Clinical trials: Disbiosis
Anterior Blepharitis
Ocular Dysbiosis in Eyelid Disease
The goal of this observational study is to determine the presence and prevalence of fungal organisms in four distinct blepharitis populations.
- Trial name
- ODYSSEY (NCT07869498)
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Brent Kramer
Constipation, End Stage Renal Disease on Dialysis
Effects of Synbiotics Supplementation on the Uremic Toxin Indoxyl Sulfate Level and Constipation in End-stage Renal Disease Patients Undergoing Hemodialysis
This is a double-blind, placebo-controlled, randomized clinical trial conducted to evaluate the effects of synbiotics supplementation on the level of the uremic toxin indoxyl sulfate, symptoms of constipation, and…
- Trial name
- NCT04527640
- Testing
- Synbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Impaired Glucose Tolerance
Effects of Artificial Sweeteners on Gut Microbiota and Glucose Metabolism
The Objectives of this study is to determine the effect(s) of daily non-caloric artificial sweetener (NAS) consumption (sucralose or aspartame) on the composition of the bacteria and also to determine the changes in glucose…
- Trial name
- NCT02569762
- Testing
- Sucralose-Aspartame, Aspartame-Sucralose
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Kidney Disease, Chronic, Renal Insufficiency, Chronic
Probiotic Supplementation and Disease Progression in CKD: A Randomized Trial
The goal of this clinical trial is to learn whether probiotic supplementation can slow disease progression in patients with moderate to severe chronic kidney disease (CKD).
- Conditions
- Kidney Disease, Chronic, Renal Insufficiency, Chronic, Gut Dysbiosis, Uremic Toxins
- Trial name
- PRO-CKD (NCT06863194)
- Testing
- Probiotic Supplementation (Lactobacillus plantarum)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Polycystic Ovary Syndrome
The Role of Dysbiosis of Gut Microbiota in the Pathogenesis of PCOS.
Polycystic ovary syndrome (PCOS) has a significant impact on women's health, but its pathogenesis is not yet clear. Dysbiosis of gut microbiota may play a role in the pathological change of PCOS.
- Trial name
- NCT03843736
- Testing
- Lifestyle intervention, Probiotic Agent, Oral contraceptive
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Acne Vulgaris
Facial Skin Microbiome in Patients With Moderate-to-Severe Acne Vulgaris Treated With Isotretinoin
Acne vulgaris is associated with changes in the facial skin microbiome, but longitudinal microbiome changes during isotretinoin therapy remain incompletely understood.
- Trial name
- FACEMICRO (NCT07834138)
- Testing
- ISOtretinoin 10 MG
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Dysbiosis, Cardiometabolic Health Indicators
Almonds, Gut Microbiome and Kids
This 8-week parallel-arm randomized controlled trial (N=70; ages 6-13) will determine the impact of daily almond butter consumption on gut microbiome composition and function, intestinal barrier integrity, and cardiometabolic…
- Trial name
- NCT07636850
- Testing
- Creamy Richards 100% Almonds! Creamy Natural Almond Butter, Cadbury Milk Chocolate Spread
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida State University
Chronic Periodontitis, Periodontal Bone Loss
Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection.
The aim of the study is to develop an in vitro model of growth of oral biofilms, and validate xCELLigence system for the selection of an effective antibiotic treatment for each patient.
- Conditions
- Chronic Periodontitis, Periodontal Bone Loss, Resistance Bacterial
- Trial name
- NCT03863249
- Testing
- SCALE AND ROOT PLANING, ADJUNTIVE ANTIBIOTICS, MICROBIAL SAMPLING
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- University of Valencia
Acute Leukemia in Remission, Myelodysplastic Syndromes
Faecal Microbiota Transplantation After Allogeneic Stem Cell Transplantation
The aim of this study is to assess the Fecal Microbiota Transplantation (FMT) efficacy in the prevention of allogeneic hematopoietic stem cell transplantation (allo-HSCT) complications and particularly Graft versus Host Disease…
- Conditions
- Acute Leukemia in Remission, Myelodysplastic Syndromes, Myeloproliferative Syndrome, Hodgkin Lymphoma
- Trial name
- TMF-Allo (NCT04935684)
- Testing
- Fecal Microbiota Transplantation
- Where
- 20 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Surgical Site Infection
INtestinal Dysbiosis and TRanslocation of Bacteria in Patients Undergoing Surgery
The goal of this observational study is to contribute to a better understanding of the perioperative kinetics of intestinal microbial composition and association with surgical site infections.
- Trial name
- INTRA (NCT05775341)
- Testing
- No Intervention
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Allergic Rhinitis
The Dysbiosis of the Intestinal Microbiota in Individuals With Allergic Rhinitis (MICRORIN)
Allergic rhinitis (AR) is triggered by environmental allergens such as pollen and mites, and is associated with several symptoms such as itching and nasal congestion, sneezing or tearing and redness of the eyes.
- Trial name
- MICRORIN (NCT03946553)
- Where
- Spain
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Atrial Fibrillation (AF), Obesity (Disorder)
Improving Outcomes After AF Ablation in Obese Patients
Improving Outcomes After AF Ablation in Obese Patients
- Trial name
- OBESE-AF (NCT07618741)
- Testing
- Cardiac Rehabilitation and Lifestyle Modification, Usual Care
- Where
- Taiwan
- Volunteers
- 520 people
- Sponsor
- National Taiwan University Hospital
Stroke, Ischemic, Dysbiosis
A Randomized Double Blinded Placebo Controlled Study on the Effects of Dietary Supplementation With a Probiotic on Stroke Patients
The aim of this study is to determine the effects of an intervention using a commercially available probiotic in a cohort of acute stroke patients.
- Trial name
- PRISE (NCT04954846)
- Testing
- OMNi-BiOTiC SR-9
- Where
- Germany
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
GERD, Dysbiosis
How Reflux Medications Affect the Microbiome of Infants
The changes in the organisms making up the gut microbiota in infants who are taking anti-acid reflux medications (histamine 2 receptor antagonists) as compared to infants who are not taking these medications is not well-studied…
- Trial name
- NCT03747991
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Chronic Granulomatous Disease, Inflammatory Bowel Disease
Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations
Background: PIDD stands for primary immune dysregulation. It is a general term that includes many different inherited immune system disorders. The immune system is the part of the body that helps fight disease and infection.
- Trial name
- NCT03278912
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Psoriasis
INulin-type Fructans-induced Gut Microbiota Modulation Impact on GUT-SKIN Axis Parameters in Psoriasis
There is increasing evidence of a strong, bidirectional correlation between the gut and the skin, that associates gastrointestinal health with skin homeostasis and allostasis.
- Trial name
- INGUTSKIN (NCT05971992)
- Testing
- Chicory-derived inulin-type β-fructans, Maltodextrin
- Where
- 2 sites in Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Polish Academy of Sciences
Clostridial Infection, Dysbiosis
Safety and Efficacy of FMT in Individuals With One or More Recurrences of Clostridium Difficile Associated Disease (CDAD)
Multi-center, randomized, placebo controlled, partially blinded trial comparing the safety and efficacy of fecal microbiota transplantation versus placebo both delivered by rectal enema in subjects 18 years of age or older with…
- Conditions
- Clostridial Infection, Dysbiosis, Probiotic Therapy
- Trial name
- NCT03548051
- Testing
- Fecal Microbiota Transplantation (FMT), Saline
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anorexia Nervosa
Discovering New Insights Into Anorexia Nervosa: Influence of MicrObial DysbiosiS (DIAMOnDS)
This study will investigate the link between the gut microbiota, the occurrence of the central adiposity phenotype, and the patients' fear to regain weight in anorexia nervosa.
- Trial name
- DIAMOnDS (NCT06043154)
- Testing
- Patients with severe to extreme anorexia nervosa admitted to hospital for refeeding
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital