Clinical trials: Disc Disease
Lumbar Disc Herniation.
Effectiveness of Global Postural Reeducation in Patients With Chronic Symptomatic Lumbar Disc Herniation
Slipped disc is the rupture of the fibrous ring, with subsequent displacement of the nucleus pulposus in intervertebral spaces, which may cause compression of nerve structures.
- Trial name
- NCT01236924
- Testing
- Global postural reeducation
- Where
- Brazil
- Sponsor
- Universidade Gama Filho
Lumbar Spinal Stenosis, Intervertebral Disc Degeneration
Minimally Invasive Decompression and Fusion Versus Open for Degenerative Lumbar Stenosis
The purpose of this study is to determine the effectiveness of minimally invasive decompression and fusion over the traditional open decompression and fusion in patients with single-level lumbar stenosis caused by degenerative…
- Trial name
- NCT04594980
- Testing
- lumbar fusion
- Where
- Russia
- Volunteers
- 96 people
- Sponsor
- N.N. Priorov National Medical Research Center of Traumatology and Orthopedics
Lumbar Disc Herniation
Comparison Between Conventional vs. Endoscopic Lumbar Discectomy
This study is aimed to compare between the results of conventional lumbar discectomy and the newly used technique in our department; endoscopic lumbar discectomy in neurosurgery department Assiut university hospitals, so that we…
- Trial name
- NCT03137485
- Testing
- Conventional open lumbar discectomy, Percutaneous Endoscopic Translaminar lumbar discectomy., Easy Go system Endoscopy
- Volunteers
- 30 people
- Sponsor
- Assiut University
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis
- Trial name
- NCT05029726
- Testing
- Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- John O'Toole
Cervical Radiculopathy, Cervical Disc Herniation
CRIS Based Evaluation of Cervical Interlaminar Epidural Steroid Injection Outcomes
This prospective single-center study aims to evaluate the clinical efficacy of fluoroscopy-guided cervical interlaminar epidural steroid injection (CIESI) in patients with unilateral, single-level cervical radiculopathy due to…
- Conditions
- Cervical Radiculopathy, Cervical Disc Herniation, Cervical Radicular Pain, Chronic Neck Pain
- Trial name
- NCT07639671
- Testing
- Cervical Interlaminar Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Saglik Bilimleri Universitesi
RADICULAR PAIN
Efficacy of Intravenous Dexamethasone for Acute Disc Herniation-Induced Sciatica
Acute low back pain is one of the most common reasons for all physician visits(1). Phospholipase A2 (PLA2), a potent inflammatory mediator, has demonstrated to be released by discs following injury(4).
- Trial name
- NCT00516009
- Testing
- DEXAMETHASONE
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Ziv Hospital
LUMBAR RADICULOPATHY, Lumbar Radiculopathy Due to Spinal Nerve Compression
Maitland Mobilization Effect On Gait Kinetics And Kinematics Parameters In Patients With Lumbosacral Radiculopathy
Effect Of Maitland Mobilization On Selected Gait Kinetic And Kinematic Parameters In Patients With Lumbosacral Radiculopathy
- Conditions
- LUMBAR RADICULOPATHY, Lumbar Radiculopathy Due to Spinal Nerve Compression, Lumbar Disc Prolapse With Radiculopathy, Lumbosacral Radiculopathy
- Trial name
- NCT07448311
- Testing
- MAITHLEND MOBILIZATION, transcutaneous electrical neuromuscular stimulation, stretching hamstrings
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University
Intervertebral Disc Disease, Intervertebral Disc Degeneration
Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine
The purpose of this study is to determine whether NuCel is effective in promoting spinal fusion in degenerative disease of the lumbar spine.
- Conditions
- Intervertebral Disc Disease, Intervertebral Disc Degeneration, Spondylosis, Spondylolisthesis
- Trial name
- NCT02023372
- Testing
- NuCel with Autograft
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- NuTech Medical, Inc
Cervical Disc Disorders
Clinical Outcome After Anterior Cervical Decompression and Fusion and Cervical Total Disc Replacement
The aim of this study is to examine the clinical outcome after anterior cervical decompression and fusion, and cervical disc prostheses in general.
- Trial name
- NCT02498028
- Testing
- Cervical Fusion, Cervical disc Prostheses
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bonn
Degenerative Disc Disease
Trial for Treating Painful Degenerative Disc Disease
To evaluate and compare two platelet-based treatments of the functional spinal unit spaced 4 weeks apart to sham procedures for the treatment of degenerative disc disease.
- Trial name
- NCT05287867
- Testing
- Platelet-rich plasma (PRP), Platelet lysate (PL), and Platelet Poor Plasma (PPP)
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Regenexx, LLC
Lumbar Discopathy, Lumbar Disc Herniation
The Effect of Physiotherapy on Respiratory Function and Psychosocial Status in Lumbar Discopathy
The aim of this study is to investigate the effects of physiotherapy on pulmonary function tests and psychosocial status in patients with lumbar discopathy. Participants undergo a 15-session physiotherapy program.
- Trial name
- NCT07789067
- Testing
- Physiotherapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Medipol University
Spinal Fusion
Artoss Prospective Spine Registry Outcomes
This prospective registry was designed as an observational study to ascertain how commercially available NanoBone Bone Graft is being used by surgeons performing spinal fusion as well as determining relevant patient outcomes.
- Trial name
- ASTRO (NCT04439032)
- Testing
- NanoBone Bone Graft Substitute
- Where
- 6 sites in United States
- Volunteers
- 330 people
- Sponsor
- Artoss Inc.
Lumbar Disc Herniation
Barricaid EU Post Market Study for Primary Lumbar Disc Herniation
The purpose of this multi-center post marketing surveillance study is to monitor the safety and performance of the Barricaid® ARD when used to surgically reconstruct the anulus of the L1 - S1 spinal disc.
- Trial name
- NCT01534065
- Testing
- Barricaid
- Volunteers
- 45 people
- Sponsor
- Intrinsic Therapeutics
Degenerative Lumbar Spondylolisthesis
Study of OP-1 Putty in Uninstrumented Posterolateral Fusions
This study is to provide additional data to support the safety and efficacy of OP-1 Putty as a replacement for autograft in patients undergoing posterolateral spinal fusion.
- Trial name
- NCT00678353
- Where
- 22 sites in United States, Canada
- Volunteers
- 202 people
- Sponsor
- Olympus Biotech Corporation
Sciatica Due to Intervertebral Disc Disorder
Effect of Sensorimotor Training on Pain and Gait Performance in Patients With Discogenic Sciatica
This study aims to investigate the effect of sensorimotor training on gait performance in patients with discogenic sciatica.
- Trial name
- NCT07805265
- Testing
- Standard physical therapy, Sensorimotor Training
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cervical Degenerative Disc Disease
PureGen: Radiographic Analysis of Fusion for ACDF
The purpose of this study is to evaluate the rate and quality of spinal fusion utilizing PureGen Osteoprogenitor Cell Allograft in Anterior Cervical Discectomy and Fusion (ACDF).
- Trial name
- NCT01291134
- Testing
- PureGen Osteoprogenitor Cell Allograft
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Alphatec Spine, Inc.
Physical Therapy, Low Back Pain
GRAVITY System Therapy on Chronic Low Back Pain
The aim of the study was to examine the effect of GRAVITY system therapy on chronic disc-related pain in lumbar spine. Investigators made a hypothesis that patients who regularly perform core strengthening exercises based on…
- Conditions
- Physical Therapy, Low Back Pain, Chronic Pain
- Trial name
- GRAVITY (NCT04765293)
- Testing
- Physical Therapy
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Józef Piłsudski University of Physical Education
Radicular Pain Related to Lumbosacral Disc Disease
Milnacipran for Lumbosacral Radicular Pain
This study investigates whether milnacipran reduces radicular pain ("sciatica") in patients with lumbosacral disc disease.
- Trial name
- NCT01777581
- Testing
- Milnacipran
- Volunteers
- 13 people
- Sponsor
- Duke University
Endometriosis, Rectum
Surgery for Lower Rectum Deep Endometriosis (Segmental/Disc) - Prospective Comparison of Digestive Symptoms and Pain
Several studies show a significant drop in pain scores, improved fertility outcomes and amelioration of impaired sexual functioning in women following surgical resection of colorectal endometriosis.
- Trial name
- NCT04398641
- Testing
- Evaluation of pre- and postoperative gastrointestinal functional outcomes
- Where
- 2 sites in Austria
- Volunteers
- 300 people
- Sponsor
- Univ.-Doz. Dr.med.univ. Gernot Hudelist, MSc.
Lumbosacral Transitional Vertebrae, Thoracolumbar Transitional Vertebra
How Reliable Are Routine Radiological Imaging Methods in Diagnosing Lumbosacral Transitional Vertebrae and Identifying the Pathological Disc Level?
The aim of this study is to evaluate how accurately transitional vertebrae can be identified using routinely employed clinical imaging methods, including thoracolumbar direct radiography and lumbar MRI with axial and sagittal…
- Conditions
- Lumbosacral Transitional Vertebrae, Thoracolumbar Transitional Vertebra, Vertebral Level Misidentification, Lumbar Radiculopathy
- Trial name
- NCT07256366
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Marmara University