Clinical trials: Disease, Acute
Stroke, Acute
Trunk Rotation And Lateral Flexion Exercises In Stroke Patients
In this study we want to introduce the beneficiary combine effects of chest mobilization and chest physiotherapy exercises by using cough peak flow meter and chest expansion in stroke patients.
- Trial name
- NCT06379854
- Testing
- chest physiotherapy, trunk rotation exercises,deep diaphragmatic also chest physiotherapy
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Stress Disorder - Post-traumatic (Acute)
Prevention of Post-traumatic Stress Disorder by Telephone Based Cognitive Behavioral Therapy
This is a randomized controlled study comparing telephone-based cognitive behavioral therapy (CBT) for recent survivors of traumatic events with Acute Stress Disorder (ASD) or acute PTSD with a waitlist control group.
- Trial name
- NCT00889005
- Testing
- Telephone Based Cognitive Behavioral Therapy
- Where
- Israel
- Volunteers
- 139 people
- Sponsor
- Hadassah Medical Organization
Alcoholism, Genetics
Genetics of the Acute Response to Alcohol in Social Drinkers
Background: Previous research has shown that a person s genes can influence how they respond to alcohol. But researchers do not yet know all the genes that might be involved.
- Trial name
- NCT01375556
- Testing
- Ethanol
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Pulmonary Embolism Acute
Vibrato Aspiration System - Simple, Intuitive Approach to Clot Removal in Acute Pulmonary Embolism - a Safety & Feasibility Study
The study is a prospective, single-arm, multicenter study to evaluate the safety and effectiveness of the Vibrato™ Aspiration System for aspiration mechanical thrombectomy in the treatment of acute PE.
- Trial name
- NCT07685522
- Testing
- Mechanical Thrombectomy
- Where
- 2 sites in Poland
- Volunteers
- 10 people
- Sponsor
- Vicora, Inc.
Acute Myocardial Infarction, Acute Coronary Syndrome
COmparisoN of High-sensitivity Cardiac TRoponin I and T ASsays Trial
Compare the analytical and clinical performance of hs-cTnI and hs-cTnT assays for the diagnosis of acute myocardial injury and myocardial infarction in patients presenting to the emergency department in whom serial cTnI…
- Trial name
- CONTRAST (NCT03214029)
- Testing
- Cardiac troponin testing
- Where
- United States
- Volunteers
- 2,286 people
- Sponsor
- Fred Apple
Healthy (For Part A), Chronic Myeloid Leukemia (for Part B and C)
Safety and Anti-leukemic Activity of Vodobatinib (K0706) for Treatment of Ph+ CML Resistant/Intolerant to ≥3 Prior CML Therapies
Phase 1/2 study to determine safety, tolerability, pharmacokinetics, and anti-leukemic activity of Vodobatinib (K0706) in treatment-refractory/intolerant CML
- Trial name
- NCT02629692
- Testing
- Vodobatinib (K0706) capsules
- Where
- 35 sites in United States, Belgium and 8 more
- Volunteers
- 124 people
- Sponsor
- Sun Pharma Advanced Research Company Limited
Chronic Obstructive Pulmonary Disease
Residential Cleaning of Indoor Air to Protect COPD Patients
This study looks at whether air cleaning devices put in the bedroom and living room of your home could reduce the irritation of your lungs and body that is caused by indoor air pollution.
- Trial name
- CARE (NCT03750292)
- Testing
- HEPAirX air filter, control air filter
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Rochester
Acute Respiratory Distress Syndrome (ARDS)
Study of Safety and Efficacy of ALT-100mAb in Participants With Moderate/Severe ARDS
A Phase 2a, multi-center, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of ALT-100mAb in patients with moderate to severe ARDS.
- Trial name
- NCT05938036
- Testing
- ALT-100 mAb
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aqualung Therapeutics Corp.
Sickle-Cell Disease Nos With Crisis
Pulmonary Ultrasound in the Diagnosis of Acute Thoracic Syndrome in Vaso-occlusive Sickle Cell Crisis
ATS (acute thoracic syndrome) refers to acute pulmonary involvement in a sickle cell patient. The diagnosis is based on the association of clinical signs (fever or respiratory symptoms) with a recent pulmonary infiltrate on the…
- Trial name
- ECHO-STA (NCT03971136)
- Testing
- pulmonary ultrasound
- Where
- 4 sites in France
- Volunteers
- 190 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Stroke
Reduce Inefficiencies in Management of Spasticity
The purpose of this study is to evaluate the effectiveness of a spasticity screener and to determine if the spasticity screener results are useful to healthcare providers and impact clinical decision making
- Trial name
- ReIMage (NCT07639632)
- Testing
- Screener, Standard of care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obsessive-Compulsive Disorder
Dextro-Amphetamine Versus Caffeine in Treatment-resistant OCD
The study hypothesis is that dextro-amphetamine (d-amphetamine) will be safe and effective when used to augment treatment for Obsessive-Compulsive Disorder (OCD), and that tolerance (loss of therapeutic effect) to the medication…
- Trial name
- NCT00363298
- Testing
- dextro-amphetamine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Obesity
Effect of High-intensity Intermittent Sprinting on Appetite Control on Obese Volunteers
Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals.
- Trial name
- NCT01143363
- Testing
- resting - control, Moderate intensity exercise, High intensity intermittent training
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Long COVID
Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19
Plain Language Summary: This study is a clinical trial to see if ketamine can help treat symptoms of Long COVID, especially fatigue and problems with thinking clearly (often called "brain fog").
- Trial name
- NCT06821087
- Testing
- Ketamine only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas at Austin
Prostate Cancer
Radiation-induced Toxicity in Prostate Cancer/ Standard-Follow-Up Program Prostate
The goal is to gain insight in the development and course of the toxicity after a curative treatment of prostate cancer
- Trial name
- SFP-PROSTATE (NCT03034187)
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
Relapsed or Refractory Acute Myeloid Leukemia (AML)
A Study of HYML-122 and Cytarabine in Patients With FLT3 Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
This is a single-arm, open, multicenter, phase 2 study to evaluate the efficacy, safety and pharmacokinetics of HYLM-122 in combination with cytarabine in Chinese subjects with FLT3 positive relapsed or refractory acute myeloid…
- Trial name
- NCT05241093
- Testing
- HYML-122; cytarabine
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Tarapeutics Science Inc.
Bipolar Disorders, Mood Disorders
A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder
The primary purpose of this study is to evaluate the effectiveness and safety of topiramate compared with placebo in the treatment of acute manic or mixed episodes in patients with Bipolar I Disorder.
- Conditions
- Bipolar Disorders, Mood Disorders, Affective Disorders, Psychotic
- Trial name
- NCT00240721
- Testing
- topiramate
- Volunteers
- 363 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Thermoregulation, Sleep Disturbance
Acute Sleep Deprivation on Whole-body Heat Exchange During Exercise-heat Stress in Young and Older Men
Sleep deprivation has long been thought to modulate thermoregulatory function. Seminal work on sleep deprivation and thermoregulation has demonstrated that sleep-deprived individuals experience greater elevations in core…
- Conditions
- Thermoregulation, Sleep Disturbance, Heat Exchange, Aging
- Trial name
- NCT05838014
- Testing
- Sleep deprivation, Normal sleep
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Pancreatitis, Acute
Resolution of Organ Injury in Acute Pancreatitis - RESORP
Acute pancreatitis (AP) is inflammation of the pancreas usually triggered by gallstones or drinking excessive alcohol. 80% of people who have an episode of AP will recover without complications.
- Trial name
- RESORP (NCT03342716)
- Where
- United Kingdom
- Volunteers
- 229 people
- Sponsor
- University of Edinburgh
HIV, Seroconversion, HIV
Accurate Staging of Immuno-virological Dynamics During Acute HIV Infection
In this prospective longitudinal study we aim to assess how immunologic and viral aspects of the human immunodeficiency virus (HIV) viral reservoir, established during early HIV infection and responsible for viral rebound at…
- Trial name
- ACS (NCT03449706)
- Testing
- Early combination anti-retroviral treatment
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia, Pediatric
CD123 Redirected T Cells for AML in Pediatric Subjects
Phase 1 open-label study to evaluate the safety of intravenously administered, lentivirally transduced T cells expressing anti-CD123 chimeric antigen receptors expressing tandem TCRζ and 4-1BB (TCRζ /4-1BB) costimulatory domains…
- Conditions
- Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia, Pediatric, Acute Myeloid Leukemia, Refractory
- Trial name
- NCT04678336
- Testing
- CART123 cells; cyclophosphamide; fludarabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pennsylvania
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