Clinical trials: Disease, Acute
Acute Disease, Coronavirus
Evaluation of Novel Diagnostic Tests for COVID-19
COVID-19 (also known as Coronavirus) originated in the Wuhan China and has since spread to at least 159 countries around the world. It was declared a pandemic by the World health organisation on the 11th of March 2020.
- Conditions
- Acute Disease, Coronavirus, Respiratory Viral Infection
- Trial name
- COVIDx (NCT04326387)
- Testing
- SAMBA II (Diagnostic for the Real World), Public Health England Gold Standard, Cambridge Validated Viral Detection Method
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- CCTU- Cancer Theme
Acute Lymphoblastic Leukemia (ALL)
Potential Role of CD9 and Implication of Motility Process in Pathogenesis of TEL/ALM1-positive ALL Relapses (LAL TEL/ALM1 and CD9).
Down regulation of CD9 in TEL/AML1-positive ALL is addressed in motility assays to explore its role in B-ALL pathogenesis and its potential implication in relapses (and prognosis).
- Trial name
- LAL TEL/ALM1 (NCT01282593)
- Testing
- Impact of CD9 expression level on motility assays, Post-transcriptional regulation of CD9
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Rennes University Hospital
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
PEG3350 in ACLF With Hepatic Encephalopathy
it is a single blind randomised control study which aims to study the effect of PEG3350 in resolution of overt hepatic encephalopathy in patients of acute on chronic liver failure.
- Trial name
- NCT03987893
- Testing
- PEG-3350 with Electolytes, Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Influenza
Immunogenicity of Standard-Dose Versus High-Dose Influenza Vaccines in Older Adults in Singapore
The goal of this clinical trial is to learn if the high-dose influenza vaccine can improve year-round protection in older adults aged 60 years and above.
- Trial name
- SingVax-01 (NCT07883421)
- Testing
- High-dose influenza vaccine, Standard-dose influenza vaccine
- Where
- Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART C (NCT05745714)
- Testing
- Ruxolitinib, Venetoclax, Dexamethasone
- Where
- 33 sites in Austria, Belgium and 12 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Acute Coronary Syndrome, Acute Myocardial Infarction
Influence of Esomeprazole on Antiplatelet Action of Clopidogrel Associated With Aspirin
The investigators examine the influence of esomeprazole versus famotidine on antiplatelet action of clopidogrel associated with aspirin.
- Trial name
- NCT01062516
- Testing
- esomeprazole 20 mg daily, famotidine 40 mg daily
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ruttonjee Hospital
Covid19, Acute Respiratory Distress Syndrome
Clinical Features of COVID-19 Patients
The data were retrospectively collected during the first and the second wave of epidemic in COVID-19 patients with Severe Acute Respiratory Syndrome Coronavirus 2, at the moment of intensive care unit admission and during the in…
- Conditions
- Covid19, Acute Respiratory Distress Syndrome, Ventilatory Failure
- Trial name
- NCT04815304
- Testing
- peripheral lymphocytes subsets
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Critical Illness, Sepsis
ICU Admission Diagnoses and ICU Mortality
This retrospective cohort study will evaluate whether syndromic clinical diagnoses present at ICU admission are associated with ICU mortality, independent of physiologic severity scores.
- Conditions
- Critical Illness, Sepsis, Septic Shock, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT07369206
- Where
- Turkey (Türkiye)
- Volunteers
- 1,248 people
- Sponsor
- Ataturk University
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test
AlloHeme is a chimerism test service that utilizes NGS technology to analyze SNP loci to quantify donor and recipient cells by measuring genomic DNA.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
- Trial name
- ACROBAT (NCT04635384)
- Where
- 10 sites in United States
- Volunteers
- 307 people
- Sponsor
- CareDx
Acute Myeloid Leukemia
Idarubicin at Different Dosages as Induction Therapy for Newly Diagnosed Acute Myeloid Leukaemia
Study Design: Treatment, Randomized, Open Label, Parallel Assignment This study is an open randomized and controlled trial aiming at assessing the efficacy and safety of Idarubicin (IDA) at different doses of 8mg/m2 and 10mg/m2…
- Trial name
- NCT02277847
- Testing
- Idarubicin(8mg/m2) and cytosine arabinoside, Idarubicin(10mg/m2), cytosine arabinoside
- Volunteers
- 400 people
- Sponsor
- Guangdong Provincial People's Hospital
Pain, Postoperative Pain
A Randomized, Double-Blind, Parallel-Arm, Placebo and Active Controlled Dose-Ranging Study of the Efficacy and Safety of Multiple Doses of Tapentadol IR for Postoperative Pain Following Bunionectomy Surgery
This study was to evaluate the efficacy and safety of dosing regimens of tapentadol HCl immediate release capsules for the treatment of postoperative pain over a period of 12 hours on the first day following a bunionectomy in men…
- Trial name
- NCT00806247
- Testing
- tapentadol HCl
- Volunteers
- 480 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Leukemia, Lymphoma
Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematological Cancer or Other Disease
RATIONALE: Giving low doses of chemotherapy and total-body irradiation before a donor umbilical cord blood transplant helps stop the growth of cancer or abnormal cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00719849
- Testing
- anti-thymocyte globulin, cyclophosphamide, cyclosporine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Fred Hutchinson Cancer Center
Symptoms of Acute Bronchitis Accompanied by Coughing
Prospan® Hustenzäpfchen - Investigation on Efficacy and Tolerability in Children
The aims of this study are Demonstrating superior efficacy of Prospan® Hustenzäpfchen compared to Placebo in children suffering from acute bronchitis accompanied by coughing Characterisation of safety and tolerability of Prospan®…
- Trial name
- NCT01127048
- Testing
- Suppositories containing Ivy leaves dry extract
- Where
- Germany
- Volunteers
- 1,400 people
- Sponsor
- Engelhard Arzneimittel GmbH & Co.KG
Preterm, Pain, Acute
Comparison Three Methods on Endotracheal Aspiration in Preterm Infants
Stress and pain control are vital for newborns, especially preterm babies. While painful procedures cause physiological changes in the short term, they negatively affect brain development in the long term.
- Conditions
- Preterm, Pain, Acute, Physiological Stress, Nursing Care
- Trial name
- NCT05434364
- Testing
- Facilitated Tucking, Swaddling, Prone Position
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
Coagulation
Left Ventricular Assist Device (LVAD) Specialized Centers of Clinically Orientated Research (SCCOR) Coagulation - Acute Intrinsic Pathway Antagonist (IPA)
The purpose of this study is to determine if post-operative administration of intrinsic pathway antagonist (TTP889) in patients on Left Ventricular Assist Device (LVAD) support will result in a 50% reduction of thrombin…
- Trial name
- NCT00909298
- Testing
- TTP889
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- vTv Therapeutics
Stroke, Acute, Ischemic Stroke, Acute
Endovascular Therapy for Large Core Patients With Uncertain Response to Thrombectomy
The purpose of this study is to assess the safety and efficacy of endovascular thrombectomy in both an early and extended time window in patients with large strokes due to large artery occlusion.
- Trial name
- OUTER LIMITS (NCT06961487)
- Testing
- EndovascularThrombectomy, Endovascular thrombectomy with any FDA-approved device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Lactose Intolerance
Does Daily Supplementation of Lactobacillus Acidophilus MPH734, for One Week, Affect Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a Placebo
The purpose of this study is to determine if twice or three times daily supplementation of Lactobacillus acidophilus MPH734 (Lacto-FreedomTM, or LF), for one week, affects acute (immediate), subacute (7 days), and post-treatment…
- Trial name
- LF (NCT04531033)
- Testing
- Lactobacillus acidophilus MPH734
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lemuel W. Taylor IV
Dengue
A Cohort Study to Determine the Incidence of Dengue Fever and to Build Capacity for Dengue Vaccine Trials in Dengue-endemic Regions of South Asia
The purpose of this study is to determine the incidence of dengue fever and to build capacity for dengue vaccine trials in dengue-endemic regions of South Asia.
- Trial name
- NCT02570152
- Testing
- Blood sample collection
- Where
- Sri Lanka
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malnutrition, Severe Acute, Malnutrition, Child
Slow Introduction of Nutrition for Ill Malnourished Children
The goal of this clinical trial is to learn if giving lower calorie feeds during the first stage of treatment helps improve survival in severely malnourished children who are ill.
- Conditions
- Malnutrition, Severe Acute, Malnutrition, Child, Malnutrition, Infant
- Trial name
- F50 (NCT06846749)
- Testing
- F75 milk feeds, F50 milk feeds, F35 milk feeds
- Where
- 2 sites in Bangladesh, Malawi
- Volunteers
- 135 people
- Sponsor
- The Hospital for Sick Children
Inflammation, Colon Cancer
Clinical Significance of Marginal Acute Inflammation for Stage II Colon Cancer
Marginal acute inflammation would make reporting the serosal involvement of tumors controversial. We aimed to investigate the clinical significance and explore the prognostic value of MAI for stage II localized colon cancer.
- Trial name
- NCT06135558
- Testing
- MAI detection
- Volunteers
- 1,167 people
- Sponsor
- Sun Yat-sen University
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