Clinical trials: Disc Prolapse With Radiculopathy
Lumbar Disc Herniation With Radiculopathy, Sciatica
FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation
The FINDISC trial studies whether common back operation, microdiscectomy, is effective and safe for treating sciatica caused by a lumbar disc herniation.
- Trial name
- FINDISC-Pain (NCT07418944)
- Testing
- Microdiscectomy
- Where
- Finland
- Volunteers
- 122 people
- Sponsor
- Helsinki University Central Hospital
Lumbar Disc Prolapse With Radiculopathy
HYBRID TELE-REHABILITATION VERSUS CLINIC-BASED THERAPY IN PATIENTS WITH LUMBAR RADICULOPATHY: A RANDOMIZED CONTROLLED TRIAL
A single blinded clinical randomized trial. A single blinded trained investigator examined all patients and collect all data to eliminate inter- investigator error.
- Trial name
- NCT07041476
- Testing
- Exercise, telemedicine
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Ahmed Adel Eid
Back Pain With Radiation, Radiculopathy
Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy 3
This study is a First in Human, prospective, multi-center clinical study intended to collect safety and performance information for the Spinal Stabilization Technologies PerQdisc® Nucleus Replacement System and procedure…
- Conditions
- Back Pain With Radiation, Radiculopathy, Back Pain, Disc Herniation
- Trial name
- LOPAIN3 (NCT05732818)
- Testing
- PerQdisc Nucleus Replacement System
- Where
- 2 sites in Paraguay, Uzbekistan
- Volunteers
- 50 people
- Sponsor
- Spinal Stabilization Technologies
Lumbar Disc Herniation
STA363 in the Treatment of Lumbar Disc Herniation
The goal of this clinical trial is to establish safety and tolerability of STA363 injected into a herniated intervertebral disc in patients with sciatica due to disc herniation. The main questions the trial aims to answer are: 1.
- Trial name
- NCT06022263
- Testing
- Lactic Acid
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Stayble Therapeutics
Disc Herniation With Radiculopathy
A Randomized Trial Comparing SpineJet® Hydrodiscectomy to Open Lumbar Microdiscectomy for Treatment of Lumbar Radiculopathy Due to Disc Herniation
The purpose of this study is to compare a standard surgical procedure, open surgical microdiscectomy, used primarily to relieve leg pain and repair disc herniation to a newer surgical procedure, hydrodiscectomy with Spinejet®.
- Trial name
- NCT00384007
- Testing
- Hydrodiscectomy with Spinejet
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Pinnacle Pain Medicine
Lumbar Disc Herniation, Lumbar Radiculopathy
Effects of SNAGS With and Without Pilates in Lumbar Disc Bulge Patients
The aim of this study is to compare the effects of Sustained Natural Apophyseal Glides with and without Pilates on pain, range of motion and disability in patients with lumbar Disc Bulge.
- Trial name
- NCT06076408
- Testing
- SNAGS with Pilates, SNAGS
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Cervical Radiculopathy, Neck Pain
A Comparison Study Between Contrast Spread and Loss of Resistance Techniques
Early epidural space identification is critical to the efficacy and safety of cervical epidural steroid injections (CESI) [1]. Currently, the accepted method for epidural space recognition is the loss of resistance technique…
- Conditions
- Cervical Radiculopathy, Neck Pain, Disc Prolapse With Radiculopathy
- Trial name
- NCT05260294
- Testing
- Epidural space identification with cervical epidural steroid injection employing CST and LORT.
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Yakov Perper, MD
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Lumbar Disc Herniation
Effectiveness of Core Stabilization Exercises With and Without Neural Mobilization Technique in Female Patients With Lumbar Radiculopathy Due to Disc Herniation - an RCT Study
Lumbar disc herniation (LDH) is the most frequent cause of lumbosacral radiculopathy and account for 39% of chronic low back pain cases. In approximately 95% of cases LDH occurs at L4-L5 and L5-S1 levels.
- Trial name
- NCT05663437
- Testing
- Core stabilization exercises, Core stabilization exercises + neural mobilization technique
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Dow University of Health Sciences
Cervical Spondylosis With Myelopathy, Cervical Radiculopathy
Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty
This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and…
- Conditions
- Cervical Spondylosis With Myelopathy, Cervical Radiculopathy, Cervical Disc Herniation, Degenerative Disc Disease
- Trial name
- NCT05701059
- Testing
- Cervical arthroplasty, Semi-Constrained Nuvasive Simplify, Unconstrained Biomet Zimmer Mobi-C
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Lumbar Disc Herniation, Radiculopathy Lumbar
Efficacy and Safety of Electroacupuncture on Lumbar Disc Herniation with Radiculopathy
Lumbar disc herniation with radiculopathy (LDHR) is the local displacement of the intervertebral disc and its contents beyond the edge of the normal intervertebral disc space, resulting in pain, weakness or numbness in the muscle…
- Trial name
- NCT06611332
- Testing
- Electroacupuncture
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Refractory Lumbar Disc Prolapse
Caudal Epidural Steroid Injection Ultrasound Guided in LDP
Patients with LDP with unilateral radiculopathy diagnosed by routine clinical examination and MRI, in whom conservative treatment (medical treatment and physiotherapy) failed for more than 6 weeks and refuse surgery or were unfit…
- Trial name
- NCT03933150
- Testing
- ultrasound guided caudal epidural injection
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Lumbar Degenerative Disease, Lumbar Radiculopathy
Comparison of Clinical Effectiveness of Full Endoscopic Lumbar Discectomy (FELD) and Microdiscectomy (MD) in Patients With Lumbar Disc Herniation
The goal of this clinical trial is to compare the clinical effectiveness of Full Endoscopic Lumbar Discectomy (FELD) and Microdiscectomy (MD) in patients aged 18-85 with single-level lumbar disc herniation who have not undergone…
- Conditions
- Lumbar Degenerative Disease, Lumbar Radiculopathy, Sciatic Leg Pain, Sciatic Nerve Compression
- Trial name
- NCT06615518
- Testing
- FELD (Full-Endoscopic Lumbar Discectomy), comprising IELD and TELD as anatomical subgroups, Microdiscectomy
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- University of Opole
Radiculopathy, Lumbosacral Region, Radiculopathy Lumbar
The Effect of High-power Laser Therapy on Pain, Functional Disability, Range of Motion and Pressure Pain Threshold in Subjects With Radicular Low Back Pain Due to Intervertebral Disc Herniation
Low back pain is the predominant cause of disability on a global scale. In the year 2015, the worldwide point prevalence of activity-limiting low back pain stood at 7·3%, suggesting that at any given moment, 540 million…
- Trial name
- NCT06151704
- Testing
- High intensity laser therapy, Motor control exercise
- Where
- Iran
- Volunteers
- 36 people
- Sponsor
- Iran University of Medical Sciences
Cervical Spondylosis, Cervical Radiculopathy
NuVasive® ACP System Study
The primary objective of this study is to evaluate the safety and performance of anterior cervical spine surgery using the NuVasive anterior cervical plate (ACP) System as measured by reported complications, radiographic…
- Conditions
- Cervical Spondylosis, Cervical Radiculopathy, Cervical Myelopathy, Cervical Disc Disease
- Trial name
- NCT05066711
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- NuVasive
Lumbar Disc Herniation, Lumbar Disc Disease
GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries
The purpose of this study is to determine the optimal anesthetic routine for lumbar decompression surgery. General Anesthesia is the standard of care in spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
- Trial name
- NCT05444751
- Testing
- General anesthetic, SA + ESP
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Low Back Pain, Herniation, Disc
Non-surgical Spinal Decompression Therapy and Outcomes
This project will determine the clinical utility of non-surgical spine decompression for chronic low back pain (LBP). LBP is one of the highest incidence medical conditions that contributes to disability, decreased activities of…
- Conditions
- Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal
- Trial name
- RESTORE (NCT06525896)
- Testing
- NSSD
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of South Florida
Lumbar Radiculopathy, Lumbar Disc Herniation
Treatment Response to TFESI and DRG Pulsed RF in Lumbar Spinal Stenosis and Disc Herniation
Lumbar radiculopathy caused by conditions such as lumbar disc herniation (LDH) and lumbar spinal stenosis (LSS) can lead to chronic pain and reduced quality of life.
- Conditions
- Lumbar Radiculopathy, Lumbar Disc Herniation, Lumbar Spinal Stenosis (LSS)
- Trial name
- NCT07509580
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Marmara University
Lumbar and Other Intervertebral Disc Disorders With Radiculopathy
Epidural Clonidine for Lumbosacral Radiculopathy
This was a randomized, blinded study of transforaminal epidural injection of clonidine versus a similar injection of corticosteroid for acute lumbosacral radiculopathy.
- Trial name
- NCT00588354
- Testing
- Clonidine, Triamcinolone hexacetonide, Lidocaine HCl
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sciatic Leg Pain, Hamstring Muscle Tightness
Acute Effects of Neurodynamics on Strength and Endurance in Athletes
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population.
- Conditions
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength
- Trial name
- NCT07721220
- Testing
- Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- High Point University