Clinical trials: Disability, Evaluation
Aneuploidy, Trisomy 21
Non-Invasive Chromosomal Evaluation of Trisomy Study
This study is being conducted to provide clinically annotated samples to support continued improvements in the Ariosa Test content, methodology, specimen processing and quality control.
- Conditions
- Aneuploidy, Trisomy 21, Trisomy 18, Trisomy 13
- Trial name
- NICHE (NCT02201862)
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Cindy Cisneros
Intellectual Disability, Healthy Subjects
Bladder and Bowel Functions, Participation and Quality of Life in Children With Intellectual Disabilities
Many neurodevelopmental, psychiatric, and medical disorders are commonly associated with intellectual disability. The presence of neurodevelopmental and psychiatric (NDP) comorbidities has been reported to negatively impact the…
- Trial name
- NCT07059858
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Abant Izzet Baysal University
Cerebral Palsy, Spine Deformity
Spine of Caregivers of Children with Cerebral Palsy
The purpose of this study was to assess pain (rest, activity, and night pain using the Visual Analog Scale), disability (neck using the Neck Disability Index; lumbar using the Oswestry Disability Index), and curvature (cervical…
- Trial name
- NCT06443398
- Testing
- There is no intervention in the study
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Duchenne Muscular Dystrophy (DMD)
Factors Influencing Physical Activity Levels in Children With Duchenne Muscular Dystrophy: An ICF-CY-Based Study
Duchenne Muscular Dystrophy (DMD) is a neuromuscular disease characterized not only by progressive muscle weakness but also by cognitive, behavioral, and psychosocial impairments.
- Trial name
- NCT07369609
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Frailty Syndrome, Aging
Optimizing Prevention of Hospital-Acquired Disability Through Multidomain Interventions
The aim of this study is to assess whether a multidomain, multidisciplinary intervention (MDI), enhanced by technological solutions, effectively improves the functional and cognitive status of older hospitalized patients at risk…
- Trial name
- OPTIMAge-IT (NCT06611228)
- Testing
- Multidomain Interventions
- Where
- Italy
- Volunteers
- 288 people
- Sponsor
- University of Milano Bicocca
Inclusive Education
A Transferability Study on the Conditions for a Successful Inclusive Education
The investigators are conducting a realist evaluation study with a multi-case and qualitative design. The study aims to identify the conditions that promote successful students with disabilities inclusive education at school.
- Trial name
- TIAP (NCT06378307)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Mastocytosis, Indolent Systemic
Evaluation of the DALY on a Cohort of Patients With Indolent Systemic Mastocytosis
Mastocytosis is a group of pathologies characterized by the accumulation and/or clonal proliferation of abnormal mast cells in various organs.
- Trial name
- DALY-MAST (NCT05923372)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Toulouse
Physical Frailty, Physical Disability
Multidomain Intervention to Prevent Disability in Elders
Prevention of physical disability represents a major priority for the public health system. Physical disability is the final result of a complex cascade of negative events occurring at different levels (i.e., environmental…
- Conditions
- Physical Frailty, Physical Disability, Mobility Disability
- Trial name
- MINDED (NCT02082171)
- Testing
- Multidomain intervention
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Down Syndrome
Trisomy 21 in Adulthood
Trisomy 21 or Down syndrome, is the most common genetic cause of cognitive disability. Currently, in Alsace, the birth prevalence is about 1 in 1600 live births, which means 10 liveborns with Down syndrome each year.If screening…
- Trial name
- NCT01663675
- Testing
- karyotype
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Neck Pain
Comparison of Two Spinal Manipulation Treatments in Patients With Chronic Mechanical Neck Pain
There is enough evidence to suggest that the spinal manipulation of the upper cervical spine and cervicothoracic spine are effective in decreasing neck pain.
- Trial name
- NCT04268667
- Testing
- Spinal manipulation
- Where
- Spain
- Volunteers
- 186 people
- Sponsor
- Clínica Ciudad de Almería
Stroke
SaeboGlove Therapy for Severe Upper Limb Disability and Severe Hand Impairment After Stroke
The study will aim to determine whether 6-weeks of using a SaeboGlove independently (with or without help from a carer) improves upper limb function (measured using the Action Research Arm Test score) in comparison to usual care…
- Trial name
- SUSHI (NCT04007315)
- Testing
- SaeboGlove therapy, Usual care
- Where
- 3 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- NHS Greater Glasgow and Clyde
Mucopolysaccharidosis Type II, Metabolic Diseases
A Multi-cohort Study of the Tolerance, Safety, and Pharmacokinetics of GNR-055 in Healthy Volunteers
It is a phase I open-label single-dose, dose-escalation cohort study to evaluate of the tolerance, safety, and pharmacokinetics of GNR-055 in healthy volunteers
- Trial name
- NCT04539340
- Testing
- GNR-055
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AO GENERIUM
Down Syndrome
Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome
The purpose of this 16-week research study is to determine whether a drug called memantine hydrochloride (memantine) has the potential to help improve memory and other cognitive abilities of young adults with Down syndrome (DS).
- Trial name
- NCT01112683
- Testing
- Memantine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Colorado, Denver
Intellectual Disabilities With Other Behavioral Symptoms, Acceptance Processes
Evaluation of an ACT and PBS Group for Parents and Education Staff
Parents and education staff who work with children with intellectual disabilities (ID) are known to be at a higher risk of experiencing psychological distress.
- Conditions
- Intellectual Disabilities With Other Behavioral Symptoms, Acceptance Processes, Psychological Distress, Burnout, Professional
- Trial name
- NCT03917329
- Testing
- ACT and PBS group workshop
- Where
- 2 sites in United Kingdom
- Volunteers
- 37 people
- Sponsor
- University of Edinburgh
Abnormalities, Failure to Thrive
Evaluation of Patients With Unresolved Chromosome Abnormalities
The purpose of this research is to study a new way to test for chromosome abnormalities. Chromosomes are strands of DNA (the genetic material in the cell nucleus) that are made up of genes-the units of heredity.
- Conditions
- Abnormalities, Failure to Thrive, Mental Retardation, Microcephaly
- Trial name
- NCT00001639
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Generalized Mental, Social and/or Motor Disability
Impact Assessment of SALSA (Sensing and Automation for Freedom, Security, Autonomy) Technological Solutions
This study evaluates the impact of assistive technologies designed to improve the independence and safety of adults with disabilities living in shared residential environments.
- Trial name
- NCT07066202
- Testing
- No intervention is planned in this study. Only the assessment of a specific condition.
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Dyslexia
Sensory Integration Therapy in Children With Dyslexia
The aim of this study is to examine the sensory and functional effects of sensory integration therapy in children with dyslexia according to the Model of Human Occupation (MOHO).
- Trial name
- Dyslexia (NCT04740853)
- Testing
- Sensory Integration Therapy+Special Education
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Biruni University
Decision Making, Critical Illness
Critically Ill Patient's Capacity
How to determine the decision-making capacity of critically-ill patients remain unclear. The investigator study the differences between standardised evaluation and subjective medical evaluation.
- Trial name
- Capacity (NCT01956045)
- Testing
- Patient's capacity
- Where
- France
- Volunteers
- 215 people
- Sponsor
- University Hospital, Clermont-Ferrand
Mental Health Wellness 1
Health Promotion on Young Adults With High Risk Disability for Mental Health
1. The positive outcomes reported by participants in experimental group after two weeks of interventions will be significantly better than before interventions. 2.
- Trial name
- HPMI (NCT01740167)
- Testing
- health promotion lifestyle program
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Social Exclusion, Chronic Disease
Protocol for a Low Threshold Exercise Intervention for Women Experiencing Homelessness and Addiction.
Background: Frailty is a complex multi-dimensional state of increased vulnerability to adverse health outcomes and is usually associated with older age but there is growing evidence of accelerated ageing and frailty in…
- Conditions
- Social Exclusion, Chronic Disease, Physical Disability, Addiction
- Trial name
- LEAP-W (NCT06264895)
- Testing
- Exercise
- Where
- Ireland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College