Clinical trials: Disability, Evaluation
Child Development Disorder
Craniosacral Test and Primitive Reflexes in Infant Neurodevelopment
Question(s): Can active primitive reflexes (APR) and cranial blocks (CB) in healthy children interfere with neurological balance causing psycho-behavioral and cognitive dysfunctions? Design: Cross-sectional and descriptive study…
- Trial name
- NCT05190029
- Testing
- Series of questions to parents of children in a virtual form., Intervention by teachers, Physiotherapeutic evaluation
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Clinica Gema Leon
Predisposition, Genetic, Cancer Childhood
EXOme Rare Cancers in Children (EXOCARE)
Other than high-dose radiation and previous chemotherapy, few strong risk factors have been identified as causes of childhood cancer.
- Conditions
- Predisposition, Genetic, Cancer Childhood, Development Delay
- Trial name
- EXOCARE (NCT03472807)
- Testing
- Collection of blood sample or saliva, Collection of a tumor sample taken before the participation of the patient in study, Collection of blood sample if tumor sample is not available
- Where
- 27 sites in France, Reunion
- Volunteers
- 169 people
- Sponsor
- University Hospital, Angers
Mastocytosis, Indolent Systemic
Evaluation of the DALY on a Cohort of Patients With Indolent Systemic Mastocytosis
Mastocytosis is a group of pathologies characterized by the accumulation and/or clonal proliferation of abnormal mast cells in various organs.
- Trial name
- DALY-MAST (NCT05923372)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Toulouse
Rib Fracture
Evaluation of Surgical Treatment on Pain and Disability for Chronic, Non-healing Rib Fracture
Individuals with non-healing rib fractures may experience significant pain and disability. This is called rib fracture non-union, an unusual problem and one that most physicians have little experience with.
- Trial name
- NCT00774618
- Testing
- Resection with or without plate fixation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Oregon Health and Science University
Sjogren-Larsson Syndrome (SLS)
Sjogren-Larsson Syndrome: Natural History, Clinical Variation and Evaluation of Biochemical Markers
Sjogren-Larsson syndrome (SLS) is a rare genetic disease in which patients typically exhibit ichthyosis (dry, scaly skin), intellectual disability, spasticity, seizures and a distinctive maculopathy.
- Trial name
- SLS (NCT01971957)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Social Exclusion, Chronic Disease
Protocol for a Low Threshold Exercise Intervention for Women Experiencing Homelessness and Addiction.
Background: Frailty is a complex multi-dimensional state of increased vulnerability to adverse health outcomes and is usually associated with older age but there is growing evidence of accelerated ageing and frailty in…
- Conditions
- Social Exclusion, Chronic Disease, Physical Disability, Addiction
- Trial name
- LEAP-W (NCT06264895)
- Testing
- Exercise
- Where
- Ireland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Glioblastoma Multiforme, Cognition Disorders
Bevacizumab and Lomustine for Recurrent GBM
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Conditions
- Glioblastoma Multiforme, Cognition Disorders, Disability Evaluation
- Trial name
- NCT01290939
- Testing
- bevacizumab, lomustine, DNA methylation analysis
- Where
- 2 sites in Netherlands
- Volunteers
- 592 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
Сohort Study to Evaluate Exacerbations, Respiratory Symptoms, Physical Exercise Intolerance and Lung Functions Among Participants Who Use IQOS With Heatsticks Compared to Smokers of Conventional Cigarettes
This study evaluates frequency of exacerbations, respiratory symptoms, physical exercise intolerance and abnormal lung functions among participants who use IQOS with heatsticks compared to smokers of conventional cigarettes
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency, Physical Disability, Respiratory Disease
- Trial name
- NCT03383601
- Testing
- Heated Tobacco product IQOS/heatstick, Smoking combustible cigarettes
- Where
- Kazakhstan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Kazakhstan Academy of Preventive Medicine
Intellectual Disability, Attention Deficit Hyperactivity Disorder
Evaluation of a Home-based Parenting Support Program: Parenting Young Children
Background: Parents with intellectual and developmental disabilities (IDDs) have a tendency to provide insufficient caregiving and often need parenting support to prevent neglect and child removal.
- Conditions
- Intellectual Disability, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
- Trial name
- PYC (NCT05935722)
- Testing
- Parenting Young Children, Treatment as Usual
- Where
- 5 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Örebro University, Sweden
Meniere Disease, Psychosocial Problem
Comprehensive Evaluation in Patients With Meniere's Disease
The aim of our study is to determine the severity of the disease in people with Meniere's Disease; physical conditions such as balance, posture, pain, physical activity level, neck joint range of motion, proprioception; to…
- Conditions
- Meniere Disease, Psychosocial Problem, Physical Disability, Quality of Life
- Trial name
- NCT05844657
- Testing
- Case report form, Tinnitus disability scale, A feeling of fullness and/or pressure in the ear
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Problem Behavior, Developmental Delay
Problem Behavior Assessment and Intervention in IDEA Part C Services
The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services.
- Conditions
- Problem Behavior, Developmental Delay, Developmental Disability
- Trial name
- NCT06771284
- Testing
- Function-based assessment and intervention
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Amputation, Functional Limitation
Impact Evaluation of Breizh Fabribus Intervention for Personalized Assistive Technology Creation or Adaptation
In France, more than 14 million individuals report severe functional limitations, and nearly 5 million struggle with essential daily activities.
- Conditions
- Amputation, Functional Limitation, Autonomy of Older People, Handicaps Physical
- Trial name
- BFB-IMPACT (NCT07314099)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondation Ildys
Hip Osteoarthritis, Knee Osteoarthritis
Prevalence,Natural History,Prognosis Factor,QualityofLife,Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France
The aim of the project is to assemble and to follow on a 10-year period a nationwide representative sample of lower limb OA patients.
- Trial name
- KHOALA (NCT00481338)
- Testing
- X-rays, biological samples, medical information about osteoarthritis
- Where
- 6 sites in France
- Volunteers
- 878 people
- Sponsor
- Central Hospital, Nancy, France
Dyslexia, Reading Disorder
Group-based Training for Parents of Children With Dyslexia
Children with dyslexia show a variety of comorbid disorders like behavior and adaptive disorders, hyperkinetic and anxiety disorders. Raising and educating a child with dyslexia is a challenging task for parents.
- Conditions
- Dyslexia, Reading Disorder, Reading Disability, Developmental Reading Disorder
- Trial name
- NCT02107534
- Testing
- parent training (dyslexia)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Heidelberg Medical Center
Down Syndrome, Autonomic Dysfunction
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS).
- Trial name
- DIVE (NCT07238465)
- Testing
- Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dystrophinopathy, Muscular Dystrophies
VirtualPark_Pediatric
The goal of this clinical trial is to assess the effects of a dual-task, multimodal training program on slowing functional motor decline in children and adolescents with neuromuscular disorders.
- Conditions
- Dystrophinopathy, Muscular Dystrophies, Congenital Myopathies
- Trial name
- NCT07580365
- Testing
- Dual-task cycling, Standard therapy
- Where
- 4 sites in Italy
- Volunteers
- 22 people
- Sponsor
- Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato
Aneuploidy, Down Syndrome
Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies
Pregnant women with low risk indicators for fetal chromosomal aneuploidy will be enrolled. Study blood will be collected in the first or second trimester at a scheduled prenatal screening visit, processed to plasma, and stored…
- Conditions
- Aneuploidy, Down Syndrome, Noninvasive Prenatal Screening
- Trial name
- NCT01597063
- Testing
- SEQureDx Trisomy Test
- Where
- 27 sites in United States
- Volunteers
- 3,333 people
- Sponsor
- Sequenom, Inc.
Leber's Hereditary Optic Neuropathy (LHON)
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection
Leber's hereditary optic neuropathy (LHON) is a rare mitochondrial genetic disorder characterized by optic nerve atrophy due to the degeneration of retinal ganglion cells, which leads to acute visual loss.
- Trial name
- NCT05555784
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Argo Sante
Mobility Limitations
Experimental Control Investigation of the Impact of Assistive Technology on the User-caregiver Dyad: a Multi-site Trial
The purpose of this study is to determine the effectiveness of an assistive technology updating and tune up intervention on users and their caregivers.
- Trial name
- ATUTI (NCT00927706)
- Testing
- Assistive technology updating and tune up intervention
- Where
- 4 sites in Canada
- Volunteers
- 88 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Mental Health Conditions, Developmental Disability
Evaluation of Telehealth Services on Mental Health Outcomes for People With Intellectual and Developmental Disabilities
Roughly 40% of those with intellectual and developmental disabilities (IDD) have mental health needs, which is twice the national average.
- Trial name
- NCT05336955
- Testing
- Intake and quarterly assessment:, Consultation & coping skills coaching:, 24-hour urgent crisis response and intervention:
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- University of New Hampshire