Clinical trials: Disease;Neurological
Amyotrophic Lateral Sclerosis
Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS)
Patients with neuropathic diseases are experiencing increasing muscle weakness, loss of muscle strength and functional abilities during their illness.
- Trial name
- ALS-project (NCT01504009)
- Testing
- Muscle training
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- University of Southern Denmark
Hip Fractures, Gait, Unsteady
Comparison of Sliding Hip Screw to Intra Medullary Nailing in the Treatment of Intertrochanteric Hip Fracture
Shortening of the abductor lever arm is a particular concern with the SHS, and the resultant biomechanical alterations may impair gait, including decreased cadence, gait speed and increased double support time on the injured…
- Conditions
- Hip Fractures, Gait, Unsteady, Function
- Trial name
- NCT03906032
- Testing
- TFNA IM Nail, Sliding hip screw
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Waterford
Periodontal Disease, Stroke
PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke
The PREMIERS study is a proposal for conducting an adequately powered two center phase III randomized controlled trial to test whether intensive periodontal treatment reduces the risk of recurrent vascular events among ischemic…
- Conditions
- Periodontal Disease, Stroke, TIA
- Trial name
- PREMIERS (NCT02541032)
- Testing
- Intensive dental treatment, Standard dental treatment, Arestin
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of South Carolina
Migraine
Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness.
- Trial name
- NCT02196532
- Testing
- Device: Optical coherence tomography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yifan Feng
Vestibular Schwannoma, Inner Ear Disease
Vestibular Precision: Physiology & Pathophysiology
This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors.
- Conditions
- Vestibular Schwannoma, Inner Ear Disease, Dizziness, Neurofibromatosis 2
- Trial name
- NCT04890132
- Testing
- VOR precision training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Fibromyalgia
The Effects of Mindfulness Meditation on Fibromyalgia-Related Pain
The purpose of this study is to examine the effects of a brief mindfulness meditation intervention on clinical and experimental pain in fibromyalgia (FM) patients as compared to a wait-list control condition.
- Trial name
- NCT02581332
- Testing
- Mindfulness Meditation Training
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Zika Virus Disease (Disorder), Dengue
The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico
This study will evaluate subjects with fever and/or rash to determine the percentage of those infected by the Zika, Chikungunya, or Dengue virus.
- Conditions
- Zika Virus Disease (Disorder), Dengue, Chikungunya
- Trial name
- Zik01 (NCT02831699)
- Where
- 6 sites in Mexico
- Volunteers
- 600 people
- Sponsor
- Mexican Emerging Infectious Diseases Clinical Research Network
Stroke Sequelae, Brain Ischemia
EEG Based BCI for Upper Limb Rehabilitation in Stroke
Biomedical and Engineering approaches form a key element to neurological rehabilitation of upper limbs. Brain Computer Interface (BCI) using Motor execution and Motor Imagery are known to aid motor recovery in stroke.
- Trial name
- NCT04188132
- Testing
- EEG -BCI based Feedback for rehabilitation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Houston
Spina Bifida, Cerebral Palsy
Grand Valley State University (GVSU) Skills on Wheels
Manual wheelchairs (MWCs) are widely used by children with physical disabilities, yet many of these children are unable to use their wheelchair independently. Instead, they depend on others to push them.
- Conditions
- Spina Bifida, Cerebral Palsy, Genetic Disease, Spinal Cord Injuries
- Trial name
- NCT05339932
- Testing
- Manual Wheelchair Skills Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Shoulder Pain, Hemiplegia
Shoulder Passive Range of Motion and Positioning Exercise on Hemiplegic Stroke Patients
Several factors associated with the hemiplegic shoulder pain after stroke includes rotator cuff injury, bicipital tendonitis, impingement, spasticity, limited external rotation of shoulder joint, adhesive capsulitis, shoulder…
- Conditions
- Shoulder Pain, Hemiplegia, Stroke, Rotator Cuff Injury
- Trial name
- NCT03045432
- Testing
- video-teaching, oral-teaching, regular rehabilitation program
- Volunteers
- 104 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Stroke
The CLOQS Trial - Countdown Lights to Optimize Quality in Stroke
To reduce door-to-needle times in acute stroke treatment. Using an organizational behaviour intervention (a large stopwatch), we will post a visual cue to remind all parties that "time is brain".
- Trial name
- CLOQS (NCT01148602)
- Testing
- LED stopwatch-clock timers
- Where
- 3 sites in Canada
- Volunteers
- 3,452 people
- Sponsor
- Sunnybrook Health Sciences Centre
Multiple Sclerosis
Testosterone Treatment for Multiple Sclerosis
Since men are less likely to develop multiple sclerosis, the hypothesis was that testosterone might be protective in MS. Men with MS for followed untreated for 6 months, followed by a 12 month treatment period with Androgel.
- Trial name
- NCT00405353
- Testing
- Androgel 10 grams of gel containing 100 mg of testosterone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Postoperative Pain
NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain
The investigators investigated whether a strictly controlled pain management with patients participating in a clinical study can attenuate persistence of post-thoracotomy pain.
- Trial name
- NCT01541137
- Testing
- Diclofenac, parecoxib/ valdecoxib, patient controlled epidural analgesia
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Suboptimal Health Status
Evaluation of Laser Acupuncture on Health Promotion of Sub-health People
Background: Suboptimal health status (SHS) is a dynamic state wherein people have not been diagnosed with a disease but tend to develop diseases. People with SHS often experience fatigue and other nonspecific symptoms.
- Trial name
- NCT04325945
- Testing
- Low level laser therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Atherosclerotic Cardiovascular Disease
In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular Disease
Study CKJX839B1FR01 in an In silico trial to predict the efficacy of Inclisiran therapy on major adverse cardiovascular events (MACE) and cardiovascular (CV) death in virtual patients with atherosclerotic cardiovascular disease…
- Trial name
- SIRIUS (NCT05974345)
- Testing
- Inclisiran sodium, Ezetimibe, Evolocumab
- Where
- France
- Volunteers
- 204,691 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Pain
VCOM Pain Free Research Collaborative
Studies estimate that 30% of people worldwide experience chronic pain. The mechanisms causing this pain can vary: a neuropathic offender, such as nerve compression; a structural offender, such as long-term effects of soft tissue…
- Trial name
- MERCI (NCT06533345)
- Testing
- Behavior Change Coaching, Nutrition, Autonomic Recalibration
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Fibromyalgia, Sexual Dysfunction
Fibromyalgia and Sexual Functıonal Dısorder and Sexual Therapy
investigators aim to re-evaluate the findings of Fibromyalgia in patients whose FSFI scores return to normal levels after sexual therapy, by identifying patients with sexual dysfunction according to the FSFI scale applied in…
- Trial name
- NCT05272345
- Testing
- sexual therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Carpal Tunnel Syndrome, Diagnosis
Statistically Analysis of Carpal Tunnel Syndrome Diagnosis
Trap neuropathies; They are compression neuropathies that occur as a result of peripheral nerves being compressed for various reasons along their anatomical paths.
- Trial name
- NCT05584839
- Testing
- Statistically Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- İSMAİL CEYLAN
Pain, Postoperative, Surgical Procedures, Operative
Postoperative Pain in Adult Patients.
Each surgical intervention associated with even a minor tissue injury is a source of pain which needs to be effectively controlled.
- Trial name
- NCT03731039
- Testing
- Observational study
- Where
- Poland
- Volunteers
- 620 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
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