectual disability (ID) but the underlying cause is not determined in many cases.
- Trial name
- MIDRID (NCT03635294)
- Testing
- Blood sample
- Where
- 6 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Angers
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Technology
Anti-wandering System for People With Intellectual Disability
The study has 6 research questions regarding the use of the anti-wandering system in day activity centre cum hostel for persons with intellectual disabilities: Primary study questions: 1.
- Trial name
- NCT05785702
- Testing
- The anti-wandering system
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Down Syndrome
Effect Of Pilates On Postural Control And Balance In Children With Down's Syndrome
Down's syndrome (DS) is a genetic condition characterized by the presence of an extra chromosome 21, leading to various clinical symptoms.
- Trial name
- NCT05969873
- Testing
- Pilates exercise, Balance training
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Borderline Intellectual Functioning (BIF), Intellectual Disability
Co-design of an AI Rehabilitation Program for Children With Borderline Intellectual Disorder
Co-design of an AI Rehabilitation Program for Children With Borderline Intellectual Disorder
- Trial name
- NCT07625592
- Testing
- Tablet-Based AI Cognitive and Language Rehabilitation Program
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Phelan-McDermid Syndrome, Autism Spectrum Disorder
Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome
The purpose of this study is to comprehensively characterize PMS using standardized medical, cognitive, and behavioral measures and to track the natural history of the syndrome using repeated longitudinal assessments.
- Conditions
- Phelan-McDermid Syndrome, Autism Spectrum Disorder, Intellectual Disability
- Trial name
- NCT02461420
- Where
- 5 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Down Syndrome, Prenatal Stress
Amniotic Fluid Ischemia Modified Albumin as a Novel e Prenatal Diagnostic Marker for Down Syndrome
Down syndrome is the most common genetic disorder in the society that causes mental retardation. Today, screening tests (combined test, triple screening, ultrasonography and age) are performed for the diagnosis of down syndrome…
- Conditions
- Down Syndrome, Prenatal Stress, Cytokines
- Trial name
- NCT04293380
- Testing
- amniosyntesis
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Down Syndrome
Gynaecological Follow-up of Women With Down Syndrom Aged 18 to 30 in France
Gynaecological check-ups for women are recommended in France. However, some groups of the population are affected by a lack or absence of medical surveillance.
- Trial name
- Gyn-T21 (NCT06117228)
- Testing
- Data collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Université de Reims Champagne-Ardenne
Physical Disability, Intellectual Impairment
HIIT Versus High-Volume Training in Competitive Para Swimmers
This study compared the effects of four weeks of reduced-volume high-intensity interval training and higher-volume moderate-intensity swimming training on repeated-sprint ability, physiological responses, and body composition in…
- Conditions
- Physical Disability, Intellectual Impairment, Athletic Performance, Exercise Training
- Trial name
- NCT07862036
- Testing
- Reduced-Volume High-Intensity Interval Swimming Training, Higher-Volume Moderate-Intensity Swimming Training
- Where
- Greece
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Fragile X Syndrome
Cognitive Training for Fragile X Syndrome
Individuals with fragile X syndrome (FXS) demonstrate profound executive function deficits that interfere with learning, socialization and emotion regulation.
- Trial name
- NCT02747394
- Testing
- Working Memory Training
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of California, Davis
Physical Conditioning, Human
Effect of Rhythmic Gymnastics Training in Children With Down Syndrome
Some of the clinical characteristics of people with Down syndrome (DS) are orthopedic, cardiovascular, neuromuscular, visual, cognitive and perceptual disorders, which directly affect the quality of their movements.
- Trial name
- NCT06284707
- Testing
- swimming training, rhythmic gymnastics training
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Rett Syndrome
Esketamine for the Treatment of Rett Syndrome
The goal of this interventional study is to learn about the efficacy and safety of Esketamine for treating children with Rett syndrome (RTT).
- Trial name
- NCT06199700
- Testing
- Esketamine hydrochloride
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Children's Hospital of Fudan University
Mental Retardation
Effect of Valproate on Propofol
The aim of this study is to evaluate the effect of valproate on the required dose of propofol for sedation in patients with mental retardation.
- Trial name
- NCT01170377
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Okayama University
Smith-Lemli-Opitz Syndrome
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
This study will evaluate the safety and effectiveness of simvastatin in treating children with Smith-Lemli-Opitz syndrome (SLOS).
- Trial name
- NCT00064792
- Testing
- Simvastatin Susp., OraPlus
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Forbes Porter, M.D.
Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II
Parental Coping With Challenging Behavior in Mucopolysaccharidosis Type I-III
The study quantitates behavioral challenges in mucopolysaccharidosis type I-III and parental coping strategies
- Conditions
- Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II, Mucopolysaccharidosis Type III, Behavior Disorders
- Trial name
- NCT03161171
- Testing
- This is an observational study
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University Hospital Heidelberg
Intellectual Disability
Search for Phenotype-modifying Genes in Patients With Intellectual Disabilities.
Each form of intellectual disability under study is a rare disease in its own right, and it is therefore difficult to study the variability of its expression.
- Trial name
- GWAS-2DI (NCT06706934)
- Where
- France
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Down Syndrome
Effects of Lower Limb Fitness Program in Children With DS
Down Syndrome is a congenital disorder resulting from the trisomy of the human chromosome 21, which will determine, among other characteristics, intellectual disability and growth retardation.
- Trial name
- NCT06407895
- Testing
- Lower Limb Fitness Program, Routine Therapy
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Developmental Disabilities, Fragile X Syndrome
Teaching Math Skills to Individuals With Fragile X Syndrome
Children with FXS are predisposed to manifesting a particular profile of intellectual strengths and weaknesses, including specific deficits in math, visual-spatial skills, executive functioning, and social skills.
- Trial name
- NCT01204151
- Testing
- discrete-trial training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Developmental Disabilities, Weight Loss
Weight Management for Adolescents With IDD
The goal of this study is to explore the impact of two different diets (conventional vs. enhanced stop light) and two different delivery systems (face-to-face vs.
- Conditions
- Developmental Disabilities, Weight Loss, Body Weight, Down Syndrome
- Trial name
- IDDAdol (NCT02561754)
- Testing
- Enhanced Stop Light Diet (eSLD), Conventional Diet (CD), Face-to-face (FTF)
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Kansas Medical Center
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