Clinical trials: Disease;Neurological
Voice Disorders
Development of Imaging Biomarkers for Voice After Pediatric Airway Reconstruction
Objective: The purpose of this proposal is to use High Speed Videoendoscopy (HSV) to develop and test an imaging biomarker to support diagnosis and predict vibratory outcome after airway reconstruction.
- Trial name
- NCT03076931
- Testing
- Microlaryngoscopy, Voice Evaluation, Airway Reconstruction
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cough, Airway Clearance Impairment
Does the Coaching Function Improve the Learning of Mechanical In-exsufflation (MI-E) in Paediatric Subjects?
The use of mechanical insufflation-exsufflation (MI-E) in children with neuromuscular diseases (NMD) is recommended by international guidelines and societies and well documented.
- Conditions
- Cough, Airway Clearance Impairment, Neuromuscular Diseases
- Trial name
- MI-Ecoaching (NCT06190431)
- Testing
- Learning the use of an in-exsufflation device with the guidance of a physiotherapist, Using the coaching mode
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sleep Disorder, Circadian Dysregulation
Implementing and Sustaining a Sleep Treatment to Improve Community Mental Part 1: Implementation Health Outcomes
The sleep disturbance commonly experienced by individuals with a severe mental illness (SMI) reduces these individuals' capacity to function and contributes to key symptoms.
- Trial name
- NCT04154631
- Testing
- Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Usual Care Delayed Treatment
- Where
- 10 sites in United States
- Volunteers
- 489 people
- Sponsor
- University of California, Berkeley
Arthritis, Rheumatoid
Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid Arthritis
The purpose of this study is to determine whether milnacipran reduces widespread, non-joint pain in patients with rheumatoid arthritis (RA).
- Trial name
- NCT01207453
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Brigham and Women's Hospital
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Diaphragmatic Pacer Placement: Anesthetic Management (DP)
The diaphragmatic pacemaker (DP) has proven its utility in replacing mechanical ventilation (MV) in patients with chronic spinal cord injury (SCI) and Amyotrophic Lateral Sclerosis (ALS), by improving the patients quality of life…
- Conditions
- Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Respiratory Paralysis
- Trial name
- DP (NCT02942953)
- Testing
- Diaphragmatic Pacer
- Volunteers
- 16 people
- Sponsor
- Institut Guttmann
Pancreatic Cancer Pain
EUS Guided Celiac Neurolysis
Hypothesis: Direct CGN enhances neurolytic drug delivery into celiac ganglia and increases the efficacy of neurolysis and subsequent pain control and survival in patients with pancreatic carcinoma.
- Trial name
- NCT01615653
- Testing
- EUS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive
An Observational Biomarker Study in Multiple Sclerosis (MS) Patients
All males and females between 18-70 years of age regardless of their race and ethnicity with a confirmed diagnosis of Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive Multiple Sclerosis (SPMS), and Relapse…
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT05663853
- Where
- 4 sites in United States
- Volunteers
- 137 people
- Sponsor
- LAPIX Therapeutics Inc.
Pain, Acute, Edema
Lornoxicam Versus Etodolac After Third Molar Surgery
Our study aimed to compare the effect of lornoxicam and etodolac on postoperative pain, edema and trismus following lower third molar extraction
- Conditions
- Pain, Acute, Edema, Trismus
- Trial name
- NCT05679453
- Testing
- Lornoxicam 8 Mg Oral Tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Obstructive Sleep Apnea
Personal Therapy Comfort Settings Pilot Clinical Study
350 participants will be enrolled in this study. The target population are patients newly diagnosed with OSA and starting CPAP treatment.
- Trial name
- NCT05376137
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Australia
- Volunteers
- 66 people
- Sponsor
- ResMed
Parkinson Disease, Cognitive Dysfunction
A Study to Evaluate the Effects of SAGE-718 in Participants With Parkinson's Disease Cognitive Impairment
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance in participants with Parkinson's disease mild cognitive impairment (PD-MCI).
- Trial name
- NCT05318937
- Testing
- SAGE-718
- Where
- 38 sites in United States
- Volunteers
- 86 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Pulpitis - Irreversible, Vitamin D Deficiency
Effect of Vitamin D on Postoperative Pain in Symptomatic Irreversible Pulpitis
Vitamin D deficiency (VDD) is a prevalent global health concern that has been linked to altered pain perception through its effects on inflammatory pathways, nociceptor activity, and neurotrophic signaling.
- Trial name
- NCT07579637
- Testing
- Vitamin D3
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Future University in Egypt
Sleep Apnea - Obstructive, Cost Effectiveness
Remote Diagnosis and Management of Obstructive Sleep Apnea
Although obstructive sleep apnea, a breathing disorder during sleep, is prevalent and recognized as a major public health concern, most Veterans with this disorder are undiagnosed and therefore untreated.
- Conditions
- Sleep Apnea - Obstructive, Cost Effectiveness, Telemedicine
- Trial name
- NCT03007745
- Testing
- autoadjusting continuous positive airway pressure
- Where
- 3 sites in United States
- Volunteers
- 435 people
- Sponsor
- VA Office of Research and Development
Brain and Central Nervous System Tumors
Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00053872
- Testing
- cisplatin, lomustine, vincristine sulfate
- Where
- 8 sites in Belgium, France and 6 more
- Volunteers
- 316 people
- Sponsor
- University of Leicester
Amblyopia
Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT05522972
- Testing
- Video Game Vision Training, Perceptual Learning, Occlusion Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Sleep Disorders
Clinical Trial on a Food Supplement With Melatonin and Herbal Products to Improve Sleep Quality
A randomized, double-blind, placebo-controlled clinical trial on the ability of a dietary supplement containing melatonin and herbal products to improve sleep quality in subjects with insomnia problems with a 15-day follow-up…
- Trial name
- NCT05459272
- Testing
- Aquilea Sueno Forte
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Uriach Consumer Healthcare
Ischemic Stroke
Assessment of Left Atrial Appendage Morphology in Patients After Ischemic Stroke
Stroke remains the most dangerous and frightening complication of atrial fibrillation (AF). Numerous factors predisposing to peripheral embolism in patients with AF have been well defined, documented and included in the…
- Trial name
- ASSAM (NCT02654795)
- Testing
- computed tomography
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Centre of Postgraduate Medical Education
Cardiovascular Surgery, Pain, Postoperative
Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery
The purpose of this study is to find out what effects (good and bad) that the study medicine called "liposomal bupivacaine" has on subjects that are undergoing a sternotomy.
- Conditions
- Cardiovascular Surgery, Pain, Postoperative, Block
- Trial name
- NCT04333095
- Testing
- Liposomal bupivacaine, Normal Saline Flush, 0.9% Injectable Solution_#1
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Baylor Research Institute
Chronic Subdural Hematoma, Anticoagulant-induced Bleeding
Management of Anticoagulants and Antithrombotics in Patients With CSDH
Primary objective of the study will be to compare, up to 6 months after surgery, number of relapses (post operative re-bleeding) or intracerebral hemorrhage (others than subdural hematomas) and thromboembolic or cardiovascular…
- Conditions
- Chronic Subdural Hematoma, Anticoagulant-induced Bleeding, Thromboembolic Stroke, Cardiovascular Stroke
- Trial name
- THERCA (NCT05079295)
- Testing
- CSDH evacuation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital of Ferrara
Syncope, Vasovagal, Pain Intensity
Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
This randomized controlled trial will examine the impact of local anesthetic on the frequency of vasovagal reactions and the patients perception of pain during femoral arterial sheath removal after percutaneous coronary…
- Trial name
- NCT00465439
- Testing
- Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Acute Brain Injury, Traumatic Brain Injury
Implementation of Neuro Lung Protective Ventilation
Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Stroke
- Trial name
- NEUROVENT (NCT03243539)
- Testing
- Lung Protective Ventilation
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Colin Grissom
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