Clinical trials: Disease, Acute
Acute Lower Respiratory Illness
Cookstove Replacement for Prevention of ALRI and Low Birthweight in Nepal
At our field site in southern Nepal, acute respiratory illness (ARI) has been a leading cause of mortality among young children.
- Trial name
- NCT00786877
- Testing
- Improved biomass cookstove with exterior ventilation, Phase 2 intervention arm (LPG stove)
- Where
- Nepal
- Volunteers
- 4,678 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Glucocorticoids, Overweight and Obesity
Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake
The investigator aim to understand whether food-induced glucocorticoids influence fat mass in overweight and obese people. In a randomized, cross-over study, 23 overweight and obese volunteers will receive a block and replace…
- Conditions
- Glucocorticoids, Overweight and Obesity, Overeating
- Trial name
- Gluco-Max (NCT06556277)
- Testing
- Metyrapone And Hydrocortisone
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Acute Appendicitis
MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA…
- Trial name
- observational (NCT04615728)
- Testing
- laparoscopic or open appendicectomy
- Where
- United Kingdom
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Acute Coronary Syndrome, Anxiety
HAND MASSAGE AFTER ACUTE CORONARY SYNDROME
Patients suffering from Acute coronary syndrome may be hospitalized again in a shorter time than expected, and after being discharged, they may live within the limitations imposed by the disease until the end of their lives.
- Trial name
- NCT06077175
- Testing
- hand massage group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Stroke, Cerebrovascular Accident
Non-invasive Brain Stimulation and Occupational Therapy To Enhance Stroke Recovery
The purpose of this study is to determine whether a non-painful, non-invasive, brain-stimulation technique called transcranial direct current stimulation (tDCS) combined with traditional physical-occupational therapy (OT) will…
- Conditions
- Stroke, Cerebrovascular Accident, CVA, Acute Stroke
- Trial name
- TDCS+OT (NCT00792428)
- Testing
- Real Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Immune Thrombocytopenia
Role of Acute Phase Proteins In Diagnosis of Immune Thrombocytopenia
Immune thrombocytopenia (ITP) are antibody-mediated disorders in which platelets are destroyed mainly through activating immunoglobulin (IgG) Fc receptors on phagocytes in the spleen and liver, eventually resulting in…
- Trial name
- NCT06715215
- Testing
- Acute phase proteins
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Alzheimer Disease 2 Due to Apoe4 Isoform
Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD
This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.
- Trial name
- NCT05591313
- Testing
- LI-40, MI-30, HI-16
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Acute Myeloid Leukemia
Safety and Efficacy of Venetoclax in Combination With Azacitidine and HA Regimen in the Treatment of AML in the Elderly
This is a prospective phase II, single-arm clinical study that plans to enroll 45 patients aged 60 years or older with primary AML diagnosed after April 1, 2023.The purpose of this trial is to evaluate the efficacy of Venetoclax…
- Trial name
- NCT05949762
- Testing
- Venetoclax in Combination With Azacitidine and HA Regimen
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- ZePing Zhou
Post-ERCP Acute Pancreatitis
A Prospective Trial of Aggressive Hydration Strategy to Reduce Post-ERCP Pancreatitis
Postendoscopic retrograde cholangiopancreatography pancreatitis is the most frequent and serious complication of ERCP procedures, occurring in approximately 5-15% of unselected patients.
- Trial name
- NCT02308891
- Testing
- lactated Ringer's solution (vigorous hydration arm), lactated Ringer's solution (standard hydration arm), endoscopic retrograde cholangiopancreatography (ERCP)
- Where
- 3 sites in South Korea
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Dankook University
Optic Neuritis, Optic; Neuritis, With Demyelination
BN201 SAD MAD Study in Healthy Subjects
The purpose of this study is to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of BN201 in healthy subjects.
- Trial name
- NCT03630497
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Accure Therapeutics
SARS-CoV2 Infection
Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals who will enter the cohort with and without SARS-CoV-2 infection and at varying stages before and after infection.
- Trial name
- NCT05172024
- Where
- 86 sites in United States, Puerto Rico
- Volunteers
- 15,172 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Stroke, Acute Myocardial Infarction
Stroke Prediction Through Internet Search Queries
Cerebrovascular disease (stroke) is a leading cause of mortality and disability. Common risk assessment tools for stroke are based on the Framingham equation, which relies on traditional cardiovascular risk factors (e.g.…
- Trial name
- NCT04755959
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Neonatal Acute Kidney Injury, Childhood Chronic Kidney Disease
Follow-up of AKI in Neonates During Childhood Years
The purpose of this study is to learn more about how to identify signs of early chronic kidney diseases in children who were born prematurely with low birth weight (less than 3 ½ pounds).
- Trial name
- FANCY (NCT02306642)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Matthew Harer, MD
Postoperative Pain, Flare up
Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence
This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical…
- Conditions
- Postoperative Pain, Flare up, Flare Up, Symptom
- Trial name
- NCT07084194
- Testing
- Chitosan Nanoparticles Irrigant, aloe vera nanoparticles irrigant, Diode Laser Activation
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Minia University
Acute Mountain Sickness
Altitude Sickness Prevention and Efficacy of Comparative Treatments
This study is designed to be the first to examine the novel drug budesonide for prevention of acute mountain sickness in comparison to acetazolamide and in the context of rapid ascent to high altitude.
- Trial name
- ASPECT (NCT02604173)
- Testing
- Budesonide, Acetazolamide
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Stanford University
Human Influenza
Transmission of Influenza Virus From Asymptomatic Healthcare Workers and Inpatients in the Acute Care Hospital Setting
The epidemiology and transmission dynamics of influenza in hospitals are only poorly understood, particularly with respect to subjects without symptoms of influenza infection (e.g.
- Trial name
- TransFLUas (NCT02478905)
- Testing
- Influenza
- Where
- Switzerland
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Migraine Disorders, Headache, Migraine
The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine
The purpose of this study is to determine the effects of triptans and doxycycline on neuroinflammatory markers in acute migraine.
- Conditions
- Migraine Disorders, Headache, Migraine, Migraine, Migraine Headache
- Trial name
- NCT01653522
- Testing
- Triptan, Doxycycline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Postpartum Hemorrhage, Pregnancy
RCT of Misoprostol for Postpartum Hemorrhage in India
Death rates for pregnant women in rural India are approximately forty-five times higher than in the United States. Bleeding after the birth of a child and underlying anemia are the primary causes of mothers' deaths and sickness…
- Trial name
- NCT00097123
- Testing
- Misoprostol
- Where
- India
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Heart Failure
Evaluation of Circulating Levels of Adult Stem Cells in the Peripheral Blood of Patients With Acute Decompensated Heart Failure and Following Stabilization, in Comparison With Healthy Volunteers
Despite advances in medical technology, heart failure remains a major cause of illness on a global scale. Medical research, over recent years, has shown that adult stem cells (as opposed to embryonic stem cells) are present in…
- Trial name
- CIRCSTEM-HF (NCT01027403)
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Monash University
Non Alcoholic Fatty Liver Diseases (NAFLD), Obesity and Overweight
Hepatoprotective Measures for Children at High Risk of NAFLD
Non Alcoholic Fatty Liver Disease (NAFLD) is a spectrum of disease, ranging from simple fatty deposition (steatosis) to inflammation (steatohepatitis), fibrosis, cirrhosis, and end-stage liver failure.
- Conditions
- Non Alcoholic Fatty Liver Diseases (NAFLD), Obesity and Overweight, Acute Lymphoblastic Leukemia
- Trial name
- NCT06918080
- Testing
- Ursodeoxycholic Acid 250 Mg Oral Capsule, Omega -3 fatty acids, Physical exercise
- Where
- 2 sites in Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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