Clinical trials: Disease;Neurological
Down Syndrome
Inspiratory Muscle Training and Physical Fitness in Children With Down Syndrome Randomized Control Trial
The purpose of this study is to investigate the effect of inspiratory muscle training on physical fitness in Down syndrome children.
- Trial name
- NCT04767412
- Testing
- aerobic exercise training, inspiratory muscle training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Spinal Muscular Atrophy
An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA)
This objectives of this study are to evaluate the safety, tolerability, and pharmacokinetics of a single dose of nusinersen (ISIS 396443) administered intrathecally to participants with Spinal Muscular Atrophy (SMA).
- Trial name
- SMNRx (NCT01494701)
- Testing
- nusinersen
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- Biogen
Cerebral Palsy, Hip Dysplasia
Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy
Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly.
- Conditions
- Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
- Trial name
- NCT06189781
- Testing
- Ropivacaine injection, Bupivacaine, lidocaine, ropivacaine
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Oculopharyngeal Muscular Dystrophy
Safety Tolerability and Efficacy Study of Cabaletta to Treat Oculopharyngeal Muscular Dystrophy (OPMD) Patients
The Purpose of this study is to assess the Safety, Tolerability and Efficacy of Intravenous Cabaletta® in Oculopharyngeal Muscular Dystrophy (OPMD) Patients.
- Trial name
- HOPEMD (NCT02015481)
- Testing
- Cabaletta
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 25 people
- Sponsor
- Bioblast Pharma Ltd.
Parkinson Disease, Idiopathic
Parkinson Disease: A Model of National Digital Interventions to Prevent or Slow a Rise of Non-Communicable
According to Parkinson's Disease Medical Center of Excellence's project which was registered Parkinson's disease patients in 2008-2011, it was found that there were more than 60,000 people with Parkinson's disease in Thailand…
- Trial name
- PDRegistry (NCT06609681)
- Where
- Thailand
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Roongrooj Bhidayasiri
Stroke Rehabilitation, Aphasia, Broca
Music Therapy for Rehabilitation in Post-stroke Non-fluent Aphasia: the Indian Adaptation
The goal of this Interventional Study is to develop and test the Indian Adaptation of Melodic Intonation Therapy (MIT) for Indian patients in with post-stroke Non-Fluent Aphasia (PSNFA).
- Trial name
- NCT06323330
- Testing
- Speech rehabilitation
- Where
- 3 sites in India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
GBM, Glioblastoma Multiforme (GBM)
Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy
The goal of this clinical trial is to evaluate the safety and feasibility of focused ultrasound (FUS)-mediated blood-brain barrier (BBB) disruption using the Next Generation Dome Helmet (NGDH) in adults with glioblastoma (GBM)…
- Conditions
- GBM, Glioblastoma Multiforme (GBM), Glioblastoma Multiforme of Brain, Glioblastoma Multiforme Glioma
- Trial name
- NCT07179328
- Testing
- Focused Ultrasound Next Generation Dome Helmet, Definity® Vial for (Perflutren Lipid Microsphere) Injectable Suspension
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Tinnitus
Daily Bi-temporal Transcranial Random Noise Stimulation in Tinnitus
Stimulation of the left and right auditory cortex with daily transcranial random noise stimulation (tRNS) is used to modulate the neural pathways involved in chronic tinnitus.
- Trial name
- tRNS-tin (NCT01965028)
- Testing
- Transcranial random noise stimulation (tRNS)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Regensburg
Pain
Oxycodone User Registry (OUR)
The purpose of this study is to describe clinical and demographic characteristics of patients receiving prescription medications containing oxycodone immediate release (OXYRX), to characterize patient and prescriber perceptions…
- Trial name
- NCT00978328
- Testing
- oxycodone immediate release (OXYRX)
- Volunteers
- 827 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Alzheimer's Disease, Dementia
Clinical Trial of Donepezil Between the Patients With Alzheimer's Disease and Mixed Dementia
To compare the clinical efficacy of donepezil between patients with Alzheimer's disease and Mixed Dementia.
- Trial name
- NCT01023867
- Testing
- donepezil
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Samsung Medical Center
Insomnia, Cognitive Impairment
The Effect of Aromatherapy on Sleep and Cognitive Level in the Elderly
This research aims to investigate the effect of aromatherapy on sleep duration, sleep quality, falling asleep time and cognitive functions of elderly individuals in the short term and to improve the general health status and…
- Conditions
- Insomnia, Cognitive Impairment, Elderly
- Trial name
- NCT06208800
- Testing
- Blend Aromatherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Teeth, Impacted
Bupivacaine in the Treatment of Postoperative Pain of Impacted Third Molar Extraction
The third molars are the teeth that are most frequently included and impacted, extraction is one of the most performed treatments by maxillofacial surgeons in their clinical practice.
- Trial name
- NCT03950700
- Testing
- Bupivacaine-epinephrine, Saline Solution
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CES University
Traumatic Brain Injury
IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance
Patients who have a functioning intracranial pressure-monitoring device (either a subarachnoid bolt, or an intraventricular catheter) in place, and are either sedated, intubated, and mechanically ventilated (i.e.
- Trial name
- NCT01205607
- Testing
- ITPR -5 mm Hg then -9 mm Hg, ITPR -9 & then -5mm Hg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Parkinson Disease
Effects of Peripheral Electrical Stimulation With Focused Ultrasound on Motor Symptoms in Parkinson's Patients
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation(NIBS) technique that can be used on both superficial and deep brain targets with a high spatial resolution as small as a few cubic…
- Trial name
- tbFUS-FES_PD (NCT06090292)
- Testing
- Real TUS, Real FES
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Osteoarthritis, Osteoarthritis, Knee
A Clinical Trial Investigating the Effect of Salmon Bone Meal on Osteoarthritis Among Men and Women
The purpose of this study is to evaluate the efficacy of hydrolyzed collagen in osteoarthritis.
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT05070871
- Testing
- Hydrolyzed Collagen, CalGo
- Where
- 3 sites in Norway
- Volunteers
- 98 people
- Sponsor
- Hofseth Biocare ASA
Hemispatial Neglect
The Effectiveness of Transcranial Magnetic Stimulation and Mirror Therapy in Hemispatial Neglect
The aim of this study is to evaluate the effectiveness of continuous Theta Burst Stimulation added to mirror therapy on neglect associated with stroke.
- Trial name
- NCT07228871
- Testing
- Mirror Therapy, cTBS, Cognitive rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Ankara Etlik City Hospital
Stroke
Efficacy Study of FES Controlled by Electromyographic Signal for the Treatment of Upper Limb in Post-stroke Patients
Goal of the present study is to evaluate the efficacy of Myoelectrically-controlled Functional Electrical Stimulation (MeCFES) for the rehabilitation of upper limb in post-stroke patients.
- Trial name
- RiSES (NCT03019744)
- Testing
- MeCFES-assisted task-oriented upper limb rehabilitation, Usual Care task-oriented upper limb rehabilitation
- Volunteers
- 82 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Fibromyalgia Syndrome
Mechanism Study of Yangyin Roujin Formula in the Treatment of Fibromyalgia Syndrome
This prospective randomized, double-blind, controlled clinical trial is designed to address the current challenges in the clinical management of fibromyalgia (FM).
- Trial name
- NCT07736144
- Testing
- Yangyin Roujin Decoction
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Juan Jiao
Dysphagia, Stroke
Wearable Biofeedback for Swallowing Disorders Rehabilitation in Stroke and Parkinson Disease
Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but its treatment is not well established or easily accessible.
- Conditions
- Dysphagia, Stroke, Parkinson Disease
- Trial name
- NCT06638944
- Testing
- In-person sEMG-biofeedback, Remote sEMG-biofeedback, Standard-of-care treatment
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Illinois at Urbana-Champaign
Pain Management, Anxiety
Effects of EFT on Postpartum Safety Perception, Anxiety, and Postoperative Pain After Cesarean Section
This study is a parallel randomized controlled trial on 60 primiparous women with cesarean section pain, randomly divided into EFT and control groups.
- Trial name
- NCT06999564
- Testing
- EFT
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
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