Clinical trials: Disc Degeneration;Cervical
Degenerative Disc Disease in Cervical Spine
Osteocel® Plus in Anterior Cervical Discectomy and Fusion (ACDF)
This is a prospective, non-randomized multi-center study to compare the use of Osteocel Plus in subjects who receive ACDF surgery at one or two levels.
- Trial name
- NCT00942045
- Testing
- Biologic - Osteocel Plus
- Where
- 17 sites in United States
- Volunteers
- 182 people
- Sponsor
- NuVasive
Radiculopathy, Cervical, Myelopathy Cervical
Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease
The goal of this pilot clinical trial is to test the safety and preliminary performance of the ZetaFuse Bone Graft in patient requiring fusion of the C3-C7 vertebral bones due to pain or loss of neurological function.
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Neurological Abnormality, Disc Disease
- Trial name
- NCT05971329
- Testing
- Cervical Fusion (ZetaFuse™ Bone Graft)
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zetagen Therapeutics, Inc
Cervical Disc Degenerative Disorder, Cervical Fusion
Post-market Observational Clinical Study With the CE-marked Implantable Class IIb Medical Device "ITC CERVICAL"
The goal of this observational post-market study is to evaluate the clinical performance and safety of the ITC CERVICAL device, a CE-marked implantable cervical interbody fusion cage, in adult patients undergoing anterior…
- Trial name
- NCT07556978
- Where
- 2 sites in Italy
- Volunteers
- 32 people
- Sponsor
- MT Ortho s.r.l.
Degenerative Disc Disease, Trauma Injury
A Safety Study on Posterior Pedicle Screw System
The goal of this study is to assess the MUST MINI system safety in patient who will undergo a posterior cervical spine fusion intervention.
- Conditions
- Degenerative Disc Disease, Trauma Injury, Tumor
- Trial name
- MUST MINI PMS (NCT05821920)
- Testing
- MUST MINI system
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Medacta International SA
Cervical Degenerative Disc Disease
The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery
A multicenter, prospective, non-randomized, historically controlled study. To demonstrate the Synergy Disc is at least as safe and effective as conventional anterior cervical discectomy and fusion (ACDF) to treat cervical…
- Trial name
- NCT05740176
- Testing
- Anterior Cervical Discectomy and Fusion
- Where
- 23 sites in United States
- Volunteers
- 200 people
- Sponsor
- Synergy Spine Solutions
Cervical Disc Degeneration
Real World Data Collection on the Synergy Cervical Disc
This trial is a real world data (RWD) collection observational study, comprised of both prospective and retrospective arms, that will examine the safety and effectiveness of the Synergy Cervical Disc System in patients with…
- Trial name
- NCT05305430
- Testing
- Synergy Cervical Disc System
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Synergy Spine Solutions
Cervical Degenerative Disc Disease
Investigation of the Simplify® Cervical Artificial Disc
This study is intended to demonstrate that the Simplify® Disc is at least as safe and effective as conventional anterior cervical discectomy and fusion (ACDF) when used to treat one level between C3 to C7 for cervical…
- Trial name
- NCT02667067
- Testing
- Simplify Disc, Anterior Cervical Discectomy & Fusion
- Where
- 16 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Cervical Radiculopathy, Degenerative Disc Disease
Restore CLINICAL TRIAL
This is a prospective, concurrently controlled, multi-center study to evaluate the safety and effectiveness of the Spinal Kinetics M6-C artificial cervical disc compared to anterior cervical discectomy and fusion (ACDF) for the…
- Trial name
- NCT01609374
- Testing
- M6-C Artificial Cervical Disc, Anterior plate system with corticocancellous allograft bone
- Volunteers
- 258 people
- Sponsor
- Spinal Kinetics
Cervical Disc Degenerative Disorder
Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)
The purpose of this study is to assess the clinical and radiographic outcomes in patients who undergo ACDF procedures using Cellentra Viable Cell Bone Matrix (VCBM), cortical allograft spacers, and the MaxAn® Anterior Cervical…
- Trial name
- VCBM/ACDF (NCT02182843)
- Testing
- Cellentra VCBM
- Where
- 6 sites in United States
- Volunteers
- 81 people
- Sponsor
- Zimmer Biomet
Intervertebral Disk Degeneration
An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation
The aim of this trial is to evaluate if P-15 bone putty (investigational device) is not inferior in effectiveness and safety to local autologous bone (control device) when applied in instrumented anterior cervical discectomy and…
- Trial name
- NCT00310440
- Testing
- P-15 Synthetic osteoconductive bone substitute, Autologous bone
- Where
- 12 sites in United States, Canada
- Volunteers
- 319 people
- Sponsor
- CeraPedics, Inc
Degenerative Cervical Disc Disease
PRESTIGE® Cervical Disc Study
The purpose of this clinical investigation is to evaluate the safety and effectiveness of the ACD in the single level surgical treatment of patients with symptomatic cervical degenerative disc disease.
- Trial name
- NCT00642876
- Testing
- Allograft Fusion and ATLANTIS™ Cervical Plate System, PRESTIGE® Cervical Disc
- Where
- 31 sites in United States
- Volunteers
- 541 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Disc Disease
Outcome Study of Patients Treated With Translational Cervical Plate Used to Treat Degenerative Disc Disease
The purpose of this study is to measure the benefits of anterior (from the front) cervical (neck) surgery for degenerative disc disease.
- Trial name
- NCT00443547
- Testing
- Vectra-T
- Where
- 13 sites in United States
- Volunteers
- 231 people
- Sponsor
- Synthes USA HQ, Inc.
Degenerative Cervical Disc Disease
INFUSE™ BONE GRAFT/CORNERSTONE-SR™ Allograft Ring/ATLANTIS™ Anterior Cervical Plate- Pilot Study
The purpose of this clinical trial is to assess the safety and effectiveness of the Investigational implant as compared to the Control implant in the treatment of patients with one level or two adjacent levels of cervical…
- Trial name
- NCT01491399
- Testing
- INFUSE™ Bone Graft/CORNERSTONE-SR™ /ATLANTIS™, Autogenous bone/CORNERSTONE-SR™ /ATLANTIS™
- Volunteers
- 33 people
- Sponsor
- Medtronic Spinal and Biologics
Cervical Disc Disease
Clinical Outcomes Study Evaluating the Zero-P PEEK
This is a multi-center, prospective, outcomes study. In this study, the Zero-P PEEK implant will be used in patients undergoing ACDF for treatment of SCDD at a single level between C3 and C7.
- Trial name
- NCT00945243
- Testing
- Zero-P
- Where
- 14 sites in United States
- Volunteers
- 11 people
- Sponsor
- Synthes USA HQ, Inc.
Degenerative Disc Disease
Retrospective/Prospective Data Collection on the LDR ROIC Interbody Fusion Device With VerteBRIDGE Plating
The purpose of this combined retrospective and prospective clinical study is to examine the clinical outcomes of the ROI-C® anterior cervical interbody fusion device with VerteBRIDGE® plating to treat single level degenerative…
- Trial name
- NCT02104167
- Testing
- ROIC interbody cage with VerteBRIDGE plating
- Where
- 7 sites in United States
- Volunteers
- 110 people
- Sponsor
- LDR Spine USA
Vertebral Cervical Fusion Syndrome, Degenerative Disc Disease
Study Using the CervicalStim Device Following Cervical Fusion
This study examines the effect of adjunctive use of the CervicalStim bone growth stimulator on cervical fusion rate in high risk subjects who have undergone cervical fusion surgery.
- Trial name
- NCT03177473
- Testing
- CervicalStim bone growth stimulator
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Orthofix Inc.
Spinal Fusion, Cervical Vertebral Fusion
Study of Titanium-Coated PEEK Cages for Degenerative Disc Disease
Prospective Follow-up study of CeSPACE XP coated PEEK cages for the treatment of degenerative cervical disc disease
- Trial name
- NCT03565224
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Aesculap AG
Degenerative Disc Disease (DDD)
Kineflex|C Artificial Disc System to Treat Cervical Degenerative Disc Disease (DDD)
The purpose of this study is to show that the Kineflex|C Spinal System is no worse than conventional Anterior Cervical Diskectomy with Fusion (ACDF) in patients with single level degenerative disc disease at any cervical level…
- Trial name
- NCT00374413
- Testing
- Artificial disk, Artificial disc
- Where
- 21 sites in United States
- Volunteers
- 343 people
- Sponsor
- SpinalMotion
Cervical Intervertebral Disc Degeneration
Post-Market Study Evaluating the Safety and Effectiveness of NuNec® Cervical Arthroplasty System
The objective of this study is to evaluate long-term safety and effectiveness of the NuNec® Cervical Arthroplasty System in a small patient population. The NuNec device is currently CE marked and commercially available in Europe.
- Trial name
- NCT01832818
- Testing
- NuNec Cervical Disc
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Pioneer Surgical Technology, Inc.
Degenerative Disc Disease, Degenerative Spondylolisthesis
Assessing Safety of Cervical Spine Fusion With NMP®
The goal of this retrospective chart review study is to assess safety of NMP® in the treatment of cervical spine degenerative conditions by assessing the incidence and nature of AEs in follow-up (minimum of 90 days and up to 2…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis Cervical
- Trial name
- NCT07245940
- Testing
- Natural Matrix Protein (NMP) Fibers, Cervical interbody fusion
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Red Rock Regeneration Inc.