Clinical trials: Disease;Neurological
Pompe Disease
The Effects of Respiratory Muscle Strength Training (RMST) on Inspiratory and Expiratory Muscle Strength in Adults and Children With Pompe Disease
The purpose of the study is to determine if respiratory muscle strength training will be beneficial for inspiratory and expiratory muscle strength in adults and children with Pompe disease.
- Trial name
- NCT01701154
- Testing
- respiratory muscle strength training
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Apathy, Schizophrenia
Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms.
This study is looking to determine if Lumateperone improves motivation in patients with schizophrenia or schizoaffective disorders who show high levels of apathy as judged by AES-C-Apathy (Apathy Evaluation Scale - Clinician …
- Conditions
- Apathy, Schizophrenia, Schizophrenia; Psychosis
- Trial name
- NCT06482554
- Testing
- Lumateperone 42 mg, Risperidone 2 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Sepsis-associated Encephalopathy
Optic Nerve Sheath Diameter / Eyeball Transverse Diameter Ratio and Prognosis of Sepsis Associated Encephalopathy
Sepsis is associated with a mortality rate of 20-25%, with significant increase in case of associated comorbidities or shock. SAE is one of the most common forms of encephalopathy encountered in critically ill patients, with…
- Trial name
- NCT05918705
- Testing
- Ultrasound optic nerve sheath diameter / eyeball transverse diameter ratio
- Where
- Egypt
- Volunteers
- 89 people
- Sponsor
- Zagazig University
Stroke, Stroke Sequelae
Neural Bases of Post-stroke Emotion Perception Disorders
This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs. healthy controls using MRI (functional and structural connectivity) and EEG.
- Conditions
- Stroke, Stroke Sequelae, Emotions
- Trial name
- STROKEM (NCT05595005)
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Multiple Sclerosis
DECISIve - DiagnosE Using the Central veIn SIgn v1.0
DECISIve - DiagnosE using the Central veIn SIgn. A prospective diagnostic superiority study comparing T2* MRI and lumbar puncture in patients presenting with possible Multiple Sclerosis
- Trial name
- DECISiVE (NCT05533905)
- Testing
- Lumbar puncture, MRI
- Where
- United Kingdom
- Volunteers
- 113 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Relapsing-remitting Multiple Sclerosis
Avonex (Interferon-beta-1a) and Avonex Plus Methylprednisolone for the Treatment of Relapsing-remitting MS
The primary objective of this study is to determine whether combination treatment (adding methylprednisolone to Avonex) reduces progression of disability over 4 years compared to Avonex alone.
- Trial name
- NCT00168766
- Testing
- Interferon-beta-1a (Avonex) plus methylprednisolone
- Where
- 9 sites in Belgium, Denmark and 6 more
- Volunteers
- 345 people
- Sponsor
- Biogen
Stroke Not Otherwise Specified
More Steps Towards an Active Life After Stroke - ActForStroke
The main goal of this quasi-experimental study is to prevent the negative consequences of mobility impairments after stroke. These include recurrent strokes, general deconditioning, and overweight on the physical side, and…
- Trial name
- ActForStroke (NCT06715566)
- Testing
- ActForStroke, Standard care
- Where
- 10 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Trisiomy 21 (Down Syndrome)
Vitamins and Minerals for Children With Downs Syndrome
The trial aimed to examine the effects of supplementation with antioxidants and folinic acid on the health, growth and psychomotor development of children with Down syndrome.
- Trial name
- NCT00378456
- Testing
- Antioxidants- (Vitamins A,C,E Selenium and Zinc), Folinic acid, Vitamins A,C,E Selenium and Zinc and Folinic acid.
- Where
- 3 sites in United Kingdom
- Sponsor
- Institute of Child Health
Subarachnoid Hemorrhage, Anxiety
Massage Technique for Pain, Anxiety and Delirium in SAH Patients
This research study seeks to explore the effects of massage techniques on pain and anxiety relief among patients with subarachnoid hemorrhages in the ICU setting in comparison to subarachnoid hemorrhagic patients using standard…
- Conditions
- Subarachnoid Hemorrhage, Anxiety, Pain, Delirium
- Trial name
- NCT01982656
- Testing
- Massage
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sara E. Hocker, M.D
Multiple Sclerosis
Pathological Basis of MRI Signal Changes in Multiple Sclerosis
Background: Multiple sclerosis (MS) is a disease that damages the central nervous system (brain and spinal cord). This leads to increased physical disability over time. The disease is lifelong once it begins.
- Trial name
- NCT02659956
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries, Cardiovascular Diseases
The Swedish Spinal Cord Injury Study on Cardiopulmonary and Autonomic Impairment
The main aim of this study is to gain an in-depth knowledge of cardiopulmonary and autonomic health consequences, and related risk factors among people with long-term high-level spinal cord injury.
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Pulmonary Disease, Autonomic Dysfunction
- Trial name
- SPICA (NCT03515122)
- Where
- Sweden
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Lund University
Parkinson's Disease, Physical Activity
Effect of High Intensity Interval Training on Mechanisms of Neuroplasticity in Parkinson's Disease Patients
There are experimental evidences of the important role of high intensity physical exercise in Parkinson's disease (PD) treatment, that induces similar effects to pharmacotherapy.
- Conditions
- Parkinson's Disease, Physical Activity, Neurorehabilitation, Neuroplasticity
- Trial name
- NCT04204551
- Testing
- high-intensity interval training (HIIT), conventional physical therapy
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Lewy Body Dementia
Non-invasive Transcranial Focused Low-intensity Ultrasound Stimulation in Patients With Mild Lewy Body Dementia
A randomized controlled clinical study was conducted in the xuanwu hospital Single Center of Capital Medical University to preliminarily explore the efficacy and safety of transcranial focused low-intensity ultrasound stimulation…
- Trial name
- tFUS in DLB (NCT05499429)
- Testing
- Transcranial low intensity focused ultrasound stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Tinnitus, Hearing Loss, Cochlear Implant Users
Sound Therapy for Tinnitus Relief in Cochlear Implant Users
The aim of this exploratory study is to evaluate the use and effectiveness of sound therapy for tinnitus relief in cochlear implant users with tinnitus.
- Trial name
- NCT03026829
- Testing
- CART sound therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 32 people
- Sponsor
- Cochlear
Voice Quality and Voice Loudness Associated With Parkinson's Disease
Singing in Groups for Parkinson's Disease; A Pilot Study of Group Singing Therapy for PD-related Voice/Speech Impairment
This study will compare group singing to group speech therapy without singing. You may be eligible for this study if you have been diagnosed with PD for one year or more and you have a quiet voice or difficulty being understood.
- Trial name
- SING-PD (NCT01163331)
- Testing
- Singing Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Drug Resistant Epilepsy, Focal Epilepsy
Electrophysiological Dose-Response to Anterior Thalamic Deep Brain Stimulation in Drug-Resistant Focal Epilepsy
This prospective, single-center mechanistic pilot study will investigate the electrophysiological dose-response to anterior thalamic deep brain stimulation (ANT-DBS) in 10 adults with drug-resistant focal epilepsy undergoing…
- Trial name
- ANT-DOSE (NCT07912931)
- Testing
- Anterior thalamic deep brain stimulation with a standardized amplitude schedule and acute stimulation challenges
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Duchenne Muscular Dystrophy
A Study of Deflazacort (Emflaza®) in Participants With Duchenne Muscular Dystrophy (DMD)
The primary objective of this study is to evaluate the safety of a 0.9 milligrams per kilogram (mg/kg) and 0.45 mg/kg daily dose of deflazacort with a comparable natural history control group after 52 weeks of treatment in males…
- Trial name
- PTCEMF (NCT03642145)
- Testing
- Deflazacort
- Sponsor
- PTC Therapeutics
Intraocular Foreign Body
Extraction Routes of Intraocular Foreign Body
Intra ocular foreign body removal is indicated to avoid further many complications such as retinal detachment, endophthalmitis. The surgical approach for a posterior segment IOFB is pars plana vitrectomy and its extraction either…
- Trial name
- IOFB (NCT05966545)
- Testing
- pars plana vitrectomy and intraocular foreign body removal
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Brain and Central Nervous System Tumors
Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00028795
- Testing
- temozolomide, adjuvant therapy, radiation therapy
- Where
- 230 sites in United States, Australia and 5 more
- Volunteers
- 170 people
- Sponsor
- Children's Oncology Group
Pain, Anxiety
Progressive Relaxation Exercises Before Mobilization:Effects on Pain, Anxiety and Physiologic Parameters CABG Patients
This study is planned as a randomized controlled experimental study to determine the effect of progressive relaxation exercises applied before mobilization on pain, anxiety and physiological parameters in patients undergoing…
- Conditions
- Pain, Anxiety, Physiological Parameter, Mobilization
- Trial name
- NCT06726239
- Testing
- Progressive relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Istanbul University - Cerrahpasa
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