Clinical trials: Disease Exacerbation
Respiratory Disease, Respiratory Failure
Clinical Evaluation of FreeO2 (Version 4) in All Patients Receiving Oxygen
Evaluation of automatic titration of oxygen with a new version of FreeO2 (V4)
- Conditions
- Respiratory Disease, Respiratory Failure, COPD Exacerbation, Asthma
- Trial name
- FreeO24G (NCT03119727)
- Testing
- FreeO2
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
T Lymphocyte Cells in Individuals Experiencing an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether the lungs of individuals with chronic obstructive pulmonary disease (COPD) contain resident memory T lymphocytes that can produce a combination of cytokines that induce the…
- Trial name
- NCT00281229
- Where
- 2 sites in United States
- Volunteers
- 481 people
- Sponsor
- University of Michigan
Primary Ciliary Dyskinesia
Utilizing Hyperpolarized 129Xe Magnetic Resonance Imaging in Children With Primary Ciliary Dyskinesia
This study investigates the use of hyperpolarized 129Xe magnetic resonance imaging (MRI) in children with primary ciliary dyskinesia (PCD) in detecting ventilation defects.
- Trial name
- PCD MRI (NCT04858191)
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- The Hospital for Sick Children
COPD - Chronic Obstructive Pulmonary Disease, Muscle Atrophy
Progressive Resistance Training of the Extensor Muscle of the Thigh in COPD-patients Hospitalized With an Exacerbation
We want to test the hypothesis, that resistance training by the use of weigth cuffs on the angle can prevent loss or improve the strength of the quadriceps muscle in COPD patients admitted to hospital due to an exacerbation.
- Trial name
- NCT01812460
- Testing
- Intervention-training-group
- Where
- Denmark
- Sponsor
- Frederikssunds Hospital, Denmark
Cystic Fibrosis
Effects of Vitamin D Supplementation on Lung Function in an Acute Pulmonary Exacerbation of Cystic Fibrosis
Vitamin D insufficiency is common in patients with cystic fibrosis. The investigators study will examine a large dose of vitamin D given to patients who have cystic fibrosis and are admitted to the hospital for a pulmonary…
- Trial name
- NCT00788138
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Cystic Fibrosis
Cystic Fibrosis Foundation (CFF) Biomarkers of Exacerbation
Clinical and translational research in cystic fibrosis (CF) is hampered by a lack of biomarkers that can be used to identify promising new therapies.
- Trial name
- NCT00788359
- Where
- 5 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Colorado, Denver
COPD, COPD Exacerbation
Chronic Obstructive Pulmonary Disease (COPD) Monitoring
The present feasibility study aims at assessing whether the EMG of respiratory muscles can serve as an objective marker of dyspnea in COPD patients.
- Trial name
- COPD (NCT04671888)
- Testing
- exercises
- Volunteers
- 30 people
- Sponsor
- Medtronic BRC
Pneumonia, Chronic Bronchitis
Adherence to Guidelines for Antibiotic Use in Respiratory Infections at Hospitals
The purpose of this study is to test a strategy to improve the quality of antibiotic use in lower respiratory tract infections (LRTIs) at hospitals.
- Conditions
- Pneumonia, Chronic Bronchitis, COPD
- Trial name
- NCT00129883
- Testing
- Professional education, Implementation of a Critical Care Pathway, Professional audit and feedback
- Where
- 7 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
COPD Exacerbation, Hypercapnia
DUET Versus Standard Interface for Hypercapnic COPD Patients
The goal of this clinical trial is to compare the new asymmetric nasal high flow interface with the conventional high flow nasal cannula in patients with COPD exacerbation.
- Conditions
- COPD Exacerbation, Hypercapnia, COPD
- Trial name
- NCT05829083
- Testing
- Asymmetric nasal cannula - DUET, Conventional nasal high flow cannula
- Where
- 2 sites in Greece
- Volunteers
- 50 people
- Sponsor
- Larissa University Hospital
COPD Exacerbation Acute, COPD With Acute Lower Respiratory Infection
RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection
Vapendavir (VPV) is a drug being developed to treat human rhinovirus (RV) infection, one virus responsible for the common cold. Vapendavir prevents the virus from entering cells and making more infectious copies of itself.
- Conditions
- COPD Exacerbation Acute, COPD With Acute Lower Respiratory Infection, Rhinovirus, Virus Diseases
- Trial name
- NCT06149494
- Testing
- Vapendavir
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Altesa Biosciences, Inc.
COPD Exacerbation
Effect of High Flow Nasal During Exercise in COPD Patients
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training.
- Trial name
- AiRehab (NCT03058081)
- Testing
- High Flow nasal cannula
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Groupe Hospitalier du Havre
Community Acquired Pneumonia (CAP), Acute Exacerbation of Chronic Bronchitis (AECB)
Ketek in CAP / AECB in Ambulatory Adult Patients
To determine the clinical effectiveness of telithromycin in the treatment of either CAP or AECB in a large population of ambulatory adult patients in a community-based setting.
- Trial name
- NCT00546676
- Testing
- Telithromycin
- Volunteers
- 174 people
- Sponsor
- Sanofi
Pulmonary Disease, Chronic Obstructive
The London COPD Exacerbation Cohort
The London COPD exacerbation (EXCEL) cohort builds on an established cohort started in 1995 and designed to study COPD exacerbations and their impact on health-status and disease progression.
- Trial name
- EXCEL_Cohort (NCT02755974)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Testing a Prediction Algorithm Into a Running Telehealth System for Patients With COPD
This trial will test a COPD prediction algorithm into a telehealth system from the previous Danish large-scale trial, TeleCare North (NCT01984840).
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, COPD Exacerbation Acute, COPD
- Trial name
- NCT05218525
- Testing
- Algorithm
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Aalborg University
Cystic Fibrosis
19F MRI of Ventilation in Subjects With Cystic Fibrosis Undergoing Treatment for Pulmonary Exacerbation
The purpose of this study is to use perfluorinated gas imaging to highlight regions of functional variation within the lungs of participants with cystic fibrosis (CF), and to correlate this with changes in spirometry, lung…
- Trial name
- NCT03497117
- Testing
- Lung Clearance Index, MRI with PFP
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
ARF Secondary to COPD Exacerbation, ARF Secondary to Cardiogenic Acute Pulmonary Oedema
HERMES STUDY: Study on the Feasibility and Efficiency of Noninvasive Positive-Pressure Ventilation (NPPV) in Prehospital Care
The purpose of this study is determine if NPPV can be performed in a pre-hospital setting very early after onset of dyspnea with a similar benefit in need of intubation and mortality as in previous study in hospital context and…
- Trial name
- NCT00375154
- Testing
- Noninvasive Positive-Pressure Ventilation (NPPV)
- Where
- 8 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Effectiveness and Feasibility of Delivering an Education Program to Patients With an Acute Exacerbation of COPD
The purpose of this study is to determine if it is effective and feasible to provide a chronic obstructive pulmonary disease (COPD) education program to patients admitted with an acute exacerbation of COPD.
- Trial name
- NCT02321215
- Testing
- Introductory Disease Education
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- West Park Healthcare Centre
Schizoaffective Disorder
α-N-acetylgalactosaminidase in Schizoaffective Disorder
Schizoaffective disorder (SAD) is a severe psychiatric condition characterized by the coexistence of psychotic symptoms and mood episodes.
- Trial name
- NCT07673718
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Chronic Obstructive Pulmonary Disease, Respiratory Failure
NHF vs NIV in Patients With Acute Exacerbation of COPD
Although non-invasive ventilation (NIV) usage has increased significantly over time in COPD exacerbation, a great percentage of patients (~30%) present contraindications to NIV or cannot tolerate it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Acute Exacerbation Copd
- Trial name
- NCT03466385
- Testing
- Nasal High Flow, Non-Invasive Ventilation
- Where
- 3 sites in Greece
- Volunteers
- 498 people
- Sponsor
- Evangelismos Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Decision-making and Optimization of Ventilatory Support for AECOPD Patients
The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- OPTIVENT-COPD (NCT07508943)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sir Run Run Shaw Hospital
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