Clinical trials: Disease;Neurological
Postpartum
Effects of Manual Lymph Drainage on Breast Engorgement in Postpartum Period.
There have been many studies on the treatment of breast engorgement, there is a lack of research comparing the effectiveness of manual lymph drainage with massage.
- Trial name
- NCT06168630
- Testing
- Manual lymph drainage, Control group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Obstructive Sleep Apnea
Zolpidem on CPAP Acclimatization in OSA
Obstructive sleep apnea (OSA) is a sleep disorder characterized by a cessation or significant decrease in airflow during sleep. CPAP is the preferred therapy and has high effectiveness at all levels of OSA severity.
- Trial name
- NCT06084130
- Testing
- Zolpidem
- Volunteers
- 30 people
- Sponsor
- Siriraj Hospital
Brain Damage, External Ventricular Drain
Pupillometry : Predictive Indicator in External Ventricular Drain Clamping ?
Pupillar diameter variation to predict success or failure of external ventricular derivation clamping. Pupillometry utilisation as a diagnostic tool in external ventricular clamping test in neurological ICU should improve…
- Conditions
- Brain Damage, External Ventricular Drain, Hydrocephalus
- Trial name
- CLAMP (NCT03823430)
- Testing
- Pupillometry
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Association Pro-arte
Pain, Depression
Stepped Care for Depression and Musculoskeletal Pain
This study will evaluate the effectiveness of a stepped care approach in treating depression and reducing pain.
- Trial name
- NCT00118430
- Testing
- Stepped Care, Antidepressants, Usual Care
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Indiana University
Muscle Atrophy, Surgery
Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study
The loss of muscle mass post-surgery confounds recovery efforts and leads to a delay in patient's ability to return to activities.
- Conditions
- Muscle Atrophy, Surgery, Knee Injuries and Disorders, Complication of Surgical Procedure
- Trial name
- NCT04456530
- Testing
- Aveed 750 MG in 3 ML IM Injection, Normal Saline 3 ML IM Injection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Stone Research Foundation for Sports Medicine and Arthritis
Organ Transplantation From Brain-dead Donors
Cooling to Optimize Organ Life in Donor Study
The purpose of this study is to assess the feasibility and safety of mild-to-moderate hypothermia as an in-vivo organ preservation strategy compared to normothermia in 60 brain-dead organ donors.
- Trial name
- COOLDonor (NCT01544530)
- Testing
- Cold isotonic fluid and central venous hypothermia catheter
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pittsburgh
Trigeminal Neuralgia
An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.
Trigeminal neuralgia (TN), also called "tic douloureux", is the most common form of craniofacial neuropathic pain and is considered the cause of one of the most painful afflictions known in medical practice.
- Trial name
- NCT05217628
- Testing
- Basimglurant
- Where
- 34 sites in United States, Denmark and 6 more
- Volunteers
- 166 people
- Sponsor
- Noema Pharma AG
Fibromyalgia, Chronic Pain
Tai Chi Intervention and Brain Imaging Study Among Fibromyalgia Patients and Healthy Controls
This exploratory study proposal is the first pilot brain imaging study to determine if Tai Chi can modulate brain resting state functional connectivity (rsFC) and brain morphometry among fibromyalgia (FM) patients and healthy…
- Trial name
- fMRI/FMEX (NCT02407665)
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
MTBI - Mild Traumatic Brain Injury, Concussion, Mild
Controlled DTI Evaluations in High School Football and Female Soccer to Evaluate Efficacy of Jugular Compression Collar
The purpose of the study is to monitor longitudinal changes in brain structure between the preseason and postseason, in a population of football and soccer playing athletes wearing the Device and compared to a similar population…
- Trial name
- NCT04068883
- Testing
- Q collar
- Where
- 2 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
HER-2 Positive Breast Cancer
A Study Of Everolimus, Trastuzumab And Vinorelbine In HER2-Positive Breast Cancer Brain Metastases
Purpose: This study is a single-arm, open-label phase II clinical trial testing the hypothesis that daily everolimus plus weekly vinorelbine and trastuzumab will be effective, safe, and tolerable among patients with human…
- Trial name
- NCT01305941
- Testing
- Everolimus, Vinorelbine, Trastuzumab
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Restless Legs Syndrome
Long-Term Safety Of Ropinirole XR In Patients With Restless Legs Syndrome
The primary objective of this study is to assess the safety and tolerability of ropinirole XR in the long-term treatment (up to 52 weeks)of adults with RLS.
- Trial name
- NCT00355641
- Testing
- Ropinirole Extended Release (XR)
- Where
- 65 sites in United States, Canada
- Volunteers
- 450 people
- Sponsor
- GlaxoSmithKline
Stroke
Extern Validation of a Predictive Score of Brain Death in Severe Stroke (DIAPASON1)
There is currently a shortage of organ in France, for patients with chronic diseases who are on the waiting list for an organ. The first source of organ donor in France is patients with brain death.
- Trial name
- DIAPASON1 (NCT03612141)
- Where
- 25 sites in France
- Volunteers
- 650 people
- Sponsor
- Central Hospital, Nancy, France
Somatosensory Tinnitus, Subjektif tınnitus
COMPARISON OF MANUAL THERAPY, TINNITUS RETRAINING THERAPY
This randomized controlled trial aims to compare the effectiveness of Manual Therapy (MT), Tinnitus Retraining Therapy (TRT), and their combination in adults with somatosensory tinnitus.
- Trial name
- TINNITUS (NCT07740954)
- Testing
- Manuel therapy
- Volunteers
- 65 people
- Sponsor
- Suleyman Demirel University
Brain Tumor, Pediatric
Neurocognitive and Psychosocial Outcomes Among Pediatric Brain Tumor
This will be the first in-depth study to evaluate pretreatment and 12 months post-treatment, neurocognitive and psychological outcomes of children with brain tumor in Pakistan.
- Trial name
- PBT (NCT05709522)
- Testing
- Neurocognitive tools
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Aga Khan University
Traumatic Intracranial Hemorrhage
Platelet Transfusion and Repeat TEG-PM in Patients With Severe TBI on Antiplatelet Therapy (Repeat TEG-PM)
The aim of this study is to see if administering platelets (cells in our blood that stop or prevent bleeding) results in improved platelet function and slows/stops the progression of a head bleed for patients who have a traumatic…
- Trial name
- NCT06433622
- Testing
- Repeat Thromboelastography with Platelet Mapping
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Lancaster General Hospital
SPINAL Fracture
Parameters of Neurological Deficit After Thoracolumbar Fractures
To detect Radiological parameters affecting neurological injury after thoracolumbar spinal fractures.
- Trial name
- NCT03269851
- Testing
- computed tomography
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Assiut University
Migraine in Children, Migraine
A Study in Children and Young People With Migraine to Learn What the Body Does to Eptinezumab
The purpose of the study is to investigate how the body absorbs, distributes, and get rid of eptinezumab when given directly into a vein.
- Trial name
- NCT04537429
- Testing
- Eptinezumab
- Where
- 9 sites in United States
- Volunteers
- 28 people
- Sponsor
- H. Lundbeck A/S
Radiculopathy Lumbar, Low Back Pain
Evaluation of Transforaminal Epidural Steroid Injection in Radicular Low Back Pain According to MSU Classification
Low back pain is a common disease in all ages and it effects seriously quality of life. Medical treatment,interventional methods and surgery are the treatment options.
- Conditions
- Radiculopathy Lumbar, Low Back Pain, Disc Herniation, Injections, Epidural
- Trial name
- NCT06275529
- Testing
- Transforaminal Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Voice Disorders
Multimodal Analysis of Structural Voice Disorders Based on Speech and Stroboscopic Laryngoscope Video
This study intends to collect clinical data such as strobary laryngoscope images and vowel audio data of patients with structural voice disorders and healthy individuals, and to establish a multimodal voice disorder diagnosis…
- Trial name
- NCT05348031
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Postoperative Sore Throat, Cough, Hoarseness
Hyaluronic Acid for Prevention of Post-Intubation Sore Throat and Hoarseness
The goal of this clinical trial is to find out whether applying Endotra Gel, a hyaluronic acid-based gel, to the endotracheal tube can help reduce sore throat and hoarseness after surgery.
- Conditions
- Breast Cancer, Postoperative Sore Throat, Cough, Hoarseness, Endotracheal Intubation, General Anesthesia
- Trial name
- NCT07040631
- Testing
- Endotra Gel
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Pusan National University Yangsan Hospital
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