Clinical trials: Disease;Neurological
Sleep Initiation and Maintenance Disorders, Insomnia
Efficacy and Safety of Eplivanserin 5mg/Day on Sleep Maintenance Insomnia
The aim of the study is to confirm the efficacy of eplivanserin 5mg/day on sleep maintenance of patients with primary insomnia using night polysomnography recordings over a 6-week treatment period corresponding to a stabilization…
- Trial name
- EPOCH (NCT00308503)
- Testing
- eplivanserin (SR46349)
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 608 people
- Sponsor
- Sanofi
Brain Abscess, Cerebral Abscess
Partial Oral Antibiotic Treatment for Bacterial Brain Abscess
The investigators aim to determine if oral antibiotics are clinically acceptable as treatment of brain abscess. Following 2 weeks of standard intravenous antibiotic therapy, half of patients will continue with this treatment for…
- Trial name
- ORAL (NCT04140903)
- Testing
- Early transition to oral antibiotics, Standard treatment of intravenous antibiotics
- Where
- 4 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Henrik Nielsen
Cardiac Surgery
Non-pharmacologial, Non-invassive Intervention Before Cardiac Surgery: a Randomized Controlled Trial
Perioperative neurological complications in cardiovascular surgical procedures are associated with a significant risk of mortality and disability.
- Trial name
- NICE (NCT06791551)
- Testing
- active RIPC and tDCS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Obstructive Sleep Apnea
Continuous Positive Airway Pressure (PAP) Titration and Treatment Versus Auto-adjusting PAP Treatment for Sleep Apnea
The purpose of this randomized prospective study is to compare the efficacy of two approaches to initiate Positive Airway Pressure (PAP) treatment in patients diagnosed as having obstructive sleep apnea (OSA) by portable…
- Trial name
- NCT00988351
- Testing
- Continuous positive airway pressure, Auto-adjusting positive airway pressure treatment
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- North Florida Foundation for Research and Education
Spinal Muscular Atrophy Type I
Clinical Trial to Assess the Safety and Efficacy of EXG001-307 in Patients with Spinal Muscular Atrophy Type 1
The purpose of this trial is to evaluate safety and efficacy of intravenous delivery of EXG001-307 as a treatment of spinal muscular atrophy Type 1 (SMN1).
- Trial name
- NCT05614531
- Testing
- EXG001-307 injection
- Where
- 2 sites in China
- Volunteers
- 12 people
- Sponsor
- Guangzhou Jiayin Biotech Ltd
Subarachnoid Hemorrhage
Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to determine the effectiveness of prophylactic administration of intra-thecal nicardipine though lumbar cerebrospinal fluid drain in prevention of symptomatic vasospasm in patients with subarachnoid…
- Trial name
- NCT07246629
- Testing
- Normal Saline, Nicardipine
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- Wake Forest University Health Sciences
Headaches
Tailored Internet Information Supply for Patients - Part 2
Medical expert systems in combination with portal searching meta-search engines are exploited to provide reliable patient-tailored information.
- Trial name
- NCT00921453
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Health & Life Sciences University, Tryol
Intracranial Neoplasm, Low Grade Glioma
Fluoroethyltyrosine for Evaluation of Intracranial Neoplasms
This phase II trial studies how well F-18 fluoroethyltyrosine (fluoroethyltyrosine) works in detecting tumors in participants with intracranial tumors that have come back.
- Conditions
- Intracranial Neoplasm, Low Grade Glioma, Recurrent Glioblastoma, Recurrent World Health Organization (WHO) Grade II Glioma
- Trial name
- UC-GlioFET (NCT04044937)
- Testing
- F-18 Fluoroethyltyrosine (FET), Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Thomas Hope
Critically Ill Patients Admitted in ICU
Effect of Stress Ball Use on Pain, Sleep Quality and Physiological Parameters
Environmental stressors, pain and sleep disorders are common in intensive care patients and non-pharmacological approaches can be effective in the management of these factors.
- Trial name
- NCT07207837
- Testing
- Stress Ball Use
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Giresun University
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Alzheimer's Disease
A Clinical Study to Evaluate the Pharmacokinetics (PK) of Corplex™ Donepezil Transdermal Delivery System (TDS) Applied to Different Body Locations
A Phase 1, Crossover Study to Evaluate the Pharmacokinetics of Corplex™ Donepezil 10 mg Transdermal Delivery System Applied to Different Body Locations
- Trial name
- NCT03432195
- Testing
- Donepezil TDS
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Corium, Inc.
Migraine, Nocebo Effects
Default Mode Network Connectivity and Nocebo Responses in Migraine: A Functional MRI Study
People with migraine sometimes experience symptoms because they expect a treatment to cause side effects. This is known as the "nocebo effect".
- Trial name
- Does not exist (NCT07720895)
- Testing
- intravenous saline infusion, Negative verbal suggestion, No intervention
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Ioanna Spanou
Breast Cancer, Breast Pain
Post Mastectomy Pain Syndrome After Preoperative Stellate Ganglion Block for Breast Cancer Surgeries
This study investigate the effect of pre-operative ultrasound guided stellate ganglion block with local anesthetic on the frequency of neuropathic pain syndromes in the first 6-month post cancer breast surgeries with axillary…
- Trial name
- NCT04238377
- Testing
- Stellate Ganglion Block, Multimodal Analgesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute, Egypt
Mild Traumatic Brain Injury, Concussion, Mild
Trends in Cohabitation Status, Academic Achievement and Socio-economic Indicators After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) accounts for 70-90% of all diagnosed traumatic brain injuries (TBI) affecting approximately 50-300 per 100.000 individuals annually.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Academic Achievement, Specific Academic or Work Inhibition
- Trial name
- NCT03678077
- Testing
- Mild traumatic brain injury
- Where
- Denmark
- Volunteers
- 45,777 people
- Sponsor
- University of Copenhagen
Prader-Willi Syndrome
Probiotic Treatment for Prader-Willi Syndrome
A whole new research area studying the function of intestinal microorganisms, also known as gut microbiota, has emerged during the last decade.
- Trial name
- NCT04685057
- Testing
- Probiotic, Follow-up probiotic
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Fundació Sant Joan de Déu
Spinal Cord Injury, Degenerative Spinal Disease.
Perfusion and Diffusion Mechanism of Intervertebral Disc-Significance With Age, Degeneration, Posture and Stress Loading.
The purpose of our study is to evaluate the perfusion of the IVDs and their diffusion ability by using the Dynamic contrast-enhanced MR perfusion technique and Diffusion weighted image with ADC value measurement, and to determine…
- Trial name
- NCT01973257
- Testing
- imaging diagnostics
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Postdural Puncture Headache
Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches
Postdural puncture headache (PDPH) is a severe, debilitating complication of dural puncture that can arise from insertion of an epidural or spinal needle for labour analgesia.
- Trial name
- SPGB (NCT04515901)
- Testing
- 2% lidocaine
- Where
- Canada
- Sponsor
- McMaster University
Pituitary Adenoma 1, Acth-Secreting
Pituitary Adenoma and Serum Lipid
Pituitary adenomas are usually benign monoclonal neoplasms caused by a mixture of pituicyte alterations together with a changed endocrine and paracrine regulatory milieu.
- Trial name
- NCT04021212
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shandong Provincial Hospital
Dizziness, Vertigo
The Relationship Between Dizziness and Neck Pain
Both dizziness and neck pain are common complaints in the Norwegian population. The cervical spine has a highly developed proprioceptive system, which is involved in head and gaze stabilization as well as postural control.
- Conditions
- Dizziness, Vertigo, Neck Pain
- Trial name
- NCT03531619
- Where
- Norway
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Intracerebral Hemorrhage
Management of Intracerebral Hemorrhage With Aminocaproic Acid - Pilot Study
This is single-arm, open-label, safety and feasibility pilot study of ɛ-aminocaproic acid in ICH patients. Consecutive ICH volume with hematoma volume less than 30 mL by ABC/2 method presenting within 3 hours of symptom onset…
- Trial name
- MANICHAN-PILOT (NCT02639819)
- Testing
- ɛ-Aminocaproic Acid
- Sponsor
- The University of Texas Health Science Center at San Antonio
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