Clinical trials: Disease Exacerbation
Schizophrenia
Study to Evaluate the Efficacy and Safety of Risperidone ISM® in Patients With Acute Schizophrenia: Open Label Extension
This is the long-term open label extension (OLE) of the study PRISMA-3 (NCT03160521). Those patients who complete participation in the main segment of the study (double blind) together with other clinically stable not previously…
- Trial name
- PRISMA-3_OLE (NCT03870880)
- Testing
- Risperidone ISM 75 mg, Risperidone ISM 100 mg
- Where
- 24 sites in United States, Ukraine
- Volunteers
- 215 people
- Sponsor
- Rovi Pharmaceuticals Laboratories
Irritable Bowel Syndrome, Visceral Hypersensitivity
Gut Permeability, Sensitivity and Symptomatology
To better understand the relationship between gut barrier function and the symptomatology and pathophysiology of irritable bowel syndrome (IBS).
- Trial name
- GPSS (NCT02358564)
- Testing
- Gastrointestinal Permeability Test, Upper Endoscopy, Rectal Barostat and Infusion of Fats
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease, Acute Exacerbation Copd
COPD Exacerbation Blood and Urine Biomarkers Study
This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population.
- Conditions
- Chronic Obstructive Pulmonary Disease, Acute Exacerbation Copd, Alpha-1 Anti-trypsin Deficiency
- Trial name
- NCT03823443
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections
Viral Infections in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
The objectives of the study are to determine the prevalence of respiratory virus infections in COPD patients, during and outside acute exacerbation to explore the impact of these viral infections on the outcome of these patients…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections, Virus Diseases, Lung Diseases, Obstructive
- Trial name
- VICE (NCT00448604)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University Hospital, Geneva
Cystic Fibrosis
PEP and OPEP Devices in Cystic Fibrosis
Cystic fibrosis (CF) is the most common severe autosomal recessive genetic disease in Caucasians. The CFTR (cystic fibrosis transmembrane regulator) gene, which encodes the chloride channel of the epithelial cell membrane, is…
- Trial name
- NCT05801952
- Testing
- Aerobika* OPEP, PARI O-PEP (Flutter), PARI PEP® S System
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
COPD, COPD Exacerbation
Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.
Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube. In ICU, a prolonged duration of invasive mechanical ventilation may be responsible for…
- Conditions
- COPD, COPD Exacerbation, Ventilated Patients, Ventilator-Associated Pneumonia (VAP)
- Trial name
- SLEECOP (NCT06653933)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
COPD
Study on COPD Corticosteroid-induced Hyperglycemia on Clinical Outcome in Patients With COPD
Hyperglycemia is a common complication of corticosteroid (cortisone) therapy. It is estimated that more than a third of patients with chronic pulmonary disease (COPD) exacerbation (16).
- Trial name
- NCT00605007
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Emory University
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD
Patient Factors Associated With Prescription of Antibiotics for Inappropriate Indication in Patients With AECOPD
Up to 90% of consulting Acute Exacerbation (AE) of COPD patients are prescribed an antibiotic(1). Rates of inappropriate antibiotic prescription percentage can be as high as 65%(2).
- Trial name
- NCT03077152
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Bronchitis, Bronchitis, Chronic
A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefaclor, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid onset of…
- Trial name
- NCT00257140
- Testing
- levofloxacin
- Volunteers
- 367 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Chronic Bronchitis
Moxifloxacin Versus Amoxicillin Clavulanic Acid in Treatment of Acute Exacerbation of Chronic Bronchitis
A study to assess the safety and efficacy of moxifloxacin compared to that of amoxicillin-clavulanic acid for the treatment of subjects with acute exacerbation of chronic bronchitis.
- Trial name
- NCT00656747
- Testing
- Avelox (Moxifloxacin, BAY12-8039), Amoxicillin clavulanic acid
- Where
- 220 sites in Andorra, Argentina and 29 more
- Volunteers
- 1,372 people
- Sponsor
- Bayer
Cystic Fibrosis, Primary Ciliary Dyskinesia
Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia
The objective of this study is to compare the lower airways inflammatory response to infection/pulmonary exacerbation among children known to have Primary Ciliary Dyskinesia (PCD) with children known to have Cystic Fibrosis (CF)…
- Trial name
- NCT01155115
- Testing
- Sputum Collection, Pulmonary Function Testing, Exhaled Nitric Oxide
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- The Hospital for Sick Children
Bronchiectasis
Study of Bronchiectasis and Associated Cardiovascular Comorbidities
Effect of cardiovascular comorbidities on disease severity and quality of life in Patients with acute exacerbation of non-cystic fibrosis bronchiectasis
- Trial name
- NCT05783869
- Testing
- Echocardiography
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease
The Characteristic of Airway Microbiome Profiling of COPD-bronchiectasis Overlap Patients and Its Association With Acute Exacerbation
The overlap between chronic obstructive pulmonary disease (COPD) and bronchiectasis is a neglected area of research, and it is not covered by guidelines for clinical practice.
- Conditions
- Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease, Overlap, Microbiome
- Trial name
- NCT04865861
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Chronic Obstructive Pulmonary Disease
Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Combinations of Long-acting β2-agonists (LABA) and Inhaled Glucocorticosteroid (ICS)
The objective of the REACT trial is to investigate the effect of roflumilast 500 μg tablets once daily versus placebo on exacerbation rate and pulmonary function in COPD patients who are concomitantly treated with a fixed…
- Trial name
- REACT (NCT01329029)
- Testing
- Roflumilast
- Where
- 180 sites in Australia, Austria and 19 more
- Volunteers
- 1,945 people
- Sponsor
- AstraZeneca
Bronchitis, Chronic Bronchitis
A Study of the Effectiveness and Safety of High Dose, Short-course Levofloxacin in the Treatment of Acute Bacterial Exacerbation (Worsening) of Chronic Bronchitis.
The purpose of this study is to evaluate the safety and effectiveness of four oral antibiotic treatment regimens for bacterial infections in patients with chronic bronchitis.
- Trial name
- NCT00042718
- Testing
- levofloxacin, azithromycin, amoxicillin/clavulanate
- Volunteers
- 659 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Complex Regional Pain Syndromes
Predicting Pain Exacerbations in Children With Complex Regional Pain Syndrome (CRPS)
objectives: identify physiologic, dietary, and environment triggers of severe pain exacerbations in children with CRPS.
- Trial name
- NCT06337526
- Testing
- Apple Watch v8
- Where
- United States
- Sponsor
- Stanford University
Chronic Obstructive Pulmonary Disease, Physical Activity
Efficacy of a Coaching Program to Promote Physical Activity and Reduce Sedentary Behavior After a COPD Hospitalization
Patients with COPD are more inactive and more sedentary than subjects of the same age and patients with other chronic diseases. This inactivity and sedentary behavior is accentuated after hospitalizations due to a COPD…
- Conditions
- Chronic Obstructive Pulmonary Disease, Physical Activity, Sedentary Lifestyle
- Trial name
- NCT03084874
- Testing
- Physical activity and sedentary behavior coaching program
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Congestive Heart Failure
Peritoneal Ultrafiltration in Cardio Renal Syndrome.
Randomized, controlled, unblinded, adaptive design clinical trial to evaluate the safety and efficacy of PolyCore (Polydextrin, L-Carnitine, D-xylitol) peritoneal ultrafiltration (PUF) in patients with heart failure and reduced…
- Trial name
- PURE (NCT03994874)
- Testing
- PolyCore (Polydextrin, L-Carnitine, D-xylitol)
- Where
- 3 sites in Italy
- Volunteers
- 84 people
- Sponsor
- Iperboreal Pharma Srl
Pulmonary Disease, Chronic Obstructive
Digihaler in Chronic Obstructive Pulmonary Disease (COPD)
This is a multi-center 3-month study to determine the variation in ProAir Digihaler metrics [peak inspiratory flow (PIF), inhalation volume, number of inhalation events] amongst COPD patients in the ambulatory setting.
- Trial name
- NCT05241288
- Testing
- Albuterol eMDPI DS
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Obstructive Pulmonary Disease (COPD)
Exacerbation Self-management in COPD: The ACCESS Study
Aim is to test the effect of ACCESS ("Adaptive Computerized COPD Exacerbation Self-management Support"), a software application designed to support patients with COPD in self-management of exacerbations.
- Trial name
- ACCESS (NCT02553096)
- Testing
- ACCESS
- Where
- Netherlands
- Volunteers
- 87 people
- Sponsor
- Radboud University Medical Center
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